LOCUS       NM_005794               1676 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 2 (DHRS2), transcript variant
            2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_005794
VERSION     NM_005794.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Ryu,T.Y., Lee,J., Kang,Y., Son,M.Y., Kim,D.S., Lee,Y.S., Kim,M.Y.
            and Cho,H.S.
  TITLE     Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis
            in renal cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 663, 41-46 (2023)
   PUBMED   37119764
  REMARK    GeneRIF: Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell
            apoptosis in renal cell carcinoma.
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Wu,X., Zeng,Z., Peng,K., Ren,D. and Zhang,L.
  TITLE     Regulatory mechanism of DHRS2-modified human umbilical cord
            mesenchymal stem cells-derived exosomes in prostate cancer cell
            proliferation and apoptosis
  JOURNAL   Tissue Cell 82, 102078 (2023)
   PUBMED   37060745
  REMARK    GeneRIF: Regulatory mechanism of DHRS2-modified human umbilical
            cord mesenchymal stem cells-derived exosomes in prostate cancer
            cell proliferation and apoptosis.
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Li,Z., Tan,Y., Li,X., Quan,J., Bode,A.M., Cao,Y. and Luo,X.
  TITLE     DHRS2 inhibits cell growth and metastasis in ovarian cancer by
            downregulation of CHKalpha to disrupt choline metabolism
  JOURNAL   Cell Death Dis 13 (10), 845 (2022)
   PUBMED   36192391
  REMARK    GeneRIF: DHRS2 inhibits cell growth and metastasis in ovarian
            cancer by downregulation of CHKalpha to disrupt choline metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Sirma Ekmekci,S., Emrence,Z., Abaci,N., Sariman,M., Salman,B.,
            Ekmekci,C.G. and Gulec,C.
  TITLE     LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat
            T-Cells
  JOURNAL   Turk J Haematol 37 (4), 226-233 (2020)
   PUBMED   32586085
  REMARK    GeneRIF: LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia
            Jurkat T-Cells
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Iida,A., Saito,S., Sekine,A., Takahashi,A., Kamatani,N. and
            Nakamura,Y.
  TITLE     Japanese single nucleotide polymorphism database for 267 possible
            drug-related genes
  JOURNAL   Cancer Sci 97 (1), 16-24 (2006)
   PUBMED   16367916
  REMARK    Review article
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Pellegrini,S., Censini,S., Guidotti,S., Iacopetti,P., Rocchi,M.,
            Bianchi,M., Covacci,A. and Gabrielli,F.
  TITLE     A human short-chain dehydrogenase/reductase gene: structure,
            chromosomal localization, tissue expression and subcellular
            localization of its product
  JOURNAL   Biochim Biophys Acta 1574 (3), 215-222 (2002)
   PUBMED   11997086
  REMARK    GeneRIF: Molecular cloning, sequence and Chr 14 localization of the
            DHRS2 gene. Nuclear and cytoplasmic localization and normal tissue
            distribution of the DHRS2-encoded Hep27 protein.
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Heinz,S., Krause,S.W., Gabrielli,F., Wagner,H.M., Andreesen,R. and
            Rehli,M.
  TITLE     Genomic organization of the human gene HEP27: alternative promoter
            usage in HepG2 cells and monocyte-derived dendritic cells
  JOURNAL   Genomics 79 (4), 608-615 (2002)
   PUBMED   11944995
  REMARK    GeneRIF: Complete genomic organization of DHRS2, including two
            alternative promoter regions: a hepatocyte-specific promoter and a
            monocyte-derived dendritic cell-specific promoter
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Gabrielli,F., Donadel,G., Bensi,G., Heguy,A. and Melli,M.
  TITLE     A nuclear protein, synthesized in growth-arrested human
            hepatoblastoma cells, is a novel member of the short-chain alcohol
            dehydrogenase family
  JOURNAL   Eur J Biochem 232 (2), 473-477 (1995)
   PUBMED   7556196
  REMARK    GeneRIF: Hep27 a cell-cycle regulated protein belongs to the SDR
            family (short-chain dehydrogenase/reductase family).
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Donadel,G., Garzelli,C., Frank,R. and Gabrielli,F.
  TITLE     Identification of a novel nuclear protein synthesized in
            growth-arrested human hepatoblastoma HepG2 cells
  JOURNAL   Eur J Biochem 195 (3), 723-729 (1991)
   PUBMED   1847869
  REMARK    GeneRIF: The synthesis of the nuclear protein D (Hep27 protein old
            name) is up-regulated in growth-inhibited HepG2 cells and is
            inhibited during DNA synthesis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK222857.1 and U31875.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005794.3.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) family, which has over 46,000
            members. Members of this family are enzymes that metabolize many
            different compounds, such as steroid hormones, prostaglandins,
            retinoids, lipids and xenobiotics. Alternative promoter use and
            alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, resulting in a
            shorter protein (isoform 2). The promoter used by this transcript
            is a hepatocyte-specific promoter.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222857.1, SRR7346977.409179.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250383.11/ ENSP00000250383.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AK222857.1         1-399
            400-1100            U31875.1           386-1086
            1101-1676           AK222857.1         1101-1676
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1676
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /note="dehydrogenase/reductase 2"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
     exon            1..409
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..587
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1290
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     short-chain alcohol dehydrogenase family member;
                     dehydrogenase/reductase member 2; protein D; dicarbonyl
                     reductase HEP27; dehydrogenase/reductase SDR family member
                     2, mitochondrial; short chain dehydrogenase/reductase
                     family 25C member 1; dehydrogenase/reductase (SDR family)
                     member 2"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform 2"
                     /protein_id="NP_005785.1"
                     /db_xref="CCDS:CCDS9604.1"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
                     /translation="MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGS
                     TSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQ
                     LVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYM
                     ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGII
                     KTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGY
                     STRL"
     exon            588..765
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..867
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..935
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..987
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1122
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1178
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1676
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /note="major polyA site"
ORIGIN      
        1 agcaacctgc tctggttccc ttccacgctg tggaagcttt gttcttttgg tcttcatgat
       61 aaatcttgct gctgctcact cgttgggtcc gtgccacctt taagagctgt aacactcacc
      121 gcgaaggtct gcaacttcac tcctggggcc agcaagacca cgaatgcacc gagaggaatg
      181 aacaactctg gacacaccat ctttaagaac cgtaatactc accgcaaggg tctgcaactt
      241 cattcttgaa gtcagtgagg ccaagaaccc atcaattccg tacacatttt ggtgactttg
      301 aagagactgt cacctatcac caagtggtga gactattgcc aagcagtgag actattgcca
      361 agtggtgaga ccatcaccaa gcggtgagac tatcacctat cgccaagtgg cctgattcag
      421 caggaagcat ctcagacacc aaccactatg ctgtcagcag ttgcccgggg ctaccagggc
      481 tggtttcatc cctgtgctag gctttctgtg aggatgagca gcaccgggat agacaggaag
      541 ggcgtcctgg ctaaccgggt agccgtggtc acggggtcca ccagtgggat cggctttgcc
      601 atcgcccgac gtctggcccg ggacggggcc cacgtggtca tcagcagccg gaagcagcag
      661 aacgtggacc gggccatggc caagctgcag ggggaggggc tgagtgtggc gggcattgtg
      721 tgccacgtgg ggaaggctga ggaccgggag cagctggtgg ccaaggccct ggagcactgt
      781 gggggcgtcg acttcctggt gtgcagcgca ggggtcaacc ctctggtagg gagcactctg
      841 gggaccagtg agcagatctg ggacaagatc ctaagtgtga acgtgaagtc cccagccctg
      901 ctgctgagcc agttgctgcc ctacatggag aacaggaggg gtgctgtcat cctggtctct
      961 tccattgcag cttataatcc agtagtggcg ctgggtgtct acaatgtcag caagacagcg
     1021 ctgctgggtc tcactagaac actggcattg gagctggccc ccaaggacat ccgggtaaac
     1081 tgcgtggttc caggaattat caaaactgac ttcagcaaag tgtttcatgg gaatgagtct
     1141 ctctggaaga acttcaagga acatcatcag ctgcagagga ttggggagtc agaggactgt
     1201 gcaggaatcg tgtccttcct gtgctctcca gatgccagct acgtcaacgg ggagaacatt
     1261 gcggtggcag gctactccac tcggctctga gaggagtggg ggcggctgcg tagctgtggt
     1321 cccaggccca ggagcctgag ggggtgtcta ggtgatcatt tggatctgga ggcagagtct
     1381 gccattctgc cagactagca atttgggggc ttactcatgc taggcttgag gaagaagaaa
     1441 aacgcttcgg cattctcctt aggacttatc tgcttgtaga tttggctgat ccaattaaca
     1501 tgtggggttc ttggtgtggg tctggggagc tgaaggattt tatggagctg gtgctttgga
     1561 ggaatcttaa gggaaaggag tagaagctca ggcctttgaa ggatttcagc tcctcctctc
     1621 tgtaatttgt gctttaagca ttttttttcc taaaataaac tcaaatttat cctcaa
//
