LOCUS       NM_012079               3653 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens diacylglycerol O-acyltransferase 1 (DGAT1), mRNA.
ACCESSION   NM_012079 XM_001125738
VERSION     NM_012079.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Deng,B., Kong,W., Shen,X., Han,C., Zhao,Z., Chen,S., Zhou,C. and
            Bae-Jump,V.
  TITLE     The role of DGAT1 and DGAT2 in regulating tumor cell growth and
            their potential clinical implications
  JOURNAL   J Transl Med 22 (1), 290 (2024)
   PUBMED   38500157
  REMARK    GeneRIF: The role of DGAT1 and DGAT2 in regulating tumor cell
            growth and their potential clinical implications.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Cui,H., Wang,Y., Zhou,T., Qu,L., Zhang,X., Wang,Y., Han,M.,
            Yang,S., Ren,X., Wang,G. and Gang,X.
  TITLE     Targeting DGAT1 inhibits prostate cancer cells growth by inducing
            autophagy flux blockage via oxidative stress
  JOURNAL   Oncogene 43 (2), 136-150 (2024)
   PUBMED   37973951
  REMARK    GeneRIF: Targeting DGAT1 inhibits prostate cancer cells growth by
            inducing autophagy flux blockage via oxidative stress.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Irshad,Z., Lund,J., Sillars,A., Lovsletten,N.G., Gharanei,S.,
            Salt,I.P., Freeman,D.J., Gill,J.M.R., Thoresen,G.H., Rustan,A.C.
            and Zammit,V.A.
  TITLE     The roles of DGAT1 and DGAT2 in human myotubes are dependent on
            donor patho-physiological background
  JOURNAL   FASEB J 37 (11), e23209 (2023)
   PUBMED   37779421
  REMARK    GeneRIF: The roles of DGAT1 and DGAT2 in human myotubes are
            dependent on donor patho-physiological background.
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Dias,S.S.G., Cunha-Fernandes,T., Soares,V.C., de Almeida,C.J. and
            Bozza,P.T.
  TITLE     Lipid droplets in Zika neuroinfection: Potential targets for
            intervention?
  JOURNAL   Mem Inst Oswaldo Cruz 118, e230044 (2023)
   PUBMED   37820117
  REMARK    GeneRIF: Lipid droplets in Zika neuroinfection: Potential targets
            for intervention?
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Buhman,K.K., Smith,S.J., Stone,S.J., Repa,J.J., Wong,J.S.,
            Knapp,F.F. Jr., Burri,B.J., Hamilton,R.L., Abumrad,N.A. and
            Farese,R.V. Jr.
  TITLE     DGAT1 is not essential for intestinal triacylglycerol absorption or
            chylomicron synthesis
  JOURNAL   J Biol Chem 277 (28), 25474-25479 (2002)
   PUBMED   11959864
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Cheng,D., Meegalla,R.L., He,B., Cromley,D.A., Billheimer,J.T. and
            Young,P.R.
  TITLE     Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric
            protein
  JOURNAL   Biochem J 359 (Pt 3), 707-714 (2001)
   PUBMED   11672446
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Smith,S.J., Cases,S., Jensen,D.R., Chen,H.C., Sande,E., Tow,B.,
            Sanan,D.A., Raber,J., Eckel,R.H. and Farese,R.V. Jr.
  TITLE     Obesity resistance and multiple mechanisms of triglyceride
            synthesis in mice lacking Dgat
  JOURNAL   Nat Genet 25 (1), 87-90 (2000)
   PUBMED   10802663
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Cases,S., Smith,S.J., Zheng,Y.W., Myers,H.M., Lear,S.R., Sande,E.,
            Novak,S., Collins,C., Welch,C.B., Lusis,A.J., Erickson,S.K. and
            Farese,R.V. Jr.
  TITLE     Identification of a gene encoding an acyl CoA:diacylglycerol
            acyltransferase, a key enzyme in triacylglycerol synthesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13018-13023 (1998)
   PUBMED   9789033
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Oelkers,P., Behari,A., Cromley,D., Billheimer,J.T. and Sturley,S.L.
  TITLE     Characterization of two human genes encoding acyl coenzyme
            A:cholesterol acyltransferase-related enzymes
  JOURNAL   J Biol Chem 273 (41), 26765-26771 (1998)
   PUBMED   9756920
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC023565.1 and AC233992.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012079.5.
            
            Summary: This gene encodes an multipass transmembrane protein that
            functions as a key metabolic enzyme. The encoded protein catalyzes
            the conversion of diacylglycerol and fatty acyl CoA to
            triacylglycerol. This enzyme can also transfer acyl CoA to retinol.
            Activity of this protein may be associated with obesity and other
            metabolic diseases. [provided by RefSeq, Jul 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015762.1, AF059202.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528718.6/ ENSP00000482264.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1946              BC023565.1         38-1983
            1947-3653           AC233992.5         76896-78602         c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3653
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /note="diacylglycerol O-acyltransferase 1"
                     /db_xref="GeneID:8694"
                     /db_xref="HGNC:HGNC:2843"
                     /db_xref="MIM:604900"
     exon            1..416
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1683
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.76"
                     /note="acyl coenzyme A:cholesterol acyltransferase related
                     gene 1; diglyceride acyltransferase; ACAT related gene
                     product 1; acyl-CoA retinol O-fatty-acyltransferase;
                     acyl-CoA:diacylglycerol acyltransferase"
                     /codon_start=1
                     /product="diacylglycerol O-acyltransferase 1"
                     /protein_id="NP_036211.2"
                     /db_xref="CCDS:CCDS6420.1"
                     /db_xref="GeneID:8694"
                     /db_xref="HGNC:HGNC:2843"
                     /db_xref="MIM:604900"
                     /translation="MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAG
                     DAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNAR
                     LFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALT
                     EQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWC
                     RRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKR
                     FLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIW
                     LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKP
                     MLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQG
                     NYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA"
     exon            417..504
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            505..545
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            546..631
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            632..684
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            685..790
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            791..892
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            893..967
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1071
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1110
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1152
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1197
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1310
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1376
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1464
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1527
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..3653
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /note="major polyA site"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
                     /note="hexamer: AATACA"
     polyA_site      3653
                     /gene="DGAT1"
                     /gene_synonym="ARAT; ARGP1; DGAT; DIAR7"
ORIGIN      
        1 agttagcggc tccggagcaa cgcagccgtt gtccttgagg ccgacgggcc cgacgcgggc
       61 gggttgaacg cgctggtgag gcggtcaccc gggctacggc ggccggcagg gggcagtggc
      121 ggccgttgtc tagggcccgg aggtggggcc gcgcgcctcg ggcgctacga acccggcggg
      181 cccacgcttg gctgcggccg ggtgcgggct gaggccatgg gcgaccgcgg cagctcccgg
      241 cgccggagga cagggtcgcg gccctcgagc cacggcggcg gcgggcctgc ggcggcggaa
      301 gaggaggtgc gggacgccgc tgcgggcccc gacgtgggag ccgcggggga cgcgccagcc
      361 ccggccccca acaaggacgg agacgccggc gtgggcagcg gccactggga gctgaggtgc
      421 catcgcctgc aggattcttt attcagctct gacagtggct tcagcaacta ccgtggcatc
      481 ctgaactggt gtgtggtgat gctgatcttg agcaatgccc ggttatttct ggagaacctc
      541 atcaagtatg gcatcctggt ggaccccatc caggtggttt ctctgttcct gaaggatccc
      601 tatagctggc ccgccccatg cctggttatt gcggccaatg tctttgctgt ggctgcattc
      661 caggttgaga agcgcctggc ggtgggtgcc ctgacggagc aggcgggact gctgctgcac
      721 gtggccaacc tggccaccat tctgtgtttc ccagcggctg tggtcttact ggttgagtct
      781 atcactccag tgggctccct gctggcgctg atggcgcaca ccatcctctt cctcaagctc
      841 ttctcctacc gcgacgtcaa ctcatggtgc cgcagggcca gggccaaggc tgcctctgca
      901 gggaagaagg ccagcagtgc tgctgccccg cacaccgtga gctacccgga caatctgacc
      961 taccgcgatc tctactactt cctcttcgcc cccaccttgt gctacgagct caactttccc
     1021 cgctctcccc gcatccggaa gcgctttctg ctgcgacgga tccttgagat gctgttcttc
     1081 acccagctcc aggtggggct gatccagcag tggatggtcc ccaccatcca gaactccatg
     1141 aagcccttca aggacatgga ctactcacgc atcatcgagc gcctcctgaa gctggcggtc
     1201 cccaatcacc tcatctggct catcttcttc tactggctct tccactcctg cctgaatgcc
     1261 gtggctgagc tcatgcagtt tggagaccgg gagttctacc gggactggtg gaactccgag
     1321 tctgtcacct acttctggca gaactggaac atccctgtgc acaagtggtg catcagacac
     1381 ttctacaagc ccatgcttcg acggggcagc agcaagtgga tggccaggac aggggtgttc
     1441 ctggcctcgg ccttcttcca cgagtacctg gtgagcgtcc ctctgcgaat gttccgcctc
     1501 tgggcgttca cgggcatgat ggctcagatc ccactggcct ggttcgtggg ccgctttttc
     1561 cagggcaact atggcaacgc agctgtgtgg ctgtcgctca tcatcggaca gccaatagcc
     1621 gtcctcatgt acgtccacga ctactacgtg ctcaactatg aggccccagc ggcagaggcc
     1681 tgagctgcac ctgagggcct ggcttctcac tgccacctca cacccgctgc cagagcccac
     1741 ctctcctcct aggcctcgag tgctggggat gggcctggct gcacagcatc ctcctctggt
     1801 cccagggagg cctctctgcc cctatggggc tctgtcctgc acccctcagg gatggcgaca
     1861 gcaggccaga cacagtctga tgccagctgg gagtcttgct gaccctgccc cgggtccgag
     1921 ggtgtcaata aagtgctgtc cagtgacctc ttcagcctgc caggggcctg gggcctggtg
     1981 gggggtatgg ccacacccac aagggcgagt gccagagctg tgtggacagc tgtcccagga
     2041 cctgccgggg agcagcagct ccactgcagc agggcgggca tggccggtag ggggagtgca
     2101 aggccaggca gacgccccca ttccccacac tcccctacct agaaaagctc agctcaggcg
     2161 tcctctcctg gtgctactcc tgctgggtgt gcgggaatcg gcactctggc cctcagtgca
     2221 ggatggtcaa cttgcaccca ccgtgctcag cttcagcttg ggaagaggtc ggccctgggt
     2281 ttgcgggaag tgggctccag ccaggatggc ccagggatgg gcagtccaca gggcctttct
     2341 ggtgtgggtc tggtgagccg aggggctacg gtacacaatg gctatgtcca tggctattcg
     2401 ccttggggca gggctcggtt tggcagcctc tttccttcac ttggaacctg ggcagccagg
     2461 tgggctggtg gctctcagct gccctccacg aggttggggc acccctgatc cccaggcctg
     2521 ccttgccctc tgctcttctg gcaccaggct gggcagtgca gacagcgcag ccctgcagcc
     2581 ttcaggacac cttgttccca ggccctgcaa tccaccaagc tggatagatg gggcccccct
     2641 tgatggtagc gggaggtcag gggtaacccc agggccctgc tgctgcctta ccttgctggg
     2701 gtgactgctt gattaaagac cccaagactg gaccaggccc tggtgtcccc agacctgcag
     2761 ctatggccca acaaggcagg tgtttgagga ggccctgcac agggtcccag gactgcacca
     2821 ggggcctcat cagcaacctg ctgaactggt ggtgtgaggg gagggtgggc tcccttggtg
     2881 gtatcctccc tctaccccag tgggggctgg tgggccctga gatggaggca tctccttggg
     2941 ccctgctgag gatggcagta gtgggtgagc tcctggtggg gggatgggtg tggggccgac
     3001 tcctccatcc cacatgggct cctgtgcctc tccctatcag ttggccagtg gagctcgaga
     3061 acaaactgtt gctgccagat aaagcagcaa agcctgctcc actgcccagc gcaggccccc
     3121 ttcccttcct ccaccaggct gagtggagaa ccctaaagct acgggacagg ctcccgttcc
     3181 ccgtgcctac acagggtgct ggctctggca gaaagacagt gtgcccgccc cgcatcacct
     3241 gtccgagtgc gaacaccttg ggaagggggt tcctggtggt cctgtgacaa ccagagaccc
     3301 ccagggccaa ggtgaggcgc ccacccctgg tccctcaata aagaactgca agcacatgct
     3361 ggtcctgggg agtcgggcag gcacggagct agctgcaagc atccgtcttc ccccaggagg
     3421 ccactgcagc ccggcccttc tgtgccctgg gcccctcctc attgcagcac cacccaccgc
     3481 accaccctgg gacagaggaa acacatggag gccatagcat agagcctgtc tgtttataga
     3541 tctctgcctg tcttgtccgt ccatccactg tgtgtatata tctgtgtatc tctgtggagc
     3601 ggggaacggg acagttgtgt aaaaatccaa aatacaattc tgactatgaa caa
//
