LOCUS       NM_181645               2641 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens deuterosome assembly protein 1 (DEUP1), mRNA.
ACCESSION   NM_181645
VERSION     NM_181645.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Hazan,R., Mori,M., Danielian,P.S., Guen,V.J., Rubin,S.M.,
            Cardoso,W.V. and Lees,J.A.
  TITLE     E2F4's cytoplasmic role in multiciliogenesis is mediated via an
            N-terminal domain that binds two components of the centriole
            replication machinery, Deup1 and SAS6
  JOURNAL   Mol Biol Cell 32 (20), ar1 (2021)
   PUBMED   34260288
  REMARK    GeneRIF: E2F4's cytoplasmic role in multiciliogenesis is mediated
            via an N-terminal domain that binds two components of the centriole
            replication machinery, Deup1 and SAS6.
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Liu,Z.M., Wu,Z.Y., Li,W.H., Wang,L.Q., Wan,J.N. and Zhong,Y.
  TITLE     MiR-96-5p promotes the proliferation, invasion and metastasis of
            papillary thyroid carcinoma through down-regulating CCDC67
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (8), 3421-3430 (2019)
   PUBMED   31081096
  REMARK    GeneRIF: MiR-96-5p promotes the proliferation, invasion and
            metastasis of papillary thyroid carcinoma through down-regulating
            CCDC67.
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Yin,D.T., Xu,J., Lei,M., Li,H., Wang,Y., Liu,Z., Zhou,Y. and
            Xing,M.
  TITLE     Characterization of the novel tumor-suppressor gene CCDC67 in
            papillary thyroid carcinoma
  JOURNAL   Oncotarget 7 (5), 5830-5841 (2016)
   PUBMED   26716505
  REMARK    GeneRIF: Loss of CCDC67 is associated with papillary thyroid
            carcinoma.
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Zhao,H., Zhu,L., Zhu,Y., Cao,J., Li,S., Huang,Q., Xu,T., Huang,X.,
            Yan,X. and Zhu,X.
  TITLE     The Cep63 paralogue Deup1 enables massive de novo centriole
            biogenesis for vertebrate multiciliogenesis
  JOURNAL   Nat Cell Biol 15 (12), 1434-1444 (2013)
   PUBMED   24240477
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Park,S.J., Jang,H.R., Kim,M., Kim,J.H., Kwon,O.H., Park,J.L.,
            Noh,S.M., Song,K.S., Kim,S.Y., Kim,Y.H. and Kim,Y.S.
  TITLE     Epigenetic alteration of CCDC67 and its tumor suppressor function
            in gastric cancer
  JOURNAL   Carcinogenesis 33 (8), 1494-1501 (2012)
   PUBMED   22610074
  REMARK    GeneRIF: suggest that CCDC67 is a putative tumor suppressor gene
            that is silenced in gastric cancers by promoter CpG methylation and
            that it may play an important role in cell signaling and migration
            related to tumorigenesis
REFERENCE   9  (bases 1 to 2641)
  AUTHORS   Imboden,M., Bouzigon,E., Curjuric,I., Ramasamy,A., Kumar,A.,
            Hancock,D.B., Wilk,J.B., Vonk,J.M., Thun,G.A., Siroux,V., Nadif,R.,
            Monier,F., Gonzalez,J.R., Wjst,M., Heinrich,J., Loehr,L.R.,
            Franceschini,N., North,K.E., Altmuller,J., Koppelman,G.H.,
            Guerra,S., Kronenberg,F., Lathrop,M., Moffatt,M.F., O'Connor,G.T.,
            Strachan,D.P., Postma,D.S., London,S.J., Schindler,C.,
            Kogevinas,M., Kauffmann,F., Jarvis,D.L., Demenais,F. and
            Probst-Hensch,N.M.
  TITLE     Genome-wide association study of lung function decline in adults
            with and without asthma
  JOURNAL   J Allergy Clin Immunol 129 (5), 1218-1228 (2012)
   PUBMED   22424883
REFERENCE   10 (bases 1 to 2641)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017929.1, AK058122.1 and BC031247.1.
            
            On Aug 13, 2020 this sequence version replaced NM_181645.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3941815.1,
                                           SRR14372080.3272398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298050.9/ ENSP00000298050.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               BC017929.1         5-245
            242-1392            AK058122.1         1-1151
            1393-2639           BC031247.1         672-1918
            2640-2641           BC031247.1         1921-1922
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2641
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /note="deuterosome assembly protein 1"
                     /db_xref="GeneID:159989"
                     /db_xref="HGNC:HGNC:26344"
                     /db_xref="MIM:617148"
     exon            1..31
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            32..104
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1890
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /note="coiled-coil domain-containing protein 67;
                     deuterosome protein 1; coiled-coil domain containing 67"
                     /codon_start=1
                     /product="deuterosome assembly protein 1"
                     /protein_id="NP_857596.2"
                     /db_xref="CCDS:CCDS44707.1"
                     /db_xref="GeneID:159989"
                     /db_xref="HGNC:HGNC:26344"
                     /db_xref="MIM:617148"
                     /translation="MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALE
                     TRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSK
                     LTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILY
                     QTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCE
                     INERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSEL
                     QSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSV
                     MQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAA
                     LLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNRE
                     QSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEER
                     LSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEE
                     EKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQNRHI"
     exon            105..276
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            277..372
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            373..507
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            508..621
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            622..864
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1010
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1116
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1314
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1401
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1598
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1713
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2641
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /note="hexamer: AATAAA"
     polyA_site      2136
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /note="hexamer: AATAAA"
     polyA_site      2641
                     /gene="DEUP1"
                     /gene_synonym="CCDC67"
                     /note="major polyA site"
ORIGIN      
        1 agacctctcg ggcgagcgcg gcgcagcgca gattaaaaat caagaaatat aaaccagatg
       61 tagcagtttc ttgacatgga gaaccaagcc cataatacga tgggaacttc tccttgtgag
      121 gctgagcttc aggaattaat ggaacaaatt gacatcatgg taagcaacaa gaaaatggat
      181 tgggaaagaa agatgcgggc tttggagaca cgattagatc ttcgggatca agaattggca
      241 aatgcacaaa cttgtttgga tcagaaaggt caagaggtag ggttacttcg acagaaattg
      301 gacagtctgg aaaaatgtaa tttagcaatg actcagaatt atgaaggaca actacaaagc
      361 ctaaaggctc aattttccaa actaacaaat aactttgaaa aactgagatt acatcagatg
      421 aaacaaaaca aagttccacg aaaagaatta ccacacctta aagaagaaat accctttgaa
      481 ctgagcaatt tgaaccagaa attagaggaa tttagagcaa agtcaagaga atgggacaag
      541 caagagatat tatatcagac tcatctgatt tctttagatg ctcaacaaaa attattatct
      601 gagaagtgta atcagtttca gaaacaggca caaagttacc aaactcaact aaatggtaaa
      661 aaacagtgct tagaagacag cagctctgaa attcctcgtt tgatatgtga cccagatccc
      721 aattgtgaaa tcaatgaaag agatgagttc attattgaaa aactgaaatc agctgtaaat
      781 gagatagcac taagcaggaa taaattacaa gatgaaaatc agaagctctt gcaagaactg
      841 aaaatgtacc aaagacagtg ccaggccatg gaagcaggtc tctcagaggt aaaaagtgag
      901 ttacagtcac gtgatgatct cttgagaatt atagaaatgg aacgattgca attacacaga
      961 gaattattaa aaataggaga gtgccaaaat gctcaaggaa ataaaacaag acttgaatca
     1021 tcttatttgc cttctattaa agaaccagaa aggaaaataa aagagctgtt ttcagtgatg
     1081 caagatcaac caaatcatga aaaagaattg aacaagataa gaagccaact ccaacaggtg
     1141 gaagagtacc ataactctga gcaggaaaga atgaggaatg aaatctctga cctaacagaa
     1201 gagcttcatc agaaggagat cactatagca actgtcacaa agaaagctgc ccttctggaa
     1261 aaacagttaa aaatggaatt agaaataaaa gaaaaaatgt tagcaaaaca aaaggtctca
     1321 gatatgaaat ataaagctgt cagaactgaa aacacacatc taaaaggaat gatgggagat
     1381 ttagaccccg gagaatacat gagtatggac ttcactaaca gggaacagtc aaggcataca
     1441 tctattaata aactgcaata tgagaatgaa aggctccgaa atgatcttgc aaaacttcat
     1501 gtcaatggaa aatcaacctg gactaatcaa aacacctatg aagaaacagg aagatatgcc
     1561 tatcaaagcc aaataaaagt ggaacaaaat gaagagagac ttagtcatga ctgtgagcca
     1621 aacagaagta caatgcctcc cttgccacct tcgacatttc aagccaaaga aatgacaagt
     1681 cctttggtta gtgatgatga tgtattccca ctgtctcccc cagatatgtc cttcccagca
     1741 tctttggctg cacagcattt ccttctggaa gaagagaaac gagcaaaaga acttgaaaaa
     1801 cttctaaata cacatattga tgaactgcaa agacacacag aatttactct taataaatac
     1861 tccaagctaa aacaaaatag acacatatga gcttttaaac ttttttattt gcttcccccc
     1921 cccacccccg ccaagaaaaa aagctctggc aaaatattta caaagctgat taatgaaacc
     1981 aagaaattct gttctgtttc cttgagtaaa taatttccgt aaggcagcta gaaaatagta
     2041 agtattttgt tctataaagc tgttcacatt tctgcattaa catgctaaat tgtcctgctg
     2101 tagagttact ataaaataaa catgactatt ccaaaagaga tttttttcca gtctaaggaa
     2161 tattttggaa tcaaatatgc agtttttttt ccccacttga atcatgtata ctgaaaaccc
     2221 atttcctcag caactacaca aaataagaga aagggaagtg ctatattcca gatacaaatg
     2281 actcaaaggc agctcagttg tactggtttt gaaaactcaa ggattttata aataaaaata
     2341 tttaagtatt tccagttatg taaacactct aaaattctat aattttttgg aaaaaaaaag
     2401 ctatagcttt attgttttta cattcacctt tataatgtct gtctgtttca acacaatgaa
     2461 ggtatatgga atgtgcaatt tacaaaccta aaatatatgt gccaaaaatt aacgcttttt
     2521 tgttagtact aattacttca tggacacaaa caagataaag gaaatataaa gcattactgt
     2581 tgctacattt tcctttgtaa tcacttctgt ttttaataca ataaaggaat gtaaaattca
     2641 a
//
