LOCUS       NM_198083               1258 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 4 like 2 (DHRS4L2), transcript
            variant 1, coding, mRNA.
ACCESSION   NM_198083
VERSION     NM_198083.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1258)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1258)
  AUTHORS   Gabrielli,F. and Tofanelli,S.
  TITLE     Molecular and functional evolution of human DHRS2 and DHRS4
            duplicated genes
  JOURNAL   Gene 511 (2), 461-469 (2012)
   PUBMED   23036705
  REMARK    GeneRIF: DHRS4L2 is a duplicate syntenic form of the human DHRS4
            gene.
REFERENCE   3  (bases 1 to 1258)
  AUTHORS   Su,Z.J., Zhang,Q.X., Liu,G.F., Song,X.H., Li,Q., Wang,R.J.,
            Chen,H.B., Xu,X.Y., Sui,X.X. and Huang,D.Y.
  TITLE     Bioinformatic analysis of the human DHRS4 gene cluster and a
            proposed mechanism for its transcriptional regulation
  JOURNAL   BMC Mol Biol 11, 43 (2010)
   PUBMED   20525226
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1258)
  AUTHORS   Zhang,Q., Li,Y., Liu,G., Xu,X., Song,X., Liang,B., Li,R., Xie,J.,
            Du,M., Xiao,L., Gan,X. and Huang,D.
  TITLE     Alternative transcription initiation and splicing variants of the
            DHRS4 gene cluster
  JOURNAL   Biosci Rep 29 (1), 47-56 (2009)
   PUBMED   18754758
REFERENCE   5  (bases 1 to 1258)
  AUTHORS   Song,X.H., Liang,B., Liu,G.F., Li,R., Xie,J.P., Du,K. and
            Huang,D.Y.
  TITLE     Expression of a novel alternatively spliced variant of
            NADP(H)-dependent retinol dehydrogenase/reductase with deletion of
            exon 3 in cervical squamous carcinoma
  JOURNAL   Int J Cancer 120 (8), 1618-1626 (2007)
   PUBMED   17230527
REFERENCE   6  (bases 1 to 1258)
  AUTHORS   Du,J., Huang,D.Y., Liu,G.F., Wang,G.L., Xu,X.L., Wang,B. and Zhu,L.
  TITLE     CDNA cloning of a short isoform of human liver NADP (H) -dependent
            retinol dehydrogenase/reductase and analysis of its characteristics
  JOURNAL   Yi Chuan Xue Bao 31 (7), 661-667 (2004)
   PUBMED   15473316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC101814.1, AL136419.3 and
            GU564234.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_198083.3.
            
            Summary: This gene encodes a member of the short chain
            dehydrogenase reductase family. The encoded protein may be an NADPH
            dependent retinol oxidoreductase. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses the 5'-most in-frame start
            codon, which is conserved in other species. An alternative
            downstream start codon, which is specific to human and has a
            slightly stronger Kozak signal, also exists. It is possible that
            leaky scanning by ribosomes would allow the downstream start codon
            to be used, at least some of the time. The use of the downstream
            start codon would result in a protein that is 2 aa shorter at the
            N-terminus. There is no experimental evidence showing which start
            codon is preferentially used in vivo.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.661016.1, BC000663.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335125.11/ ENSP00000334801.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               BC101814.1         50-815
            767-1135            AL136419.3         142062-142430
            1136-1258           GU564234.1         1114-1236
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1258
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /note="dehydrogenase/reductase 4 like 2"
                     /db_xref="GeneID:317749"
                     /db_xref="HGNC:HGNC:19731"
                     /db_xref="MIM:615196"
     exon            1..147
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..718
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1, coding; short chain dehydrogenase/reductase
                     family 25C member 3; dehydrogenase/reductase (SDR family)
                     member 4 like 2A3; NADPH-dependent retinol
                     dehydrogenase/reductase-like protein 2"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 4-like
                     2 isoform 1 precursor"
                     /protein_id="NP_932349.2"
                     /db_xref="CCDS:CCDS9606.2"
                     /db_xref="GeneID:317749"
                     /db_xref="HGNC:HGNC:19731"
                     /db_xref="MIM:615196"
                     /translation="MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGI
                     GFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAM
                     AVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRG
                     GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNCLHLDLSRLA
                     SAGCSGWTRKKRKA"
     exon            148..325
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..427
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..498
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..550
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..684
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..740
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1258
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /note="hexamer: AATAAA"
     polyA_site      1258
                     /gene="DHRS4L2"
                     /gene_synonym="SDR25C3"
                     /note="major polyA site"
ORIGIN      
        1 agacttgctg gtctgatcca tgcagatggc caggctgcta ggcctctgtg cctgggcacg
       61 gaagtcggtg cggatggcca gctccaggat gacccgccgg gacccgctca caaataaggt
      121 ggccctggta acggcctcca ccgacgggat cggcttcgcc atcgcccggc gtttggccca
      181 ggacagggcc cacgtggtcg tcagcagccg gaagcagcag aatgtggacc aggcggtggc
      241 cacgctgcag ggggaggggc tgagcgtgac gggcactgtg tgccatgtgg ggaaggcgga
      301 ggaccgggag cggctggtgg ccatggctgt gaagcttcat ggaggtatcg atatcctagt
      361 ctccaatgct gctgtcaacc ctttctttgg aagcctaatg gatgtcaccg aggaggtgtg
      421 ggacaagact ctggacatta atgtgaaggc cccagccctg atgacaaagg cagtggtgcc
      481 agaaatggag aaacgaggag gcggctcagt ggtgatcgtg tcttccatag cagccttcag
      541 tccatctcct ggcttcagtc cttacaatgt cagtaaaaca gccttgctgg gcctcaacaa
      601 taccctggcc atagagctgg ccccaaggaa cattagggtg aactgcctgc acctggactt
      661 atcaagacta gcttcagcag gatgctctgg atggacaagg aaaaagagga aagcatgaaa
      721 gaaaccctgc ggataagaag gttaggcgag ccagaggatt gtgctggcat cgtgtctttc
      781 ctgtgctctg aagatgccag ctacatcact ggggaaacag tggtggtggg tggaggaacc
      841 ccgtcccgcc tctgaggacc gggagacagc ccacaggcca gagttgggct ctagctcctg
      901 gtgctgttcc tgcattcacc cactggcctt tcccacctct gctcacctta ctgttcacct
      961 catcaaatca gttctgccct gtgaaaagat ccagccttcc ctgccgtcaa ggtggcgtct
     1021 tactcgggat tcctgctgtt gttgtggcct tgggtaaagg cctcccctga gaacacagga
     1081 caggcctgct gacaaggctg agtctacctt ggcaaagacc aagatatttt ttcctgggcc
     1141 actggggaat ctgaggggtg atgggagaga aggaacctgg agtggaagga gcagagttgc
     1201 aaattaacaa cttgcaaatg aggtgcaaat aaaatgcaga tgattgcgcg gctttgaa
//
