LOCUS       NM_001376924            1574 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 9 (DHRS9), transcript variant
            6, mRNA.
ACCESSION   NM_001376924
VERSION     NM_001376924.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Zhao,J., Wang,Y., Wang,Y., Gao,J., Yang,H., Wu,X. and Li,H.
  TITLE     Transcription Factor FXR Activates DHRS9 to Inhibit the Cell
            Oxidative Phosphorylation and Suppress Colon Cancer Progression
  JOURNAL   Anal Cell Pathol (Amst) 2022, 8275574 (2022)
   PUBMED   36340269
  REMARK    GeneRIF: Transcription Factor FXR Activates DHRS9 to Inhibit the
            Cell Oxidative Phosphorylation and Suppress Colon Cancer
            Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Cali,F., Elia,M., Vinci,M., Vetri,L., Correnti,E., Trapolino,E.,
            Roccella,M., Vanadia,F. and Romano,V.
  TITLE     Are Mutations in the DHRS9 Gene Causally Linked to Epilepsy? A Case
            Report
  JOURNAL   Medicina (Kaunas) 56 (8), 387 (2020)
   PUBMED   32752300
  REMARK    GeneRIF: Are Mutations in the DHRS9 Gene Causally Linked to
            Epilepsy? A Case Report.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Shimomura,H., Sasahira,T., Nakashima,C., Shimomura-Kurihara,M. and
            Kirita,T.
  TITLE     Downregulation of DHRS9 is associated with poor prognosis in oral
            squamous cell carcinoma
  JOURNAL   Pathology 50 (6), 642-647 (2018)
   PUBMED   30149992
  REMARK    GeneRIF: The study findings suggest that DHRS9 might be a useful
            diagnostic and prognostic marker for oral squamous cell carcinoma
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Markova,N.G., Pinkas-Sarafova,A. and Simon,M.
  TITLE     A metabolic enzyme of the short-chain dehydrogenase/reductase
            superfamily may moonlight in the nucleus as a repressor of promoter
            activity
  JOURNAL   J Invest Dermatol 126 (9), 2019-2031 (2006)
   PUBMED   16691198
  REMARK    GeneRIF: Dehydrogenase/reductase SDR family member 9 is a
            moonlighting protein that functions as both a metabolic enzyme and
            as a transcriptional repressor.
REFERENCE   7  (bases 1 to 1574)
  AUTHORS   Markova,N.G., Pinkas-Sarafova,A., Karaman-Jurukovska,N.,
            Jurukovski,V. and Simon,M.
  TITLE     Expression pattern and biochemical characteristics of a major
            epidermal retinol dehydrogenase
  JOURNAL   Mol Genet Metab 78 (2), 119-135 (2003)
   PUBMED   12618084
REFERENCE   8  (bases 1 to 1574)
  AUTHORS   Soref,C.M., Di,Y.P., Hayden,L., Zhao,Y.H., Satre,M.A. and Wu,R.
  TITLE     Characterization of a novel airway epithelial cell-specific short
            chain alcohol dehydrogenase/reductase gene whose expression is
            up-regulated by retinoids and is involved in the metabolism of
            retinol
  JOURNAL   J Biol Chem 276 (26), 24194-24202 (2001)
   PUBMED   11304534
REFERENCE   9  (bases 1 to 1574)
  AUTHORS   Chetyrkin,S.V., Belyaeva,O.V., Gough,W.H. and Kedishvili,N.Y.
  TITLE     Characterization of a novel type of human microsomal 3alpha
            -hydroxysteroid dehydrogenase: unique tissue distribution and
            catalytic properties
  JOURNAL   J Biol Chem 276 (25), 22278-22286 (2001)
   PUBMED   11294878
REFERENCE   10 (bases 1 to 1574)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Short-chain dehydrogenases/reductases in retina
  JOURNAL   Methods Enzymol 316, 372-383 (2000)
   PUBMED   10800688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008177.3 and AC007556.3.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) family. The encoded protein has
            been identified as a moonlighting protein based on its ability to
            perform mechanistically distinct functions. This protein
            demonstrates oxidoreductase activity toward hydroxysteroids and is
            able to convert 3-alpha-tetrahydroprogesterone to
            dihydroxyprogesterone and 3-alpha-androstanediol to
            dihydroxyprogesterone in the cytoplasm, and may additionally
            function as a transcriptional repressor in the nucleus. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF343729.1, BC058883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000674881.1/
                                               ENSP00000502399.1
            multifunctional gene product(s) :: PMID: 16691198
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC008177.3         130375-130529
            156-527             AC008177.3         142335-142706
            528-786             AC008177.3         144141-144399
            787-950             AC008177.3         152602-152765
            951-1574            AC007556.3         3560-4183
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1574
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /note="dehydrogenase/reductase 9"
                     /db_xref="GeneID:10170"
                     /db_xref="HGNC:HGNC:16888"
                     /db_xref="MIM:612131"
     exon            1..155
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /inference="alignment:Splign:2.1.0"
     exon            156..527
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1174
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="isoform 1 is encoded by transcript variant 6;
                     NADP-dependent retinol dehydrogenase/reductase; 3-alpha
                     hydroxysteroid dehydrogenase; retinol dehydrogenase
                     homolog; tracheobronchial epithelial cell-specific retinol
                     dehydrogenase; retinol dehydrogenase 15;
                     dehydrogenase/reductase (SDR family) member 9; short chain
                     dehydrogenase/reductase family 9C member 4; short-chain
                     dehydrogenase/reductase retSDR8"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 9
                     isoform 1"
                     /protein_id="NP_001363853.1"
                     /db_xref="CCDS:CCDS2231.1"
                     /db_xref="GeneID:10170"
                     /db_xref="HGNC:HGNC:16888"
                     /db_xref="MIM:612131"
                     /translation="MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNL
                     AARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVG
                     EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVI
                     NVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVK
                     VIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLF
                     PKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV"
     exon            528..786
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /inference="alignment:Splign:2.1.0"
     exon            787..950
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1574
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /note="hexamer: ATTAAA"
     polyA_site      1574
                     /gene="DHRS9"
                     /gene_synonym="3-alpha-HSD; 3ALPHA-HSD; hRoDH-E2; RDH-TBE;
                     RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4"
                     /note="major polyA site"
ORIGIN      
        1 actcagagct ctacggaaac ccaggcacct cgacctcaag aggatcagcc tggccagggt
       61 ggcacaactc ttccttcccc gtgcacagca ggaaagctgc catcagctga gcaagtccac
      121 caacagtttc tgtgtcccac ttcatcttta ataaggacac catcttcttg tattatacaa
      181 gaaaggagtg tacctatcac acacaggggg aaaaatgctc ttttgggtgc taggcctcct
      241 aatcctctgt ggttttctgt ggactcgtaa aggaaaacta aagattgaag acatcactga
      301 taagtacatt tttatcactg gatgtgactc gggctttgga aacttggcag ccagaacttt
      361 tgataaaaag ggatttcatg taatcgctgc ctgtctgact gaatcaggat caacagcttt
      421 aaaggcagaa acctcagaga gacttcgtac tgtgcttctg gatgtgaccg acccagagaa
      481 tgtcaagagg actgcccagt gggtgaagaa ccaagttggg gagaaaggtc tctggggtct
      541 gatcaataat gctggtgttc ccggcgtgct ggctcccact gactggctga cactagagga
      601 ctacagagaa cctattgaag tgaacctgtt tggactcatc agtgtgacac taaatatgct
      661 tcctttggtc aagaaagctc aagggagagt tattaatgtc tccagtgttg gaggtcgcct
      721 tgcaatcgtt ggagggggct atactccatc caaatatgca gtggaaggtt tcaatgacag
      781 cttaagacgg gacatgaaag cttttggtgt gcacgtctca tgcattgaac caggattgtt
      841 caaaacaaac ttggcagatc cagtaaaggt aattgaaaaa aaactcgcca tttgggagca
      901 gctgtctcca gacatcaaac aacaatatgg agaaggttac attgaaaaaa gtctagacaa
      961 actgaaaggc aataaatcct atgtgaacat ggacctctct ccggtggtag agtgcatgga
     1021 ccacgctcta acaagtctct tccctaagac tcattatgcc gctggaaaag atgccaaaat
     1081 tttctggata cctctgtctc acatgccagc agctttgcaa gactttttat tgttgaaaca
     1141 gaaagcagag ctggctaatc ccaaggcagt gtgactcagc taaccacaaa tgtctcctcc
     1201 aggctatgaa attggccgat ttcaagaaca catctccttt tcaaccccat tccttatctg
     1261 ctccaacctg gactcattta gatcgtgctt atttggattg caaaagggag tcccaccatc
     1321 gctggtggta tcccagggtc cctgctcaag ttttctttga aaaggagggc tggaatggta
     1381 catcacatag gcaagtcctg ccctgtattt aggctttgcc tgcttggtgt gatgtaaggg
     1441 aaattgaaag acttgcccat tcaaaatgat ctttaccgtg gcctgcccca tgcttatggt
     1501 ccccagcatt tacagtaact tgtgaatgtt aagtatcatc tcttatctaa atattaaaag
     1561 ataagtcaaa catt
//
