LOCUS       NM_016041               4167 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens derlin 2 (DERL2), transcript variant 1, mRNA.
ACCESSION   NM_016041
VERSION     NM_016041.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4167)
  AUTHORS   Liu,L., Wu,J., Yan,Y., Cheng,S., Yu,S. and Wang,Y.
  TITLE     DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in
            chemotherapy resistance of cholangiocarcinoma
  JOURNAL   J Physiol Biochem 80 (1), 81-97 (2024)
   PUBMED   37815698
  REMARK    GeneRIF: DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in
            chemotherapy resistance of cholangiocarcinoma.
REFERENCE   2  (bases 1 to 4167)
  AUTHORS   Tabata,K., Arakawa,M., Ishida,K., Kobayashi,M., Nara,A.,
            Sugimoto,T., Okada,T., Mori,K. and Morita,E.
  TITLE     Endoplasmic Reticulum-Associated Degradation Controls Virus Protein
            Homeostasis, Which Is Required for Flavivirus Propagation
  JOURNAL   J Virol 95 (15), e0223420 (2021)
   PUBMED   33980593
  REMARK    GeneRIF: Endoplasmic Reticulum-Associated Degradation Controls
            Virus Protein Homeostasis, Which Is Required for Flavivirus
            Propagation.
REFERENCE   3  (bases 1 to 4167)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4167)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4167)
  AUTHORS   Ren,G., Tardi,N.J., Matsuda,F., Koh,K.H., Ruiz,P., Wei,C.,
            Altintas,M.M., Ploegh,H. and Reiser,J.
  TITLE     Podocytes exhibit a specialized protein quality control employing
            derlin-2 in kidney disease
  JOURNAL   Am J Physiol Renal Physiol 314 (3), F471-F482 (2018)
   PUBMED   29167172
  REMARK    GeneRIF: Derlin-2 is part of a protein quality control mechanism
            that can rescue glomerular injury attributable to impaired protein
            folding pathways in the endoplasmic reticulum.
REFERENCE   6  (bases 1 to 4167)
  AUTHORS   Rhee,S. and Grinnell,F.
  TITLE     P21-activated kinase 1: convergence point in PDGF- and
            LPA-stimulated collagen matrix contraction by human fibroblasts
  JOURNAL   J Cell Biol 172 (3), 423-432 (2006)
   PUBMED   16449192
REFERENCE   7  (bases 1 to 4167)
  AUTHORS   Oda,Y., Okada,T., Yoshida,H., Kaufman,R.J., Nagata,K. and Mori,K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
  REMARK    GeneRIF: Findings indicate that Derlin-2 provides the missing link
            between EDEM and p97 in the process of degrading misfolded
            glycoproteins.
REFERENCE   8  (bases 1 to 4167)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     Multiprotein complexes that link dislocation, ubiquitination, and
            extraction of misfolded proteins from the endoplasmic reticulum
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14296-14301 (2005)
   PUBMED   16186509
  REMARK    GeneRIF: Derlin-2 forms a robust multiprotein complex with the p97
            AAA ATPase as well as the mammalian orthologs of the yeast
            Hrd1p/Hrd3p ubiquitin-ligase complex, and participates in the
            degradation of proteins from the ER.
REFERENCE   9  (bases 1 to 4167)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
REFERENCE   10 (bases 1 to 4167)
  AUTHORS   Ying,H., Yu,Y. and Xu,Y.
  TITLE     Cloning and characterization of F-LANa, upregulated in human liver
            cancer
  JOURNAL   Biochem Biophys Res Commun 286 (2), 394-400 (2001)
   PUBMED   11500051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051246.1, AF242523.1, AC004148.1 and BM675359.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016041.4.
            
            Summary: Proteins that are unfolded or misfolded in the endoplasmic
            reticulum (ER) must be refolded or degraded to maintain the
            homeostasis of the ER. DERL2 is involved in the degradation of
            misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed
            16449189]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.13220.1,
                                           SRR11853561.11925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000158771.9/ ENSP00000158771.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                HY051246.1         53-64
            13-1131             AF242523.1         1-1119
            1132-3778           AC004148.1         99182-101828        c
            3779-4167           BM675359.1         21-409              c
FEATURES             Location/Qualifiers
     source          1..4167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..4167
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /note="derlin 2"
                     /db_xref="GeneID:51009"
                     /db_xref="HGNC:HGNC:17943"
                     /db_xref="MIM:610304"
     exon            1..110
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..737
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /note="isoform a is encoded by transcript variant 1;
                     carcinoma related; degradation in endoplasmic reticulum
                     protein 2; Der1-like domain family, member 2"
                     /codon_start=1
                     /product="derlin-2 isoform a"
                     /protein_id="NP_057125.2"
                     /db_xref="CCDS:CCDS11073.1"
                     /db_xref="GeneID:51009"
                     /db_xref="HGNC:HGNC:17943"
                     /db_xref="MIM:610304"
                     /translation="MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFN
                     PELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFL
                     FGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMG
                     FSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNY
                     NPLPEERPGGFAWGEGQRLGG"
     exon            111..176
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     exon            177..250
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     exon            251..344
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     exon            345..540
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     exon            541..631
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     exon            632..4167
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /note="hexamer: AATAAA"
     polyA_site      1131
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /note="major polyA site"
     regulatory      4138..4143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
                     /note="hexamer: AATAAA"
     polyA_site      4167
                     /gene="DERL2"
                     /gene_synonym="CGI-101; derlin-2; DERtrin-2; F-LAN-1;
                     F-LANa; FLANa"
ORIGIN      
        1 aggcgacggt ggggaagatg gcgtaccaga gcttgcggct ggagtacctg cagatcccac
       61 cggtcagccg cgcctacacc actgcctgcg tcctcaccac cgccgccgtg cagttggaat
      121 tgatcacacc ttttcagttg tacttcaatc ctgaattaat ctttaaacac tttcaaatat
      181 ggagattaat caccaacttc ttattttttg ggccagttgg attcaatttt ttatttaaca
      241 tgatttttct atatcgttac tgtcgaatgc tagaagaagg ctctttccga ggtcggacag
      301 cagactttgt atttatgttc ctttttggtg gattcttaat gacccttttt ggtctgtttg
      361 tgagcttagt tttcttgggc caggccttta caataatgct cgtctatgtg tggagccgaa
      421 ggaaccccta tgtccgcatg aacttcttcg gccttctcaa cttccaggcc ccctttctgc
      481 cctgggtgct catgggattt tccttgttgt tggggaactc aatcattgtg gaccttttgg
      541 gtattgcagt tggacacata tattttttct tggaagatgt atttcccaat caacctggtg
      601 gaataagaat tctgaaaaca ccatctattt tgaaagctat ttttgataca ccagatgagg
      661 atccaaatta caatccacta cctgaggaac ggccaggagg cttcgcctgg ggtgagggcc
      721 agcggcttgg aggttaaagc agcagtgcca ataatgagac ccagctggga aggactcggt
      781 gatacccact gggatctttt atcctttgtt gcaaaagtgt ggacactttt gacagcttgg
      841 cagattttaa ctccagaagc actttatgaa atggtacact gactaatcca gaagacattt
      901 ccaacagttt gccagtggtt cctcactaca ctggtactga aagtgtaatt tcttagagcc
      961 aaaaaactgg agaaacaaat atcctgccac ctctaacaag tacatgagta cttgattttt
     1021 atggtataag gcagagcctt ttcttcctct tcttgataga tgaggccatg gtgtaaatgg
     1081 aagtttcaga gaggacaaaa taaaacggaa ttccattttt ctctcactgt attaaagctt
     1141 ttgtgtgtga tcttttaaat tctgataatg tattgtagcc ctcctgcgta gatctgagct
     1201 cagaacagtt tacacagctg ttcttcctgt gtcttcacaa cttttaactg gatttcattt
     1261 caggattgga aatacgtggc tgtcatgctg tggttgtgta catcttacta actcagaatg
     1321 caagattcag caggaagatg atttatttct gtcatctgga taggttgttt tgcatctggg
     1381 ttttgccaaa ctttgtcaga caacatgaaa aaaaaggagg gaggatggtt cttgtagcag
     1441 taggaattca gctataggaa agtcagctgt aagctaatgt ggcatcttat ttgctttact
     1501 tacatttctc cattaagaag tatccaggga aagattggta agggccacat ttttgtaaaa
     1561 ctaggaagat tttcattaga cttttttttt cttttatttt taaaaaagtt ttaattaaaa
     1621 attttttttt aaatacagat ggggtctcac tgtgttgccc aggctggtct tgaactcctg
     1681 gactcaagca atcctcccac ctcagcctcc caaagtgcta ggatgacagg catgagccac
     1741 catgcccagc catttttttt ttttttgcct tttttgtttt gttttgtttt ttgttttttt
     1801 aattaaaaaa aaaaaataga gacagggtct cagattttca ttagatttgg aaaccaagtt
     1861 agaatgttga ctttggagcc agacgaacag ataccagtta gctaggcata tgttcttcca
     1921 gggtctttgg ctagttaaca ttagtcattt gcttcgtgaa aattcaagaa ccttttcaga
     1981 gccaagtacc tggattacct tcccaatcag gtagaaatta gacagggtcc acagaagtag
     2041 acacttaatg ctgtggttca ataaatactt cccctaaata ttaagtcttc cctgagtctc
     2101 agcaggtttg cattcacact gcttaagtaa cttccagaac ctggaagagt cgaaagagca
     2161 cccctaggaa agagatgatt ccaaacagct ttcattaacg gcatgtaggc acaggtccct
     2221 ttcccaaaag tggattgtta gtagtagttc attcaacctt tgttaagggg tagctttcca
     2281 gaatgtgaca ttgtcctcag aaagatagac ataggcttaa acataatgga catcctaaat
     2341 aggaattttc agattgtttt tgaagtgaaa agtgttttaa tgtctttaaa tggaattgca
     2401 taactaatgg tatttaagta ttttacatgt tgctaataac tttgaatatg attgttgcaa
     2461 ttttatggaa cctgggtcta tgggactgct ttttaagcag tttaaaaaag gttttcaaag
     2521 tttaaaagcc aatcttagca tgtataatcc ttatgggatt cttaagtttt atcctatctt
     2581 gtttttgctc aagaacgctt tatcagtgac gtttgttaga attttgtttt ttgttttttt
     2641 tttttaaatt gtttttgggc tagaaatgag tttctctagt tttatttgtt ctccctgagt
     2701 tggagttatg caatgaatgg catttttgtg gtaaaatact aatcctaaaa tctgttaact
     2761 cactgttcat ttaagtaggg aatatctgta tacattaatg actaggtaaa acaggaaata
     2821 cattttgaat atacagccta aaggcaggca gttacagggt ttttgatttc tccgatttta
     2881 tagggtgcaa gttcccagtg gcaggatgcc ctgctgtgtg actgactaca ctgtgtcctg
     2941 agcagtggta atttcaatca cctctcatca gtttggccag ccctacaacc accattccta
     3001 gccctgtgtt gcttgacagg atacctgtgc ttgaatggac ataaggaaaa gtccttactt
     3061 tctccccaat ttacctctca atcttagttc ttccagaaca cacttccctt tcacaatgca
     3121 aataaactga aagtgagatt tgatacatgg aattttgaga ccaaccaact aaccttacac
     3181 ataatttgag ggattcctgg attcttctag tgatactgaa aagcacactt gactaaagca
     3241 tagtgttttt tgtttgttat ggaaatacgg tatacgttca tttaaaaata aatggacata
     3301 caaattgcat ctccttagga gatacatttt atatacattt cggtgcgttt ttttccagta
     3361 tggatttcta tttgtttctc tcttcctctt gttttttctg tgtcactctt gtatgtcctc
     3421 atatctttca tacctcttgt gtagtctcta gaagcagaac acctaagtcc tgggtctgga
     3481 taatgaaacc ctcagtctct ggggcctctg aaaataagga agcattggag ctattgccat
     3541 gttgagtaat gggcttccta gaactattgt catctatcct gccagtgttt tatgttgtag
     3601 ctgtttttct ttgacaggtg agttccagct atgttgttag tcatgatcct gccattattt
     3661 tctgtgttct gtaggatgtc tccaggctac ttaaacatat tttatgagtt tgcaataaaa
     3721 ttgttgaatc ttgtatgatc aagtcactcc tctgctcaga aatccacagt gacttcttag
     3781 taagccccta cattatatgc atacttgttt ttttcttaac tttactccca cttctaccta
     3841 acagggacct caacttaagt ctcttcagtt cttcaaggcc tggccttgtt cctgattcct
     3901 caaaaaatct tgactctaag gcctatttta ttgtctgtct ctgaatccct ataaagcttc
     3961 aagtctgtat gacattctta acgccaaatt atatattgtc ttgtactgtt cctagctggt
     4021 acatgtatat tagtcttgtc tccctcatga gaatgtaagc tccttaaggg cagggaccat
     4081 gtcttaattt ttgtatccac cacagtgcct agcacagtgc ttggcacatg ggtgctgaat
     4141 aaataccttt gtttattgat cagcaaa
//
