LOCUS       NM_015510               1253 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 7B (DHRS7B), transcript
            variant 1, mRNA.
ACCESSION   NM_015510 NM_016036
VERSION     NM_015510.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087393.7.
            
            On Feb 25, 2021 this sequence version replaced NM_015510.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004126.2, AF151851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395511.8/ ENSP00000378887.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC087393.7         84187-84214         c
            29-207              AC087393.7         38982-39160         c
            208-317             AC087393.7         32836-32945         c
            318-534             AC087393.7         27368-27584         c
            535-627             AC087393.7         26715-26807         c
            628-780             AC087393.7         22315-22467         c
            781-1253            AC087393.7         19758-20230         c
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1253
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /note="dehydrogenase/reductase 7B"
                     /db_xref="GeneID:25979"
                     /db_xref="HGNC:HGNC:24547"
                     /db_xref="MIM:616160"
     exon            1..28
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..986
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /EC_number="1.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dehydrogenase/reductase (SDR family) member 7B;
                     short-chain dehydrogenase/reductase family 32C member 1"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 7B
                     isoform 1"
                     /protein_id="NP_056325.2"
                     /db_xref="CCDS:CCDS11215.1"
                     /db_xref="GeneID:25979"
                     /db_xref="HGNC:HGNC:24547"
                     /db_xref="MIM:616160"
                     /translation="MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWV
                     RGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHAT
                     KVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDK
                     RVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFF
                     DCLRAEMEQYEIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDV
                     LAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRARKERKSKNS"
     exon            29..207
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..317
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..534
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..627
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..780
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1253
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /note="hexamer: AATAAA"
     polyA_site      1253
                     /gene="DHRS7B"
                     /gene_synonym="CGI-93; SDR32C1"
                     /note="major polyA site"
ORIGIN      
        1 gattgactat ggtctctccg gctaccagga agagtctgcc gaaggtgaag gccatggact
       61 tcatcacctc cacagccatc ctgcccctgc tgttcggctg cctgggcgtc ttcggcctct
      121 tccggctgct gcagtgggtg cgcgggaagg cctacctgcg gaatgctgtg gtggtgatca
      181 caggcgccac ctcagggctg ggcaaagaat gtgcaaaagt cttctatgct gcgggtgcta
      241 aactggtgct ctgtggccgg aatggtgggg ccctagaaga gctcatcaga gaactcaccg
      301 cttctcatgc caccaaggtg cagacacaca agccttactt ggtgaccttc gacctcacag
      361 actctggggc catagttgca gcagcagctg agatcctgca gtgctttggc tatgtcgaca
      421 tacttgtcaa caatgctggg atcagctacc gtggtaccat catggacacc acagtggatg
      481 tggacaagag ggtcatggag acaaactact ttggcccagt tgctctaacg aaagcactcc
      541 tgccctccat gatcaagagg aggcaaggcc acattgtcgc catcagcagc atccagggca
      601 agatgagcat tccttttcga tcagcatatg cagcctccaa gcacgcaacc caggctttct
      661 ttgactgtct gcgtgccgag atggaacagt atgaaattga ggtgaccgtc atcagccccg
      721 gctacatcca caccaacctc tctgtaaatg ccatcaccgc ggatggatct aggtatggag
      781 ttatggacac caccacagcc cagggccgaa gccctgtgga ggtggcccag gatgttcttg
      841 ctgctgtggg gaagaagaag aaagatgtga tcctggctga cttactgcct tccttggctg
      901 tttatcttcg aactctggct cctgggctct tcttcagcct catggcctcc agggccagaa
      961 aagagcggaa atccaagaac tcctagtact ctgaccagcc agggccaggg cagagaagca
     1021 gcactcttag gcttgcttac tctacaaggg acagttgcat ttgttgagac tttaatggag
     1081 atttgtctca caagtgggaa agactgaaga aacacatctc gtgcagatct gctggcagag
     1141 gacaatcaaa aacgacaaca agcttcttcc cagggtgagg ggaaacactt aaggaataaa
     1201 tatggagctg gggtttaaca ctaaaaacta gaaataaaca tctcaaacag taa
//
