LOCUS       NM_001199267            3588 bp    mRNA    linear   PRI 17-MAR-2025
DEFINITION  Homo sapiens diacylglycerol kinase zeta (DGKZ), transcript variant
            6, mRNA.
ACCESSION   NM_001199267
VERSION     NM_001199267.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Harris,R.A., Bush,A.H., Eagar,T.N., Qian,J., Greenwood,M.P.,
            Opekun,A.R., Baldassano,R., Guthery,S.L., Noe,J.D., Otley,A.,
            Rosh,J.R., Kugathasan,S. and Kellermayer,R.
  TITLE     Exome Sequencing Implicates DGKZ, ESRRA, and GXYLT1 for Modulating
            Granuloma Formation in Crohn Disease
  JOURNAL   J Pediatr Gastroenterol Nutr 77 (3), 354-357 (2023)
   PUBMED   37347142
  REMARK    GeneRIF: Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for
            Modulating Granuloma Formation in Crohn Disease.
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Liu,X.F., Zhao,S.W., Cui,J.J., Gu,Y.W., Fan,J.W., Fu,Y.F.,
            Zhang,Y.H., Yin,H., Chen,K. and Cui,L.B.
  TITLE     Differential expression of diacylglycerol kinase zeta is involved
            in inferior parietal lobule-related dysfunction in schizophrenia
            with cognitive impairments
  JOURNAL   BMC Psychiatry 23 (1), 526 (2023)
   PUBMED   37479996
  REMARK    GeneRIF: Differential expression of diacylglycerol kinase zeta is
            involved in inferior parietal lobule-related dysfunction in
            schizophrenia with cognitive impairments.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Furuta,M., Murakami,C., Numagami,Y., Suzuki,R. and Sakane,F.
  TITLE     Diacylglycerol kinase zeta interacts with sphingomyelin synthase 1
            and sphingomyelin synthase-related protein via different regions
  JOURNAL   FEBS Open Bio 13 (7), 1333-1345 (2023)
   PUBMED   37166445
  REMARK    GeneRIF: Diacylglycerol kinase zeta interacts with sphingomyelin
            synthase 1 and sphingomyelin synthase-related protein via different
            regions.
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Yamazaki,A., Kawashima,A., Honda,T., Kohama,T., Murakami,C.,
            Sakane,F., Murayama,T. and Nakamura,H.
  TITLE     Identification and characterization of diacylglycerol kinase zeta
            as a novel enzyme producing ceramide-1-phosphate
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (6), 159307 (2023)
   PUBMED   36906254
  REMARK    GeneRIF: Identification and characterization of diacylglycerol
            kinase zeta as a novel enzyme producing ceramide-1-phosphate.
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Zhao,Y., Sun,H., Li,X., Liu,Q., Liu,Y., Hou,Y. and Jin,W.
  TITLE     DGKZ promotes TGFbeta signaling pathway and metastasis in
            triple-negative breast cancer by suppressing lipid raft-dependent
            endocytosis of TGFbetaR2
  JOURNAL   Cell Death Dis 13 (2), 105 (2022)
   PUBMED   35115500
  REMARK    GeneRIF: DGKZ promotes TGFbeta signaling pathway and metastasis in
            triple-negative breast cancer by suppressing lipid raft-dependent
            endocytosis of TGFbetaR2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Topham,M.K. and Prescott,S.M.
  TITLE     Diacylglycerol kinase zeta regulates Ras activation by a novel
            mechanism
  JOURNAL   J Cell Biol 152 (6), 1135-1143 (2001)
   PUBMED   11257115
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Liu,Z., Chang,G.Q. and Leibowitz,S.F.
  TITLE     Diacylglycerol kinase zeta in hypothalamus interacts with long form
            leptin receptor. Relation to dietary fat and body weight regulation
  JOURNAL   J Biol Chem 276 (8), 5900-5907 (2001)
   PUBMED   11078732
REFERENCE   8  (bases 1 to 3588)
  AUTHORS   Topham,M.K., Bunting,M., Zimmerman,G.A., McIntyre,T.M.,
            Blackshear,P.J. and Prescott,S.M.
  TITLE     Protein kinase C regulates the nuclear localization of
            diacylglycerol kinase-zeta
  JOURNAL   Nature 394 (6694), 697-700 (1998)
   PUBMED   9716136
REFERENCE   9  (bases 1 to 3588)
  AUTHORS   Ding,L., Bunting,M., Topham,M.K., McIntyre,T.M., Zimmerman,G.A. and
            Prescott,S.M.
  TITLE     Alternative splicing of the human diacylglycerol kinase zeta gene
            in muscle
  JOURNAL   Proc Natl Acad Sci U S A 94 (11), 5519-5524 (1997)
   PUBMED   9159104
REFERENCE   10 (bases 1 to 3588)
  AUTHORS   Bunting,M., Tang,W., Zimmerman,G.A., McIntyre,T.M. and
            Prescott,S.M.
  TITLE     Molecular cloning and characterization of a novel human
            diacylglycerol kinase zeta
  JOURNAL   J Biol Chem 271 (17), 10230-10236 (1996)
   PUBMED   8626588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB959911.1 and U51477.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001199267.1.
            
            Summary: The protein encoded by this gene belongs to the eukaryotic
            diacylglycerol kinase family. It may attenuate protein kinase C
            activity by regulating diacylglycerol levels in intracellular
            signaling cascade and signal transduction. Alternative splicing
            occurs at this locus and multiple transcript variants encoding
            distinct isoforms have been identified. [provided by RefSeq, Nov
            2010].
            
            Transcript Variant: This variant (6) has an alternate 5' sequence
            including the coding region compared to variant 4. The resulting
            isoform (6) has a shorter and distinct N-terminus, compared to
            isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51477.1, SRR7346977.2093114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456247.7/ ENSP00000395684.2
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               CB959911.1         85-193
            110-3588            U51477.1           1-3479
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..3588
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /note="diacylglycerol kinase zeta"
                     /db_xref="GeneID:8525"
                     /db_xref="HGNC:HGNC:2857"
                     /db_xref="MIM:601441"
     exon            1..358
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2984
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="isoform 6 is encoded by transcript variant 6;
                     diacylglycerol kinase, zeta 104kDa; DAG kinase zeta;
                     diglyceride kinase zeta"
                     /codon_start=1
                     /product="diacylglycerol kinase zeta isoform 6"
                     /protein_id="NP_001186196.1"
                     /db_xref="CCDS:CCDS55759.1"
                     /db_xref="GeneID:8525"
                     /db_xref="HGNC:HGNC:2857"
                     /db_xref="MIM:601441"
                     /translation="MEPRDGSPEARSSDSESASASSSGSERDAGPEPDKAPRRLNKRR
                     FPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFE
                     TNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESG
                     SRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKV
                     SCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPE
                     EGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPK
                     EALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNW
                     GGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY
                     FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVC
                     DGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTM
                     TSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQK
                     AKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDS
                     DLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVT
                     EIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAA
                     KRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE
                     NGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQ
                     HYQMIQREDQETAV"
     exon            359..467
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            468..563
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            564..638
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            639..695
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            696..764
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            765..836
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            837..953
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1025
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1121
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1204
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1265
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1379
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1520
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1599
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1655
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1718
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1792
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1904
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2104
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2205
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2285
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2355
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2396
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2536
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2568
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2612
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2733
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2767
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2867
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3588
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3568..3573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /note="hexamer: AGTAAA"
     polyA_site      3588
                     /gene="DGKZ"
                     /gene_synonym="DAGK5; DAGK6; DGK-ZETA; hDGKzeta"
                     /note="major polyA site"
ORIGIN      
        1 ggcacttcct ggagcggcgg cggcagcggc ttcccgggca cctgggcgtg gggagcgggg
       61 gcgcgcggcg cggggcgggc ggagcgagcg cgcgccatgg aggtggcggg cggcgcggag
      121 cgggcgtgct gagccccggc cgccggcccg gcatgggcgt ctcccgcggg ccctccgccg
      181 gccggggcta gggccggatg gagccgcggg acggtagccc cgaggcccgg agcagcgact
      241 ccgagtcggc ttccgcctcg tccagcggct ccgagcgcga cgccggtccc gagccggaca
      301 aggcgccgcg gcgactcaac aagcggcgct tcccggggct gcggctcttc gggcacagga
      361 aagccatcac caagtcgggc ctccagcacc tggccccccc tccgcccacc cctggggccc
      421 cgtgcagcga gtcagagcgg cagatccgga gtacagtgga ctggagcgag tcagcgacat
      481 atggggagca catctggttc gagaccaacg tgtccgggga cttctgctac gttggggagc
      541 agtactgtgt agccaggatg ctgaagtcag tgtctcgaag aaagtgcgca gcctgcaaga
      601 ttgtggtgca cacgccctgc atcgagcagc tggagaagat aaatttccgc tgtaagccgt
      661 ccttccgtga atcaggctcc aggaatgtcc gcgagccaac ctttgtacgg caccactggg
      721 tacacagacg acgccaggac ggcaagtgtc ggcactgtgg gaagggattc cagcagaagt
      781 tcaccttcca cagcaaggag attgtggcca tcagctgctc gtggtgcaag caggcatacc
      841 acagcaaggt gtcctgcttc atgctgcagc agatcgagga gccgtgctcg ctgggggtcc
      901 acgcagccgt ggtcatcccg cccacctgga tcctccgcgc ccggaggccc cagaatactc
      961 tgaaagcaag caagaagaag aagagggcat ccttcaagag gaagtccagc aagaaagggc
     1021 ctgaggaggg ccgctggaga cccttcatca tcaggcccac cccctccccg ctcatgaagc
     1081 ccctgctggt gtttgtgaac cccaagagtg ggggcaacca gggtgcaaag atcatccagt
     1141 ctttcctctg gtatctcaat ccccgacaag tcttcgacct gagccaggga gggcccaagg
     1201 aggcgctgga gatgtaccgc aaagtgcaca acctgcggat cctggcgtgc gggggcgacg
     1261 gcacggtggg ctggatcctc tccaccctgg accagctacg cctgaagccg ccaccccctg
     1321 ttgccatcct gcccctgggt actggcaacg acttggcccg aaccctcaac tggggtgggg
     1381 gctacacaga tgagcctgtg tccaagatcc tctcccacgt ggaggagggg aacgtggtac
     1441 agctggaccg ctgggacctc cacgctgagc ccaaccccga ggcagggcct gaggaccgag
     1501 atgaaggcgc caccgaccgg ttgcccctgg atgtcttcaa caactacttc agcctgggct
     1561 ttgacgccca cgtcaccctg gagttccacg agtctcgaga ggccaaccca gagaaattca
     1621 acagccgctt tcggaataag atgttctacg ccgggacagc tttctctgac ttcctgatgg
     1681 gcagctccaa ggacctggcc aagcacatcc gagtggtgtg tgatggaatg gacttgactc
     1741 ccaagatcca ggacctgaaa ccccagtgtg ttgttttcct gaacatcccc aggtactgtg
     1801 cgggcaccat gccctggggc caccctgggg agcaccacga ctttgagccc cagcggcatg
     1861 acgacggcta cctcgaggtc attggcttca ccatgacgtc gttggccgcg ctgcaggtgg
     1921 gcggacacgg cgagcggctg acgcagtgtc gcgaggtggt gctcaccaca tccaaggcca
     1981 tcccggtgca ggtggatggc gagccctgca agcttgcagc ctcacgcatc cgcatcgccc
     2041 tgcgcaacca ggccaccatg gtgcagaagg ccaagcggcg gagcgccgcc cccctgcaca
     2101 gcgaccagca gccggtgcca gagcagttgc gcatccaggt gagtcgcgtc agcatgcacg
     2161 actatgaggc cctgcactac gacaaggagc agctcaagga ggcctctgtg ccgctgggca
     2221 ctgtggtggt cccaggagac agtgacctag agctctgccg tgcccacatt gagagactcc
     2281 agcaggagcc cgatggtgct ggagccaagt ccccgacatg ccagaaactg tcccccaagt
     2341 ggtgcttcct ggacgccacc actgccagcc gcttctacag gatcgaccga gcccaggagc
     2401 acctcaacta tgtgactgag atcgcacagg atgagattta tatcctggac cctgagctgc
     2461 tgggggcatc ggcccggcct gacctcccaa cccccacttc ccctctcccc acctcaccct
     2521 gctcacccac gccccggtca ctgcaagggg atgctgcacc ccctcaaggt gaagagctga
     2581 ttgaggctgc caagaggaac gacttctgta agctccagga gctgcaccga gctgggggcg
     2641 acctcatgca ccgagacgag cagagtcgca cgctcctgca ccacgcagtc agcactggca
     2701 gcaaggatgt ggtccgctac ctgctggacc acgccccccc agagatcctt gatgcggtgg
     2761 aggaaaacgg ggagacctgt ttgcaccaag cagcggccct gggccagcgc accatctgcc
     2821 actacatcgt ggaggccggg gcctcgctca tgaagacaga ccagcagggc gacactcccc
     2881 ggcagcgggc tgagaaggct caggacaccg agctggccgc ctacctggag aaccggcagc
     2941 actaccagat gatccagcgg gaggaccagg agacggctgt gtagcgggcc gcccacgggc
     3001 agcaggaggg acaatgcggc caggggacga gcgccttcct tgcccacctc actgccacat
     3061 tccagtggga cggccacggg gggacctagg ccccagggaa agagccccat gccgccccct
     3121 aaggagccgc ccagacctag ggctggactc aggagctggg ggggcctcac ctgttcccct
     3181 gaggaccccg ccggacccgg aggctcacag ggaacaagac acggctgggt tggatatgcc
     3241 tttgccgggg ttctggggca gggcgctccc tggccgcagc agatgccctc ccaggagtgg
     3301 aggggctgga gagggggagg ccttcgggaa gaggcttcct gggccccctg gtcttcggcc
     3361 gggtccccag cccccgctcc tgccccaccc cacctcctcc gggcttcctc ccggaaactc
     3421 agcgcctgct gcacttgcct gccctgcctt gcttggcacc cgctccggcg accctccccg
     3481 ctcccctgtc atttcatcgc ggactgtgcg gcctgggggt ggggggcggg actctcacgg
     3541 tgacatgttt acagctgggt gtgactcagt aaagtggatt tttttttc
//
