LOCUS       NM_001136050            1427 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dehydrogenase/reductase 1 (DHRS1), transcript variant
            1, mRNA.
ACCESSION   NM_001136050
VERSION     NM_001136050.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Xu,S., Wang,W., Meng,T., Wang,F., Wang,G., Huang,F., Wang,G.,
            Yu,X., Wu,R., Hou,L., Ye,Z., Zhang,X., Zhao,H. and Shen,Y.
  TITLE     Construction and validation of a immune-related prognostic gene
            DHRS1 in hepatocellular carcinoma based on bioinformatic analysis
  JOURNAL   Medicine (Baltimore) 102 (42), e35268 (2023)
   PUBMED   37861541
  REMARK    GeneRIF: Construction and validation of a immune-related prognostic
            gene DHRS1 in hepatocellular carcinoma based on bioinformatic
            analysis.
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Li,L., Situ,H.J., Ma,W.C., Liu,X. and Wang,L.L.
  TITLE     Decreased DHRS1 expression is a novel predictor of poor survival in
            patients with hepatocellular carcinoma
  JOURNAL   Biomark Med 15 (15), 1319-1331 (2021)
   PUBMED   34498498
  REMARK    GeneRIF: Decreased DHRS1 expression is a novel predictor of poor
            survival in patients with hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Zemanova,L., Navratilova,H., Andrys,R., Sperkova,K., Andrejs,J.,
            Kozakova,K., Meier,M., Moller,G., Novotna,E., Safr,M., Adamski,J.
            and Wsol,V.
  TITLE     Initial characterization of human DHRS1 (SDR19C1), a member of the
            short-chain dehydrogenase/reductase superfamily
  JOURNAL   J Steroid Biochem Mol Biol 185, 80-89 (2019)
   PUBMED   30031147
  REMARK    GeneRIF: DHRS1 was proven to be an NADPH-dependent reductase that
            is able to catalyse the in vitro reductive conversion of some
            steroids (estrone, androstene-3,17-dione and cortisone), as well as
            other endogenous substances and xenobiotics.
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Tiwari,P., Singh,N., Dixit,A. and Choudhury,D.
  TITLE     Multivariate sequence analysis reveals additional function
            impacting residues in the SDR superfamily
  JOURNAL   Proteins 82 (10), 2842-2856 (2014)
   PUBMED   25052469
  REMARK    GeneRIF: Data suggest that members of short chain
            dehydrogenase/reductase superfamily (human DHRS1; E coli galE)
            exhibit conserved residues and tertiary structure in active site
            domain that are essential for biocatalysis.
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Nudel,R., Simpson,N.H., Baird,G., O'Hare,A., Conti-Ramsden,G.,
            Bolton,P.F., Hennessy,E.R., Ring,S.M., Davey Smith,G., Francks,C.,
            Paracchini,S., Monaco,A.P., Fisher,S.E. and Newbury,D.F.
  CONSRTM   SLI Consortium
  TITLE     Genome-wide association analyses of child genotype effects and
            parent-of-origin effects in specific language impairment
  JOURNAL   Genes Brain Behav 13 (4), 418-429 (2014)
   PUBMED   24571439
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   Wu,Q., Xu,M., Cheng,C., Zhou,Z., Huang,Y., Zhao,W., Zeng,L., Xu,J.,
            Fu,X., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel
            Dehydrogenase/reductase (SDR family) member 1 genea from human
            fetal brain
  JOURNAL   Mol Biol Rep 28 (4), 193-198 (2001)
   PUBMED   12153138
  REMARK    GeneRIF: novel human SDR-type dehydrogenase/reductase gene named
            Dehydrogenase/reductase (SDR family) member 1 (DHRS1)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB272453.1, AF418205.1 and
            AL833917.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001136050.2.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) family. The encoded enzyme contains
            a conserved catalytic domain and likely functions as an
            oxidoreductase. Multiple alternatively spliced variants, encoding
            the same protein, have been identified. [provided by RefSeq, Nov
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014057.2, AL833917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288111.12/ ENSP00000288111.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB272453.1         54-64
            12-1422             AF418205.1         1-1411
            1423-1427           AL833917.1         1371-1375
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1427
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /note="dehydrogenase/reductase 1"
                     /db_xref="GeneID:115817"
                     /db_xref="HGNC:HGNC:16445"
                     /db_xref="MIM:610410"
     exon            1..200
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..374
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1166
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /note="dehydrogenase/reductase (SDR family) member 1;
                     short chain dehydrogenase/reductase family 19C member 1"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 1"
                     /protein_id="NP_001129522.1"
                     /db_xref="CCDS:CCDS9623.1"
                     /db_xref="GeneID:115817"
                     /db_xref="HGNC:HGNC:16445"
                     /db_xref="MIM:610410"
                     /translation="MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTL
                     RVVAQEAQSLGGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILN
                     TRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFN
                     VPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ
                     FKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYL
                     SLSSVLSHVSGLGWLASYLPSFLRVPKWIIALYTSKF"
     exon            375..518
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..598
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..731
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..948
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1029
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1427
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /note="hexamer: AATAAA"
     polyA_site      1427
                     /gene="DHRS1"
                     /gene_synonym="SDR19C1"
                     /note="major polyA site"
ORIGIN      
        1 agatcgctcc gcccccatcc gcaggttcta actttggcct gggactctgc ccctctacct
       61 cagcacagaa tcgccccggg tcctactaca gaatcaatcc ttgaacactg cctccacgtc
      121 gccggctcaa tctgggcgag aacccagact tccaccgcag ccccgcaatc tgcagacctc
      181 agcggcagcg caggtggcag acctgcctcc tttgcctgtg agtcatggca gctcccatga
      241 atggccaagt gtgtgtggtg actggtgcct ccaggggtat tggccgtggc attgccttgc
      301 agctctgcaa agcaggcgcc acagtttaca tcactggccg ccatctggac acccttcgcg
      361 ttgttgctca ggaggcacaa tccctcgggg gccaatgtgt gcctgtggtg tgcgattcaa
      421 gccaggagag tgaagtgcga agcctgtttg agcaagtgga tcgggaacag caagggcgtc
      481 tagatgtgct ggtcaacaat gcttatgcag gggtccagac gatcctgaac accaggaata
      541 aggcattctg ggaaacccct gcctccatgt gggatgatat caacaacgtc ggactcagag
      601 gccactactt ttgctcagtg tatggggcac ggctgatggt accagctggc caggggctca
      661 tcgtggtcat ctcctcccca ggaagcctgc agtatatgtt caatgtcccc tatggtgtgg
      721 gcaaagctgc gtgtgacaag ctggctgctg actgtgccca cgagctgcgg cgccatgggg
      781 tcagctgtgt gtctctgtgg ccggggattg tgcagacaga actgctgaag gagcatatgg
      841 caaaggagga ggtcctgcag gatcctgtgt tgaagcagtt caaatcagcc ttctcatctg
      901 cggaaaccac agaattgagt ggcaaatgtg tggtggcttt ggcaacagat cccaatatcc
      961 tgagcctgag tggtaaggtg ctgccatcct gtgaccttgc tcgacgctat ggccttcggg
     1021 atgtggacgg ccgccccgtc caagactatt tgtctttgag ctctgttctc tcacacgtgt
     1081 ccggcctggg ctggctggcc tcctacctgc cctccttcct ccgtgtgccc aagtggatta
     1141 ttgccctcta cactagcaag ttctaaccct cctggtctga cactacgtct ctgcttgtct
     1201 tctcatttgg acttggtggt tcgtcctgtc tcagtgaaac agcagccttt cttgtttacc
     1261 catacccttg atatgaagag aagccctctg ctgtgtgtcc gtggtgagtt ctggggtgcg
     1321 cctaggtccc ttctttgtgc cttggttttc cttgtccttc tttttacttt ttgccttagt
     1381 attgaaaaat gctcttggag ctaataaaag tctcatttct ctttcaa
//
