LOCUS       NM_020162               5535 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DEAH-box helicase 33 (DHX33), transcript variant 1,
            mRNA.
ACCESSION   NM_020162
VERSION     NM_020162.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5535)
  AUTHORS   Wang,X., Chen,S., Wen,F., Zeng,Y. and Zhang,Y.
  TITLE     RNA helicase DHX33 regulates HMGB family genes in human cancer
            cells
  JOURNAL   Cell Signal 110, 110832 (2023)
   PUBMED   37543097
  REMARK    GeneRIF: RNA helicase DHX33 regulates HMGB family genes in human
            cancer cells.
REFERENCE   2  (bases 1 to 5535)
  AUTHORS   Ding,J., Zhou,J., Shen,X., Zhang,M., Feng,X. and Xu,Z.
  TITLE     Systematic analysis of the prognostic and immunological role of
            DHX33 in pan-cancer
  JOURNAL   Environ Toxicol 38 (8), 2011-2021 (2023)
   PUBMED   37256545
  REMARK    GeneRIF: Systematic analysis of the prognostic and immunological
            role of DHX33 in pan-cancer.
REFERENCE   3  (bases 1 to 5535)
  AUTHORS   Zhang,X., Shao,Y., Zhou,Y., Zhu,Z. and Wang,X.
  TITLE     Comprehensive analysis of immune implication and prognostic value
            of DHX33 in sarcoma
  JOURNAL   Medicine (Baltimore) 102 (17), e33654 (2023)
   PUBMED   37115050
  REMARK    GeneRIF: Comprehensive analysis of immune implication and
            prognostic value of DHX33 in sarcoma.
REFERENCE   4  (bases 1 to 5535)
  AUTHORS   Zhang,Y., Chen,S. and Peng,C.
  TITLE     GSK-3beta phosphorylation of DHX33 leads to its ubiquitination
            mediated protein degradation
  JOURNAL   Cell Signal 101, 110526 (2023)
   PUBMED   36403931
  REMARK    GeneRIF: GSK-3beta phosphorylation of DHX33 leads to its
            ubiquitination mediated protein degradation.
REFERENCE   5  (bases 1 to 5535)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5535)
  AUTHORS   Zhang,Y., Forys,J.T., Miceli,A.P., Gwinn,A.S. and Weber,J.D.
  TITLE     Identification of DHX33 as a mediator of rRNA synthesis and cell
            growth
  JOURNAL   Mol Cell Biol 31 (23), 4676-4691 (2011)
   PUBMED   21930779
  REMARK    GeneRIF: we show the mechanistic importance of DHX33 in rRNA
            transcription and proliferation
REFERENCE   7  (bases 1 to 5535)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5535)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   9  (bases 1 to 5535)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5535)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295760.1, AC004148.1 and
            BQ775963.1.
            
            On Nov 24, 2018 this sequence version replaced NM_020162.3.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            The DEAD box proteins are characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this DEAD box
            protein family are believed to be involved in embryogenesis,
            spermatogenesis, and cellular growth and division. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025625.1, SRR1803612.231335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225296.8/ ENSP00000225296.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-803               AK295760.1         79-881
            804-804             AC004148.1         88646-88646         c
            805-1658            AK295760.1         883-1736
            1659-1659           AC004148.1         77934-77934         c
            1660-2443           AK295760.1         1738-2521
            2444-4833           AC004148.1         69158-71547         c
            4834-5535           BQ775963.1         23-724              c
FEATURES             Location/Qualifiers
     source          1..5535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..5535
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /note="DEAH-box helicase 33"
                     /db_xref="GeneID:56919"
                     /db_xref="HGNC:HGNC:16718"
                     /db_xref="MIM:614405"
     exon            1..412
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2247
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33; putative
                     ATP-dependent RNA helicase DHX33; DEAH box protein 33;
                     DEAH (Asp-Glu-Ala-His) box polypeptide 33"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX33 isoform 1"
                     /protein_id="NP_064547.2"
                     /db_xref="CCDS:CCDS11072.1"
                     /db_xref="GeneID:56919"
                     /db_xref="HGNC:HGNC:16718"
                     /db_xref="MIM:614405"
                     /translation="MPEEAGFPPAKRFRPGSGPPSRAGSFPPGRQVVMLLTAGSGGRG
                     GGGGRRQQPPLAQPSASPYPEAVELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSG
                     KTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDV
                     TSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRK
                     ELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQVFYTKQPQNDYLHAALV
                     SVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYA
                     QQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQ
                     RVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMK
                     VPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAK
                     TILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIY
                     RTFKNLGGNKDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCL
                     AHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDL
                     CVIDAQWLYEAAPEYFRRKLRTARN"
     exon            413..573
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            574..801
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            802..972
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1158
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1270
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1430
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1519
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1647
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1851
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1938
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..5535
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5517..5522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /note="hexamer: ATTAAA"
     polyA_site      5535
                     /gene="DHX33"
                     /gene_synonym="DDX33"
                     /note="major polyA site"
ORIGIN      
        1 ggtggtcgcc gggagccgcc agcacgtggc ggcgaggaag gggcggtgtg ctcctgttgt
       61 ctgcacctga gagggggcag gagctctcgg cgcttgcgcc tcccgccgcg gtgccctccc
      121 gacatgccgg aggaggcggg cttcccgccg gccaagagat tccggccagg ctctggacct
      181 ccgagccgcg ctgggtcctt ccctcccggg aggcaagtgg tgatgctgct gactgcgggc
      241 agcggcggca gaggaggagg aggaggccgg aggcagcagc cgcccctggc ccagccctcg
      301 gccagtccct accctgaagc tgtggagctg cagcgccgga gtctgcccat cttccaagcg
      361 cgggggcaac tgttggccca gctccgaaac ctggacaacg cggtcctcat cggggaaact
      421 ggctctggga agacaactca gatccctcag tacctgtatg aaggagggat cagccgccag
      481 ggcatcattg ctgtgaccca gcctcgtcga gtagctgcca tctctcttgc tactagagtc
      541 tcagatgaga agagaactga acttgggaag ctggttggct atacagtgcg ctttgatgat
      601 gtcacctcag aagacaccag gatcaagttt ctgacagatg gcatgcttct gcgtgaagca
      661 atttcagact ctttgcttcg gaaatacagc tgtgtcattt tggatgaagc tcacgaacgg
      721 actatccaca cagatgtgct ctttggagtg gtgaaagctg cacagaagag gagaaaggaa
      781 ctcgggaaac ttcctctgaa agtgattgtg atgtcagcta cgatggatgt ggacctgttc
      841 tctcagtatt tcaatggcgc ccccgtcctc tacctagagg gtcggcagca tccgatccag
      901 gtgttttaca ccaaacagcc tcagaatgat tacctgcacg ccgcgcttgt ctccgtcttc
      961 cagatccacc aggaagcccc ttcttcacag gacatcctgg tgttcctcac tgggcaggag
     1021 gagatcgaag ccatgagcaa gacgtgccga gacattgcaa agcacctccc agacggctgc
     1081 cctgcgatgc tggtccttcc tctgtacgcc tccctgccct atgcacagca gctccgagtc
     1141 ttccaagggg ccccaaaggg ctatcgcaaa gtgatcattt caaccaacat cgctgaaacc
     1201 tccataacca ttacaggaat aaaatatgta gttgacacgg gcatggttaa agcaaagaag
     1261 tataaccctg acagtggtct tgaggtgtta gcagtgcagc gggtatcgaa gacgcaggct
     1321 tggcagcgca cagggagggc tggcagagag gacagtggca tctgctaccg gctctacacg
     1381 gaggacgagt ttgagaagtt tgataagatg accgtgccag agatccagag gtgtaacctg
     1441 gccagtgtga tgcttcagct tctagcaatg aaagtcccaa atgtgctcac ctttgacttc
     1501 atgtcgaagc catctccaga tcacattcag gcggccattg cccaactgga cctgttaggt
     1561 gctcttgaac ataaggatga ccagcttacc ctgactccaa tgggaagaaa gatggcagca
     1621 tttcctttag aacccaaatt tgccaaaacc atcctcatgt cccccaaatt ccactgtaca
     1681 gaggagatcc tgaccattgt ctccctgctg tctgtggaca gcgtcctcca caaccctcct
     1741 tcccggcgag aggaagtgca aggggtccgc aagaagttca tatccagcga gggggatcac
     1801 atgaccctgc tcaatatcta tcggaccttc aaaaacctag gcggaaataa ggattggtgc
     1861 aaagagaatt ttgtcaacag caagaatatg acgctggtag cagaagtcag agcacagctg
     1921 agggacatct gcttaaagat gtcaatgcca atcgcatcat cccgaggaga cgtggagagt
     1981 gtccgccgct gcctggctca cagcctcttc atgagcaccg ccgagcttca gccagatggc
     2041 acctatgcca ccacggacac ccaccagcca gtggccatcc acccgtcgtc tgtcctcttc
     2101 cactgcaagc cggcctgcgt cgtgtacact gagctgctct acaccaacaa gtgctacatg
     2161 cgggacctct gcgtcataga tgcacagtgg ctgtacgagg ctgcccctga gtactttagg
     2221 aggaagctga gaaccgccag aaactgagcc gccccaggat gccgccagaa tcactggtcc
     2281 ctgggagctt ggactacagt tgtccttaca gcaggcttcc aggttggcgc ttagagaagc
     2341 cttggaatca gctgaaggtg cctgacttcc aggagcgtga aagcatcttt gctcaactcc
     2401 tgggactgaa ccatatagac atggacatat catttgtacc tggaaacctc aaaattatgc
     2461 ttttggttct tactgggtga ctttgactta atttaacacc tgagcctcag ttttctcatc
     2521 tgccaaatgg gagtaataat aataatcctt ataaaattgg gttcataaag tttagagaaa
     2581 aggaatggaa agtacccaga actatgcctg gagcacgcac gacacacgta cagtgagttg
     2641 ggagccgtta ggctgaatgt tactgcttgc catatgatgt gaagtacagc aatatcccaa
     2701 gttcttgtga ctgagggaga ttttctggaa gggccacagg aggttgcgga gcttggatgt
     2761 tgcccttagt tcttgtttaa tgtctctctg aatgcagttt taaaatagaa aacaaaactg
     2821 acttctgtag aagtttccag agggaggtgc tgttatctcg tacctcctgg gatggcgatc
     2881 cctactgaac gcttgtgtct cagggtggac cactctgtgt ctgtctccaa gcagagacca
     2941 gtaaaggagc ctcctggtcc tcagtgcgtg accctgtcag tgctttcagg agacatgtaa
     3001 gcttcctggg tgaaggttga tttgtacctt ctgaatcctg tcacgtgtag acatgggaaa
     3061 ctgacctatc agtgttttgt gtgtgtaggt gactcccaca tacacagttg ccatttttct
     3121 ctctaactgg gcaccagtga acatgcgggc atgaggagtg actgtgtacc atttcagctg
     3181 tttcttttcg ggcagtcccc tggtcagagg gggtgggggt gggggagggg agaggggtac
     3241 ctagaaccca gagaacattg gcttatgcca gataccacac cacatctggg cttacattct
     3301 tgtatctttt ttggtgtgtg ggcggggggg gtggggggca gttcagtgaa gtctagaaga
     3361 cctgctggac aaattctaaa agagctagag ctgtaacact tattcttgca tcttattaat
     3421 tttctatgat attttttcct tcttcgtagg gacttgggac aatctggctt tgctgctttc
     3481 taactgctag gcacctctct ctaaccctca ttgtcagagg gaattggagg atatccacag
     3541 tctgttcctg ttctgatatt ctgagcagag aaaaggcact aacggttcct cttagctatt
     3601 taattatcag aagcaagtaa tctttcccca gataatattt tgccctagaa gaagccgtga
     3661 tttagctctt ttattgtgct tacttggtcc aaatacatct gtggggtgtt ttgtcatttc
     3721 ttaatgaatg aatcatagtt ataaccaggg gccaagctgc ccaagaggct cttcagagat
     3781 catggatgct ctctttctgg aagctgtggc ctgatggagc agccccattc cagggtccca
     3841 tctgtccgga gttgtgtatg tcaagtccgg ctcagtcttt atttccaaca ctagccgtgg
     3901 tcctgtgcag tcaagctctc agctagtgtt tagggctgtc tgtcagaaat ggttatacgt
     3961 gggcaaaaga agatctgaca gctcctatat accttatctt actgaattct taaactttga
     4021 accagttctt ccacttactg acttgttacc actgctgact ttctgaaaag ttttccagtt
     4081 tttgtttttt gttttttgtt ttccagtagg ggattagaat gtttagtcct acttagtaag
     4141 aaaaatattg tatttttaat cattcatagt gctggtaaaa aaaaaaaaaa aaaaaaaaaa
     4201 attggggggt ggccgggcgc agtggctcac acctgtaatc ccagcacttt gggaggccaa
     4261 ggcgggcgga tcacctcatg cctgtaatcc cagcattggg atgggaggct gaggtgggtg
     4321 gattgcttga gaagttcaag accagcctgg ccaacatggc aaaaccccgt ctctactaaa
     4381 aatagaaaac ttagctgggc atggtggcac acgcctgtaa tcccagctac cggggaggct
     4441 gaggcacaag aattgcttga acttgggagg cagagtttgt agtgagccaa gatcacgcca
     4501 ctgcattcca gcctggccga cagtgtgaga cggtctcaga aaaaaaaaga aagaaagaaa
     4561 gaaaaagaaa aaacttgggg taatttatgt ccagcttaag tacctgaaca gtttccggaa
     4621 atgtatattt tttttctgag aggcaaagga tgtaaacagc ttctaagtag ctttaatgtt
     4681 tctgtacaga aataagttta tccctgtaac attgtggtag agttttaata cagtatttag
     4741 ttttttattg ggctttttta aaaagttaac ttttaacata gctgctcagg gattaaatca
     4801 gattggaaaa cccattctga ctccacatac tgctacaaag aaatacatcg ttgtttatat
     4861 tgagctgcag gagatagtac actttaaact taagaaagtt aaatgtttca caataacatt
     4921 gcaatataat cttcagctac tctctttcca ttggtaaaat ctctgatggt gtgataactc
     4981 tttgccaacc tacgaaaccc atatctggaa gaatcaccag ctcccgtgag cagcttcatg
     5041 taaatagatg cactccaagc agattgcatg cctcaggtgt ttgtcttcta gtaatcatgg
     5101 agtgtgcaac acccagagta acactacaag gggcaggact gcaaacagca ggtcctggct
     5161 aaaaaccctt aatgctgcat tgctgccagt tgtaaagaga tgcctgaatg gaggcaagtt
     5221 ctgccctgtg ggtgaaactg atgatgtact gtactgtcat atataaatcc actaaatcca
     5281 gctaccagga actgcctgga actgtggcca tgcatttttt tttttcttta aagaccagtg
     5341 tgatagtagg ccatgcatct gagatacgat attccttggt aactagaggg agaaaaaaaa
     5401 atcaagtagg ttcaggctta tgttgtattt tgagagtctg gttttatttg aacagaaata
     5461 actctacaga aagctcttgt aaataatgct caaatttgca cccgacgatc aaatccatta
     5521 aaaatgaatc ttgta
//
