LOCUS       NM_003587               3406 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens DEAH-box helicase 16 (DHX16), transcript variant 1,
            mRNA.
ACCESSION   NM_003587
VERSION     NM_003587.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Hautakangas,M.R., Widgren,P., Korpelainen,P., Kangas,S.M.,
            Komulainen,T., Vieira,P., Rahikkala,E., Pylkas,K., Tuominen,H.,
            Kokkonen,H., Miinalainen,I., Nadaf,J., Majewski,J., Hinttala,R. and
            Uusimaa,J.
  TITLE     Infantile onset encephalomyopathy, retinopathy, optic atrophy, and
            mitochondrial DNA depletion associated with a novel pathogenic
            DHX16 variant
  JOURNAL   Clin Genet 104 (6), 686-693 (2023)
   PUBMED   37574199
  REMARK    GeneRIF: Infantile onset encephalomyopathy, retinopathy, optic
            atrophy, and mitochondrial DNA depletion associated with a novel
            pathogenic DHX16 variant.
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Hage,A., Bharaj,P., van Tol,S., Giraldo,M.I., Gonzalez-Orozco,M.,
            Valerdi,K.M., Warren,A.N., Aguilera-Aguirre,L., Xie,X., Widen,S.G.,
            Moulton,H.M., Lee,B., Johnson,J.R., Krogan,N.J., Garcia-Sastre,A.,
            Shi,P.Y., Freiberg,A.N. and Rajsbaum,R.
  TITLE     The RNA helicase DHX16 recognizes specific viral RNA to trigger
            RIG-I-dependent innate antiviral immunity
  JOURNAL   Cell Rep 38 (10), 110434 (2022)
   PUBMED   35263596
  REMARK    GeneRIF: The RNA helicase DHX16 recognizes specific viral RNA to
            trigger RIG-I-dependent innate antiviral immunity.
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Paine,I., Posey,J.E., Grochowski,C.M., Jhangiani,S.N.,
            Rosenheck,S., Kleyner,R., Marmorale,T., Yoon,M., Wang,K.,
            Robison,R., Cappuccio,G., Pinelli,M., Magli,A., Coban Akdemir,Z.,
            Hui,J., Yeung,W.L., Wong,B.K.Y., Ortega,L., Bekheirnia,M.R.,
            Bierhals,T., Hempel,M., Johannsen,J., Santer,R., Aktas,D.,
            Alikasifoglu,M., Bozdogan,S., Aydin,H., Karaca,E., Bayram,Y.,
            Ityel,H., Dorschner,M., White,J.J., Wilichowski,E., Wortmann,S.B.,
            Casella,E.B., Kitajima,J.P., Kok,F., Monteiro,F., Muzny,D.M.,
            Bamshad,M., Gibbs,R.A., Sutton,V.R., Van Esch,H.,
            Brunetti-Pierri,N., Hildebrandt,F., Brautbar,A., Van den
            Veyver,I.B., Glass,I., Lessel,D., Lyon,G.J. and Lupski,J.R.
  CONSRTM   University of Washington Center for Mendelian Genomics,
            Baylor-Hopkins Center for Mendelian Genomics, Telethon Undiagnosed
            Diseases Program
  TITLE     Paralog Studies Augment Gene Discovery: DDX and DHX Genes
  JOURNAL   Am J Hum Genet 105 (2), 302-316 (2019)
   PUBMED   31256877
  REMARK    GeneRIF: Missense mutation in DHX16 gene is associated with
            neurodevelopmental disorder.
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Shiina,T., Ota,M., Shimizu,S., Katsuyama,Y., Hashimoto,N.,
            Takasu,M., Anzai,T., Kulski,J.K., Kikkawa,E., Naruse,T., Kimura,N.,
            Yanagiya,K., Watanabe,A., Hosomichi,K., Kohara,S., Iwamoto,C.,
            Umehara,Y., Meyer,A., Wanner,V., Sano,K., Macquin,C., Ikeo,K.,
            Tokunaga,K., Gojobori,T., Inoko,H. and Bahram,S.
  TITLE     Rapid evolution of major histocompatibility complex class I genes
            in primates generates new disease alleles in humans via hitchhiking
            diversity
  JOURNAL   Genetics 173 (3), 1555-1570 (2006)
   PUBMED   16702430
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Imamura,O., Saiki,K., Tani,T., Ohshima,Y., Sugawara,M. and
            Furuichi,Y.
  TITLE     Cloning and characterization of a human DEAH-box RNA helicase, a
            functional homolog of fission yeast Cdc28/Prp8
  JOURNAL   Nucleic Acids Res 26 (9), 2063-2068 (1998)
   PUBMED   9547260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB072495.1, BC008825.2 and
            BQ772493.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003587.4.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which is a functional homolog of fission yeast Prp8 protein
            involved in cell cycle progression. This gene is mapped to the MHC
            region on chromosome 6p21.3, a region where many malignant, genetic
            and autoimmune disease genes are linked. Three transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2018].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001601.1, BC009392.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376442.8/ ENSP00000365625.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB072495.1         49-50
            3-3262              BC008825.2         1-3260
            3263-3406           BQ772493.1         25-168              c
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3406
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /note="DEAH-box helicase 16"
                     /db_xref="GeneID:8449"
                     /db_xref="HGNC:HGNC:2739"
                     /db_xref="MIM:603405"
     exon            1..372
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..3291
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-dependent RNA helicase #3; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 16; DEAD/H box 16;
                     putative pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX16; DEAH-box protein 16; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 16; pre-mRNA processing
                     factor 2"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX16 isoform 1"
                     /protein_id="NP_003578.2"
                     /db_xref="CCDS:CCDS4685.1"
                     /db_xref="GeneID:8449"
                     /db_xref="HGNC:HGNC:2739"
                     /db_xref="MIM:603405"
                     /translation="MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFV
                     QRLRDTDTLDLSGPARDFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLED
                     SEESSEETVSRAGSSLQKKRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPES
                     EDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEED
                     RKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQELKYKRRV
                     RDLAREYRAAGEQEKLEATNRYHMPKETRGQPARAVDLVEEESGAPGEEQRRWEEARL
                     GAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESI
                     QAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIAC
                     TQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSE
                     PDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDD
                     APVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAA
                     CEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLT
                     IEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTA
                     WAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYA
                     LGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYR
                     PKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDV
                     REQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYRTVKQQQTVFIHP
                     NSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMP
                     KKIGKTREELG"
     exon            373..611
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..774
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..831
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1086
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1290
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1482
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1593
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1709
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1920
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2019
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2172
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2313
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2476
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2595
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2663
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2826
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2988
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3162
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3406
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3358..3363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /note="hexamer: AATAAA"
     regulatory      3375..3380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /note="hexamer: AATAAA"
     polyA_site      3380
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
     polyA_site      3406
                     /gene="DHX16"
                     /gene_synonym="DBP2; DDX16; NMOAS; PRO2014; Prp2; PRP8;
                     PRPF2"
                     /note="major polyA site"
ORIGIN      
        1 gcggtacggg aagacagctt tgggatgtcg gaagatccta gaggtcccaa ggtagctgac
       61 ttgcgaagct gaggctccag ccgagggctc caggcctctg accggcccag cagtgagcgc
      121 ggctgcccga cgcttcaggg ccgggagcag ggagcgtgag tcgccatggc gacgccggcg
      181 ggtctggagc gctgggttca ggacgagctg cactcggtgt tggggctgag cgagcggcac
      241 gtcgcccagt ttctgatcgg taccgcacag cgctgcacct ctgccgagga gttcgtgcag
      301 cgcctacgag acactgatac cttggatctc agtgggccgg cccgggactt cgccctgaga
      361 ctctggaaca aggtaccacg aaaggcagtg gtagaaaagc cagctcgggc agcagagcga
      421 gaggcccggg ccctgctgga gaagaaccga tcttataggt tactggaaga cagtgaagag
      481 agcagtgagg agactgtgag tagggctgga agcagcctcc agaagaaacg taaaaagcgg
      541 aaacacctca ggaagaagcg tgaggaagaa gaggaggaag aggcttctga gaaagggaag
      601 aagaaaacag gggggagtaa acagcagaca gagaagccag agtcggaaga tgagtgggaa
      661 cggacagagc gtgaacgcct tcaggacctg gaggagcgtg atgcctttgc tgagcgggtt
      721 cgacagcggg acaaggatcg gactcgaaat gtcctggaac ggtcagacaa gaaggcttat
      781 gaagaggctc agaagcgcct caagatggcc gaggaagacc ggaaggccat ggtccctgag
      841 ctgcggaaga aatctcgccg agagtacctg gctaagcggg agcgagagaa gcttgaggac
      901 ctggaggcgg agctggctga tgaggagttc ctttttgggg acgtggagct gagccggcac
      961 gagcggcagg agctcaaata taagcggcga gtgcgggatc tcgcccggga gtaccgggca
     1021 gctggggagc aggagaagct ggaggccacc aatcgctacc acatgcccaa ggaaacccga
     1081 ggacagccag cccgagctgt ggatctagtg gaggaggaat caggagcccc tggggaggag
     1141 cagcggcgct gggaggaggc gcggcttggg gcagcgtccc tgaagtttgg ggcccgagat
     1201 gctgcctctc aggagcccaa gtatcaactg gtgctggagg aggaggagac cattgagttt
     1261 gtccgggcca ctcagctcca gggtgatgag gagccgtcag ctccacccac ttcaactcag
     1321 gcccagcaga aagagtccat ccaggccgtc cgccgcagcc tcccggtgtt cccatttcga
     1381 gaggagctcc tggctgctat tgcaaatcac caagtcctca tcattgaagg cgagacaggc
     1441 tcagggaaga ccacccagat cccgcagtat ctctttgagg agggttatac aaacaagggt
     1501 atgaagattg cctgcaccca accccggaga gtggctgcca tgagtgtggc cgcccgagtg
     1561 gcccgggaga tgggtgtgaa gcttgggaat gaggttggct acagcatccg ctttgaggac
     1621 tgcacatcag agcgaactgt cctccgctac atgacagatg ggatgcttct ccgggagttc
     1681 ctctctgagc ctgacctggc gagttacagc gtggtgatgg tggatgaggc acacgaaagg
     1741 accctacaca cagacattct ctttggattg atcaaggatg ttgctcgctt ccgacctgag
     1801 ctcaaggtcc tggtggcttc agccacaatg gacactgccc gtttttccac cttctttgat
     1861 gacgcccctg tgtttcgaat ccccggacgc aggtttcctg tggacatctt ctacaccaag
     1921 gctccagagg ctgactactt ggaagcttgt gtagtatctg tgttgcagat ccatgtgacc
     1981 cagccccctg gggatatcct ggtgttcctg acaggacagg aggagattga ggctgcctgt
     2041 gagatgctcc aggatcgctg ccgccgcctg ggctccaaaa tccgggagct cctggtgctg
     2101 cccatttatg ccaatctgcc ctctgacatg caggcccgta tcttccagcc cacaccacct
     2161 ggggcacgaa aggtggttgt ggcaacgaac attgctgaga catcactcac cattgagggc
     2221 atcatttatg tgctggatcc agggttctgt aagcagaaga gctacaaccc ccgcacaggc
     2281 atggaatcgc tcactgtcac accctgcagc aaggcctcag ccaatcagcg agctggcagg
     2341 gcaggtcggg tggctgcagg gaagtgcttc cgcctgtata ccgcctgggc ctatcagcac
     2401 gagcttgagg aaaccacagt gcctgagatc cagaggacca gcttgggcaa tgtcgtgttg
     2461 ctgctcaaga gcttagggat ccatgaccta atgcactttg atttcctgga ccctccacca
     2521 tatgagacac tgctgctggc tttggagcag ctgtatgctc tgggagccct caaccacctt
     2581 ggggagctca ccacgtctgg tcgaaagatg gcagagctgc cggtggaccc catgctgtcc
     2641 aaaatgatct tagcctctga gaagtacagc tgttcagagg agatcctgac agtggctgcc
     2701 atgctctctg tcaacaactc catcttctac cgaccaaagg acaaggtcgt ccatgctgac
     2761 aatgcccgtg tcaacttctt tctccctggc ggtgaccacc tggttctgct aaatgtttac
     2821 acacagtggg ctgagagtgg ttactcttcc cagtggtgct atgagaactt tgtacagttc
     2881 agatcgatgc gccgagcccg ggatgtgcgg gaacagctgg aagggctctt ggaacgtgtg
     2941 gaagttggtc tcagttcctg ccagggggac tatatccgtg tacgcaaggc catcactgct
     3001 ggttactttt accacacggc acggttgact cggagtggct accgcacagt gaaacagcag
     3061 cagacagtct tcattcatcc caactcctcc ctctttgagc aacagccacg ctggctgctc
     3121 taccacgaac ttgtcttgac caccaaagag ttcatgagac aggtactgga gattgagagc
     3181 agttggcttc tggaggtggc tccccattat tataaggcca aggagctaga agatccccat
     3241 gctaagaaaa tgcccaaaaa aataggcaaa acacgagaag agctagggta agagaaggac
     3301 gtaaacagaa cctgacacca gctccttttc cttctataca ttatttaata cctattaaat
     3361 aaaattattt ttggaataaa gcttgtggga acatttggga tctaga
//
