LOCUS       NM_001013742            7494 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens diacylglycerol kinase kappa (DGKK), mRNA.
ACCESSION   NM_001013742 XM_066534
VERSION     NM_001013742.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7494)
  AUTHORS   Richard,M.A., Sok,P., Canon,S., Brown,A.L., Peckham-Gregory,E.C.,
            Nembhard,W.N., Carmichael,S.L., Ehli,E.A., Kallsen,N.A.,
            Peyton,S.A., Davies,G.E., Patel,A., Zamilpa,I., Wyatt,R.A.,
            Hobbs,C.A., Scheurer,M.E. and Lupo,P.J.
  TITLE     The role of genetic variation in DGKK on moderate and severe
            hypospadias
  JOURNAL   Birth Defects Res 111 (13), 932-937 (2019)
   PUBMED   31102501
  REMARK    GeneRIF: Five DGKK variants previously reported as associated with
            hypospadias were identified in the genotype data. None of the
            variants were associated with second- or third-degree hypospadias
            (range of odds ratios = 0.7-0.9, all p > .05).  None of the
            variants were associated with second- or third-degree hypospadias
            (range of odds ratios = 0.7-0.9, all p > .05).
REFERENCE   2  (bases 1 to 7494)
  AUTHORS   Hozyasz,K.K., Mostowska,A., Kowal,A., Mydlak,D., Tsibulski,A. and
            Jagodzinski,P.P.
  TITLE     Further Evidence of the Association of the Diacylglycerol Kinase
            Kappa (DGKK) Gene With Hypospadias
  JOURNAL   Urol J 15 (5), 272-276 (2018)
   PUBMED   29464676
  REMARK    GeneRIF: Our study provides strong evidence of an association
            between DGKK nucleotide variants, haplotypes and hypospadias
            susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7494)
  AUTHORS   Xie,H., Lin,X.L., Zhang,S., Yu,L., Li,X.X., Huang,Y.C., Lyu,Y.Q.,
            Chen,H.T., Xu,J. and Chen,F.
  TITLE     Association between diacylglycerol kinase kappa variants and
            hypospadias susceptibility in a Han Chinese population
  JOURNAL   Asian J Androl 20 (1), 85-89 (2018)
   PUBMED   28597849
  REMARK    GeneRIF: This study successfully implicated DGKK variants in
            hypospadias risk among a Han Chinese population, especially for
            mild/moderate cases. Severe forms of hypospadias are likely due to
            other genetic factors
REFERENCE   4  (bases 1 to 7494)
  AUTHORS   Tabet,R., Moutin,E., Becker,J.A., Heintz,D., Fouillen,L.,
            Flatter,E., Krezel,W., Alunni,V., Koebel,P., Dembele,D.,
            Tassone,F., Bardoni,B., Mandel,J.L., Vitale,N., Muller,D., Le
            Merrer,J. and Moine,H.
  TITLE     Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol
            kinase activity in neurons
  JOURNAL   Proc Natl Acad Sci U S A 113 (26), E3619-E3628 (2016)
   PUBMED   27233938
  REMARK    GeneRIF: FMRP is mostly associated diacylglycerol kinase kappa
            (Dgkkappa), a master regulator that controls the switch between
            diacylglycerol and phosphatidic acid signaling pathways.
REFERENCE   5  (bases 1 to 7494)
  AUTHORS   Ma,Q., Tang,Y., Lin,H., Xu,M., Xu,G., Fang,X., Chen,J., Song,Z.,
            Li,Z., Shi,Y. and Geng,H.
  TITLE     Diacylglycerol kinase kappa (DGKK) variants and hypospadias in Han
            Chinese: association and meta-analysis
  JOURNAL   BJU Int 116 (4), 634-640 (2015)
   PUBMED   25327554
  REMARK    GeneRIF: Studied the relationship between DGKK single nucleotide
            polymorphisms (SNPs) and hypospadias risk in the Han Chinese
            population.
REFERENCE   6  (bases 1 to 7494)
  AUTHORS   Geller,F., Feenstra,B., Carstensen,L., Pers,T.H., van Rooij,I.A.,
            Korberg,I.B., Choudhry,S., Karjalainen,J.M., Schnack,T.H.,
            Hollegaard,M.V., Feitz,W.F., Roeleveld,N., Hougaard,D.M.,
            Hirschhorn,J.N., Franke,L., Baskin,L.S., Nordenskjold,A., van der
            Zanden,L.F. and Melbye,M.
  TITLE     Genome-wide association analyses identify variants in developmental
            genes associated with hypospadias
  JOURNAL   Nat Genet 46 (9), 957-963 (2014)
   PUBMED   25108383
REFERENCE   7  (bases 1 to 7494)
  AUTHORS   Carmichael,S.L., Mohammed,N., Ma,C., Iovannisci,D., Choudhry,S.,
            Baskin,L.S., Witte,J.S., Shaw,G.M. and Lammer,E.J.
  TITLE     Diacylglycerol kinase K variants impact hypospadias in a California
            study population
  JOURNAL   J Urol 189 (1), 305-311 (2013)
   PUBMED   23177175
REFERENCE   8  (bases 1 to 7494)
  AUTHORS   van der Zanden,L.F., van Rooij,I.A., Feitz,W.F., Franke,B.,
            Knoers,N.V. and Roeleveld,N.
  TITLE     Aetiology of hypospadias: a systematic review of genes and
            environment
  JOURNAL   Hum Reprod Update 18 (3), 260-283 (2012)
   PUBMED   22371315
  REMARK    Review article
REFERENCE   9  (bases 1 to 7494)
  AUTHORS   van der Zanden,L.F., van Rooij,I.A., Feitz,W.F., Knight,J.,
            Donders,A.R., Renkema,K.Y., Bongers,E.M., Vermeulen,S.H.,
            Kiemeney,L.A., Veltman,J.A., Arias-Vasquez,A., Zhang,X.,
            Markljung,E., Qiao,L., Baskin,L.S., Nordenskjold,A., Roeleveld,N.,
            Franke,B. and Knoers,N.V.
  TITLE     Common variants in DGKK are strongly associated with risk of
            hypospadias
  JOURNAL   Nat Genet 43 (1), 48-50 (2011)
   PUBMED   21113153
  REMARK    GeneRIF: Common variants in DGKK are strongly associated with risk
            of hypospadias
            Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   10 (bases 1 to 7494)
  AUTHORS   Imai,S., Kai,M., Yasuda,S., Kanoh,H. and Sakane,F.
  TITLE     Identification and characterization of a novel human type II
            diacylglycerol kinase, DGK kappa
  JOURNAL   J Biol Chem 280 (48), 39870-39881 (2005)
   PUBMED   16210324
  REMARK    GeneRIF: DGK kappa is a novel human type II diacylglycerol kinase
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233286.2, AB183864.1,
            AC239396.3 and AI591038.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001013742.3.
            
            Summary: The protein encoded by this gene is an enzyme that
            phosphorylates diacylglycerol, converting it to phosphatidic acid.
            The encoded protein is a membrane protein and is inhibited by
            hydrogen peroxide. Variations in this gene have been associated
            with hypospadias. [provided by RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB183864.1, BC137319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2162841
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611977.2/ ENSP00000477515.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC233286.2         138476-138562
            88-4005             AB183864.1         1-3918
            4006-7056           AC239396.3         90761-93811
            7057-7494           AI591038.1         3-440               c
FEATURES             Location/Qualifiers
     source          1..7494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..7494
                     /gene="DGKK"
                     /note="diacylglycerol kinase kappa"
                     /db_xref="GeneID:139189"
                     /db_xref="HGNC:HGNC:32395"
                     /db_xref="MIM:300837"
     exon            1..792
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..3963
                     /gene="DGKK"
                     /EC_number="2.7.1.107"
                     /note="DGK-kappa; DAG kinase kappa; diglyceride kinase
                     kappa; 142 kDa diacylglycerol kinase"
                     /codon_start=1
                     /product="diacylglycerol kinase kappa"
                     /protein_id="NP_001013764.1"
                     /db_xref="CCDS:CCDS75980.1"
                     /db_xref="GeneID:139189"
                     /db_xref="HGNC:HGNC:32395"
                     /db_xref="MIM:300837"
                     /translation="MDRGAAAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPP
                     LLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPA
                     PEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVTE
                     LAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTPMSWSRIKKIL
                     KEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCH
                     SFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSY
                     SHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPA
                     DEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECC
                     FRSHRSSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVF
                     LRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLH
                     EKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETP
                     RQTPLLKGQVEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDF
                     VVDIVKAWGQIKQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKSATEYADS
                     SKADRKPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFS
                     STFFLEDDPEDINQTSPRRRSRRGTLSSISSLKSEDLDNLNLDHLHFTPESIRFKEKC
                     VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEER
                     VHLECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIF
                     GSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAA
                     QMLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDSQESLSDEEYAQMQHLARLAENL
                     ISKLNDLSKIHQHVSVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAV
                     DVTFSLKGLYDDTTAFLDEKLLRSAEDETALQSALDAMNKEFKKLSEIDWMNPIFVPE
                     EKSSDTDSRSLRLKIKFPKLGKKKVEEERKPKSGQSVQSFIGNLWHRRHREDEAEGDD
                     PLTPSRSQL"
     exon            793..903
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            904..984
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1089
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1225
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1332
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1455
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1558
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1742
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1851
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1991
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2073
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2165
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2265
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2494
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2599
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2696
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2804
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2901
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3009
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3123
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3258
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3419
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3561
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3648
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3759
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3883
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..7494
                     /gene="DGKK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7476..7481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGKK"
                     /note="hexamer: AATAAA"
     polyA_site      7494
                     /gene="DGKK"
                     /note="major polyA site"
ORIGIN      
        1 agagccaagc cagccatgga gtgggatggg ggaaagtttg gcaccctgcg aggggctgcc
       61 ggactggagt gggcggggcg cccgagggta ctttagcctt ccaggcttag ggactcaggc
      121 tgcccagacc tgaagcggtg tgcggccatg gaccgcggag ctgccgcagc ccagggcact
      181 gccccgcctc aggatggaga gcagcccgct gagtctccag agcctccgcc gccttggccg
      241 ccgccgccac caccaccggc tccgccgccg gctccgccgc tgctctccga ggcttcgcca
      301 gaacccatac cagagccctg tccagagctt gctccaggtc cctgtccaga ggcgacctca
      361 gaatcagcca cagaactgta cacagaaccg accccagaac cagccacaga gccggcctca
      421 gaaccggccc cagaacctgc cacagagccg gccccagaac ctgccacaga gccggcccca
      481 gaaccggccc cagaacctgc cacagagtct gccccagagc cgactccaga acctgcccta
      541 gagtcggtcc cagagccggc cccagagctg actccagaag ttgccccaga gctggcccca
      601 gagccgaccc cagaacctgt gacagagctg gccccagagt tctgccctga ggcggctcca
      661 gagttccgtc caagtccagc accatgtcta ttgcaatgtc cggtggacac tcgagagaga
      721 ggtctaaaga cctcgccatc gccatcgcca tcgccatcgc ccagaacgcc aatgtcgtgg
      781 tccagaataa agaaaatatt gaaggaagga cctatgctga agaactgtaa ctctttcaag
      841 agatggaagc ttagatattt tctggttcaa ggacagaagc tctactttgc acaccatccc
      901 gcgtttgcac actttgaaac gattgatctg tctcaagcca ctgtggcaga aagcagctgt
      961 agaaaccttt gccacagttt ttgtgttatt acaccacaac gaaaaatcac tctggctgca
     1021 cccaaccgga aagacatgga agaatggatt aacatcataa aaaccatcca acagggagaa
     1081 atttataaga tacctgcagc agaaaacaac ccttttcttg ttggaatgca ttgttggtac
     1141 tccagttaca gccaccggac ccagcactgc aatgtttgtc gagagagcat tcctgcctta
     1201 tctagagatg ccatcatctg tgaagtgtgc aaagtgaaat ctcacagatt gtgtgctttg
     1261 agagcaagca aagactgcaa gtggaataca ttgtctatca ctgatgacct ccttctgcct
     1321 gcagatgaag taaacatgcc ccatcaatgg gtagaaggaa acatgcctgt cagctctcag
     1381 tgtgcagtgt gtcatgagag ctgtggcagt tatcaaagac ttcaagactt ccgctgcctg
     1441 tggtgtaatt ctacggtgca tgatgactgt aggagacggt tttccaagga atgttgcttc
     1501 agaagccatc gctcatcagt cattcctccc actgctctaa gcgaccccaa aggcgatggc
     1561 caattagtag tatcttcaga cttctggaat cttgattggt catcagcctg ttcatgtccc
     1621 ttgctcatct tcatcaactc caaaagtggc gatcatcagg ggatcgtctt cctccgaaaa
     1681 ttcaagcaat accttaaccc atctcaagtg ttcgacttat tgaagggtgg acctgaagca
     1741 gggctgtcta tgttcaagaa ctttgctcgc tttcgcattc tggtttgtgg tggagatggc
     1801 agcgtgagct gggtcttatc tctgattgat gcctttggat tacatgaaaa gtgtcagttg
     1861 gcagtcatcc cacttggaac cggcaatgat ctggctcgtg ttctgggctg gggtgcattc
     1921 tggaacaaaa gcaagtcacc tctggacatc ctcaacagag tggagcaggc tagtgtgagg
     1981 atcctagaca gatggagtgt gatgattcgt gagactccca gacaaacccc gctgctaaaa
     2041 ggacaggttg aaatggatgt accacgattt gaggctgctg ccatccaaca cttagaatct
     2101 gcagccaccg agttgaacaa aatcctgaag gccaagtacc ccacagagat gatcatcgca
     2161 accagattct tgtgttcagc tgtggaagat tttgtggttg atattgtaaa ggcctggggt
     2221 cagataaaac agaacaacac tgcaatagtg tctgtgattt tgaaaagtga cttaatgtat
     2281 gataggctca gtgtcctgat cgatgtcctg gctgaggagg cagcagctac ttctgctgaa
     2341 aaaagtgcta cagaatatgc agacagcagc aaggcagata ggaagccctt cattcctcaa
     2401 atagaccaca tagccaagtg caagttggag ctggctacaa aggcccagag tctccagaaa
     2461 tccttgaaac tcatcatatt tcaagttgaa caagctctgg atgaggaaag cagacagaca
     2521 atatctgtta agaactttag ttcaactttc ttcctggaag atgacccaga agatattaac
     2581 cagacaagcc cacgacgccg ttctcgtcgt ggcactttgt cttctatatc ttctctcaaa
     2641 agtgaggacc tggacaacct taacttggat cacttacatt ttacacctga atctatacgc
     2701 ttcaaagaaa aatgtgtcat gaacaactac ttcggaattg gactggatgc taaaatttct
     2761 ctggacttca acaccagaag agatgaacac ccagggcaat acaatagccg ccttaagaac
     2821 aagatgtggt atggccttct gggaaccaaa gaacttttgc agcgctctta caggaaactg
     2881 gaagaacgag tgcatttgga gtgtgatgga gaaaccatct ccttgccaaa cctgcaaggc
     2941 attgtagtgc tcaacattac cagctatgct ggaggtatca acttctgggg aagcaacaca
     3001 gcaaccacgg aatatgaggc tcctgcaatc gatgatggga aactggaggt ggtggcaatc
     3061 tttggttctg tgcagatggc aatgtcccgt atcatcaacc tgcatcatca tcgcattgcc
     3121 cagtgccatg aggtgatgat aaccattgat ggtgaagaag gtatcccagt gcaggtggat
     3181 ggggaggcct ggattcagag accaggcctt atcaaaatta gatacaagaa cgctgcccag
     3241 atgctgacaa gagatcggga ctttgagaac tcaatgaaaa tgtgggaata caagcatact
     3301 gaaattcaag ctgcccctca accccagctg gacttccagg actctcaaga gagcctctct
     3361 gacgaggagt atgcccagat gcagcactta gctcggcttg cagaaaacct catcagcaaa
     3421 cttaatgacc tgagcaagat ccaccagcat gtgtctgtcc tcatgggttc tgtgaatgcc
     3481 agcgctaaca tcctgaatga tatattttac ggccaagaca gtggcaatga gatgggtgca
     3541 gcttcctgta ttcccattga aactctaagc agaaatgatg ccgtagatgt tacatttagt
     3601 cttaaaggtc tctacgatga caccacagct ttcctggatg aaaagctgct gagaagtgct
     3661 gaggatgaga ctgcactaca aagcgccctg gatgccatga ataaggagtt caaaaagcta
     3721 tctgagattg actggatgaa tccaatcttt gttccagagg aaaaatcttc ggacactgac
     3781 agtagaagcc tcaggctgaa aattaagttc cccaaattgg gaaagaaaaa ggtagaagag
     3841 gaacgcaagc ctaaatcagg ccagagtgtc cagagtttta ttggcaattt atggcaccgc
     3901 agacatcgtg aagatgaagc agagggtgat gatcctctaa caccatcgag atctcaactg
     3961 tagcccttga aagctggaag aactcacaac attgagaatt ctactaaaaa aactctcaaa
     4021 acctcaatac aggctagact aaatcatttc agaacaaaca tgagcaccac caagaaagac
     4081 cctccaattc ttttcactaa tgcattttcc tggacttaat ctggtctcct tagaggttta
     4141 catttcctca ttggccaaag gttcttgttc cgagttgtct tgttcagttc tccttctctt
     4201 tgtgcatctt gagcaactac agtatttatt gggataagct ctttatgaat ggcctgggat
     4261 ctataaagga ttcaagggag ttcacctctt cagggagttt tggaatggtt ttctctgacc
     4321 agcagagaaa ctatcaatgc taaggaatga atgaaagaca cacagactcc cagggagatg
     4381 aagagaaggg ggcaggcagg acagccagac ttggttgtgt gtctctccga atccctgcca
     4441 actgcaactt gcaccttcag gagatctctt ctagttggct cattaaaatg agaactagat
     4501 cctgggggct tgtccacttt cctgttaaga tgaccatgtg aaatctcttt ttgtagatat
     4561 ggtaacctct ctctctctct gcaaaccctt tgcgtttttc tatgtgtgct tgtatgtctg
     4621 catatgtcca ggtggtgctc tggtgggctc attggttgga actcacccct catggcaacc
     4681 atacaggctc ccctcctgct gccttgatcc tagcctgcat gcctccacgg agtgtttgcc
     4741 tgcattcttg ctggattttt taactaaatg ttttgccgct gtgctgcagt atagattatg
     4801 tatagagaca taaagatgta tatatatata catacgcata tatattttta agagctgaaa
     4861 atacaactcg acctctaagt gaccctataa tttattgtgc taatccagga atcccttccc
     4921 actccccctt actctacata acaataacac atacacctct accaactgcc ctatttcttg
     4981 gtggagcttc taaatctttt ggtgcatttt cagcgtctta gaggtggctg ggatctatgg
     5041 cccagctgat tctgacgccc ccttaaaatt ctgagccagg ccatggaaag gggaacaaaa
     5101 acaccaatgc cctaaagaag gggtttaagc tggcatgctg cctttttttg ctctatctgt
     5161 cctagactct tcatcagcaa ctgtgccctt ccccaataaa aagactatat ggagcaacca
     5221 ggccttgagc tctgtgactt agatgcctga actagggact gcctgacaat taagtcacag
     5281 cctaggccct tccccacaag ctccatcttg gcctgatctt ctggacaggc tgttgggtca
     5341 gtcctcaagt caccttcaaa tctcccatct tgcccttttc ccttgagtac agaggggcat
     5401 tgaagtgatc agaaaaaaca tgggcctgga gaaatgaagg ctagaagcct gtgctttcct
     5461 gtggttcttc ttgcaaattt ctcatgaaaa caaactattc ctaaatcgct ccaaatacta
     5521 attcacattt ttcaaaaatg ccttctccca gtcagggcaa atctaatcaa accccaatgc
     5581 ccagagaggt tctctctggt cagccttgca tcttcacccc acccttgact cataccttta
     5641 gttaactgtc ccttcccact tatcaagaga aaactggcct ctccctactt ctcagacaaa
     5701 cttagcgtgc tcaattacct gattcagtcc aatggctggt tcattgaggt gcacaattca
     5761 gattccaagc actggttctc aactctggaa ctccaccagc ctaacccact taaaccagcc
     5821 acctgtgctc cacctccgca ggggtgagga gaaaaatatt aacaagggga tagtccccaa
     5881 atgtctgatt gctgtgccaa actaagtcct agctctacaa ctagagaaga aagtcaatgg
     5941 aaaaagatga cagaaaacat ttaaaactta tttaagcatc agaatgtgtt agcttgttgt
     6001 acatatttga gtagtgagtg tgctgttgtt gtgtctttga ctttctctgt tattagtctt
     6061 tcttcccagg aggaggtatt agatgaaatc agcaagctca ctattgcagc ctgacttggc
     6121 tcctctatgg ctgcatgcat tgacacctgc acacacactc acagagtggg aaccaagttg
     6181 cattttcttc agaagagctt tttccgaagg ggaaaatgtc caaatgagca aatttaggac
     6241 tacagaagga agtcctggga gaagatagct ttatcttggc agtgactaag cagggctgtg
     6301 tcttataatt atttttatca ctgatgatag taaactgtaa taagactcca tctcttgtgc
     6361 ttactttgct gcaataatta ggtctttgtg cacagtgatg ctgctgttgc tctgttgtgc
     6421 catgtggatt ccctttcacc taccctgtcc tcccactctg agtcagaatg atattgactg
     6481 aaaccactag tatttggggc tagagtcagc tcatggagca cagttgatag atgacaaggc
     6541 ccaggagcag gtgtggcttg ctcaatccct cagttacctc ctaaattgct aagttaccag
     6601 tagtttccca aaaaggaaga tagcttgcca agcacctgtt cttgcatatg ctcacttgga
     6661 aacaaagcaa gaagtgatgc ctcaagggag ttgtcttagc tctgggagtg tgagctcctt
     6721 taaggacttt gttaaccact tgcagtaatt aatacaattg cttgggtggt gggaccaaac
     6781 accaaatatc catctcaatt atgttcagac atcattaaga cccaaagctc tagggtttgg
     6841 ttgtatcttt ggtagcactt tctgacgaat tggttgggta ggcaattcct ggccagaaga
     6901 atagtggaga agaaaaagcc gatacatttg aactgccacc aactgcttct ggtgtcaata
     6961 ctataggagg taaacagtta tgggtcccct tctccagaaa ggccctgtgc tgtgtccata
     7021 agagcaggtt aagaataaga aagagatttt ttaccttaat aaaactgggc cagaagaaac
     7081 agtcagggtc aacgtcatct tccctcagga cacaaatgga agaatttttc tttcacgaga
     7141 ggtggaaaat aataccaaag caaccaaacc cattagcacc attccatcct atatgagacc
     7201 ttgcttggct atatgatttg tggaattgca tttgtctatt tgtcagtgaa tctgtaaccc
     7261 attgttgttt tctgctctgt gttttttatt tcctcagagg cccctgcaaa taagcagcag
     7321 ggccaggggc tggttggggg aggaagctgg ggtatttaca tggtaacagg aaaaagcaga
     7381 aaaaaaagat ccacaaagtg tgcctattcc tctccccccg ccaaatggaa caccagtcct
     7441 caatgttaat aaagtattgc ttctttaaat attttaataa atggataaac ataa
//
