LOCUS       NM_001105571            1294 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 7C (DHRS7C), transcript
            variant 2, mRNA.
ACCESSION   NM_001105571 XM_113912 XM_938490
VERSION     NM_001105571.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Lu,B., Tigchelaar,W., Ruifrok,W.P., van Gilst,W.H., de Boer,R.A.
            and Sillje,H.H.
  TITLE     DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated
            by adrenergic stimulation and in heart failure
  JOURNAL   Eur J Heart Fail 14 (1), 5-13 (2012)
   PUBMED   22143674
  REMARK    GeneRIF: The expression of DHRS7c, a novel endo/sarcoplasmic
            reticulum-localized a short chain dehydrogenase/reductase, is
            inversely correlated with adrenergic stimulation and heart failure
            development.
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027045.21, BC147024.1, AI091419.1 and AI168267.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001105571.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147025.1, DN831947.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142348,
                                           SAMEA2146411 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000571134.2/ ENSP00000459579.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC027045.21        27413-27707
            296-1279            BC147024.1         1-984
            1280-1289           AI091419.1         8-17                c
            1290-1294           AI168267.1         13-17               c
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1294
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /note="dehydrogenase/reductase 7C"
                     /db_xref="GeneID:201140"
                     /db_xref="HGNC:HGNC:32423"
                     /db_xref="MIM:616161"
     exon            1..462
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1244
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /EC_number="1.1.1.105"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; short-chain dehydrogenase/reductase family 32C
                     member 2; dehydrogenase/reductase (SDR family) member 7C;
                     sarcoplasmic reticulum protein of 35 kDa"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 7C
                     isoform 2 precursor"
                     /protein_id="NP_001099041.1"
                     /db_xref="CCDS:CCDS58517.1"
                     /db_xref="GeneID:201140"
                     /db_xref="HGNC:HGNC:32423"
                     /db_xref="MIM:616161"
                     /translation="MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITD
                     AISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSD
                     ISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKA
                     LLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVIST
                     VSPTFIRSYHVYPEQGNWEASIWKFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMAN
                     PIPKAAVYVRTFFPEFFFAVVACGVKEKLNVPEEG"
     exon            463..575
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..786
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..879
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1035
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1294
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /note="hexamer: AATAAA"
     polyA_site      1294
                     /gene="DHRS7C"
                     /gene_synonym="SDR32C2"
                     /note="major polyA site"
ORIGIN      
        1 attagggccc aagcaagtgg ccttaacaca tggattttct tccaaaaatg cagacccatt
       61 ttaattaagt ttgtaattaa ccactgggga gggcaggccc cctggattcg gtctgctttc
      121 ggagacactg tgagtaactt cctatttgtt gaacatttgg ggattagcac gcccactggg
      181 tgttcagctt ggaggcttgc acagagctga gctccctgca gccttgggcc tccccctgcc
      241 ctgggagtcc tgatcagcgt ctctttgcaa agccaatccc cttttactcc gttgtccccc
      301 agaacaagat gggagtcatg gccatgctga tgctccccct gctgctgctg ggaatcagcg
      361 gcctcctctt catttaccaa gaggtgtcca ggctgtggtc aaagtcagct gtgcagaaca
      421 aagtggtggt gatcaccgat gccatctcag gactgggcaa ggagtgtgct cgggtgttcc
      481 acacaggtgg ggcaaggctg gtgctgtgtg gaaagaactg ggagaggcta gagaacctat
      541 atgatgcctt gatcagcgtg gctgacccca gcaagacatt caccccaaag ctggtcctgt
      601 tggacctctc agacatcagc tgtgtcccag atgtggcaaa agaagtcctg gattgctatg
      661 gctgtgtgga catcctcatc aacaatgcca gtgtgaaggt gaaggggcct gcccataaga
      721 tttctctgga gctcgacaaa aagatcatgg atgccaatta ctttggcccc atcacattga
      781 cgaaagccct gcttcccaac atgatctccc ggagaacagg ccaaatcgtg ttagtgaata
      841 atatccaagg gaagtttgga atcccgttcc gtacgactta cgctgcctcc aagcacgcag
      901 ccctgggctt ctttgactgc ctccgagccg aagtggagga atacgatgtt gtcatcagca
      961 ccgtgagccc gactttcatc cggtcgtacc acgtgtatcc agagcaagga aactgggaag
     1021 cttccatttg gaaattcttt ttcaggaagc tgacctacgg cgtgcaccca gtagaggtgg
     1081 cggaggaggt gatgcgcacc gtgcggagga agaagcaaga ggtgtttatg gccaacccca
     1141 tccccaaggc cgccgtgtac gtccgcacct tcttcccgga gttctttttc gccgtggtgg
     1201 cctgtggggt gaaggagaag ctcaatgtcc cggaggaggg gtaactgcag gaggccaaat
     1261 gggccacccc ttggaaataa aggtttttct ggca
//
