LOCUS       NM_001102368            2957 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens D-glutamate cyclase (DGLUCY), transcript variant 4,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001102368
VERSION     NM_001102368.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2957)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2957)
  AUTHORS   Ariyoshi,M., Katane,M., Hamase,K., Miyoshi,Y., Nakane,M.,
            Hoshino,A., Okawa,Y., Mita,Y., Kaimoto,S., Uchihashi,M., Fukai,K.,
            Ono,K., Tateishi,S., Hato,D., Yamanaka,R., Honda,S., Fushimura,Y.,
            Iwai-Kanai,E., Ishihara,N., Mita,M., Homma,H. and Matoba,S.
  TITLE     D-Glutamate is metabolized in the heart mitochondria
  JOURNAL   Sci Rep 7, 43911 (2017)
   PUBMED   28266638
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2957)
  AUTHORS   Sohn,Y.S., Lee,S.G., Lee,K.H., Ku,B., Shin,H.C., Cha,S.S.,
            Kim,Y.G., Lee,H.S., Kang,S.G. and Oh,B.H.
  TITLE     Identification of a Highly Conserved Hypothetical Protein TON_0340
            as a Probable Manganese-Dependent Phosphatase
  JOURNAL   PLoS One 11 (12), e0167549 (2016)
   PUBMED   27907125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2957)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   5  (bases 1 to 2957)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2957)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA296867.1, AB210031.1, BC065558.1, DR003467.1, BX642394.1 and
            AL135818.3.
            
            On May 20, 2020 this sequence version replaced NM_001102368.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and uses
            an alternate in-frame splice site, compared to variant 1. The
            encoded isoform (b) is longer than isoform a. Variants 4 and 6
            encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX161393.1, AK097294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000256324.15/
                                                  ENSP00000256324.9
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA296867.1         61-99
            40-1016             AB210031.1         1-977
            1017-2334           BC065558.1         1101-2418
            2335-2663           DR003467.1         272-600
            2664-2684           BX642394.1         20-40               c
            2685-2721           DR003467.1         624-660
            2722-2957           AL135818.3         9457-9692
FEATURES             Location/Qualifiers
     source          1..2957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11"
     gene            1..2957
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /note="D-glutamate cyclase"
                     /db_xref="GeneID:80017"
                     /db_xref="HGNC:HGNC:20498"
                     /db_xref="MIM:620716"
     exon            1..211
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            212..263
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            264..395
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2158
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /EC_number="4.2.1.48"
                     /note="isoform b precursor is encoded by transcript
                     variant 4; UPF0317 protein C14orf159, mitochondrial;
                     D-glutamate cyclase, mitochondrial"
                     /codon_start=1
                     /product="D-glutamate cyclase, mitochondrial isoform b
                     precursor"
                     /protein_id="NP_001095838.1"
                     /db_xref="CCDS:CCDS41979.1"
                     /db_xref="GeneID:80017"
                     /db_xref="HGNC:HGNC:20498"
                     /db_xref="MIM:620716"
                     /translation="MPFTLHLRSRLPSAIRSLILQKKPNIRNTSSMAGELRPASLVVL
                     PRSLAPAFERFCQVNTGPLPLLGQSEPEKWMLPPQGAISETRMGHPQFWKYEFGACTG
                     SLASLEQYSEQLKDMVAFFLGCSFSLEEALEKAGLPRRDPAGHSQAGAYKTTVPCVTH
                     AGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPVHMGDPELLGIKELSKPAYGDA
                     MVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTDLKDAKAPPGCLTPERI
                     PEVHHISQDPLHYSIASVSASQKIRELESMIGIDPGNRGIGHLLCKDELLKASLSLSH
                     ARSVLITTGFPTHFNHEPPEETDGPPGAVALVAFLQALEKEVAIIVDQRAWNLHQKIV
                     EDAVEQGVLKTQIPILTYQGGSVEAAQAFLCKNGDPQTPRFDHLVAIERAGRAADGNY
                     YNARKMNIKHLVDPIDDLFLAAKKIPGISSTGVGDGGNELGMGKVKEAVRRHIRHGDV
                     IACDVEADFAVIAGVSNWGGYALACALYILYSCAVHSQYLRKAVGPSRAPGDQAWTQA
                     LPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHNTHAEMIQKLVDVTTAQV"
     exon            396..549
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            550..748
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            749..899
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1022
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1226
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1487
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1587
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1736
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1856
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2008
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2957
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /note="hexamer: AATAAA"
     polyA_site      2680
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /note="major polyA site"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
                     /note="hexamer: CATAAA"
     polyA_site      2957
                     /gene="DGLUCY"
                     /gene_synonym="C14orf159"
ORIGIN      
        1 aggctgtggg agcggatgga gctgctacag tcagcgcttg gggctggcct cagcttgtag
       61 acccgagccc tgcagaacaa ccccccgtgg cgcaggagag cagaagaaag ggggccttta
      121 tgcccttttg agggaagcac acattctgca aggccgtgga aacaaaggga ggaactgttt
      181 gtagccctcg tccagacgcc ccaaacaaac agagccaagt tacaccctgt ttaaccctgc
      241 cttcaaaggg acgactctgt aagattctct gctacttatt caagttgaca cgatgccctt
      301 cacactccac ctgaggtccc gccttccctc tgccataagg agtttgattc tacaaaagaa
      361 accaaacatc agaaatacat ccagcatggc tggagagctc cgaccagcca gcctggtggt
      421 cctgcccagg tcccttgctc cagcttttga aagattctgc caggtcaaca ctggtcctct
      481 acccctgctg ggccagagtg agccagaaaa gtggatgctg ccccctcaag gtgctatctc
      541 agagaccagg atgggccatc cccagttctg gaaatacgag ttcggtgcct gcaccggcag
      601 cctggcttcg ctggagcagt actcggagca gctgaaggac atggtggcct tcttcctggg
      661 ctgcagcttc tccctggagg aggccttgga gaaagcgggg ctccccagaa gagacccagc
      721 aggtcacagc caggcgggtg catacaagac aacagtgcct tgtgttaccc atgctggctt
      781 ctgctgccct ctggtggtca cgatgaggcc cattcccaag gacaagctgg aagggctggt
      841 gcgggcctgc tgctccctcg gaggtgagca ggggcaacct gttcacatgg gcgacccaga
      901 actgttggga atcaaagagc tttccaaacc tgcctacggg gatgccatgg tgtgtccccc
      961 aggggaggtt ccagtgttct ggccttctcc gctgaccagt ctcggagctg tcagcagctg
     1021 tgagacccca ctggcttttg ccagcatccc aggctgcaca gttatgactg acctgaagga
     1081 tgcaaaggct ccacctggtt gtctcacccc agagagaatt ccagaggtcc atcacatttc
     1141 ccaagatcct ctgcactaca gcatcgcgtc agtctctgct tctcagaaga tcagagaact
     1201 agagtctatg atcggcatag acccagggaa ccgggggatt gggcacctgc tctgtaaaga
     1261 tgagctgctg aaggcctctc tctcgctgtc ccatgcccgc tcagtgctca tcaccactgg
     1321 gttccccaca catttcaatc atgagcctcc agaagagaca gatggcccac caggagctgt
     1381 tgctctggtt gccttcctgc aggccttgga gaaggaggtc gccataatcg ttgaccagag
     1441 agcctggaac ttgcaccaga agattgttga agatgctgtt gagcaaggtg ttctgaagac
     1501 gcagatcccg atattaactt accaaggtgg atcagtggaa gctgctcagg cattcctgtg
     1561 caaaaatggg gacccgcaga cacctagatt tgaccacctg gtggccatag agcgtgccgg
     1621 aagagctgct gatggcaatt actacaatgc aaggaagatg aacatcaagc acttggttga
     1681 ccccattgac gatctttttc ttgctgcgaa gaagattcct ggaatctcat caactggagt
     1741 cggtgatgga ggcaacgagc ttgggatggg taaagtcaag gaggctgtga ggaggcacat
     1801 acggcacggg gatgtcatcg cctgcgacgt ggaggctgac tttgccgtca ttgctggtgt
     1861 ttctaactgg ggaggctatg ccctggcctg cgcactctac atcctgtact catgtgctgt
     1921 ccacagtcag tacctgagga aagcagtcgg accctccagg gcacctggag atcaggcctg
     1981 gactcaggcc ctcccgtcgg tcattaagga agaaaaaatg ctgggcatct tggtgcagca
     2041 caaagtccgg agtggcgtct cgggcatcgt gggcatggag gtggatgggc tgcccttcca
     2101 caacacccac gccgagatga tccagaagct ggtggacgtc accacggcac aggtgtaacc
     2161 gtccatgttc cgtgtgagca gagtccctac caacgggcag gtctgcatcc ggggagaatg
     2221 cagctgcttc tggcgacaat cctgctagta aacactggtc ttcggtgagc aacgaacact
     2281 cgcctggcct gggaaactgc atgcccactt tctgggaggg gttagtgcag gtgctgtgga
     2341 caaaggacaa catttctctg gggcttttta acttttattc ctaagactct aaaggcgttg
     2401 atttcaaccc tccttcactc tggcttcttc aggcaaccca cgtggtctcc tgtgagaatc
     2461 ttctcgacag ttacttatgg ggacacttgt gaacaattaa ctgccaggca gagcatgaga
     2521 acaaacattc ccaggccatg taggatagga tactccagac tccagtcatc ctcccccatc
     2581 catggtttct gttactcatg gtttcagtta ctcatagcca actgcagacc gaaaatacta
     2641 aatgaaaaat ttcagaaata aacaactctt aagttttaaa ttgtgtactc ttcggaatat
     2701 cgtgatgaaa tctcacacca tcctgctcca tcctacctag gacgtgaatc ctccctttgt
     2761 ccagggtacc cgtgctgtct acaccacccg cctgccagtc acccagcagg tgatcagatc
     2821 gactgtcatg gtattgcagt gcttatattc aagaacctct tatgtgactc agtaatgtcc
     2881 tcaaagtgca agagcagaga tgctggcaat ttggatatgc caaaaagagg ccataaaggg
     2941 cttcctttaa gtgaaaa
//
