LOCUS       NM_021931               3314 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens DEAH-box helicase 35 (DHX35), transcript variant 1,
            mRNA.
ACCESSION   NM_021931
VERSION     NM_021931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Qiao,Y., Zhu,S., Yang,N., Zou,S.S., Gao,B., Wu,J., Liu,C., Li,X.,
            Liu,Y.J. and Chen,J.
  TITLE     The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated
            innate immunity
  JOURNAL   PLoS Pathog 20 (7), e1012379 (2024)
   PUBMED   39037956
  REMARK    GeneRIF: The RNA helicase DHX35 functions as a co-sensor for
            RIG-I-mediated innate immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Weiland,T., Eckert,A., Tomazic,P.V., Wolf,A., Pondorfer,P.,
            Vasicek,S., Graupp,M., Holzmeister,C., Moser,U., Andrianakis,A.,
            Kangler,G., Kiss,P., Brcic,L., Kappler,M., Wickenhauser,C.,
            Haak,A., Kruger,M., Al-Nawas,B., Blatt,S., Brockmeyer,N.,
            Skaletz-Rorowski,A., Potthoff,A., French,L.E., Charnowski,S.,
            Reinholz,M., Kaufmann,A.M., Thies,S., Lambrecht,H.G., Seliger,B.,
            Wild,D.C. and Thurnher,D.
  TITLE     DRH1 - a novel blood-based HPV tumour marker
  JOURNAL   EBioMedicine 56, 102804 (2020)
   PUBMED   32535546
  REMARK    GeneRIF: DRH1 - a novel blood-based HPV tumour marker.
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   4  (bases 1 to 3314)
  AUTHORS   Gu,J., Chen,M., Shete,S., Amos,C.I., Kamat,A., Ye,Y., Lin,J.,
            Dinney,C.P. and Wu,X.
  TITLE     A genome-wide association study identifies a locus on chromosome
            14q21 as a predictor of leukocyte telomere length and as a marker
            of susceptibility for bladder cancer
  JOURNAL   Cancer Prev Res (Phila) 4 (4), 514-521 (2011)
   PUBMED   21460395
REFERENCE   5  (bases 1 to 3314)
  AUTHORS   Murea,M., Lu,L., Ma,L., Hicks,P.J., Divers,J., McDonough,C.W.,
            Langefeld,C.D., Bowden,D.W. and Freedman,B.I.
  TITLE     Genome-wide association scan for survival on dialysis in
            African-Americans with type 2 diabetes
  JOURNAL   Am J Nephrol 33 (6), 502-509 (2011)
   PUBMED   21546767
REFERENCE   6  (bases 1 to 3314)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 3314)
  AUTHORS   Xu,J., Wu,H., Zhang,C., Cao,Y., Wang,L., Zeng,L., Ye,X., Wu,Q.,
            Dai,J., Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human DDX40gene, a new member of the
            DEAH-box protein family
  JOURNAL   J Hum Genet 47 (12), 681-683 (2002)
   PUBMED   12522690
  REMARK    GeneRIF: human DDX40gene, a new member of the DEAH-box protein
            family shares 53% and 43% amino acid identity with human DDX8 and
            yeast Drh1.DDX40 may play roles in pre-mRNA splicing, ribosome
            biogenesis and other RNA processing functions
REFERENCE   8  (bases 1 to 3314)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA725122.1 and BC033453.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021931.3.
            
            Summary: DEAD box proteins characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of the DEAD box
            protein family are believed to be involved in embryogenesis,
            spermatogenesis, and cellular growth and division. The function of
            this gene product which is a member of this family, has not been
            determined. Alternatively spliced transcript variants have been
            found for this gene. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059369.1, SRR1803615.23579.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252011.8/ ENSP00000252011.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               DA725122.1         7-551
            546-3314            BC033453.1         534-3302
FEATURES             Location/Qualifiers
     source          1..3314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23-q12"
     gene            1..3314
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /note="DEAH-box helicase 35"
                     /db_xref="GeneID:60625"
                     /db_xref="HGNC:HGNC:15861"
     exon            1..64
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2136
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35; DEAH-box
                     protein 35; probable ATP-dependent RNA helicase DHX35;
                     DEAH (Asp-Glu-Ala-His) box polypeptide 35"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX35
                     isoform 1"
                     /protein_id="NP_068750.2"
                     /db_xref="CCDS:CCDS13310.1"
                     /db_xref="GeneID:60625"
                     /db_xref="HGNC:HGNC:15861"
                     /translation="MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAA
                     LSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRV
                     VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVRE
                     MMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRD
                     FFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGD
                     VLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRS
                     VRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAG
                     RGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSP
                     PPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEI
                     LSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQ
                     EHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHST
                     GAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP
                     HFYQQGTHLSLKAKRAKVQDP"
     exon            65..198
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            199..291
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            292..369
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            370..474
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            475..536
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            537..606
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            607..666
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            667..779
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            780..876
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1035
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1246
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1371
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1426
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1522
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1617
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1695
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1825
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1907
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1979
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2091
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..3314
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /note="hexamer: AGTAAA"
     polyA_site      3314
                     /gene="DHX35"
                     /gene_synonym="C20orf15; DDX35; KAIA0875"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgtga ccttttaccc caacatggct gcgcccgtgg gaccggtgaa gttctggcga
       61 cccggtacag aggggccagg tgtaagcatc tctgaagaga gacaaagtct ggctgaaaac
      121 tctgggacaa cggttgttta caacccttat gctgcccttt ccatagagca gcagaggcag
      181 aagctgccgg tattcaagct taggaatcat attttatact tgatagaaaa ttatcagaca
      241 gtggtgattg ttggtgaaac aggatgtggg aagagcacac agattcctca gtaccttgca
      301 gaagccggct ggacagctga aggaagagtg gtaggagtga cccagcctcg aagagtggct
      361 gctgttacag ttgcagggag agtagctgaa gaaaggggtg cagtgctggg ccacgaggtg
      421 ggctactgca tccgctttga tgactgcacc gaccagctgg ccacgagaat taagtttctt
      481 actgatggaa tgctggtcag ggaaatgatg gttgatccgt tgttaacaaa atatagtgtc
      541 atcatgctgg atgaagccca cgagaggacc ttgtacactg acattgccat tggcttgcta
      601 aaaaagattc agaaaaagcg aggggatctt cgattgattg tagcttcagc cactctggat
      661 gcagacaaat tccgggattt ctttaatcaa aatgaaacca gtgatccagc aagggataca
      721 tgtgtgatcc ttacagtgga agggagaaca tttccggtgg atatctttta tctacaaagt
      781 cctgttccag attatatcaa atcaactgtc gaaactgtgg tgaaaattca ccagacagag
      841 ggagacggag acgttttagc atttcttact ggccaggaag aggtagaaac tgttgtgtcg
      901 atgctcatcg agcaggctcg agcactagct cgcactggga tgaagagaca cctccgagtt
      961 ctccccatgt atgcaggact gccttccttt gagcaaatga aagtgtttga aagggtgtca
     1021 cgcagtgtca gaaaggtgat agtggccacc aatgtggcag aaacctctat cacaatcagc
     1081 ggcattgtgt atgtgatcga ctgtggcttt gtgaaactcc gagcctacaa tcccaggaca
     1141 gctattgaat gcttggtggt ggtgccagtc tcccaggcat cagctaatca gcgagcagga
     1201 cgtggtggtc gtagtcgctc gggaaaatgt tatcgccttt atacagagga agcctttgac
     1261 aagttgcctc agtctacggt tcctgagatg cagcgtagta atttggcacc tgtcatcctg
     1321 cagctgaaag cactaggaat tgacaatgtc ctcaggttcc acttcatgtc gccccctcca
     1381 gcacagtcga tggttcaagc cttggagtta ctgtatgctc tgggaggtct ggacaaagac
     1441 tgtcgcctaa ctgaaccgct tggcatgaga attgcagagt ttcctttgaa tcccatgttt
     1501 gccaaaatgc tgcttgaatc aggaaacttc ggctgttctc aggaaattct aagcatcgct
     1561 gccatgatgc agatccagaa tatctttgtg gtccccccaa accagaagtc tcacgcaatt
     1621 cgagtgcacc gtaaatttgc tgtggaggag ggcgaccacc tcactatgct caatatatat
     1681 gaagcattta tcaaacacaa taaggactct aaatggtgtc aggaacattt cctgaattac
     1741 aagggtcttg tcagagctgc gactgtaaga gaacaattga aaaagcttct tgtcaagttt
     1801 caagtgccca ggaagtctag tgaaggtgac ccggatctgg ttctgaggtg cattgtctcc
     1861 ggcttcttcg ccaatgcagc gaggtttcat tctactggag cttataggac catccgtgat
     1921 gaccatgagc tgcacataca ccctgcgtca gtcctctatg cagagaagcc gcctcgctgg
     1981 gtcatctata acgaagttat acagacctcc aagtactaca tgagagatgt gactgccatt
     2041 gaatcggcct ggctgttgga gctggctcca cacttttatc aacaaggaac gcacctgtct
     2101 ctgaaagcca aaagggccaa ggtccaggac ccgtgagagg agcccacagc tacagctgca
     2161 gggactgctg gcgtcctctc ctccatgctg ctgcccctgg tcccaggtgg ggtgagctgg
     2221 caccagctcc tgtggaatgt ttggttgctc tgaagtgggc tgcggcctgt tcattagtcc
     2281 tttcttcccg ctgcccacag catttgcatc cttgctggga tcctggagga ctttgtgcat
     2341 gggcaggcat ccttctgtgc tgcagcgggc agagtgggag ttggctcact cagcacgctc
     2401 actaacccag catgccactt ccagcaggca tgcagtcctg gcccagctct atgggaaaca
     2461 aggaggaaag ttagccactg aaggccaaaa caccatgtgg ggtggacaga gggtttgctg
     2521 ggctggcttt gctttccctg ctggggccac agctgtgtta accaatgagg tctgctgcca
     2581 ggtgtgaaca agcatgtctc tacgaatgaa cgaaacattg gggatctctg ccgaaaccac
     2641 caaagggcat gtctgatggg cacagggtct cccaaaccca gtggcttctg tctgtcctca
     2701 gcccttgtcc ctgtttatct gcagccagga gacttgcaag ggattggtga ttgacagaga
     2761 ggactcgtgc gctgttttgt gttagcagag gatttgtgtt tcacaggtag gcttagcgtc
     2821 ctctcagagt gtagtgccag gtcctggtgc cacgctagct gagcactcag gagagttcat
     2881 cagctcagat cccacagggc ctcctcttta gcaggaattc acaacagttt ggatgcccta
     2941 aacttctgta gctcaggaac atcactggtg tatttgtttt tttgtttgtt tgcttgggtt
     3001 cttgcaagag cgcgtgggga cagttcttcc agcaggcact ggttttgttg ccccagggct
     3061 gctttgctgt gatgatgatt gcatttcaac acatgccaga tgcagatttt ttccccctta
     3121 ctgtttcaat gacctttatt ttaaaaacac atagcttgaa aatttatttt tatactgata
     3181 ttagtttgga tgtgccactt ttggcaccaa acgtgtatgt catttttatt tccattttat
     3241 aaacatgtaa ataatagtga taacttgtta ataatagtaa acctttatac ctaaagtaaa
     3301 tgtcttccct ccca
//
