LOCUS       NM_014015               1569 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Dexi homolog (DEXI), mRNA.
ACCESSION   NM_014015
VERSION     NM_014015.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Dos Santos,R.S., Marroqui,L., Velayos,T., Olazagoitia-Garmendia,A.,
            Jauregi-Miguel,A., Castellanos-Rubio,A., Eizirik,D.L., Castano,L.
            and Santin,I.
  TITLE     DEXI, a candidate gene for type 1 diabetes, modulates rat and human
            pancreatic beta cell inflammation via regulation of the type I
            IFN/STAT signalling pathway
  JOURNAL   Diabetologia 62 (3), 459-472 (2019)
   PUBMED   30478640
  REMARK    GeneRIF: These observations support DEXI as the aetiological gene
            in the type 1 diabetes-associated 16p13 genomic region, and provide
            the first indication of a link between this candidate gene and the
            regulation of local antiviral immune responses in beta cells.
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Tomlinson,M.J. 4th, Pitsillides,A., Pickin,R., Mika,M., Keene,K.L.,
            Hou,X., Mychaleckyj,J., Chen,W.M., Concannon,P. and
            Onengut-Gumuscu,S.
  TITLE     Fine mapping and functional studies of risk variants for type 1
            diabetes at chromosome 16p13.13
  JOURNAL   Diabetes 63 (12), 4360-4368 (2014)
   PUBMED   25008175
  REMARK    GeneRIF: Reduced DEXI mRNA level was associated with type 1
            diabetes risk alleles of CLEC16A.
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Leikfoss,I.S., Mero,I.L., Dahle,M.K., Lie,B.A., Harbo,H.F.,
            Spurkland,A. and Berge,T.
  TITLE     Multiple sclerosis-associated single-nucleotide polymorphisms in
            CLEC16A correlate with reduced SOCS1 and DEXI expression in the
            thymus
  JOURNAL   Genes Immun 14 (1), 62-66 (2013)
   PUBMED   23151489
  REMARK    GeneRIF: The data indicates a possible regulatory role for multiple
            sclerosis-associated non-coding CLEC16A SNPs and a common control
            mechanism for the expression of CLEC16A, SOCS1 and DEXI.
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Miyaki,Y., Suzuki,K., Koizumi,K., Kato,T., Saito,M., Kamiyama,H.,
            Maeda,T., Shibata,K., Shiya,N. and Konishi,F.
  TITLE     Identification of a potent epigenetic biomarker for resistance to
            camptothecin and poor outcome to irinotecan-based chemotherapy in
            colon cancer
  JOURNAL   Int J Oncol 40 (1), 217-226 (2012)
   PUBMED   21901246
  REMARK    GeneRIF: Silencing of DEXI leads to drug resistance in colon
            cancer.
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Edgar,A.J., Birks,E.J., Yacoub,M.H. and Polak,J.M.
  TITLE     Cloning of dexamethasone-induced transcript: a novel
            glucocorticoid-induced gene that is upregulated in emphysema
  JOURNAL   Am J Respir Cell Mol Biol 25 (1), 119-124 (2001)
   PUBMED   11472984
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Kelly,M., Edgar,A.J. and Wevrick,R.
  TITLE     Analysis of DEXI/Dexi refines the organization of the mouse 7C and
            human 15q11-->q13 imprinting clusters
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 149-152 (2001)
   PUBMED   11306815
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Christian,S.L., Fantes,J.A., Mewborn,S.K., Huang,B. and
            Ledbetter,D.H.
  TITLE     Large genomic duplicons map to sites of instability in the
            Prader-Willi/Angelman syndrome chromosome region (15q11-q13)
  JOURNAL   Hum Mol Genet 8 (6), 1025-1037 (1999)
   PUBMED   10332034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133065.3 and BC037569.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.986743.1,
                                           SRR3476690.913599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331808.5/ ENSP00000330509.4
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC133065.3         122316-122383       c
            69-1569             BC037569.1         1-1501
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..1569
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /note="Dexi homolog"
                     /db_xref="GeneID:28955"
                     /db_xref="HGNC:HGNC:13267"
                     /db_xref="MIM:617901"
     exon            1..900
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..751
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /note="dexamethasone-induced transcript"
                     /codon_start=1
                     /product="dexamethasone-induced protein"
                     /protein_id="NP_054734.2"
                     /db_xref="CCDS:CCDS10545.1"
                     /db_xref="GeneID:28955"
                     /db_xref="HGNC:HGNC:13267"
                     /db_xref="MIM:617901"
                     /translation="MLGARVAAHLDALGPLVPYVPPPLLPSMFYVGLFFVNVLILYYA
                     FLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDAYLE"
     exon            901..1569
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /note="hexamer: ATTAAA"
     polyA_site      1569
                     /gene="DEXI"
                     /gene_synonym="MYLE"
                     /note="major polyA site"
ORIGIN      
        1 gagcgccacc gggagggcta cgcggcggcc gcagccatgg gtgctgggcc tgcgggggcg
       61 cggggggtgc gcgaggacct gcggggcggg gcgggagaga aggctgccgg gaccggccct
      121 agacactgag ccgcggtggg atccccaccg gctctgcgag gccctgcgag cgccagggag
      181 gcgccacgag ggagccgggc agccgcgggc cacttcaggg gggcccgcct cgccgcccgg
      241 gcggtcgaga gatccttggg ggcacatctc ggggtgcggt gacccgcccg gcgcatttcg
      301 ggggtcgggg cgcaattgcc aggggacatc tggagcccgg ccctgcttct gtcgggctcc
      361 agggtacccc tggatggctg cgctgtgccc tcgccggccg cccgggcgcc gcagcggctg
      421 agttcgccgg gatcgccggg ccgccgccct tgccacccgc tgcatgctcg gcgcccgggt
      481 cgcggcccac ctggacgcac tgggccccct ggtcccctac gtgccgccgc cgctgctgcc
      541 ctctatgttc tacgtgggcc tgttcttcgt caatgtgctg atcctgtact acgccttcct
      601 catggagtac atcgtcctca acgtgggcct cgtcttcctg cccgaggaca tggaccaggc
      661 gctcgtggac ctcggcgtgc tctccgaccc cggctcgggc ctttacgatg ctgactcgga
      721 gctcgacgtc tttgatgcgt acttggagta gggtctcgac tgctgttccc ctcttcccta
      781 cacgatccgc aacccatgcc ctggaccagc cgcccagatc atgccgccgc agctggttgg
      841 gggcaccatc tggacgggga tggttcccca ggaggagacc ctcccctgcc tccgaggcct
      901 acctgctccc ctcaaaagct tcgtgccaac agagaggttc ctgtttgaac ccaggagagt
      961 ggaagagaga ttgggactga gtgctgaggt tgggaaggca cctgctccca cagaaggggg
     1021 aacgcaagag gcatcccaag acctcatctg cctgcagtgt caaatcgatg gcctggcctt
     1081 ggcttctgat tatttgcagc tgcgatggat gtttacagga acccagccag agtttgcctc
     1141 cctgcacttc atcccggagc gcacctgctt cccccacttc accttcggag aggacacttc
     1201 aaactgcgga cacacgcaaa agcgactccc agctccgttt gatgtgagtt gagccttcag
     1261 gccagctggg tttagcccga ggctggtctt agatgcagcg actgtttcag gggtgactca
     1321 gaagaaaaag aagctgagga agctgttggg gggctgaggg tgggattctc gctccttcat
     1381 ttcaggttac tcgttcttca gcaagttggc aaaacagaca tcatgctggt gagtgccacg
     1441 ttactcccct ggctggaaat gcttttctga aagtatgagt gttgtgccta cttaattctg
     1501 ataaacctgt ctaagcaata cttaggaggc ttacttcttt ggattaaaaa aaaatgtatg
     1561 caactccaa
//
