LOCUS       NM_004753               2201 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 3 (DHRS3), transcript variant
            1, mRNA.
ACCESSION   NM_004753
VERSION     NM_004753.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2201)
  AUTHORS   Dai,X., Chen,X., Chen,W., Ou,Y., Chen,Y., Wu,S., Zhou,Q., Yang,C.,
            Zhang,L. and Jiang,H.
  TITLE     CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis
  JOURNAL   Epigenetics 18 (1), 2178802 (2023)
   PUBMED   36840946
  REMARK    GeneRIF: CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis.
REFERENCE   2  (bases 1 to 2201)
  AUTHORS   Lou,S., Gao,H., Hong,H., Zhu,Z. and Zhao,H.
  TITLE     Inhibition of retinoic acid receptor alpha phosphorylation
            represses the progression of triple-negative breast cancer via
            transactivating miR-3074-5p to target DHRS3
  JOURNAL   J Exp Clin Cancer Res 40 (1), 141 (2021)
   PUBMED   33902658
  REMARK    GeneRIF: Inhibition of retinoic acid receptor alpha phosphorylation
            represses the progression of triple-negative breast cancer via
            transactivating miR-3074-5p to target DHRS3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2201)
  AUTHORS   Wang,S., Yu,J., Jones,J.W., Pierzchalski,K., Kane,M.A.,
            Trainor,P.A., Xavier-Neto,J. and Moise,A.R.
  TITLE     Retinoic acid signaling promotes the cytoskeletal rearrangement of
            embryonic epicardial cells
  JOURNAL   FASEB J 32 (7), 3765-3781 (2018)
   PUBMED   29447006
  REMARK    GeneRIF: Mouse Dhrs3 plays critical roles in the development of the
            heart by controlling the formation of retinoic acid.
REFERENCE   4  (bases 1 to 2201)
  AUTHORS   Xiao,Y., Hill,M.C., Zhang,M., Martin,T.J., Morikawa,Y., Wang,S.,
            Moise,A.R., Wythe,J.D. and Martin,J.F.
  TITLE     Hippo Signaling Plays an Essential Role in Cell State Transitions
            during Cardiac Fibroblast Development
  JOURNAL   Dev Cell 45 (2), 153-169 (2018)
   PUBMED   29689192
  REMARK    GeneRIF: Yap targets Dhrs3, to reduce retinoic acid synthesis and
            inhibit cardiac fibroblast differentiation during development.
REFERENCE   5  (bases 1 to 2201)
  AUTHORS   Wang,H., Guo,J., Jiang,J., Wu,W., Chang,X., Zhou,H., Li,Z. and
            Zhao,J.
  TITLE     New genes associated with rheumatoid arthritis identified by gene
            expression profiling
  JOURNAL   Int J Immunogenet 44 (3), 107-113 (2017)
   PUBMED   28371410
  REMARK    GeneRIF: we proposed that four newly identified peripheral blood
            mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2
            )could be integrated with previously reported rheumatoid arthritis
            (RA)-associated genes to monitor and/or diagnose RA.
REFERENCE   6  (bases 1 to 2201)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2201)
  AUTHORS   Haeseleer,F., Jang,G.F., Imanishi,Y., Driessen,C.A.G.G.,
            Matsumura,M., Nelson,P.S. and Palczewski,K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
REFERENCE   8  (bases 1 to 2201)
  AUTHORS   Cerignoli,F., Guo,X., Cardinali,B., Rinaldi,C., Casaletto,J.,
            Frati,L., Screpanti,I., Gudas,L.J., Gulino,A., Thiele,C.J. and
            Giannini,G.
  TITLE     retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic
            acid-inducible and frequently deleted in human neuroblastoma cell
            lines
  JOURNAL   Cancer Res 62 (4), 1196-1204 (2002)
   PUBMED   11861404
REFERENCE   9  (bases 1 to 2201)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Short-chain dehydrogenases/reductases in retina
  JOURNAL   Methods Enzymol 316, 372-383 (2000)
   PUBMED   10800688
REFERENCE   10 (bases 1 to 2201)
  AUTHORS   Haeseleer,F., Huang,J., Lebioda,L., Saari,J.C. and Palczewski,K.
  TITLE     Molecular characterization of a novel short-chain
            dehydrogenase/reductase that reduces all-trans-retinal
  JOURNAL   J Biol Chem 273 (34), 21790-21799 (1998)
   PUBMED   9705317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC254633.1 and BX648476.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004753.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648476.1, SRR5189667.214862.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616661.5/ ENSP00000480439.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AC254633.1         57960-58438
            480-2201            BX648476.1         7-1728
FEATURES             Location/Qualifiers
     source          1..2201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2201
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /note="dehydrogenase/reductase 3"
                     /db_xref="GeneID:9249"
                     /db_xref="HGNC:HGNC:17693"
                     /db_xref="MIM:612830"
     exon            1..1057
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             863..1771
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 is encoded by transcript variant 1;
                     short-chain dehydrogenase/reductase 1; short-chain
                     dehydrogenase/reductase 3; retinal short-chain
                     dehydrogenase/reductase 1; retinol dehydrogenase 17; short
                     chain dehydrogenase/reductase family 16C member 1;
                     dehydrogenase/reductase (SDR family) member 3;
                     dehydrogenase/reductase member 3; copy number amplified
                     long noncoding RNA in papillary thyroid cancer 1"
                     /codon_start=1
                     /product="short-chain dehydrogenase/reductase 3 isoform 1"
                     /protein_id="NP_004744.2"
                     /db_xref="CCDS:CCDS146.1"
                     /db_xref="GeneID:9249"
                     /db_xref="HGNC:HGNC:17693"
                     /db_xref="MIM:612830"
                     /translation="MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLIT
                     GGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREE
                     VYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLP
                     RMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVL
                     PFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSI
                     LPQAALEEIHKFSGTYTCMNTFKGRT"
     exon            1058..1201
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1321
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1560
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1686
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..2201
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /note="hexamer: AATAAA"
     polyA_site      2201
                     /gene="DHRS3"
                     /gene_synonym="CNALPTC1; DD83.1; RDH17; retSDR1; Rsdr1;
                     SDR1; SDR16C1"
                     /note="major polyA site"
ORIGIN      
        1 cgatccacgc gcgctccaca cccggaccct ctccaagttg gaaaggacaa aaagaaggca
       61 ataaatgcta aaaagggaga gaaggggagc tggatcgagc ggcaactccc agcctctgct
      121 ggaacagaga gggagggagg gagccggagc gagcgagcgc gcgcgagggc gagcgctgca
      181 cgtaaagaaa ctgacacccg gaccccccac ttctcctgca cgttgctggc aatcagatcg
      241 cgtttaagca atttcctgag cccaagaata gcaatgagtc gggagacttt cgcgggctga
      301 aattgggagc tccaagcact ttttcccccc actttttttt tttttttttt tctggagacg
      361 gggtgggggt gggggcgcta caatttggaa tcagcttttt tttttttttt tttttttttt
      421 ttaatcttgc actttgaaac cgcgggaccg aggcagggtg cgcgcgtgtg gttggtgcct
      481 tttttttttt ttcttcccct ccctaaactc ctctgtcagt ctgtaaacat tacctgagaa
      541 ttccccagcc gaaacggctg ctggggcaag aaacttcttg ttagaacttt ccacctccgg
      601 cttccccctc cacctctttt accgtcccaa ccttaggaga cgctttttct cccccagagg
      661 agaatttatc tttttttttt tttttttttt ctttttctca cccggtgctt tgcatttggg
      721 aagaggtgat ttcaagagtg gccaggtggg acgcctctct cctccttatt cggtttacta
      781 tttattgttc ggggtgtttt ttaattcctg tattgctcgg cccggggagt ttcgccccct
      841 gcccggctcc gcggcgcgga ggatggtgtg gaaacggctg ggcgcgctgg tgatgttccc
      901 tctacagatg atctatctgg tggtgaaagc agccgtcgga ctggtgctgc ccgccaagct
      961 gcgggacctg tcgcgggaga acgtcctcat caccggcggc gggagaggca tcgggcgtca
     1021 gctcgcccgc gagttcgcgg agcgcggcgc cagaaagatt gttctctggg gccggactga
     1081 gaaatgcctg aaggagacga cggaggagat ccggcagatg ggcactgagt gccattactt
     1141 catctgtgat gtgggcaacc gggaggaggt gtaccagacg gccaaggccg tccgggagaa
     1201 ggtgggtgac atcaccatcc tggtgaacaa tgccgccgtg gtccatggga agagcctaat
     1261 ggacagtgat gatgatgccc tcctcaagtc ccaacacatc aacaccctgg gccagttctg
     1321 gaccaccaag gccttcctgc cgcgtatgct ggagctgcag aatggccaca tcgtgtgcct
     1381 caactccgtg ctggcactgt ctgccatccc cggtgccatc gactactgca catccaaagc
     1441 gtcagccttc gccttcatgg agagcctgac cctggggctg ctggactgtc cgggagtcag
     1501 cgccaccaca gtgctgccct tccacaccag caccgagatg ttccagggca tgagagtcag
     1561 gtttcccaac ctctttcccc cactgaagcc ggagacggtg gcccggagga cagtggaagc
     1621 tgtgcagctc aaccaggccc tcctcctcct cccatggaca atgcatgccc tcgttatctt
     1681 gaaaagcata cttccacagg ctgcactcga ggagatccac aaattctcag gaacctacac
     1741 ctgcatgaac actttcaaag ggcggacata gagacaggat gaagacatgc ttgaggagcc
     1801 acggagtttg ggggccacag cacctgggca cacacccgag cacctgtcca ttggcatgct
     1861 tctgctgggt gagcaggaca gctcctgtcc ccagcgaaga atccggctgc ccctgggcca
     1921 gtcccaggac ctttgcacag gactgatggg tataactgac ccccacaggg aggcaggaaa
     1981 acagccagaa gccaccttga cacttttgaa catttccagt tctgtagagt ttattgtcaa
     2041 ttgcttctca agtctaacca gcctcagcag tgtgcataga ccatttccag gagggtctgt
     2101 ccccagatgc tctgcctccc gttccaaaac ccactcatcc tcagcttgca caaactggtt
     2161 gaacggcagg aatgaaaaat aaagagagat ggcttttgtg a
//
