LOCUS       NM_024308               1515 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 11 (DHRS11), mRNA.
ACCESSION   NM_024308
VERSION     NM_024308.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Endo,S., Morikawa,Y., Kudo,Y., Suenami,K., Matsunaga,T., Ikari,A.
            and Hara,A.
  TITLE     Human dehydrogenase/reductase SDR family member 11 (DHRS11) and
            aldo-keto reductase 1C isoforms in comparison: Substrate and
            reaction specificity in the reduction of 11-keto-C19-steroids
  JOURNAL   J Steroid Biochem Mol Biol 199, 105586 (2020)
   PUBMED   31926269
  REMARK    GeneRIF: Human dehydrogenase/reductase SDR family member 11
            (DHRS11) and aldo-keto reductase 1C isoforms in comparison:
            Substrate and reaction specificity in the reduction of
            11-keto-C19-steroids.
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Endo,S., Miyagi,N., Matsunaga,T., Hara,A. and Ikari,A.
  TITLE     Human dehydrogenase/reductase (SDR family) member 11 is a novel
            type of 17beta-hydroxysteroid dehydrogenase
  JOURNAL   Biochem Biophys Res Commun 472 (1), 231-236 (2016)
   PUBMED   26920053
  REMARK    GeneRIF: The recombinant protein (DHRS11) efficiently catalyzed the
            conversion of the 17-keto group of estrone, 4- and 5-androstenes
            and 5alpha-androstanes into their 17beta-hydroxyl metabolites with
            NADPH as a coenzyme.
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG037061.1 and AY358712.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024308.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.342264.1,
                                           SRR3476690.69859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618403.5/ ENSP00000482704.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BG037061.1         87-106
            21-1515             AY358712.1         1-1495
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1515
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /note="dehydrogenase/reductase 11"
                     /db_xref="GeneID:79154"
                     /db_xref="HGNC:HGNC:28639"
                     /db_xref="MIM:616159"
     exon            1..278
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..914
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.270"
                     /note="short-chain dehydrogenase/reductase family 24C
                     member 1; dehydrogenase/reductase (SDR family) member 11;
                     estradiol 17-beta-dehydrogenase; 17-beta-hydroxysteroid
                     dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 11
                     precursor"
                     /protein_id="NP_077284.2"
                     /db_xref="CCDS:CCDS11315.2"
                     /db_xref="GeneID:79154"
                     /db_xref="HGNC:HGNC:28639"
                     /db_xref="MIM:616159"
                     /translation="MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCART
                     VGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLAR
                     PDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPL
                     SVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAA
                     ATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT"
     exon            279..488
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            489..583
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            584..713
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            714..806
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            807..872
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1515
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /note="hexamer: AAGAAA"
     polyA_site      1515
                     /gene="DHRS11"
                     /gene_synonym="ARPG836; SDR24C1; spDHRS11"
                     /note="major polyA site"
ORIGIN      
        1 gggactctgg tgggtctagg cgcggatcgg acccaagcag gtcggcggcg gcggcaggag
       61 agcggccggg cgtcagctcc tcgacccccg tgtcgggcta gtccagcgag gcggacgggc
      121 ggcgtgggcc catggccagg cccggcatgg agcggtggcg cgaccggctg gcgctggtga
      181 cgggggcctc ggggggcatc ggcgcggccg tggcccgggc cctggtccag cagggactga
      241 aggtggtggg ctgcgcccgc actgtgggca acatcgagga gctggctgct gaatgtaaga
      301 gtgcaggcta ccccgggact ttgatcccct acagatgtga cctatcaaat gaagaggaca
      361 tcctctccat gttctcagct atccgttctc agcacagcgg tgtagacatc tgcatcaaca
      421 atgctggctt ggcccggcct gacaccctgc tctcaggcag caccagtggt tggaaggaca
      481 tgttcaatgt gaacgtgctg gccctcagca tctgcacacg ggaagcctac cagtccatga
      541 aggagcggaa tgtggacgat gggcacatca ttaacatcaa tagcatgtct ggccaccgag
      601 tgttacccct gtctgtgacc cacttctata gtgccaccaa gtatgccgtc actgcgctga
      661 cagagggact gaggcaagag cttcgggagg cccagaccca catccgagcc acgtgcatct
      721 ctccaggtgt ggtggagaca caattcgcct tcaaactcca cgacaaggac cctgagaagg
      781 cagctgccac ctatgagcaa atgaagtgtc tcaaacccga ggatgtggcc gaggctgtta
      841 tctacgtcct cagcaccccc gcacacatcc agattggaga catccagatg aggcccacgg
      901 agcaggtgac ctagtgactg tgggagctcc tccttccctc cccacccttc atggcttgcc
      961 tcctgcctct ggattttagg tgttgatttc tggatcacgg gataccactt cctgtccaca
     1021 ccccgaccag gggctagaaa atttgtttga gatttttata tcatcttgtc aaattgcttc
     1081 agttgtaaat gtgaaaaatg ggctggggaa aggaggtggt gtccctaatt gttttacttg
     1141 ttaacttgtt cttgtgcccc tgggcacttg gcctttgtct gctctcagtg tcttcccttt
     1201 gacatgggaa aggagttgtg gccaaaatcc ccatcttctt gcacctcaac gtctgtggct
     1261 cagggctggg gtggcagagg gaggccttca ccttatatct gtgttgttat ccagggctcc
     1321 agacttcctc ctctgcctgc cccactgcac cctctccccc ttatctatct ccttctcggc
     1381 tccccagccc agtcttggct tcttgtcccc tcctggggtc atccctccac tctgactctg
     1441 actatggcag cagaacacca gggcctggcc cagtggattt catggtgatc attaaaaaag
     1501 aaaaatcgca accaa
//
