LOCUS       NM_014681               4338 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DExH-box helicase 34 (DHX34), mRNA.
ACCESSION   NM_014681
VERSION     NM_014681.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4338)
  AUTHORS   Hug,N., Aitken,S., Longman,D., Raab,M., Armes,H., Mann,A.R.,
            Rio-Machin,A., Fitzgibbon,J., Rouault-Pierre,K. and Caceres,J.F.
  TITLE     A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing
            and its function in hematopoietic differentiation
  JOURNAL   RNA 28 (9), 1224-1238 (2022)
   PUBMED   35768279
  REMARK    GeneRIF: A dual role for the RNA helicase DHX34 in NMD and pre-mRNA
            splicing and its function in hematopoietic differentiation.
REFERENCE   2  (bases 1 to 4338)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4338)
  AUTHORS   Lopez-Perrote,A., Hug,N., Gonzalez-Corpas,A., Rodriguez,C.F.,
            Serna,M., Garcia-Martin,C., Boskovic,J., Fernandez-Leiro,R.,
            Caceres,J.F. and Llorca,O.
  TITLE     Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated
            mRNA decay factor DHX34, as evidenced by Cryo-EM
  JOURNAL   Elife 9, e63042 (2020)
   PUBMED   33205750
  REMARK    GeneRIF: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the
            nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4338)
  AUTHORS   Paine,I., Posey,J.E., Grochowski,C.M., Jhangiani,S.N.,
            Rosenheck,S., Kleyner,R., Marmorale,T., Yoon,M., Wang,K.,
            Robison,R., Cappuccio,G., Pinelli,M., Magli,A., Coban Akdemir,Z.,
            Hui,J., Yeung,W.L., Wong,B.K.Y., Ortega,L., Bekheirnia,M.R.,
            Bierhals,T., Hempel,M., Johannsen,J., Santer,R., Aktas,D.,
            Alikasifoglu,M., Bozdogan,S., Aydin,H., Karaca,E., Bayram,Y.,
            Ityel,H., Dorschner,M., White,J.J., Wilichowski,E., Wortmann,S.B.,
            Casella,E.B., Kitajima,J.P., Kok,F., Monteiro,F., Muzny,D.M.,
            Bamshad,M., Gibbs,R.A., Sutton,V.R., Van Esch,H.,
            Brunetti-Pierri,N., Hildebrandt,F., Brautbar,A., Van den
            Veyver,I.B., Glass,I., Lessel,D., Lyon,G.J. and Lupski,J.R.
  CONSRTM   University of Washington Center for Mendelian Genomics,
            Baylor-Hopkins Center for Mendelian Genomics, Telethon Undiagnosed
            Diseases Program
  TITLE     Paralog Studies Augment Gene Discovery: DDX and DHX Genes
  JOURNAL   Am J Hum Genet 105 (2), 302-316 (2019)
   PUBMED   31256877
  REMARK    GeneRIF: Missense mutation in DHX34 gene is associated with
            neurodevelopmental disorder.
REFERENCE   5  (bases 1 to 4338)
  AUTHORS   Melero,R., Hug,N., Lopez-Perrote,A., Yamashita,A., Caceres,J.F. and
            Llorca,O.
  TITLE     The RNA helicase DHX34 functions as a scaffold for SMG1-mediated
            UPF1 phosphorylation
  JOURNAL   Nat Commun 7, 10585 (2016)
   PUBMED   26841701
  REMARK    GeneRIF: DHX34 activates nonsense-mediated mRNA decay by
            functioning as a scaffold for SMG1-mediated UPF1 phosphorylation
            via complex formation with SMG1 and UPF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4338)
  AUTHORS   Hug,N. and Caceres,J.F.
  TITLE     The RNA helicase DHX34 activates NMD by promoting a transition from
            the surveillance to the decay-inducing complex
  JOURNAL   Cell Rep 8 (6), 1845-1856 (2014)
   PUBMED   25220460
  REMARK    GeneRIF: DHX34 promotes mRNP remodeling and triggers the conversion
            from the SURF complex to the DECID complex resulting in NMD
            activation.
REFERENCE   7  (bases 1 to 4338)
  AUTHORS   Longman,D., Hug,N., Keith,M., Anastasaki,C., Patton,E.E., Grimes,G.
            and Caceres,J.F.
  TITLE     DHX34 and NBAS form part of an autoregulatory NMD circuit that
            regulates endogenous RNA targets in human cells, zebrafish and
            Caenorhabditis elegans
  JOURNAL   Nucleic Acids Res 41 (17), 8319-8331 (2013)
   PUBMED   23828042
  REMARK    GeneRIF: DHX34 and NBAS act in concert with core nonsense-mediated
            mRNA decay factors to co-regulate a large number of endogenous RNA
            targets.
REFERENCE   8  (bases 1 to 4338)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 4338)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 4338)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI826597.1, CN307402.1,
            DR762320.1, CF125648.1, AK297692.1 and BU732557.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014681.5.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this DEAD box
            protein family are believed to be involved in embryogenesis,
            spermatogenesis, and cellular growth and division. This gene
            encodes a member of this family. It is mapped to the glioma 19q
            tumor suppressor region and is a tumor suppressor candidate gene.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.129868.1,
                                           SRR1803613.168126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328771.9/ ENSP00000331907.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BI826597.1         35-61
            28-746              CN307402.1         7-725
            747-1403            DR762320.1         149-805
            1404-1935           CF125648.1         74-605
            1936-3823           AK297692.1         129-2016
            3824-4338           BU732557.1         19-533              c
FEATURES             Location/Qualifiers
     source          1..4338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..4338
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="DExH-box helicase 34"
                     /db_xref="GeneID:9704"
                     /db_xref="HGNC:HGNC:16719"
                     /db_xref="MIM:615475"
     exon            1..38
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            39..1020
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..3747
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34;
                     probable ATP-dependent helicase DHX34; DEAH box protein
                     34; DEAH (Asp-Glu-Ala-His) box polypeptide 34; DEAH-box
                     helicase 34"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX34"
                     /protein_id="NP_055496.2"
                     /db_xref="CCDS:CCDS12700.1"
                     /db_xref="GeneID:9704"
                     /db_xref="HGNC:HGNC:16719"
                     /db_xref="MIM:615475"
                     /translation="MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFF
                     REEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDP
                     RYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERA
                     ALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACI
                     SLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVL
                     IVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGR
                     LFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEIS
                     AVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTID
                     GIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESD
                     YDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGA
                     LDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQS
                     SPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMAN
                     LRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLR
                     LQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLA
                     LLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQE
                     LEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTN
                     GDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEED
                     TPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSS
                     TLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHEN
                     TCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV"
     exon            1021..1332
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1587
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1690
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1908
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2083
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2277
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2379
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2622
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2796
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2914
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3021
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3297
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3474
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3613
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..4338
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3892..3897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="hexamer: AATAAA"
     polyA_site      3913
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="major polyA site"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="hexamer: AATAAA"
     polyA_site      4279
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="major polyA site"
     regulatory      4307..4312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
                     /note="hexamer: AATAAA"
     polyA_site      4321
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
     polyA_site      4338
                     /gene="DHX34"
                     /gene_synonym="DDX34; HRH1"
ORIGIN      
        1 gctcttggga ccggaagtta aggcgttcgc ggcgtgtgaa tccagggcct gaaaacccag
       61 aatgaacttg tgtccatccc agagatcact gcagatgtca tgaggtaccc tttgtgtcac
      121 cagctcaagc aggcctctgg ccactttatc atctgtggtg gtcctgtgcc gtgaccagga
      181 ggaaaaatta gctctttgaa gagaaagtag ttctctattg caggcactgg cctcttaaat
      241 tgttgcaggt ggggaatgga tgagaatatt tgttttgggt gatcagaact gagactccta
      301 ttgtggatta gtaacatgcc tcctcctaga acaagggagg gcagggatcg ccgagaccac
      361 caccgggctc ccagcgagga agaggccttg gagaaatggg actggaattg tccagagacg
      421 cgtcgcctct tggaagatgc cttcttccgt gaagaggatt acatccgtca gggttctgag
      481 gaatgtcaga agttttggac cttctttgaa cgcctgcaga gattccagaa tctcaagacc
      541 tccaggaagg aggagaaaga ccctggacag cccaagcaca gcatcccagc gctggccgac
      601 ctacctcgca cttacgaccc acgttaccgc atcaacctct ctgttcttgg ccctgccacg
      661 cggggctctc agggactggg caggcacttg cccgcggaga gagtggctga gttccgccga
      721 gccctgttgc actacctgga ctttggccag aagcaggcat ttgggcgtct ggccaagctg
      781 cagcgtgagc gggcagccct ccccatcgcc cagtatggga accgcatcct gcagacgctg
      841 aaggagcacc aggtggtggt agtggccggt gacaccggct gtggcaagtc cactcaggtg
      901 ccccagtacc tgctggctgc tggcttcagt catgtggcgt gcacccagcc ccggcggatc
      961 gcctgcatct cactggccaa gcgtgtgggc tttgagagcc tcagtcagta tggctcacag
     1021 gtcggctacc agatccgctt tgagagcaca cgttcggcgg ccaccaagat tgtattcctg
     1081 acagtggggc tgctcctgcg acaaatccag cgggaaccca gcctgcccca gtatgaggtc
     1141 ctgattgtgg atgaagtcca tgagcggcat ctccacaacg atttcctcct gggcgtcctc
     1201 cagcgcctgt tgcccacgcg gcctgacctc aaggtcatcc tcatgtcggc caccatcaac
     1261 atctcgctct tctccagcta tttcagcaat gcccctgtgg tacaggtgcc tgggaggctg
     1321 ttccccatca cggttgtgta ccagccgcag gaggcggagc cgaccacgtc caagtcagag
     1381 aagctggacc cgcggccttt cctgagggtg ctggagtcca ttgaccacaa gtacccgcct
     1441 gaggagcggg gtgacctcct cgtcttcctc agcggcatgg cggagatcag cgccgtgctg
     1501 gaggctgccc agacctatgc cagccacacc cagcgctggg tggtactgcc actgcacagc
     1561 gccctgtctg tggccgacca ggacaaggta tttgatgtgg caccccctgg agtccggaaa
     1621 tgcatcctct ccaccaacat tgctgagacc tcagtcacca ttgacgggat ccgcttcgta
     1681 gtagattccg gaaaggtgaa ggagatgagc tacgatccgc aggccaagct gcaacggctg
     1741 caggagttct ggattagtca ggccagcgca gagcagcgga agggccgggc gggccgcacg
     1801 ggccccggag tctgcttccg cctctatgcc gaatcggact atgatgcctt cgccccctac
     1861 cccgtcccag aaattcggag ggtggccctg gactcgttgg tgctgcagat gaagagcatg
     1921 agtgtggggg acccccgaac cttccccttc atcgagcccc caccaccagc cagcctggaa
     1981 accgccatcc tctacctccg ggaccagggg gccctggaca gctcagaggc cctcacaccc
     2041 attgggtccc tgctagccca gctgcctgtg gacgttgtga ttgggaagat gctgatcctg
     2101 ggctccatgt tcagcctggt ggagcctgtg ctcaccatcg cagccgcact tagcgtccag
     2161 tcgcccttca cccgcagcgc ccagagcagc ccagagtgcg cggcagcacg gcggccgctg
     2221 gagagcgacc agggtgaccc cttcacgctc ttcaacgtct tcaacgcctg ggtgcaggtg
     2281 aaatctgaac ggagcagaaa ctctcgcaag tggtgccgcc gccggggcat agaggagcat
     2341 cgactgtacg aaatggccaa ccttcggcgc cagttcaagg agctgttgga ggaccacggg
     2401 ctgctggctg gggcccaggc cgcgcaggta ggggacagct acagtcggtt gcagcagcgc
     2461 cgggagcgcc gggccctgca ccagctgaaa cgccagcacg aggagggcgc ggggcgcagg
     2521 cgcaaggtgc tgcggctgca ggaggagcag gacggcggct ccagtgacga ggacagggct
     2581 ggcccagccc ccccaggggc cagtgatggc gtggacatcc aggatgtgaa gttcaagctt
     2641 cggcatgacc tggcgcagct gcaggccgct gccagctcag cccaggacct gagccgcgag
     2701 cagctggctc tgctgaagct ggtgctgggc cggggcctgt acccacagct ggccgtcccc
     2761 gacgccttca acagcagccg aaaggactca gaccagattt tccacacgca ggccaagcag
     2821 ggcgccgtgc tgcaccccac ctgcgtcttc gctggcagcc ccgaggtgct gcacgcacag
     2881 gagctggagg ccagcaactg cgacggaagc cgagacgaca aggacaagat gagcagcaaa
     2941 caccagctcc tcagcttcgt gtccctgctg gagaccaaca agccgtacct ggtgaactgc
     3001 gtccgcatcc ctgccctcca gtccctcctg ctttttagcc ggtctttgga caccaatggt
     3061 gactgctccc gcctggtggc cgatggctgg ctggagctgc agctagcaga cagtgaaagt
     3121 gccatccgac tcctggcggc ttccctgcgg ctccgtgccc gctgggaaag tgccctggac
     3181 cggcagctgg cgcaccaggc ccagcagcag ctggaggagg aggaggagga tacgccagtc
     3241 agccccaagg aggtggccac cctgagcaag gaactcctgc aattcacggc atccaagatt
     3301 ccttacagcc tccggcggct cacagggcta gaagtccaga acatgtatgt gggaccccag
     3361 accatcccag ccacccccca tcttcctggc ctctttggca gctccaccct gtccccccac
     3421 cccacaaagg ggggctacgc agtcactgac ttcctcacct acaactgcct cacgaatgac
     3481 acagacctgt acagcgactg tctccgaacc ttctggacct gcccccactg tggcctgcat
     3541 gcgcccctca cgcccctgga gcgcatcgcc catgagaaca cctgccccca ggccccacag
     3601 gatgggcccc caggggctga ggaagctgcc ctcgaaaccc tccagaagac atctgtcctg
     3661 cagaggccct accactgcga ggcctgcggg aaggacttcc tctttacacc cacagaggtg
     3721 ctgcgccacc ggaagcagca cgtgtgagct gggccaggag ccctgcccac ctccgtgcag
     3781 ctgacctgcc ctccagccca ggactagggg caggactctt gcctgaaccc ccagcctggg
     3841 cttagccctg tggtcctgtc ccagtgcaga gggcctggag cacggattgt gaataaagcc
     3901 tcacatgctg atacacactg ttaggcctgc acctgcccat ccagaaagca gcagctgcct
     3961 tgttagtcct ccccagggtc tagctttcct tcttcctgct gcagggtgct gcctgagggg
     4021 tcctgggtag gaggggcgtt agagccagca gggacctccc atgtctccag attccaggtg
     4081 caggttctta gcacctccgc agccgctctc tcttgagtcc atcctcagtc tctcctaccc
     4141 cttgaagtag ggggaccctg aatttgccca tccacctggg tcactttgag agttgtgcag
     4201 gggggctggg agcactggtg ttcacgtggg accacaggct gcaccataag acccactcac
     4261 aataaaaaaa taaaaggccg agccgggcat ggttgctcac tcccgtaata aaaaaataaa
     4321 agaacaggct gagccggg
//
