LOCUS       NM_001347               4649 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens diacylglycerol kinase theta (DGKQ), mRNA.
ACCESSION   NM_001347
VERSION     NM_001347.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4649)
  AUTHORS   Lim,J.L., Ng,E.Y., Lim,S.Y., Tan,A.H., Abdul-Aziz,Z., Ibrahim,K.A.,
            Gopalai,A.A., Tay,Y.W., Vijayanathan,Y., Toh,T.S., Lim,S.K.,
            Bee,P.C., Puvanarajah,S.D., Viswanathan,S., Looi,I., Lim,T.T.,
            Eow,G.B., Cheah,W.K., Tan,E.K. and Ahmad-Annuar,A.
  TITLE     Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's
            disease in patients of Malay ancestry
  JOURNAL   Neurol Sci 42 (10), 4203-4207 (2021)
   PUBMED   33559030
  REMARK    GeneRIF: Association study of MCCC1/LAMP3 and DGKQ variants with
            Parkinson's disease in patients of Malay ancestry.
REFERENCE   2  (bases 1 to 4649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4649)
  AUTHORS   Barber,C.N. and Raben,D.M.
  TITLE     Roles of DGKs in neurons: Postsynaptic functions?
  JOURNAL   Adv Biol Regul 75, 100688 (2020)
   PUBMED   31836314
  REMARK    GeneRIF: Roles of DGKs in neurons: Postsynaptic functions?
            Review article
            Erratum:[Adv Biol Regul. 2021 Dec;82:100846. doi:
            10.1016/j.jbior.2021.100846. PMID: 34862141]
REFERENCE   4  (bases 1 to 4649)
  AUTHORS   Nalls,M.A., Pankratz,N., Lill,C.M., Do,C.B., Hernandez,D.G.,
            Saad,M., DeStefano,A.L., Kara,E., Bras,J., Sharma,M., Schulte,C.,
            Keller,M.F., Arepalli,S., Letson,C., Edsall,C., Stefansson,H.,
            Liu,X., Pliner,H., Lee,J.H., Cheng,R., Ikram,M.A., Ioannidis,J.P.,
            Hadjigeorgiou,G.M., Bis,J.C., Martinez,M., Perlmutter,J.S.,
            Goate,A., Marder,K., Fiske,B., Sutherland,M., Xiromerisiou,G.,
            Myers,R.H., Clark,L.N., Stefansson,K., Hardy,J.A., Heutink,P.,
            Chen,H., Wood,N.W., Houlden,H., Payami,H., Brice,A., Scott,W.K.,
            Gasser,T., Bertram,L., Eriksson,N., Foroud,T. and Singleton,A.B.
  CONSRTM   International Parkinson's Disease Genomics Consortium (IPDGC);
            Parkinson's Study Group (PSG) Parkinson's Research: The Organized
            GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics
            Research Consortium (NGRC); Hussman Institute of Human Genomics
            (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health
            and Aging Research in Genetic Epidemiology (CHARGE); North American
            Brain Expression Consortium (NABEC); United Kingdom Brain
            Expression Consortium (UKBEC); Greek Parkinson's Disease
            Consortium; Alzheimer Genetic Analysis Group
  TITLE     Large-scale meta-analysis of genome-wide association data
            identifies six new risk loci for Parkinson's disease
  JOURNAL   Nat Genet 46 (9), 989-993 (2014)
   PUBMED   25064009
REFERENCE   5  (bases 1 to 4649)
  AUTHORS   Cai,K., Lucki,N.C. and Sewer,M.B.
  TITLE     Silencing diacylglycerol kinase-theta expression reduces steroid
            hormone biosynthesis and cholesterol metabolism in human
            adrenocortical cells
  JOURNAL   Biochim Biophys Acta 1841 (4), 552-562 (2014)
   PUBMED   24369117
  REMARK    GeneRIF: these data demonstrate that DGKtheta; plays an important
            role in steroid hormone production in human adrenocortical cells
REFERENCE   6  (bases 1 to 4649)
  AUTHORS   Houssa,B., de Widt,J., Kranenburg,O., Moolenaar,W.H. and van
            Blitterswijk,W.J.
  TITLE     Diacylglycerol kinase theta binds to and is negatively regulated by
            active RhoA
  JOURNAL   J Biol Chem 274 (11), 6820-6822 (1999)
   PUBMED   10066731
REFERENCE   7  (bases 1 to 4649)
  AUTHORS   Sakane,F. and Kanoh,H.
  TITLE     Molecules in focus: diacylglycerol kinase
  JOURNAL   Int J Biochem Cell Biol 29 (10), 1139-1143 (1997)
   PUBMED   9438377
  REMARK    Review article
REFERENCE   8  (bases 1 to 4649)
  AUTHORS   Houssa,B., Schaap,D., van der Wal,J., Goto,K., Kondo,H.,
            Yamakawa,A., Shibata,M., Takenawa,T. and van Blitterswijk,W.J.
  TITLE     Cloning of a novel human diacylglycerol kinase (DGKtheta)
            containing three cysteine-rich domains, a proline-rich region, and
            a pleckstrin homology domain with an overlapping Ras-associating
            domain
  JOURNAL   J Biol Chem 272 (16), 10422-10428 (1997)
   PUBMED   9099683
REFERENCE   9  (bases 1 to 4649)
  AUTHORS   Sakane,F., Imai,S., Kai,M., Wada,I. and Kanoh,H.
  TITLE     Molecular cloning of a novel diacylglycerol kinase isozyme with a
            pleckstrin homology domain and a C-terminal tail similar to those
            of the EPH family of protein-tyrosine kinases
  JOURNAL   J Biol Chem 271 (14), 8394-8401 (1996)
   PUBMED   8626538
REFERENCE   10 (bases 1 to 4649)
  AUTHORS   Endele,S., Zabel,B. and Winterpacht,A.
  TITLE     Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to
            chromosome 4p16.3
  JOURNAL   Genomics 33 (1), 145-146 (1996)
   PUBMED   8617502
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019103.8, BC063801.1,
            DN990411.1 and AB209503.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001347.3.
            
            Summary: The protein encoded by this gene contains three
            cysteine-rich domains, a proline-rich region, and a pleckstrin
            homology domain with an overlapping Ras-associating domain. It is
            localized in the speckle domains of the nucleus, and mediates the
            regeneration of phosphatidylinositol (PI) from diacylglycerol in
            the PI-cycle during cell signal transduction. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063801.1, GU727647.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273814.8/ ENSP00000273814.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC019103.8         50546-50572         c
            28-166              BC063801.1         27-165
            167-538             DN990411.1         156-527
            539-1666            AB209503.1         320-1447
            1667-3046           BC063801.1         1666-3045
            3047-3808           AC019103.8         36731-37492         c
            3809-4649           BC063801.1         3809-4649
FEATURES             Location/Qualifiers
     source          1..4649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4649
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /note="diacylglycerol kinase theta"
                     /db_xref="GeneID:1609"
                     /db_xref="HGNC:HGNC:2856"
                     /db_xref="MIM:601207"
     exon            1..358
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2916
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="DGK-theta; DAG kinase theta; diglyceride kinase
                     theta; diacylglycerol kinase, theta 110kDa; testis tissue
                     sperm-binding protein Li 38a; DGKtheta"
                     /codon_start=1
                     /product="diacylglycerol kinase theta"
                     /protein_id="NP_001338.2"
                     /db_xref="CCDS:CCDS3342.1"
                     /db_xref="GeneID:1609"
                     /db_xref="HGNC:HGNC:2856"
                     /db_xref="MIM:601207"
                     /translation="MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPG
                     PERAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLK
                     HVRIPCTSVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDC
                     VPFACSDCRQCHQDGHQDHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWC
                     GVQAHSLCSAALAPECGFGRLRSLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDG
                     ADGSAAVGPGRETQATPESGKQTLKIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALR
                     AHHIPEDPGHLELCRLPPSSQACDAWAGGKAGSAVISEEGRSPGSGEATPEAWVIRAL
                     PRAQEVLKIYPGWLKVGVAYVSVRVTPKSTARSVVLEVLPLLGRQAESPESFQLVEVA
                     MGCRHVQRTMLMDEQPLLDRLQDIRQMSVRQVSQTRFYVAESRDVAPHVSLFVGGLPP
                     GLSPEEYSSLLHEAGATKATVVSVSHIYSSQGAVVLDVACFAEAERLYMLLKDMAVRG
                     RLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNG
                     GPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDL
                     GRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIV
                     QMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISHSRSLHKQIR
                     LQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVV
                     HMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLR
                     KAKQKPRRAGTTRDARADAAPAPESDPR"
     exon            359..438
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            439..538
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            539..624
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..750
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            751..898
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            899..973
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1074
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1307
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1398
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1453
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1515
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1666
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1705
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1821
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1973
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2122
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2301
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2402
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2549
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2661
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2814
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..4649
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4624..4629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /note="hexamer: AATACA"
     polyA_site      4649
                     /gene="DGKQ"
                     /gene_synonym="DAGK; DAGK4; DAGK7"
                     /note="major polyA site"
ORIGIN      
        1 agtcggaagc agtgtaccgg gccgtggagc ggcggctcct gtacccccgg cgcggaccta
       61 aaggggctcg ggccgctcgg gccgggaatg gcggcggcgg ccgagcccgg ggcccgcgcc
      121 tggctgggcg gcggctcccc gcgccccggc agcccggcct gcagccccgt gctgggctca
      181 ggaggccgcg cgcgcccggg gccggggccg gggccgggac ccgagcgggc gggcgtcaga
      241 gccccgggcc ccgctgccgc gccgggacac agcttccgga aggtgacgct caccaagccc
      301 accttctgcc acctctgctc cgacttcatc tgggggctgg ccggcttcct gtgcgacgtc
      361 tgcaatttca tgtctcatga gaagtgcctg aagcacgtga ggatcccgtg cacgagtgtg
      421 gcacccagcc tggtccgggt tcctgtagcc cactgcttcg gcccccgggg gctccacaag
      481 cgcaagttct gtgctgtctg ccgcaaggtc ctggaggcac cggcgctcca ctgcgaagtg
      541 tgtgagctgc acctccaccc agactgtgtg cccttcgcct gcagtgactg ccgccagtgc
      601 caccaggatg ggcaccagga tcacgacacc catcaccacc actggcggga ggggaacctg
      661 ccctcgggag cgcgctgcga ggtctgcagg aagacgtgcg gctcctctga cgtgctggcc
      721 ggcgtgcgct gcgagtggtg cggggtccag gcgcactccc tctgctccgc ggcgctggct
      781 cccgagtgtg gcttcgggcg tctgcgctcc ctggtcctgc ctcccgcgtg cgtgcgcctt
      841 ctgcccggcg gcttcagcaa gacgcagagc ttccgcatcg tggaggccgc ggagccgggc
      901 gaggggggcg acggcgccga cgggagcgct gccgtgggtc caggcagaga gacacaggca
      961 actccggagt ccgggaagca aacgctgaag atctttgatg gcgacgacgc ggtgagaaga
     1021 agccagttcc gcctcgtcac ggtgtcccgc ctggccggtg ccgaggaggt gctggaggcc
     1081 gcactgcggg cccaccacat ccccgaggac cctggccacc tggagctgtg ccggctgccc
     1141 ccttcctctc aggcctgtga cgcctgggct gggggcaagg ctgggagtgc tgtgatctcg
     1201 gaggagggca gaagccccgg gtccggcgag gccacgccag aggcctgggt catccgggct
     1261 ctgccgcggg cccaggaggt cctgaagatc taccctggct ggctcaaggt gggcgtggcc
     1321 tacgtgtccg tgcgagtgac cccgaagagc acggcccgct ctgtggtgct ggaggtcctg
     1381 ccgctgctcg gccgccaggc cgagagtccc gagagcttcc agctggtgga ggtggcgatg
     1441 ggctgcaggc acgtccagcg gacgatgctg atggacgaac agcccctgct ggaccggcta
     1501 caggacatcc ggcagatgtc tgtgcggcag gtgagccaga cgcggttcta cgtggcagag
     1561 agcagggatg tagccccgca cgtctccctg tttgttggcg gcctgcctcc cggcctgtct
     1621 cccgaggagt acagcagcct gctgcatgag gccggggcta ccaaagccac cgtggtgtcc
     1681 gtgagtcaca tctactcctc ccaaggcgcg gtagtgttgg acgttgcctg ctttgcggag
     1741 gccgagcggc tgtacatgct gctgaaggac atggctgtgc ggggccggct gctcactgcc
     1801 ctggtgctcc ccgacctgct gcacgcgaag ctgcccccag acagctgtcc cctccttgtg
     1861 ttcgtgaacc ccaagagtgg aggcctcaag ggccgagacc tgctctgcag cttccggaag
     1921 ctactgaacc ctcatcaggt cttcgacctg accaacggag gtcctcttcc cgggctccac
     1981 ctgttctccc aggtgccctg cttccgggtg ctggtgtgtg gtggcgatgg cactgtgggc
     2041 tgggtgcttg gcgccctgga ggagacacgg taccgactgg cctgcccgga gccttctgtg
     2101 gccatcctgc ccctgggcac agggaatgac cttggtcgag tcctccgctg gggggcgggc
     2161 tacagcggcg aggacccgtt ctccgtactg ctgtctgtgg acgaggccga cgccgtgctc
     2221 atggaccgct ggaccatcct gctggatgcc cacgaggctg gcagtgcaga gaacgacacg
     2281 gcagacgcag agccccccaa gatcgtgcag atgagtaact actgtggcat tggcatcgac
     2341 gcggagctga gcctggactt ccaccaggca cgggaagagg agcctggcaa gttcacaagc
     2401 aggctgcaca acaagggtgt gtacgtgcgg gtggggctgc agaagatcag tcactctcgg
     2461 agcctgcaca agcagatccg gctgcaggtg gagcggcagg aggtggagct gcccagtatt
     2521 gaaggcctca tcttcatcaa catccccagc tggggctcgg gggccgacct gtggggctcc
     2581 gacagcgaca ccaggtttga gaagccacgc atggacgacg ggctgctgga ggttgtgggc
     2641 gtgacgggcg tcgtgcacat gggccaggtc cagggtgggc tgcgctccgg aatccggatt
     2701 gcccagggtt cctacttccg agtcacgctc ctcaaggcca ccccggtgca ggtggacggg
     2761 gagccctggg tccaggcccc ggggcacatg atcatctcag ctgctggccc taaggtgcac
     2821 atgctgagga aggccaagca gaagccgagg agggccggga ccaccaggga tgcccgggcg
     2881 gatgctgcgc ctgcccctga gagcgatcct aggtaggggt ggctggggca gcccaagggc
     2941 tcgagccatc tctgctcccg ccagccttgt tttcaggtgg tctggaggca gctccacgtc
     3001 cacacagtgg ccggccctgt ggtcggacct ggctacagcc ctgaccacag catcttccca
     3061 gtgacggagc gggacccgcc ctcatcccat tggtgacaca tgttggtgtc acagccctca
     3121 tcccactgga gactggtgtg cgggtggcag tgttaccccg tgtcccgggt gggcgcaggg
     3181 ctctggatgg tgagccctct gccctgtggg ggcctggtcc tctcctcagg ggtgggcacc
     3241 catccctctc cccactgagc cccttgagct ggacagtgct ggatgcaggc cgtccaggtg
     3301 ggtctgatct cactttgtgc ccctcgggcc gtccccctgg ccagtcctta agagcagcag
     3361 gctccctggt gtgtccctgc cccagcagac acaggctgcc agtccctcca gcctcacctc
     3421 cccgccctgg gcagcaggtg tgggcagcgt gtgaggctgc cgggtggtgg tgactggtga
     3481 cttccttgtg ttcagggaag ggagaaggtg ccttcccttg ttttctggcc ttgttatata
     3541 cagatggcag cttggatctc aggtacagct ccaggggcag gcagtgccca gctggacctg
     3601 gtggcccttt cctagtgcct ctgcttgggg aggagaacct ctgtccacgt ggaggctagg
     3661 aggtctcagg tgctgccctg gcagcaccag agtgtgggcc gggcccgagt gtctgcccct
     3721 cggccctcag ggtggggcac ttagcaccca gaagggacca aaagcagggc atggcggtgc
     3781 agaggagttt gggaggtgta aacagcccat gcacgtggag gaggagctgg ctttcagccc
     3841 cagaccccac gctagcactt tccacgctgc ttgcccgctg ttgatgtgca gttcccagtg
     3901 cctgtgtgag ccgacatctg ctcagtccta tccctcgtca gcgtgtggag acccagctcc
     3961 tgcagccctc ctgctcccac gcccccagac agcttggtgg agggtcctgc atctgggcca
     4021 ggctggggtg cacccagcca aagacaaagc tgcctccacg tgcccaagga ttcagatggt
     4081 gcactggccc cgggaggagt ctgaccaaaa atggagcccg ctctgtgggg aagccccgac
     4141 tcccccacga gaaacggtcc cacggtgcgg atctccccct tcccttgtgg ggcacagctg
     4201 gcctgggcct ccaatcctgc ggagctttcc tgggtgtggc tttgacctca gaagtggctc
     4261 tggtttggcc tcaggagtgt ggcctggccc agcctgctgc agcctcctgg ggggcccttg
     4321 atgccactaa tcccccgacc ccccgcatct gccaaactgc acagacacac gcattgtaag
     4381 gccgcttgtg gcctccagcg tgcactcttg tttacgtcat tgtcatcttc aagaccagtc
     4441 ctttgtgatt agttttgctt cgcgagccct ggtgtggact gtggtctgta tgaatcgtgt
     4501 gtaactgtgg tgaggggctt gtcctgtatg tgagtctgta cccaggtggg gtctgtgccc
     4561 tgcacaccgg gcccctctgt atttatcgct gcctgaatgc aacagtaatt tatatccagg
     4621 acaaatacag tctgggcgtc actatccta
//
