LOCUS       NM_001002847            2803 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens DERPC proline and glycine rich nuclear protein
            (DERPC), transcript variant 4, mRNA.
ACCESSION   NM_001002847
VERSION     NM_001002847.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Bigaud,E. and Corrales,F.J.
  TITLE     Methylthioadenosine (MTA) Regulates Liver Cells Proteome and
            Methylproteome: Implications in Liver Biology and Disease
  JOURNAL   Mol Cell Proteomics 15 (5), 1498-1510 (2016)
   PUBMED   26819315
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Zhou,H., Di Palma,S., Preisinger,C., Peng,M., Polat,A.N., Heck,A.J.
            and Mohammed,S.
  TITLE     Toward a comprehensive characterization of a human cancer cell
            phosphoproteome
  JOURNAL   J Proteome Res 12 (1), 260-271 (2013)
   PUBMED   23186163
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Murakami,T., Takano,R., Takeo,S., Taniguchi,R., Ogawa,K., Ohashi,E.
            and Tsurimoto,T.
  TITLE     Stable interaction between the human proliferating cell nuclear
            antigen loader complex Ctf18-replication factor C (RFC) and DNA
            polymerase {epsilon} is mediated by the cohesion-specific subunits,
            Ctf18, Dcc1, and Ctf8
  JOURNAL   J Biol Chem 285 (45), 34608-34615 (2010)
   PUBMED   20826785
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Mayya,V., Lundgren,D.H., Hwang,S.I., Rezaul,K., Wu,L., Eng,J.K.,
            Rodionov,V. and Han,D.K.
  TITLE     Quantitative phosphoproteomic analysis of T cell receptor signaling
            reveals system-wide modulation of protein-protein interactions
  JOURNAL   Sci Signal 2 (84), ra46 (2009)
   PUBMED   19690332
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Green,A.R., Krivinskas,S., Young,P., Rakha,E.A., Paish,E.C.,
            Powe,D.G. and Ellis,I.O.
  TITLE     Loss of expression of chromosome 16q genes DPEP1 and CTCF in
            lobular carcinoma in situ of the breast
  JOURNAL   Breast Cancer Res Treat 113 (1), 59-66 (2009)
   PUBMED   18213475
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   7  (bases 1 to 2803)
  AUTHORS   Bermudez,V.P., Maniwa,Y., Tappin,I., Ozato,K., Yokomori,K. and
            Hurwitz,J.
  TITLE     The alternative Ctf18-Dcc1-Ctf8-replication factor C complex
            required for sister chromatid cohesion loads proliferating cell
            nuclear antigen onto DNA
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10237-10242 (2003)
   PUBMED   12930902
REFERENCE   8  (bases 1 to 2803)
  AUTHORS   Merkle,C.J., Karnitz,L.M., Henry-Sanchez,J.T. and Chen,J.
  TITLE     Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human
            homologs of a Saccharomyces cerevisiae complex involved in sister
            chromatid cohesion establishment
  JOURNAL   J Biol Chem 278 (32), 30051-30056 (2003)
   PUBMED   12766176
REFERENCE   9  (bases 1 to 2803)
  AUTHORS   Sun,M., Ma,L., Xu,L., Li,J., Zhang,W., Petrovics,G., Makarem,M.,
            Sesterhenn,I., Zhang,M., Blanchette-Mackie,E.J., Moul,J.,
            Srivastava,S. and Zou,Z.
  TITLE     A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell
            growth and its expression is decreased in prostate and renal tumors
  JOURNAL   Mol Med 8 (10), 655-663 (2002)
   PUBMED   12477976
  REMARK    GeneRIF: decreased expression of DERPC may be implicated in
            tumorigenesis of prostate and renal tumors
REFERENCE   10 (bases 1 to 2803)
  AUTHORS   Mayer,M.L., Gygi,S.P., Aebersold,R. and Hieter,P.
  TITLE     Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC
            complex required for sister chromatid cohesion in S. cerevisiae
  JOURNAL   Mol Cell 7 (5), 959-970 (2001)
   PUBMED   11389843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009027.10.
            
            On Aug 14, 2020 this sequence version replaced NM_001002847.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.11022.1,
                                           SRR18074969.1682743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155770, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519520.7/ ENSP00000427718.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC009027.10        7563-7667
            106-163             AC009027.10        18658-18715
            164-2803            AC009027.10        19502-22141
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2803
                     /gene="DERPC"
                     /note="DERPC proline and glycine rich nuclear protein"
                     /db_xref="GeneID:113455421"
                     /db_xref="HGNC:HGNC:54084"
     exon            1..105
                     /gene="DERPC"
                     /inference="alignment:Splign:2.1.0"
     exon            106..163
                     /gene="DERPC"
                     /inference="alignment:Splign:2.1.0"
     exon            164..2803
                     /gene="DERPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1959
                     /gene="DERPC"
                     /note="isoform 1 is encoded by transcript variant 4;
                     decreased expression in renal and prostate cancer protein;
                     Protein DERPC; chromosome transmission fidelity protein 8
                     homolog"
                     /codon_start=1
                     /product="decreased expression in renal and prostate
                     cancer protein isoform 1"
                     /protein_id="NP_001002847.1"
                     /db_xref="CCDS:CCDS92188.1"
                     /db_xref="GeneID:113455421"
                     /db_xref="HGNC:HGNC:54084"
                     /translation="MKEPRIFPRERPTPWTRAPLPPRGRLDGSLGPQGGPVLNTGHPL
                     GVNSDPFLMAAGSLGGNLTPFPRNPSPFPASSGSLASNPAPFPAGARDPSMASFPRGM
                     NPTGTGAVSFPRPGGLLGPGPGPGPTLNPRTGALPGPGPLSNPRLGGLPGPGPMSNPR
                     AGGLLGAGPDPRGGGPMGPGSGPNLRAGVLLTSGNGPPNPRPVGLGPGPNPNLRSGFL
                     GTNPAPRSGVFPGPGLGPNPRPSGLGPGPNLDARAGGLLGTGSGLNLRMAGPQGLDLA
                     PILRAAGLLGANSASFSQASGNMGTSPSSMARVPGPMGPNSGPSSRGIGLPGPNPSPM
                     SRAPGPIGPNSAHFSRPVGPMGVNANPFPRGAGSSAFSQSSGTLASNPATFQRSAGLQ
                     GSNPTIFPRASGPLGPNPANFPRATGLQGPSPTTFPRSTGPLGPGQVTFPRPAAGHLG
                     PSPAGPVGINPAPFTRPTGTLGLNPASFPRMNGPAGKSFVPFPRVGSLPGTNPAAFPR
                     PGGPMAAMYPNGMLPP"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DERPC"
                     /note="hexamer: AATAAA"
     polyA_site      2803
                     /gene="DERPC"
                     /note="major polyA site"
ORIGIN      
        1 agtcggaagt gcgcaggcag tgctcgcggc ggcggcgacg gcggcgggag gttcggttgt
       61 cgcccgttgg ccgcgcggcg ccgcgctcgg cggccgccat tgcagcttgt tttcacttgc
      121 tttttaaaga cagaaagctc atggtgcaaa ttgttatttc cagggaatcc ctgtgctgat
      181 cgtggggcat catatcctgt atgggaaaat catccacctg gagaaacctt ttgcagtcct
      241 tgtcaaacac actcctgggg atcaggactg tgatgagctt ggccgcgaga ctggcacccg
      301 gtacctggtg acagcactca tcaaagacaa gatccttttc aaaacccgcc ccaagcccat
      361 tatcaccagc gtccccaaga aagtatgaaa gaacctcgga ttttccctag agagcggcca
      421 actccttgga ctcgtgctcc gctgccacct cgaggacggc tcgacggttc cctgggacca
      481 caggggggtc ctgttctgaa cacaggccac ccactgggtg tgaactcgga tcccttcctt
      541 atggcggccg gttctcttgg tggaaatctg accccatttc caaggaaccc atctcctttt
      601 ccagcttcat caggctcatt ggcttcaaat ccagcacctt tcccggctgg tgctcgtgac
      661 ccaagtatgg cttcttttcc aagagggatg aatcccactg gcacaggtgc agtttctttc
      721 ccaaggcctg gtggcctctt ggggccaggc ccaggcccag gccccaccct aaaccctagg
      781 acaggggctc tgccaggccc agggcctctg tctaacccca ggttaggggg tctcccagga
      841 ccaggtccta tgtccaaccc aagggcaggt ggtctcctgg gagcaggtcc tgaccccaga
      901 ggtggtggtc ccatgggccc tggatctgga cctaacctga gagccggtgt tctgttaacc
      961 tctgggaatg gtcctcccaa tcctaggcca gttggcctgg gcccaggacc aaaccccaat
     1021 ctgagatcag gctttttagg gacaaaccct gcccccaggt caggtgtgtt tccaggccca
     1081 ggccttgggc ccaacccaag accaagtggc ctgggcccag gccctaatct agatgccaga
     1141 gcaggtggcc tcttgggcac aggatctggt cttaacttaa gaatggctgg acctcaaggc
     1201 ctcgatcttg cccccattct aagagcagca ggtcttttag gagcaaattc agcttctttc
     1261 tcacaggctt ctggaaacat gggcacaagc ccatcctcca tggcaagagt acctggcccc
     1321 atgggcccaa actcgggtcc tagctctcgg ggaattggcc ttccagggcc aaatccatct
     1381 cccatgtcaa gggctcctgg ccccataggc cctaattcag ctcatttctc aaggccagtt
     1441 ggccccatgg gggtaaatgc caatcccttt cccaggggag caggttcatc tgccttttct
     1501 cagtcttctg gcacattggc atcaaaccca gctaccttcc aaaggtccgc tggcctccag
     1561 ggctcaaatc caaccatttt cccaagagcc tctgggccac ttggccccaa cccagctaac
     1621 ttcccaaggg ccactggcct gcagggtcca agtccaacta ccttcccaag gtctactggc
     1681 ccattaggcc ctggtcaagt tactttcccc aggccagctg ccgggcatct gggcccttct
     1741 ccagctggcc ctgtgggtat caacccagct cctttcacaa ggccaactgg gaccctgggt
     1801 ctcaacccag cttcctttcc aaggatgaat ggccctgcag gcaagagttt cgtcccattt
     1861 cctagagtgg ggagcctccc tggcacaaac ccagctgctt tccccagacc agggggtcca
     1921 atggctgcaa tgtacccaaa tggaatgttg cccccttaaa caccattttc cctccaggac
     1981 caccttggtt tctaggcact gtggttcttg gcaggggctg tcttaggtaa aagggtagtt
     2041 gtggagctac agtctgaaga acatagcttg ggctcaagtt caaatgagcc atctttttcc
     2101 tttgcgtttt tcttgactga aggtgagatg ttatttgtgg catgtgaact gtggcaggtg
     2161 ggaataatcc tgcccttgag agaaaggatc tccagcctcc cagaagcctg ctgtgctttc
     2221 gtcccacagc tttctgccca ttgtttctta ctagtttctt gaattgttct tgtggacttt
     2281 tcctcaggga tacattggcc tgcaggtccc agttcacatg tagtcccctg ctcaccattg
     2341 gagaatcagc tcactgctct ctagaaacgt ggcgttggtg aacggaccat gcttccgtag
     2401 ctctgacctg ggcagcttgg acctggtcat cctctactgc catacctttc cctgggggct
     2461 tgaacacaga acagggagat ggacaaccac ttcaaagaaa gacccaccga atgcagtttc
     2521 tgcttgactg actgggcctg cagctccctt ctcctgggac ttagaggtgg ccagatttaa
     2581 ggcccctcta ctcatccaac tccctcttca ctggtactcc caatcaatca aagaacctca
     2641 aaatttaaac tgatgtggat gggaatatgg gaattagggt gggggtgggg gatgaaggga
     2701 agaaatcact gtgctttgtt cggcctggtg tgcaaggatg gttggtggtt ttcctgcatt
     2761 gtatcttttc ttactgtttc tttaataaat gggatgagag ggc
//
