LOCUS       NM_145177               2579 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens dehydrogenase/reductase X-linked (DHRSX), mRNA.
ACCESSION   NM_145177 XM_499567
VERSION     NM_145177.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Wilson,M.P., Kentache,T., Althoff,C.R., Schulz,C., de
            Bettignies,G., Mateu Cabrera,G., Cimbalistiene,L., Burnyte,B.,
            Yoon,G., Costain,G., Vuillaumier-Barrot,S., Cheillan,D., Rymen,D.,
            Rychtarova,L., Hansikova,H., Bury,M., Dewulf,J.P., Caligiore,F.,
            Jaeken,J., Cantagrel,V., Van Schaftingen,E., Matthijs,G.,
            Foulquier,F. and Bommer,G.T.
  TITLE     A pseudoautosomal glycosylation disorder prompts the revision of
            dolichol biosynthesis
  JOURNAL   Cell 187 (14), 3585-3601 (2024)
   PUBMED   38821050
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3784. doi:
            10.1016/j.cell.2024.06.004.. PMID: 38870945]
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2579)
  AUTHORS   Zhang,G., Luo,Y., Li,G., Wang,L., Na,D., Wu,X., Zhang,Y., Mo,X. and
            Wang,L.
  TITLE     DHRSX, a novel non-classical secretory protein associated with
            starvation induced autophagy
  JOURNAL   Int J Med Sci 11 (9), 962-970 (2014)
   PUBMED   25076851
  REMARK    GeneRIF: these results demonstrate that DHRSX is a novel
            non-classical secretory protein involved in the positive regulation
            of starvation induced autophagy and provide a new avenue for
            research on this protein family and autophagy regulation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2579)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   7  (bases 1 to 2579)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 2579)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2579)
  AUTHORS   Gianfrancesco,F., Sanges,R., Esposito,T., Tempesta,S., Rao,E.,
            Rappold,G., Archidiacono,N., Graves,J.A., Forabosco,A. and
            D'Urso,M.
  TITLE     Differential divergence of three human pseudoautosomal genes and
            their mouse homologs: implications for sex chromosome evolution
  JOURNAL   Genome Res 11 (12), 2095-2100 (2001)
   PUBMED   11731500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079176.15, BG703185.1, AJ293620.1, BM794858.1 and CR856018.10.
            
            On May 17, 2019 this sequence version replaced NM_145177.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ293620.1, SRR1660803.148625.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334651.11/ ENSP00000334113.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC079176.15        85575-85576
            3-42                BG703185.1         6-45
            43-647              AJ293620.1         1-605
            648-855             BM794858.1         326-533
            856-1512            CR856018.10        20376-21032         c
            1513-2579           AJ293620.1         1470-2536
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="Xp22.33 and Yp11.2"
     gene            1..2579
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="dehydrogenase/reductase X-linked"
                     /db_xref="GeneID:207063"
                     /db_xref="HGNC:HGNC:18399"
                     /db_xref="MIM:301034"
     exon            1..160
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1044
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="dehydrogenase/reductase (SDR family) Y-linked;
                     dolichal reductase; dehydrogenase/reductase SDR family
                     member on chromosome X; dehydrogenase/reductase (SDR
                     family) X chromosome; short chain dehydrogenase/reductase
                     family 7C member 6; dehydrogenase/reductase (SDR family)
                     X-linked; short chain dehydrogenase/reductase family 46C
                     member 1"
                     /codon_start=1
                     /product="polyprenol dehydrogenase"
                     /protein_id="NP_660160.2"
                     /db_xref="CCDS:CCDS35195.1"
                     /db_xref="GeneID:207063"
                     /db_xref="HGNC:HGNC:18399"
                     /db_xref="MIM:301034"
                     /translation="MSPLSAARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDR
                     VAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD
                     LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTN
                     LLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLF
                     TYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWT
                     SIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVLDVTL"
     exon            161..268
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     exon            269..337
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     exon            338..439
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     exon            440..647
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..855
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     exon            856..2579
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="hexamer: AATAAT"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="hexamer: ATTACA"
     polyA_site      1321
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="major polyA site"
     polyA_site      1325
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="major polyA site"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="hexamer: AATACA"
     polyA_site      1367
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
                     /note="hexamer: AATAAA"
     polyA_site      2062
                     /gene="DHRSX"
                     /gene_synonym="CDG1DD; CXorf11; DHRS5X; DHRS5Y; DHRSXY;
                     DHRSY; SDR46C1; SDR7C6"
ORIGIN      
        1 gcagagtccc gcgggcggcg cggaagcggc ggcggcgcgg ccggggcagc catgtcgcca
       61 ttgtctgcgg cgcgggcggc cctgcgggtc tacgcggtag gcgccgcggt gatcctggcg
      121 cagctgctgc ggcgctgccg cgggggcttc ctggagccag ttttcccccc acgacctgac
      181 cgtgtcgcta tagtgacggg agggacagat ggcattggct attctacagc gaagcatctg
      241 gcgagacttg gcatgcatgt tatcatagct ggaaataatg acagcaaagc caaacaagtt
      301 gtaagcaaaa taaaagaaga aaccttgaac gacaaagtgg aatttttata ctgtgacttg
      361 gcttccatga cttccatccg gcagtttgtg cagaagttca agatgaagaa gattcctctc
      421 catgtcctga tcaacaatgc tggggtgatg atggtccctc agaggaaaac cagagatgga
      481 ttcgaagaac atttcggcct gaactaccta gggcacttcc tgctgaccaa ccttctcttg
      541 gatacgctga aagagtctgg gtcccctggc cacagtgcga gggtggtcac cgtctcctct
      601 gccacccatt acgtcgctga gctgaacatg gatgaccttc agagcagtgc ctgctactca
      661 ccccacgcag cctacgccca gagcaagctg gcccttgtcc tgttcaccta ccacctccag
      721 cggctgctgg cggctgaggg aagccacgtg accgccaacg tggtggaccc cggggtggtc
      781 aacacggacg tctacaagca cgtgttctgg gccacccgtc tggcgaagaa gcttctcggc
      841 tggttgcttt tcaagacccc cgatgaagga gcgtggactt ccatctacgc agcagtcacc
      901 ccagagctgg aaggagttgg tggccattac ctatacaacg agaaagagac caagtccctc
      961 cacgtcacct acaaccagaa actgcagcag cagctgtggt ctaagagttg tgagatgact
     1021 ggggtccttg atgtgaccct gtgatatcct gtctcaggat agctgctgcc ccaagaaaca
     1081 cattgcacct gccaatagct tgtgggtctg tgaagactgc ggtgtttgag tttctcacac
     1141 ccacctgccc acagggctct gtcctctagt tttgagacag ctgcctcaac ctctgcagaa
     1201 cttcaagaag ccaaataaac attttggagg ataatcaccc caagtggtct tcaaccataa
     1261 actttgtgat tccaaagtgc ccagttgtca caggtgccat aaataattac attttccaac
     1321 ataaatgtgc cattttcctt gccgcgttaa tacaactgag tacaaaagtt ccaagagaga
     1381 tgctctcttt tcaggggctg caatgtcctc tctgagacct agtggtggat gaggtctcct
     1441 gtttgatttt gttcctgcac tcactcattt ttccagagac ccagctgtga ttcacaggtg
     1501 tcagacatgg ggaggtgtga gccttgcttg ctacagcctg taggatgagt ttgacgtggc
     1561 cagcagcacc atctggtcaa cctcattcca gaatggcaca gtcacaagtg aagcatgcca
     1621 ctgtcaaatc cgagaatgta aaccgctgaa cagctatgga tcaaatggta gccctcaaaa
     1681 gatatgttca tgccctaacc ctcagaacct ataaatatta ctttatttgg aaaagaatct
     1741 ttgcagatag aattaagaat tttgagatgg gtcattatgg atcatcccag tgaacctaat
     1801 gccatcacga gggttcttat cagagacagg tagagggaga tttgagtaca gaagacaaga
     1861 tattcgtgtg atgatgcaga cagagactgg agtgatgcca ccacaagcca agcaatgcct
     1921 ggagccacca ggagctggga caggcaggaa ggattctccc ttatacccct cagagcaatc
     1981 ttggcccctc tgacgtcttg actttagact tctggtcccc agaacggaga gagaataaat
     2041 ctttcttgtt ttaaggctcc aacaaattgg tagtcacttg ttacagcaac cacaggaaat
     2101 gtatacagct tctgatactt ctgaaaacct cacacagcca aagggtacat ccttggtata
     2161 gaggctcact cttactcacc agccaggcaa ggaaggctca atcctttggt gttagagaga
     2221 tagatgttgg gttttcaaat ttcaacatag agaaatcagt catttgcaat gcttttgaga
     2281 aagtactgtg tataccctac gagcctgcac tccttatgtg tgagactgat gaccattggt
     2341 tggcttatta tccattccac taagtgacaa aatcccactg actattcaaa tccaggctcc
     2401 tggcatgcct gtaccttaga atcacaacca gctgcaattc caggatggag ttcaaactaa
     2461 ttgtgggggc atgtgcttct tacatgactg ctagattgtt cccagatggg gaaggttgcc
     2521 ctgataagca acttaaatga aaataataaa tgtattgttt ggcctcttta aaaaaaaaa
//
