LOCUS       NM_001377533            1119 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 12 (DHRS12), transcript
            variant 4, mRNA.
ACCESSION   NM_001377533
VERSION     NM_001377533.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Chang,X., March,M., Mentch,F., Qu,H., Liu,Y., Glessner,J.,
            Sleiman,P. and Hakonarson,H.
  TITLE     Genetic architecture of asthma in African American patients
  JOURNAL   J Allergy Clin Immunol 151 (4), 1132-1136 (2023)
   PUBMED   36089080
  REMARK    GeneRIF: Genetic architecture of asthma in African American
            patients.
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Xu,Z., He,W., Ke,T., Zhang,Y. and Zhang,G.
  TITLE     DHRS12 inhibits the proliferation and metastasis of osteosarcoma
            via Wnt3a/beta-catenin pathway
  JOURNAL   Future Oncol 16 (11), 665-674 (2020)
   PUBMED   32250163
  REMARK    GeneRIF: DHRS12 inhibits the proliferation and metastasis of
            osteosarcoma via Wnt3a/beta-catenin pathway.
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162377.10 and AL136525.17.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) family, which has over 46,000
            members. Members in this family are enzymes that metabolize many
            different compounds, such as steroid hormones, prostaglandins,
            retinoids, lipids and xenobiotics. Alternative splicing results in
            multiple transcript variants and protein isoforms. [provided by
            RefSeq, Jul 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.5532605.1,
                                           SRR18074968.705914.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444610.8/ ENSP00000411565.3
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL162377.10        33090-33199         c
            111-244             AL162377.10        28570-28703         c
            245-337             AL162377.10        20201-20293         c
            338-419             AL162377.10        19047-19128         c
            420-481             AL162377.10        6096-6157           c
            482-586             AL162377.10        2966-3070           c
            587-677             AL162377.10        857-947             c
            678-815             AL136525.17        143432-143569       c
            816-1119            AL136525.17        142269-142572       c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..1119
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /note="dehydrogenase/reductase 12"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
     exon            1..110
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..244
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..925
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     short-chain dehydrogenase/reductase family 40C member 1;
                     dehydrogenase/reductase (SDR family) member 12"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform 4"
                     /protein_id="NP_001364462.1"
                     /db_xref="CCDS:CCDS91809.1"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
                     /translation="MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENI
                     FLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGV
                     YILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQV
                     VLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLAL
                     SSAAAAQPSGRFFQDRKPVSTHLPLATASSSPAEEEKLIEILEQLAQTFK"
     exon            245..337
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..419
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..481
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..586
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..677
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..815
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1119
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /note="hexamer: AATAAA"
     polyA_site      1119
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /note="major polyA site"
ORIGIN      
        1 agggcggagg ccgcgccggg agcgcggtgg ggctaggcgt ggggcgctcc cggcatgtcc
       61 ctgtaccgca gcgtcgtgtg gttcgccaag gggctgcgcg agtacaccaa gagtggctat
      121 gaatctgcat gtaaagactt tgtccctcat gacttggagg tccagattcc tggaagagtc
      181 tttttggtca ctggaggaaa cagcggcatt ggcaaagcaa ctgcccttga aatcgccaag
      241 cgagaacatt tttctgcaca ttgtggactt gtctgatccc aagcaaatct ggaaatttgt
      301 tgaaaatttc aagcaggaac ataaactcca tgttctgatc aataatgcag gttgcatggt
      361 caataaaaga gagctcacag aagatggact tgaaaaaaac tttgctgcca atactctggg
      421 tgtgtacatt ctcacgaccg gcctgatccc tgtgctggag aaagaacacg acccccgagt
      481 gataaccgtc tcctcaggag gaatgttggt tcagaaactg aacaccaatg atctccagtc
      541 cgaaagaaca ccatttgatg gaactatggt ctatgcacaa aacaagaggc agcaagtggt
      601 tctgacggag cggtgggccc aagggcaccc ggccatccat ttttcttcca tgcatcctgg
      661 ctgggccgac accccaggtg tgaggcaggc gatgccgggg ttccacgcca ggttcgggga
      721 ccgcctgcgc tccgaggccc agggcgcgga caccatgctg tggctggccc tctcctctgc
      781 cgcagccgca cagcccagcg gccgcttctt tcaagatcgg aagccagttt ctacacactt
      841 gcctctcgct acagcgtcct cctcaccggc cgaagaggag aaactcattg aaatcctgga
      901 acagctggct cagacattta aataggccaa cccagacaca gtgcggtacc agaattgcct
      961 tagaagatac cagaaggtgc ggtctaggga ccagtgaata agaagacccc acttcaactt
     1021 cccctcgaag acgttgtgcc tcacagcgag gcctacaagg gatgggaact tttatttcaa
     1081 aataaatact accgaggctg tgatcaggct caccttgaa
//
