LOCUS       NM_019030               4664 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DExH-box helicase 29 (DHX29), transcript variant 1,
            mRNA.
ACCESSION   NM_019030
VERSION     NM_019030.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Sweeney,T.R., Dhote,V., Guca,E., Hellen,C.U.T., Hashem,Y. and
            Pestova,T.V.
  TITLE     Functional role and ribosomal position of the unique N-terminal
            region of DHX29, a factor required for initiation on structured
            mammalian mRNAs
  JOURNAL   Nucleic Acids Res 49 (22), 12955-12969 (2021)
   PUBMED   34883515
  REMARK    GeneRIF: Functional role and ribosomal position of the unique
            N-terminal region of DHX29, a factor required for initiation on
            structured mammalian mRNAs.
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Bayat,A., Bayat,M., Broers,C., Polstra,A.M., Zwijnenburg,P.J.G. and
            Hjortshoj,T.D.
  TITLE     5q11.2 deletion syndrome revisited-Further narrowing of the
            smallest region of overlap for the main clinical characteristics of
            the syndrome
  JOURNAL   Am J Med Genet A 185 (12), 3844-3850 (2021)
   PUBMED   34322994
  REMARK    GeneRIF: 5q11.2 deletion syndrome revisited-Further narrowing of
            the smallest region of overlap for the main clinical
            characteristics of the syndrome.
REFERENCE   3  (bases 1 to 4664)
  AUTHORS   Zhu,Q., Tan,P., Li,Y., Lin,M., Li,C., Mao,J., Cui,J., Zhao,W.,
            Wang,H.Y. and Wang,R.F.
  TITLE     DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific
            antiviral immunity
  JOURNAL   PLoS Pathog 14 (2), e1006886 (2018)
   PUBMED   29462185
  REMARK    GeneRIF: A critical role for DHX29 in innate immune response;
            molecular insights into the mechanisms by which DHX29 recognizes 5'
            structured EMCV RNA and interacts with MDA5 for potent type I
            interferon signaling and antiviral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4664)
  AUTHORS   Pisareva,V.P. and Pisarev,A.V.
  TITLE     DHX29 and eIF3 cooperate in ribosomal scanning on structured mRNAs
            during translation initiation
  JOURNAL   RNA 22 (12), 1859-1870 (2016)
   PUBMED   27733651
  REMARK    GeneRIF: DHX29 and eIF3 cooperate in scanning on structured mRNAs.
            Our findings support previous genetic data on the role of eIF3
            during scanning
REFERENCE   5  (bases 1 to 4664)
  AUTHORS   Pisareva,V.P. and Pisarev,A.V.
  TITLE     DHX29 reduces leaky scanning through an upstream AUG codon
            regardless of its nucleotide context
  JOURNAL   Nucleic Acids Res 44 (9), 4252-4265 (2016)
   PUBMED   27067542
  REMARK    GeneRIF: DHX29 is another example of an initiation factor
            contributing to start codon selection.
REFERENCE   6  (bases 1 to 4664)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4664)
  AUTHORS   Parsyan,A., Shahbazian,D., Martineau,Y., Petroulakis,E., Alain,T.,
            Larsson,O., Mathonnet,G., Tettweiler,G., Hellen,C.U., Pestova,T.V.,
            Svitkin,Y.V. and Sonenberg,N.
  TITLE     The helicase protein DHX29 promotes translation initiation, cell
            proliferation, and tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 106 (52), 22217-22222 (2009)
   PUBMED   20018725
  REMARK    GeneRIF: Down-regulation of DHX29 leads to impaired translation,
            resulting in disassembly of polysomes and accumulation of mRNA-free
            80S monomers. DHX29 depletion also impedes cancer cell growth in
            culture and in xenografts.
REFERENCE   8  (bases 1 to 4664)
  AUTHORS   Pisareva,V.P., Pisarev,A.V., Komar,A.A., Hellen,C.U. and
            Pestova,T.V.
  TITLE     Translation initiation on mammalian mRNAs with structured 5'UTRs
            requires DExH-box protein DHX29
  JOURNAL   Cell 135 (7), 1237-1250 (2008)
   PUBMED   19109895
  REMARK    GeneRIF: Study reports that these 7 eIFs are not sufficient for
            efficient 48S complex formation on mRNAs with highly structured
            5'UTRs, and that this process requires the DExH-box protein DHX29.
REFERENCE   9  (bases 1 to 4664)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 4664)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB122058.1, BX649135.1,
            AY036974.1 and AL834496.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019030.3.
            
            Summary: This gene encodes a member of the DEAH (Asp-Glu-Ala-His)
            subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box
            family of RNA helicases. The encoded protein functions in
            translation initiation, and is specifically required for ribosomal
            scanning across stable mRNA secondary structures during initiation
            codon selection. This protein may also play a role in sensing
            virally derived cytosolic nucleic acids. Knockdown of this gene
            results in reduced protein translation and impaired proliferation
            of cancer cells. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.172947.1,
                                           SRR1660809.85794.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251636.10/ ENSP00000251636.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB122058.1         29-29
            2-1010              BX649135.1         2-1010
            1011-2086           BX649135.1         1012-2087
            2087-4260           BX649135.1         2175-4348
            4261-4474           AY036974.1         4235-4448
            4475-4664           AL834496.1         2741-2930
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..4664
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /note="DExH-box helicase 29"
                     /db_xref="GeneID:54505"
                     /db_xref="HGNC:HGNC:15815"
                     /db_xref="MIM:612720"
     exon            1..308
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..4231
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29; nucleic
                     acid helicase DDXx; ATP-dependent RNA helicase DHX29; DEAH
                     box protein 29; DEAH (Asp-Glu-Ala-His) box polypeptide 29;
                     DEAH-box helicase 29"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX29 isoform 1"
                     /protein_id="NP_061903.2"
                     /db_xref="CCDS:CCDS34158.1"
                     /db_xref="GeneID:54505"
                     /db_xref="HGNC:HGNC:15815"
                     /db_xref="MIM:612720"
                     /translation="MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSR
                     PATAAAAAAGSREPRVKQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVI
                     NEHKKQNNDKGMISGRLTAKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALD
                     WLCLNLSDDALPEGFSQEFEEQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKP
                     KKEEKNMEVNMKEWILRYAEQQNEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKE
                     QAATFKLEKNKQGQKEAQEKIRKFQREMETLEDHPVFNPAMKISHQQNERKKPPVATE
                     GESALNFNLFEKSAAATEEEKDKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKNLP
                     KSPNPSFEKVPVGRYWKCRVRVIKSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVK
                     GQSVHQLLPPTYRDVWLEWSDAEKKREELNKMETNKPRDLFIAKLLNKLKQQQQQQQQ
                     HSENKRENSEDPEESWENLVSDEDFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLL
                     KERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCN
                     IVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGV
                     LLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSE
                     KFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKDSEYCQKFLEEEEEVTINV
                     TSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYMNPHKINLDLILELLAY
                     LDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKVIALHSILSTQDQAA
                     AFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSK
                     ASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSP
                     EDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNVKIGKMLIF
                     GAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYNAYLGWK
                     KARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWEGNRA
                     SQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSSVN
                     RDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQ
                     APVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN"
     exon            309..382
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            383..496
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            497..626
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            627..772
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            773..901
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1028
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1187
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1353
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1477
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2086
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2230
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2407
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2548
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2693
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2811
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2896
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2985
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3114
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3190
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3415
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3552
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3646
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3949
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4081
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4178
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4664
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4452..4457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /note="hexamer: AATAAA"
     polyA_site      4474
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /note="major polyA site"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX29"
                     /gene_synonym="DDX29"
                     /note="hexamer: ATTAAA"
     polyA_site      4664
                     /gene="DHX29"
                     /gene_synonym="DDX29"
ORIGIN      
        1 gagaagcccg gatcgaagcg cagggtggca gccccggagc cggggaatgt gaagagctct
       61 cggctgtgca gtggtaccgt cggggcctgg gccgcgaagg atcttctgcc acagctgcaa
      121 catgggcggc aagaacaaga aacacaaggc tccagcggcc gcggtggtcc gggccgccgt
      181 gtctgcttcc agagccaaat ctgccgaggc tggaattgcc ggggaggccc aaagcaagaa
      241 gccagtgtcc aggccggcca ccgctgccgc tgccgctgcc ggctccaggg agccccgtgt
      301 caagcaaggt ccaaaaattt atagttttaa ttctacaaat gattctagtg gtcctgcaaa
      361 tctggataaa tctattttga aagtggtaat taataacaaa ctagagcaaa gaattattgg
      421 agtgatcaat gagcataaaa agcaaaataa tgacaaagga atgatttctg gaagacttac
      481 tgccaaaaaa ttgcaggatt tatacatggc tttacaagca ttttcattta agacaaagga
      541 cattgaagat gccatgacca atacactctt atatggaggt gaccttcatt ctgccttgga
      601 ttggctctgt ttaaaccttt cagatgatgc acttcctgaa ggattcagtc aggaatttga
      661 agagcagcaa cctaaaagta ggcctaaatt tcagtctcct caaatacaag ccactatttc
      721 acctccattg caacctaaaa caaaaacata tgaagaggac cctaagagta agccaaaaaa
      781 ggaagaaaaa aatatggaag taaatatgaa agagtggatt ttacgatatg ctgaacaaca
      841 aaatgaagaa gaaaagaatg agaattctaa aagtttagaa gaggaggaaa aatttgaccc
      901 taatgaaagg tacttacatc ttgcagcaaa actgctggat gcaaaagaac aagcagctac
      961 ctttaaacta gaaaaaaaca agcaaggcca aaaagaggct caggaaaaaa taaggaaatt
     1021 tcaaagagaa atggaaactt tagaagacca tccagtattt aacccagcca tgaagatttc
     1081 acatcaacaa aatgaaagga aaaagcctcc tgtagccaca gaaggagaaa gtgcattgaa
     1141 ttttaattta tttgaaaaat ctgcagctgc tactgaagaa gagaaagata aaaagaaaga
     1201 acctcatgat gtaagaaatt ttgactatac tgctcgaagt tggactggaa aatctcccaa
     1261 acaatttctg attgattggg tcaggaagaa tcttcccaag agtccaaatc cttcctttga
     1321 aaaagttcca gtaggtagat actggaaatg tagggttagg gtaatcaagt ctgaagatga
     1381 tgtcctggta gtatgcccta caatcttaac agaagatggc atgcaagctc agcacctggg
     1441 agctacttta gccctttacc gtttagttaa agggcagtca gttcatcagt tacttcctcc
     1501 cacttaccga gatgtttggc tggagtggag tgatgcagaa aagaaaaggg aagaattaaa
     1561 taaaatggaa accaataaac cacgtgatct ttttattgcc aaacttctga ataaactgaa
     1621 acagcagcaa cagcagcaac aacagcattc tgaaaataag agagaaaact ctgaagatcc
     1681 cgaggaatct tgggaaaatt tagtttcgga tgaggatttt tctgcactgt ccttggaatc
     1741 agcaaatgtg gaagatttgg aacctgttag aaacctcttt agaaagttgc aaagcacacc
     1801 taagtatcag aaacttctaa aggaaagaca acagctacct gtatttaaac atcgggactc
     1861 aattgttgaa actcttaaaa ggcatcgggt agtggttgtg gcaggtgaaa cagggagtgg
     1921 taaaagtact caggtaccac attttctatt ggaagatttg cttctaaatg agtgggaagc
     1981 aagtaaatgt aacattgtct gtacccaacc ccgaagaatc tcagcagtta gtttagccaa
     2041 cagagtatgt gatgaattgg gctgtgaaaa tggacctgga ggaaggaatt ccttgtgtgg
     2101 atatcagatc cggatggaat ctcgagcttg tgaatctacc aggttactct attgtacaac
     2161 aggggttttg ctaaggaaac ttcaagaaga tggtcttcta agtaatgtgt ctcatgttat
     2221 tgtagatgag gttcatgaaa gaagtgtcca gtcagacttc ctactaatta tcttgaagga
     2281 aattttacag aaacgttctg atctacactt gattctaatg agtgccactg tggacagcga
     2341 aaaattttct acatatttca cacactgccc cattctcaga atttcaggaa gaagttatcc
     2401 tgttgaggtt tttcatcttg aagatataat agaagaaaca ggctttgtac tggaaaaaga
     2461 ctcagaatat tgtcagaaat ttctggaaga ggaagaagaa gtaaccatta atgttacaag
     2521 caaagcaggg ggaataaaaa aatatcagga atacatccca gttcagactg gagcacatgc
     2581 tgatttaaat ccattttacc aaaagtacag cagccgcact cagcatgcta ttctatacat
     2641 gaatcctcat aaaatcaacc tggatctcat tttggaactt cttgcatact tagataaaag
     2701 tccccaattc agaaatattg aaggagcagt attgatcttt ttaccaggac ttgctcatat
     2761 tcagcagttg tatgatcttc tatcaaatga tagaagattt tattctgaac gatataaagt
     2821 gatagctctg cattctattc tttcaaccca agatcaagct gcagcattca cacttccccc
     2881 tccaggagtc aggaagattg ttttagcaac caatattgca gagacgggta tcactattcc
     2941 tgatgttgta tttgtaattg atactggaag aacaaaagaa aataagtacc atgaaagcag
     3001 tcagatgagt tctttggtgg agacgtttgt cagtaaagcc agtgctttgc agcgccaggg
     3061 aagagctggg cgggtcagag atggcttctg tttccgaatg tacacaagag aaagatttga
     3121 aggctttatg gattattctg ttcctgaaat cttacgtgta cctttggagg aattatgcct
     3181 tcatattatg aaatgtaatc ttggttctcc tgaagatttc ctctccaaag ccttagatcc
     3241 tcctcagctc caagtgatca gcaatgcaat gaatttgctc cgaaaaattg gagcttgtga
     3301 attaaatgag cctaaactga ctccgttggg ccaacacctt gcagctttac ctgtgaatgt
     3361 caagattggc aagatgctta tttttggtgc catatttggc tgccttgacc cagtggcaac
     3421 actagctgca gttatgacag agaagtctcc ttttaccaca ccaattggtc gaaaagatga
     3481 agcagatctt gcaaaatcag ctttggccat ggcggattca gaccacctga cgatctacaa
     3541 tgcatatcta ggatggaaga aagcacgaca agaaggaggt tatcgttctg aaatcacata
     3601 ctgccggagg aactttctta atagaacatc actgttaacc ctagaggatg taaagcagga
     3661 gttaataaag ttggttaagg cagcaggatt ttcatcttcc acaacttcta ccagctggga
     3721 aggaaacaga gcctcacaga ccctctcatt ccaagaaatt gcccttctta aagctgtact
     3781 ggtggctgga ctgtatgaca atgtggggaa gataatctat acaaagtcag tggatgttac
     3841 agaaaaattg gcttgcattg tggagacggc ccaaggcaaa gcacaagtac acccatcctc
     3901 agtaaatcga gatttgcaaa ctcatggatg gctcttatac caggagaaga taaggtatgc
     3961 cagagtgtat ttgagagaaa ctaccctaat aacccctttt ccagttttac tttttggtgg
     4021 tgatatagaa gttcagcacc gagaacgtct tctttctatt gatggctgga tctattttca
     4081 ggcccctgta aagatagctg tcattttcaa gcagctgaga gttctcattg attcagtttt
     4141 aagaaaaaag cttgaaaatc caaagatgtc ccttgaaaat gacaagattc tgcagatcat
     4201 tacggaattg ataaaaacag agaataactg aaactgaaat tcatggtcaa ctgctttaaa
     4261 aattaagatg aagatacagt catgaaatta tctgaaaatg ggtcatcaca ttaagtattt
     4321 cattacttaa aatgttggta ctagccatta acttaaaggt ggtgggaaaa aagcacatac
     4381 tttaaacatg tataattttc tagttccttt ttaatgatga ttattctgaa tgtatttgcc
     4441 actacattta caataaattc tttggtatta tgcatgtttt gctcatcgtt gtgttaataa
     4501 gggcaaggcc tatgtctgtg gtatctgtag cttaatgttg tgattccctg tgtagctgcc
     4561 tcatccccta tcagtccttg atgtctgcag aatttaaacc ctatagaccc agaagggaaa
     4621 ataatctcca aaaccaatta taattaaatt tccatgaaaa ggaa
//
