LOCUS       NM_198512               1712 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens diacylglycerol O-acyltransferase 2 like 6 (DGAT2L6),
            mRNA.
ACCESSION   NM_198512 XM_293397
VERSION     NM_198512.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Ma,Z., Onorato,J.M., Chen,L., Nelson,D.W., Yen,C.E. and Cheng,D.
  TITLE     Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid
            acyltransferases
  JOURNAL   J Lipid Res 58 (6), 1091-1099 (2017)
   PUBMED   28420705
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Holmes,R.S.
  TITLE     Comparative genomics and proteomics of vertebrate diacylglycerol
            acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT)
            and monoacylglycerol acyltransferase (MGAT)
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 5 (1), 45-54 (2010)
   PUBMED   20374941
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Turkish,A.R., Henneberry,A.L., Cromley,D., Padamsee,M., Oelkers,P.,
            Bazzi,H., Christiano,A.M., Billheimer,J.T. and Sturley,S.L.
  TITLE     Identification of two novel human acyl-CoA wax alcohol
            acyltransferases: members of the diacylglycerol acyltransferase 2
            (DGAT2) gene superfamily
  JOURNAL   J Biol Chem 280 (15), 14755-14764 (2005)
   PUBMED   15671038
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Winter,A., van Eckeveld,M., Bininda-Emonds,O.R., Habermann,F.A. and
            Fries,R.
  TITLE     Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos
            taurus) and other mammals
  JOURNAL   Cytogenet Genome Res 102 (1-4), 42-47 (2003)
   PUBMED   14970677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG696880.1, AK129500.1,
            BG739793.1 and AL357752.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_198512.2.
            
            Summary: This gene is a member of the diacylglycerol
            acyltransferase 2 family. The encoded protein is a putative
            acyltransferase and is most likely involved in the synthesis of di-
            or triacylglycerol, however its substrate specificity is currently
            unknown. [provided by RefSeq, Feb 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163623 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333026.4/ ENSP00000328036.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BG696880.1         1-3
            4-1368              AK129500.1         1-1365
            1369-1369           BG739793.1         542-542
            1370-1711           AK129500.1         1367-1708
            1712-1712           AL357752.19        173885-173885       c
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1712
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /note="diacylglycerol O-acyltransferase 2 like 6"
                     /db_xref="GeneID:347516"
                     /db_xref="HGNC:HGNC:23250"
                     /db_xref="MIM:300926"
     exon            1..185
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1114
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /note="diacylglycerol O-acyltransferase candidate 3"
                     /codon_start=1
                     /product="diacylglycerol O-acyltransferase 2-like protein
                     6"
                     /protein_id="NP_940914.1"
                     /db_xref="CCDS:CCDS14397.1"
                     /db_xref="GeneID:347516"
                     /db_xref="HGNC:HGNC:23250"
                     /db_xref="MIM:300926"
                     /translation="MAFFSRLNLQEGLQTFFVLQWIPVYIFLGAIPILLIPYFLLFSK
                     FWPLAVLSLAWLTYDWNTHSQGGRRSAWVRNWTLWKYFRNYFPVKLVKTHDLSPKHNY
                     IIANHPHGILSFGVFINFATEATGIARIFPSITPFVGTLERIFWIPIVREYVMSMGVC
                     PVSSSALKYLLTQKGSGNAVVIVVGGAAEALLCRPGASTLFLKQRKGFVKMALQTGAY
                     LVPSYSFGENEVFNQETFPEGTWLRLFQKTFQDTFKKILGLNFCTFHGRGFTRGSWGF
                     LPFNRPITTVVGEPLPIPRIKRPNQKTVDKYHALYISALRKLFDQHKVEYGLPETQEL
                     TIT"
     exon            186..296
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..367
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..572
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..747
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..959
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1712
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="DGAT2L6"
                     /gene_synonym="DC3"
                     /note="major polyA site"
ORIGIN      
        1 cacagtaaga gattatagca aagcatctat aatcaactca gcttaagaag ttttgacctt
       61 ctggttaggc ttcttgccac aacagaacag caccataacc atggctttct tctcccgact
      121 gaatctccag gagggcctcc aaaccttctt tgttttgcaa tggatcccag tctatatatt
      181 tttaggagct attcccattc tccttatacc ctactttctg ttattcagta agttctggcc
      241 cttggctgtg ctctccttag cctggctcac ctatgattgg aacacccaca gtcaaggtgg
      301 caggcgttca gcttgggtac gaaactggac cctatggaag tatttccgaa attacttccc
      361 agtaaagctg gtgaagactc atgatctttc tcccaaacac aactacatca ttgccaatca
      421 cccccatggc attctctctt ttggtgtctt catcaacttt gccactgagg ccactggcat
      481 tgctcggatt ttcccatcca tcactccctt tgtagggacc ttagaaagga tattttggat
      541 cccaattgtg cgagaatatg tgatgtcaat gggtgtgtgc cctgtgagta gctcagcctt
      601 gaagtacttg ctgacccaga aaggctcagg caatgccgtg gttattgtgg tgggtggagc
      661 tgctgaagct ctcttgtgcc gaccaggagc ctccactctc ttcctcaagc agcgtaaagg
      721 ttttgtgaag atggcactgc aaacaggggc ataccttgtc ccttcatatt cctttggtga
      781 gaacgaagtt ttcaatcagg agaccttccc tgagggcacg tggttaaggt tgttccaaaa
      841 aaccttccag gacacattca aaaaaatcct gggactaaat ttctgtacct tccatggccg
      901 gggcttcact cgcggatcct ggggcttcct gcctttcaat cggcccatta ccactgttgt
      961 tggggaaccc cttccaattc ccaggattaa gaggccaaac cagaagacag tagacaagta
     1021 tcacgcactc tacatcagtg ccctgcgcaa gctctttgac caacacaaag ttgaatatgg
     1081 cctccctgag acccaagagc tgacaattac ataacaggag ccacattccc cattgatcaa
     1141 cccccaaagc catgagggat ccaagtagag ccacagaaaa agaagaattc caggagaggg
     1201 aaagatcgta aggatgagag aggagaccat ccaagccaga aattatttaa taaatcagag
     1261 ttctagcaat agagtcctct cccaagtggc tgaggcaggc ttaggggaaa gaaccagagg
     1321 ggcaggggag gactggggag ggctggctag ccagaggagt tggctgtatc acccctggtt
     1381 attttagggc aacaacccag ttggggagtc ttatgaatca ttccagccaa ctctctgatc
     1441 acaaagaata ctgtgcccct ttctcctaaa ccttagttca ccatcactac gtaggtttag
     1501 acttagaagc tttatttgga acagggatag tttgtttcct cttggtcctt tccttacaac
     1561 ttgggaactg ccacaaggta aaccagggac ctgaactgta gctgcctggt ccaagcagac
     1621 aggattccgt cagttgtgat agagttctag attggcaatg cagttacatt gtttcttctt
     1681 tgaaaataaa gttctagaca tataaaacag ga
//
