LOCUS       NM_018706               5173 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens dehydrogenase E1 and transketolase domain containing 1
            (DHTKD1), mRNA.
ACCESSION   NM_018706
VERSION     NM_018706.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Osmanovic,A., Gogol,I., Martens,H., Widjaja,M., Muller,K.,
            Schreiber-Katz,O., Feuerhake,F., Langhans,C.D., Schmidt,G.,
            Andersen,P.M., Ludolph,A.C., Weishaupt,J.H., Brand,F., Petri,S. and
            Weber,R.G.
  TITLE     Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic
            Lateral Sclerosis Patients
  JOURNAL   Genes (Basel) 13 (1), 84 (2021)
   PUBMED   35052424
  REMARK    GeneRIF: Heterozygous DHTKD1 Variants in Two European Cohorts of
            Amyotrophic Lateral Sclerosis Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Wang,C., Calcutt,M.W. and Ferguson,J.F.
  TITLE     Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function,
            and May Represent a Novel Pathway in Cardiometabolic Disease Risk
  JOURNAL   Front Endocrinol (Lausanne) 12, 710698 (2021)
   PUBMED   34484123
  REMARK    GeneRIF: Knock-Out of DHTKD1 Alters Mitochondrial Respiration and
            Function, and May Represent a Novel Pathway in Cardiometabolic
            Disease Risk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5173)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5173)
  AUTHORS   Leandro,J., Khamrui,S., Wang,H., Suebsuwong,C., Nemeria,N.S.,
            Huynh,K., Moustakim,M., Secor,C., Wang,M., Dodatko,T., Stauffer,B.,
            Wilson,C.G., Yu,C., Arkin,M.R., Jordan,F., Sanchez,R., DeVita,R.J.,
            Lazarus,M.B. and Houten,S.M.
  TITLE     Inhibition and Crystal Structure of the Human DHTKD1-Thiamin
            Diphosphate Complex
  JOURNAL   ACS Chem Biol 15 (8), 2041-2047 (2020)
   PUBMED   32633484
  REMARK    GeneRIF: Inhibition and Crystal Structure of the Human
            DHTKD1-Thiamin Diphosphate Complex.
REFERENCE   6  (bases 1 to 5173)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5173)
  AUTHORS   Bunik,V.I. and Degtyarev,D.
  TITLE     Structure-function relationships in the 2-oxo acid dehydrogenase
            family: substrate-specific signatures and functional predictions
            for the 2-oxoglutarate dehydrogenase-like proteins
  JOURNAL   Proteins 71 (2), 874-890 (2008)
   PUBMED   18004749
REFERENCE   8  (bases 1 to 5173)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 5173)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5173)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 2 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301462
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073160.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018706.6.
            
            Summary: This gene encodes a component of a mitochondrial
            2-oxoglutarate-dehydrogenase-complex-like protein involved in the
            degradation pathways of several amino acids, including lysine.
            Mutations in this gene are associated with 2-aminoadipic
            2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q.
            [provided by RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.121170.1,
                                           SRR1803615.207230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000263035.9/
                                                  ENSP00000263035.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC073160.8         65836-66069
            235-390             AC073160.8         78354-78509
            391-602             AC073160.8         81422-81633
            603-797             AC073160.8         84417-84611
            798-1067            AC073160.8         85868-86137
            1068-1239           AC073160.8         88395-88566
            1240-1438           AC073160.8         90955-91153
            1439-1751           AC073160.8         94566-94878
            1752-1836           AC073160.8         97060-97144
            1837-1976           AC073160.8         97924-98063
            1977-2127           AC073160.8         103128-103278
            2128-2234           AC073160.8         104791-104897
            2235-2399           AC073160.8         109782-109946
            2400-2482           AC073160.8         114555-114637
            2483-2652           AC073160.8         115631-115800
            2653-2738           AC073160.8         117064-117149
            2739-5173           AC073160.8         117669-120103
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..5173
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="dehydrogenase E1 and transketolase domain
                     containing 1"
                     /db_xref="GeneID:55526"
                     /db_xref="HGNC:HGNC:23537"
                     /db_xref="MIM:614984"
     exon            1..234
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2840
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /EC_number="1.2.4.2"
                     /note="probable 2-oxoglutarate dehydrogenase E1 component
                     DHKTD1, mitochondrial; dehydrogenase E1 and transketolase
                     domain-containing protein 1; alpha-KADH-E1;
                     alpha-ketoadipate dehydrogenase; 2-oxoadipate
                     dehydrogenase, mitochondrial"
                     /codon_start=1
                     /product="2-oxoadipate dehydrogenase complex component E1"
                     /protein_id="NP_061176.4"
                     /db_xref="CCDS:CCDS7087.1"
                     /db_xref="GeneID:55526"
                     /db_xref="HGNC:HGNC:23537"
                     /db_xref="MIM:614984"
                     /translation="MASATAAAARRGLGRALPLFWRGYQTERGVYGYRPRKPESREPQ
                     GALERPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHT
                     AGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTT
                     EERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVI
                     IGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAH
                     HPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDA
                     SFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGC
                     AIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYK
                     IIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAH
                     WQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRMEKMMDG
                     IKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMD
                     PNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISG
                     GEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPT
                     TPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVD
                     PKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHV
                     KDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDIL
                     AKTFA"
     exon            235..390
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..602
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..797
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1067
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1239
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1438
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1751
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1836
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1976
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2127
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2234
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2399
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2482
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2652
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2738
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..5173
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="hexamer: AAGAAA"
     polyA_site      3418
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="major polyA site"
     regulatory      5079..5084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="hexamer: AGTAAA"
     polyA_site      5109
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="major polyA site"
     regulatory      5147..5152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="hexamer: AATAAA"
     polyA_site      5173
                     /gene="DHTKD1"
                     /gene_synonym="AAKAD; AMOXAD; CMT2Q; E1a; OADC-E1;
                     OADH-E1"
                     /note="major polyA site"
ORIGIN      
        1 gacgagtccc ggatttacca gggccggtgg gatcccctcg ggctcccgcc ttagcatgct
       61 ggccgggaca tctggtgaac atggcctctg ctactgcggc agcagcacga cggggcctcg
      121 gccgggctct ccctctcttc tggcgtggct accagaccga gcggggcgtt tacggctacc
      181 ggccgaggaa gcccgagagc cgcgagcccc agggcgccct ggagcgcccc ccagttgatc
      241 atggccttgc caggttggtg acagtatatt gtgagcatgg tcataaagct gccaaaatca
      301 accccctctt caccggacaa gccctgctgg agaatgtgcc tgaaatccaa gccctggtgc
      361 agacactgca gggacccttc cacacggcag gattattgaa catggggaag gaagaggcct
      421 cacttgagga agtgttagtc tatctcaatc aaatctactg tgggcagatt tctattgaaa
      481 cctcccaact tcagagccag gatgagaaag actggtttgc caagcggttt gaggaactgc
      541 aaaaggagac gtttaccaca gaagagcgaa aacatctgtc gaaactaatg ctggaatctc
      601 aggagtttga ccactttctg gccaccaagt tctcgacagt gaagcgatat ggaggcgaag
      661 gggctgaaag catgatgggc tttttccacg agctgctgaa aatgtcggcc tacagcggga
      721 tcactgatgt cattattggg atgccccata gagggaggct gaatttattg acaggccttc
      781 tgcagttccc tccagagctg atgttccgta aaatgcgagg cttaagtgaa tttccagaga
      841 atttctcagc cactggagac gtcctgtctc acctgacctc ctctgtggac ctgtactttg
      901 gggcgcacca tcccctccat gtgacaatgt tgcccaatcc ctcgcacctg gaggccgtca
      961 accccgtggc cgtgggcaaa actcgcggca ggcagcagtc tcgccaagac ggcgattact
     1021 ctccagacaa ctcagcccag ccgggggaca gggtcatttg cttacaggtc catggtgatg
     1081 cttctttctg tggtcaaggg attgttcctg aaacattcac gctgtccaat ctcccacatt
     1141 tcagaattgg tgggagtgtg catttgattg ttaataacca gctgggttac accactccag
     1201 ctgaaagagg aaggtcttct ttatactgca gtgatattgg gaagcttgtg ggctgtgcca
     1261 tcatccatgt caatggagac agcccagagg aagtggtccg tgccacacga ctggcttttg
     1321 aataccaacg ccagttccgc aaggatgtga ttattgatct gttgtgctac aggcagtggg
     1381 gccacaatga gctggatgag ccattctaca ccaaccccat catgtacaaa atcatcagag
     1441 ctcgaaagag cattccagac acatatgcag agcacctcat tgctggcgga ctcatgacgc
     1501 aggaggaggt gtctgaaata aaatcctcct actatgccaa gttgaatgat cacttaaata
     1561 acatggccca ctacaggccc cctgccctga acctgcaggc ccactggcag ggcctggctc
     1621 agccagaagc gcaaatcacc acctggagta caggtgtgcc cctcgacctc ctgcggtttg
     1681 ttggcatgaa gtctgtagag gtgccaagag agctgcagat gcacagtcac ctgctgaaga
     1741 cacatgttca gtccagaatg gagaagatga tggacggaat caagctagac tgggccaccg
     1801 cggaagctct tgccttgggt tctttacttg ctcaaggttt taatgttcgt ctaagtggcc
     1861 aagatgttgg tcgtggaact ttcagtcaga ggcatgcaat cgtggtttgc caggagacgg
     1921 atgacaccta catccccctg aaccatatgg acccaaatca gaaggggttt ctagaggtca
     1981 gcaacagccc actgtcagaa gaggccgtcc tgggatttga atatgggatg agcattgaga
     2041 gcccaaagtt actgcccctg tgggaggcac agtttggcga tttcttcaat ggtgcccaga
     2101 tcatctttga cacattcatc tctggaggag aggccaagtg gctcctacaa agcggcatcg
     2161 tcatcctcct tccacatggc tacgatgggg ctgggccaga ccactcatcc tgtcgaatag
     2221 agcgtttcct gcagatgtgt gacagtgcgg aagagggggt ggacggagac actgtgaaca
     2281 tgtttgtggt tcacccaaca actcctgcac agtatttcca cttgcttagg agacagatgg
     2341 tccggaactt cagaaaacca ctcattgttg cttcccctaa gatgttactc aggctcccgg
     2401 cagccgtgtc aactcttcaa gaaatggcac caggaacaac atttaacccg gtcattggtg
     2461 attcatctgt ggatccaaaa aaggttaaga ccctcgtgtt ctgctccggc aaacatttct
     2521 actccctggt gaaacaaaga gaatctctgg gggccaagaa gcatgacttt gccatcatcc
     2581 gagtagagga actctgcccc ttcccgttgg attctttaca gcaagagatg agcaaataca
     2641 aacatgttaa agatcatatt tggagtcagg aggaacctca gaacatgggt ccgtggtcgt
     2701 ttgtttctcc aaggtttgaa aagcagctgg cctgcaagct ccgtctggtg ggccggcccc
     2761 ctttgccagt acccgctgta ggaattggca cagttcactt gcaccagcat gaagatatcc
     2821 tcgccaagac cttcgcttga tgatgacttt tgaagaaaca ctatttctct ttaagaaaat
     2881 ggccattaag gccgggtggg gtggcacatg cctgtaatcc cagcactttg ggaggccaag
     2941 gctggtggat cacctgaggt caggagttcg agaccagcct ggccaacacg gtgaaacccc
     3001 gcctctacta aaaatacaaa aaatagccgg gtgtggtggt gggcacctgt gatcccagct
     3061 tcctgggagg ctgaggcaag agaatcgctt gaatctggga ggcggaggtt gcagtgagcc
     3121 aggatcacac cattgctgtc cagcctgggt gacagagcaa gactgcgttt caaaaaaaaa
     3181 aaaaaaaaaa cccattaaaa gaggcctcct tcctccactc tctcaacccc tctgttgggt
     3241 aacatgaaaa gactgtattc ctctaagatg ttgggattga tatacgtgat ttaatctgca
     3301 ataggtggaa taaccagggg aactggttat gaatatgtga atgcaaccag caaatttatc
     3361 cttgaaggtg tgatggtaga aataggaaaa caacaaaaga aaaacaataa caaaaaaaga
     3421 aagtgtgatg gctgggtgca gtggctcacg cctgtaatcc cagcactttg ggaggcttag
     3481 gcggctggat cacctgaggt caggagttca agaccagcct ggtcaacgtg gtgaaacgcc
     3541 gtttctacta aaaatatgaa aattagttgg gtgtggtggc atgcgcttgt agtctcagct
     3601 actccggagg ctgaggcagg agaattgctt gaacctggaa ggcagaggtt gcagtgagcc
     3661 gaaatggcgc cactgtactc caacctgggc gacagagcaa gactccatct cataaattaa
     3721 aaggaaagta tgatagtgtt atggatttta gctctgagtg agctggaaaa ctaggtcatt
     3781 atctagatga tttcagactt gaccctaatt gaccatatat gaccaggaaa cacttctgag
     3841 tttacagctc cgtggagatg acctcaacac tgcctcttga tttgtttgat gcatgtcact
     3901 ttcattaatt ttccccctcc tttttgaaag tcctgtggca gtactaatat tttcatttta
     3961 tgtaatctct ggtgctgctt tccagtcact gtatgaagtg tctccccaac actagcaaat
     4021 ctaggtccta ctaaatacaa atctctgggt ggatgatctt ctagtactgt atttttaaat
     4081 taaggagttt tagttataat gaaattgatt tgtagtctgt tttgccgtaa acttgttttt
     4141 ctttaaattg ttcttacagt gatatcttac tatttttaac tgtctggggt ttctgatatg
     4201 gggatttcag cccctggtta atcagtcttg tccctacaag tccctgatgc agtatgttta
     4261 tttgtgatgt ttaaagaaca tttcttggct gggcgctgcg gcttgcgcct gtaatctcag
     4321 cactttggga ggctgagatg ggtggatcac ctgaggttgg gagttcgaga ccagcctgac
     4381 aaaacatagt gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc gtggtggtgg
     4441 gtgtctgtaa tcccagctat tcgggaggct gaggcaggag aatcgcttga acccaggagg
     4501 tggaggttgc agtgagctga gatcctgcca ctgcactcca gtctgggtga cagagcaaga
     4561 ctccatctca aaaaataaat aaatagaaag agagagagag gaaaaaaaaa gaaaagaaca
     4621 cttctttatt tgagggactt tcccaacacc aggtgcttgg ggatttctta gagatcacca
     4681 accgactccc tcactgtgaa attaaaccaa gtactggaaa cgtaactaaa cagcgaacca
     4741 tgtagcttca cctgactcag tgctgggggc ctctaccatc tactgtgctt gtgtcatgat
     4801 gctttttctc tgaagtggtg tgggaagtac caggggactg gcagaagccc aggccctctc
     4861 tacttttacc agcaactgat catgtctttc agaatccatg tacatatagg ctgttctagc
     4921 cacagtggta gatttatgat tcacatccga aagtgtgcct tagttatcaa tttaacattt
     4981 ctctagtatt catatccctt ttcttaccat atacctcagt gtatccttcc tgtgtcaagc
     5041 cttataaatc atgtaattta gtgccactca tgtaaatcag taaaatcaca aaggtctatt
     5101 taatgaaaac gatttaccaa tgttgttttt ttttaacaag aaaaaaaata aaagcacatt
     5161 gtcatttttt ttc
//
