LOCUS       NM_021004               1264 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 4 (DHRS4), transcript variant
            1, mRNA.
ACCESSION   NM_021004
VERSION     NM_021004.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Zhou,Y., Li,K., Zou,X., Hua,Z., Wang,H., Bian,W., Wang,H., Chen,F.
            and Dai,T.
  TITLE     LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by
            suppressing proliferation and promoting apoptosis via
            miR-522-3p/SOCS5 axis
  JOURNAL   Bioengineered 12 (2), 10862-10877 (2021)
   PUBMED   34666613
  REMARK    GeneRIF: LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by
            suppressing proliferation and promoting apoptosis via
            miR-522-3p/SOCS5 axis.
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Su,Z., Liu,G., Song,X., Liang,B., Chang,X. and Huang,D.
  TITLE     CpG island evolution in the mammalian DHRS4 gene cluster and its
            role in the regulation of gene transcription
  JOURNAL   Genet Mol Res 15 (2) (2016)
   PUBMED   27323117
  REMARK    GeneRIF: An analysis of the relationship between the promoter
            characteristics and RNA expression of the DHRS4 gene cluster
            indicated that the development of CpG islands, in addition to the
            promoter sequence, during mammalian evolution could modulate the
            dose compensatory regulation of the copy number-varied DHRS4 gene
            cluster
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Yang,Y., Su,Z., Song,X., Liang,B., Zeng,F., Chang,X. and Huang,D.
  TITLE     Enhancer RNA-driven looping enhances the transcription of the long
            noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster
  JOURNAL   Sci Rep 6, 20961 (2016)
   PUBMED   26864944
  REMARK    GeneRIF: AS1eRNA-driven DNA looping and activating histone
            modifications promote the expression of DHRS4-AS1 to economically
            control the DHRS4 gene cluster.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Yan,Y., Song,X., Liu,G., Su,Z., Du,Y., Sui,X., Chang,X. and
            Huang,D.
  TITLE     Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent
            retinol dehydrogenase/reductase enhanced enzymatic activity of
            benzil
  JOURNAL   Cell Physiol Biochem 30 (6), 1371-1382 (2012)
   PUBMED   23128527
  REMARK    GeneRIF: NRDRB1, an alternatively spliced isoform of NRDR in vivo
            functions better than NRDR as a dicarbonyl reductase for
            xenobiotics containing reactive carbonyls.
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Matsunaga,T., Endo,S., Maeda,S., Ishikura,S., Tajima,K., Tanaka,N.,
            Nakamura,K.T., Imamura,Y. and Hara,A.
  TITLE     Characterization of human DHRS4: an inducible short-chain
            dehydrogenase/reductase enzyme with 3beta-hydroxysteroid
            dehydrogenase activity
  JOURNAL   Arch Biochem Biophys 477 (2), 339-347 (2008)
   PUBMED   18571493
  REMARK    GeneRIF: Results suggest a novel mechanism of cold inactivation and
            role of the inducible human DHRS4 in 3beta-hydroxysteroid synthesis
            and xenobiotic carbonyl metabolism
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Song,X.H., Liang,B., Liu,G.F., Li,R., Xie,J.P., Du,K. and
            Huang,D.Y.
  TITLE     Expression of a novel alternatively spliced variant of
            NADP(H)-dependent retinol dehydrogenase/reductase with deletion of
            exon 3 in cervical squamous carcinoma
  JOURNAL   Int J Cancer 120 (8), 1618-1626 (2007)
   PUBMED   17230527
  REMARK    GeneRIF: Alternatively spliced variant of NADP(H)-dependent retinol
            dehydrogenase/reductase with deletion of exon 3 is associated with
            cervical squamous carcinoma
REFERENCE   8  (bases 1 to 1264)
  AUTHORS   Du,J., Huang,D.Y., Liu,G.F., Wang,G.L., Xu,X.L., Wang,B. and Zhu,L.
  TITLE     CDNA cloning of a short isoform of human liver NADP (H) -dependent
            retinol dehydrogenase/reductase and analysis of its characteristics
  JOURNAL   Yi Chuan Xue Bao 31 (7), 661-667 (2004)
   PUBMED   15473316
REFERENCE   9  (bases 1 to 1264)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1264)
  AUTHORS   Fransen,M., Van Veldhoven,P.P. and Subramani,S.
  TITLE     Identification of peroxisomal proteins by using M13 phage protein
            VI phage display: molecular evidence that mammalian peroxisomes
            contain a 2,4-dienoyl-CoA reductase
  JOURNAL   Biochem J 340 (Pt 2) (Pt 2), 561-568 (1999)
   PUBMED   10333503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU529016.1, BC003019.1, BQ030242.1 and CA438339.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021004.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044127.1, AY358638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313250.10/ ENSP00000326219.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               BU529016.1         15-441
            428-911             BC003019.1         411-894
            912-1259            BQ030242.1         17-364              c
            1260-1264           CA438339.1         17-21               c
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1264
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /note="dehydrogenase/reductase 4"
                     /db_xref="GeneID:10901"
                     /db_xref="HGNC:HGNC:16985"
                     /db_xref="MIM:611596"
     exon            1..147
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..856
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /EC_number="1.1.1.184"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal short-chain alcohol dehydrogenase; short chain
                     dehydrogenase/reductase family 25C, member 1; short chain
                     dehydrogenase/reductase family 25C member 2;
                     NADPH-dependent retinol dehydrogenase/reductase;
                     NADPH-dependent carbonyl reductase;
                     dehydrogenase/reductase (SDR family) member 4 like 2A;
                     short-chain dehydrogenase/reductase family member 4;
                     NADPH-dependent carbonyl reductase/NADP-retinol
                     dehydrogenase"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 4
                     isoform 1"
                     /protein_id="NP_066284.2"
                     /db_xref="CCDS:CCDS9605.1"
                     /db_xref="GeneID:10901"
                     /db_xref="HGNC:HGNC:16985"
                     /db_xref="MIM:611596"
                     /translation="MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGI
                     GFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAT
                     AVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRG
                     GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTS
                     FSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPS
                     RL"
     exon            148..325
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..427
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..498
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..550
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..685
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..741
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1264
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /note="hexamer: AATAAA"
     polyA_site      1264
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /note="major polyA site"
ORIGIN      
        1 atacttgctg gtctgatcca tgcacaaggc ggggctgcta ggcctctgtg cccgggcttg
       61 gaattcggtg cggatggcca gctccgggat gacccgccgg gacccgctcg caaataaggt
      121 ggccctggta acggcctcca ccgacgggat cggcttcgcc atcgcccggc gtttggccca
      181 ggacggggcc catgtggtcg tcagcagccg gaagcagcag aatgtggacc aggcggtggc
      241 cacgctgcag ggggaggggc tgagcgtgac gggcaccgtg tgccatgtgg ggaaggcgga
      301 ggaccgggag cggctggtgg ccacggctgt gaagcttcat ggaggtatcg atatcctagt
      361 ctccaatgct gctgtcaacc ctttctttgg aagcataatg gatgtcactg aggaggtgtg
      421 ggacaagact ctggacatta atgtgaaggc cccagccctg atgacaaagg cagtggtgcc
      481 agaaatggag aaacgaggag gcggctcagt ggtgatcgtg tcttccatag cagccttcag
      541 tccatctcct ggcttcagtc cttacaatgt cagtaaaaca gccttgctgg gcctgaccaa
      601 gaccctggcc atagagctgg ccccaaggaa cattagggtg aactgcctag cacctggact
      661 tatcaagact agcttcagca ggatgctctg gatggacaag gaaaaagagg aaagcatgaa
      721 agaaaccctg cggataagaa ggttaggcga gccagaggat tgtgctggca tcgtgtcttt
      781 cctgtgctct gaagatgcca gctacatcac tggggaaaca gtggtggtgg gtggaggaac
      841 cccgtcccgc ctctgaggac cgggagacag cccacaggcc agagttgggc tctagctcct
      901 ggtgctgttc ccgcattcac ccactggcct ttcccacctc tgctcacctt actgttcacc
      961 tcatcaaatc agttctgccc tgtgaaaaga tccagccttc cctgccgtca aggtggcgtc
     1021 ttactcggga tttctgctgt tgttgtggcc ttgggtaaag gcctcccctg agaacacagg
     1081 acaggcctgc tgacaaggct gagtctacct tggcaaagac caagatattt tttcccgggc
     1141 cactggggaa tctgaggggt gatgggagag aaggaacctg gagtggaagg agcagagttg
     1201 caaattaaca acttgcaaat gaggtgcaaa taaaatgcag atgattgcgc ggctttgaat
     1261 ccaa
//
