LOCUS       NM_016029               1956 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens dehydrogenase/reductase 7 (DHRS7), transcript variant
            1, mRNA.
ACCESSION   NM_016029
VERSION     NM_016029.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Rizzotto,A., Tollis,S., Pham,N.T., Zheng,Y., Abad,M.A.,
            Wildenhain,J., Jeyaprakash,A.A., Auer,M., Tyers,M. and
            Schirmer,E.C.
  TITLE     Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by
            Estradiol Propionate in DHRS7-Depleted Cells
  JOURNAL   Cells 13 (1), 57 (2023)
   PUBMED   38201261
  REMARK    GeneRIF: Reduction in Nuclear Size by DHRS7 in Prostate Cancer
            Cells and by Estradiol Propionate in DHRS7-Depleted Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Jiang,K., Yang,Z., Cui,W., Su,K., Ma,J.Z., Payne,T.J. and Li,M.D.
  TITLE     An Exome-Wide Association Study Identifies New Susceptibility Loci
            for Age of Smoking Initiation in African- and European-American
            Populations
  JOURNAL   Nicotine Tob Res 21 (6), 707-713 (2019)
   PUBMED   29216386
  REMARK    GeneRIF: Single nucleotide polymorphism in DHRS7 gene is associated
            with smoking in African americans.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Zemanova,L., Kirubakaran,P., Pato,I.H., Stambergova,H. and
            Vondrasek,J.
  TITLE     The identification of new substrates of human DHRS7 by molecular
            modeling and in vitro testing
  JOURNAL   Int J Biol Macromol 105 (Pt 1), 171-182 (2017)
   PUBMED   28687384
  REMARK    GeneRIF: identification of new substrates of human DHRS7
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Ramasamy,A., Curjuric,I., Coin,L.J., Kumar,A., McArdle,W.L.,
            Imboden,M., Leynaert,B., Kogevinas,M., Schmid-Grendelmeier,P.,
            Pekkanen,J., Wjst,M., Bircher,A.J., Sovio,U., Rochat,T.,
            Hartikainen,A.L., Balding,D.J., Jarvelin,M.R., Probst-Hensch,N.,
            Strachan,D.P. and Jarvis,D.L.
  TITLE     A genome-wide meta-analysis of genetic variants associated with
            allergic rhinitis and grass sensitization and their interaction
            with birth order
  JOURNAL   J Allergy Clin Immunol 128 (5), 996-1005 (2011)
   PUBMED   22036096
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Short-chain dehydrogenases/reductases in retina
  JOURNAL   Methods Enzymol 316, 372-383 (2000)
   PUBMED   10800688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL163853.4.
            
            On Nov 22, 2018 this sequence version replaced NM_016029.3.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) family, which has over 46,000
            members. Members in this family are enzymes that metabolize many
            different compounds, such as steroid hormones, prostaglandins,
            retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.247767.1,
                                           SRR1660803.234503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2155984
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557185.6/ ENSP00000451882.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AL163853.4         133952-134173       c
            223-375             AL163853.4         124775-124927       c
            376-482             AL163853.4         122734-122840       c
            483-722             AL163853.4         121714-121953       c
            723-845             AL163853.4         118840-118962       c
            846-1061            AL163853.4         118128-118343       c
            1062-1956           AL163853.4         112894-113788       c
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..1956
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="dehydrogenase/reductase 7"
                     /db_xref="GeneID:51635"
                     /db_xref="HGNC:HGNC:21524"
                     /db_xref="MIM:612833"
     exon            1..222
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1109
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; retinal short-chain dehydrogenase/reductase 4;
                     dehydrogenase/reductase (SDR family) member 7; short chain
                     dehydrogenase/reductase family 34C member 1"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 7
                     isoform 1 precursor"
                     /protein_id="NP_057113.1"
                     /db_xref="CCDS:CCDS9743.1"
                     /db_xref="GeneID:51635"
                     /db_xref="HGNC:HGNC:21524"
                     /db_xref="MIM:612833"
                     /translation="MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRP
                     EWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE
                     KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIE
                     LNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLR
                     TELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLIS
                     MANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIF
                     KTKHD"
     exon            223..375
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..482
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..722
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..845
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1061
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1956
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1267..1272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="hexamer: AATAAA"
     polyA_site      1297
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="major polyA site"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="hexamer: GATAAA"
     polyA_site      1344
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
                     /note="hexamer: ATTAAA"
     polyA_site      1956
                     /gene="DHRS7"
                     /gene_synonym="CGI-86; retDSR4; retSDR4; SDR34C1"
ORIGIN      
        1 gaaggggtgg cgctgcgatc ccgcagggca gcgacgcgac tctggtgcgg gccgtcttct
       61 tccccccgag ctgggcgtgc gcggccgcaa tgaactggga gctgctgctg tggctgctgg
      121 tgctgtgcgc gctgctcctg ctcttggtgc agctgctgcg cttcctgagg gctgacggcg
      181 acctgacgct actatgggcc gagtggcagg gacgacgccc agaatgggag ctgactgata
      241 tggtggtgtg ggtgactgga gcctcgagtg gaattggtga ggagctggct taccagttgt
      301 ctaaactagg agtttctctt gtgctgtcag ccagaagagt gcatgagctg gaaagggtga
      361 aaagaagatg cctagagaat ggcaatttaa aagaaaaaga tatacttgtt ttgccccttg
      421 acctgaccga cactggttcc catgaagcgg ctaccaaagc tgttctccag gagtttggta
      481 gaatcgacat tctggtcaac aatggtggaa tgtcccagcg ttctctgtgc atggatacca
      541 gcttggatgt ctacagaaag ctaatagagc ttaactactt agggacggtg tccttgacaa
      601 aatgtgttct gcctcacatg atcgagagga agcaaggaaa gattgttact gtgaatagca
      661 tcctgggtat catatctgta cctctttcca ttggatactg tgctagcaag catgctctcc
      721 ggggtttttt taatggcctt cgaacagaac ttgccacata cccaggtata atagtttcta
      781 acatttgccc aggacctgtg caatcaaata ttgtggagaa ttccctagct ggagaagtca
      841 caaagactat aggcaataat ggagaccagt cccacaagat gacaaccagt cgttgtgtgc
      901 ggctgatgtt aatcagcatg gccaatgatt tgaaagaagt ttggatctca gaacaacctt
      961 tcttgttagt aacatatttg tggcaataca tgccaacctg ggcctggtgg ataaccaaca
     1021 agatggggaa gaaaaggatt gagaacttta agagtggtgt ggatgcagac tcttcttatt
     1081 ttaaaatctt taagacaaaa catgactgaa aagagcacct gtacttttca agccactgga
     1141 gggagaaatg gaaaacatga aaacagcaat cttcttatgc ttctgaataa tcaaagacta
     1201 atttgtgatt ttacttttta atagatatga ctttgcttcc aacatggaat gaaataaaaa
     1261 ataaataata aaagattgcc atgaatcttg caaaaaaggt attaactcat actatattct
     1321 tggataaaat aaccttttaa aatactttag cacatatgct taaaatctaa gttaacagat
     1381 ttgtcttagt ccatttgtgc tgctataaca aaataccaca gatttggtaa tttataaaca
     1441 acagaaatct gtttttcctg gctcttgagg ctgggaattc caagaccaat gcaccagcag
     1501 aattagtgtc tggtgaaggc tgatctctgc ttccaagatg gcacctcatt gctgcatcct
     1561 ccacagtgga ggaatgtatg tcctcacatg gtggaaggga cagaagggaa agaggagcaa
     1621 aatgctttca aaagagcatt taatctcatt cattactcag tcacctctta aaggccacat
     1681 cctttaatac tgttgctttg gggattaagt ttcgacatga attttggagg ggacaaaaac
     1741 atccaaacca tagcaacata aatgtataga atatttcaca caaagcagag tgctgggtaa
     1801 tgaccagata taaagaagta tttgaaatga ccttacctcc aagatgctta tactcttaga
     1861 aaagttgaca ggtacagatg gctgtaattt gaagcagcag gtaggattca ttgcacctat
     1921 tattcattaa acacctgttg tatgtcttct actgta
//
