LOCUS       NM_144683               1929 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 13 (DHRS13), mRNA.
ACCESSION   NM_144683
VERSION     NM_144683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024267.18, AY358566.1 and BQ052759.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144683.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.974093.1,
                                           SRR3476690.390985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378895.9/ ENSP00000368173.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC024267.18        96220-96227         c
            9-1328              AY358566.1         1-1320
            1329-1873           BQ052759.1         141-685
            1874-1926           AY358566.1         1866-1918
            1927-1929           BQ052759.1         740-742
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1929
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /note="dehydrogenase/reductase 13"
                     /db_xref="GeneID:147015"
                     /db_xref="HGNC:HGNC:28326"
                     /db_xref="MIM:616157"
     exon            1..262
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1269
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /note="dehydrogenase/reductase (SDR family) member 13;
                     short chain dehydrogenase/reductase family 7C member 5"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 13
                     precursor"
                     /protein_id="NP_653284.2"
                     /db_xref="CCDS:CCDS11246.2"
                     /db_xref="GeneID:147015"
                     /db_xref="HGNC:HGNC:28326"
                     /db_xref="MIM:616157"
                     /translation="MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGA
                     NSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASV
                     RAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKAC
                     APSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEAT
                     GVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEP
                     LSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPS
                     SLSTPHPEEPTVSQPYPSPQSSPDLSKMTHRIQAKVEPEIQLS"
     exon            263..381
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..505
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /inference="alignment:Splign:2.1.0"
     exon            506..817
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1929
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /note="hexamer: AATAAA"
     polyA_site      1929
                     /gene="DHRS13"
                     /gene_synonym="SDR7C5"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgcccg cctccgcctt cggaggctga cgcgcccggg cgccgttcca ggcctgtgca
       61 gggcggatcg gcagccgcct ggcggcgatc cagggcggtg cggggcctgg gcgggagccg
      121 ggaggcgcgg ccggcatgga ggcgctgctg ctgggcgcgg ggttgctgct gggcgcttac
      181 gtgcttgtct actacaacct ggtgaaggcc ccgccgtgcg gcggcatggg caacctgcgg
      241 ggccgcacgg ccgtggtcac gggcgccaac agcggcatcg gaaagatgac ggcgctggag
      301 ctggcgcgcc ggggagcgcg cgtggtgctg gcctgccgca gccaggagcg cggggaggcg
      361 gctgccttcg acctccgcca ggagagtggg aacaatgagg tcatcttcat ggccttggac
      421 ttggccagtc tggcctcggt gcgggccttt gccactgcct ttctgagctc tgagccacgg
      481 ttggacatcc tcatccacaa tgccggtatc agttcctgtg gccggacccg tgaggcgttt
      541 aacctgctgc ttcgggtgaa ccatatcggt ccctttctgc tgacacatct gctgctgcct
      601 tgcctgaagg catgtgcccc tagccgcgtg gtggtggtag cctcagctgc ccactgtcgg
      661 ggacgtcttg acttcaaacg cctggaccgc ccagtggtgg gctggcggca ggagctgcgg
      721 gcatatgctg acactaagct ggctaatgta ctgtttgccc gggagctcgc caaccagctt
      781 gaggccactg gcgtcacctg ctatgcagcc cacccagggc ctgtgaactc ggagctgttc
      841 ctgcgccatg ttcctggatg gctgcgccca cttttgcgcc cattggcttg gctggtgctc
      901 cgggcaccaa gagggggtgc ccagacaccc ctgtattgtg ctctacaaga gggcatcgag
      961 cccctcagtg ggagatattt tgccaactgc catgtggaag aggtgcctcc agctgcccga
     1021 gacgaccggg cagcccatcg gctatgggag gccagcaaga ggctggcagg gcttgggcct
     1081 ggggaggatg ctgaacccga tgaagacccc cagtctgagg actcagaggc cccatcttct
     1141 ctaagcaccc cccaccctga ggagcccaca gtttctcaac cttaccccag ccctcagagc
     1201 tcaccagatt tgtctaagat gacgcaccga attcaggcta aagttgagcc tgagatccag
     1261 ctctcctaac cctcaggcca ggatgcttgc catggcactt catggtcctt gaaaacctcg
     1321 gatgtgtgcg aggccatgcc ctggacactg acgggtttgt gatcttgacc tccgtggtta
     1381 ctttctgggg ccccaagctg tgccctggac atctcttttc ctggttgaag gaataatggg
     1441 tgattatttc ttcctgagag tgacagtaac cccagatgga gagatagggg tatgctagac
     1501 actgtgcttc tcggaaattt ggatgtagta ttttcaggcc ccacccttat tgattctgat
     1561 cagctctgga gcagaggcag ggagtttgca atgtgatgca ctgccaacat tgagaattag
     1621 tgaactgatc cctttgcaac cgtctagcta ggtagttaaa ttacccccat gttaatgaag
     1681 cggaattagg ctcccgagct aagggactcg cctagggtct cacagtgagt aggaggaggg
     1741 cctgggatct gaacccaagg gtctgaggcc agggccgact gccgtaagat gggtgctgag
     1801 aagtgagtca gggcagggca gctggtatcg aggtgcccca tgggagtaag gggacgcctt
     1861 ccgggcggat gcagggctgg ggtcatctgt atctgaagcc cctcggaata aagcgcgttg
     1921 accgccgaa
//
