LOCUS       NM_015954               1644 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens deoxyribose-phosphate aldolase (DERA), transcript
            variant 1, mRNA.
ACCESSION   NM_015954
VERSION     NM_015954.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Nitta,Y., Takeda,M., Fujii,T., Itami,H., Tsukamoto,S., Honoki,K.
            and Ohbayashi,C.
  TITLE     A case of pericytic neoplasm in the shoulder with a novel DERA-GLI1
            gene fusion
  JOURNAL   Histopathology 78 (3), 466-469 (2021)
   PUBMED   33067875
  REMARK    GeneRIF: A case of pericytic neoplasm in the shoulder with a novel
            DERA-GLI1 gene fusion.
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Gu,N., Dai,W., Liu,H., Ge,J., Luo,S., Cho,E., Amos,C.I., Lee,J.E.,
            Li,X., Nan,H., Yuan,H. and Wei,Q.
  TITLE     Genetic variants in TKT and DERA in the nicotinamide adenine
            dinucleotide phosphate pathway predict melanoma survival
  JOURNAL   Eur J Cancer 136, 84-94 (2020)
   PUBMED   32659474
  REMARK    GeneRIF: Genetic variants in TKT and DERA in the nicotinamide
            adenine dinucleotide phosphate pathway predict melanoma survival.
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Hoffmann,T.J., Tang,H., Thornton,T.A., Caan,B., Haan,M.,
            Millen,A.E., Thomas,F. and Risch,N.
  TITLE     Genome-wide association and admixture analysis of glaucoma in the
            Women's Health Initiative
  JOURNAL   Hum Mol Genet 23 (24), 6634-6643 (2014)
   PUBMED   25027321
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Salleron,L., Magistrelli,G., Mary,C., Fischer,N., Bairoch,A. and
            Lane,L.
  TITLE     DERA is the human deoxyribose phosphate aldolase and is involved in
            stress response
  JOURNAL   Biochim Biophys Acta 1843 (12), 2913-2925 (2014)
   PUBMED   25229427
REFERENCE   8  (bases 1 to 1644)
  AUTHORS   Andersson,J.O., Sjogren,A.M., Davis,L.A., Embley,T.M. and
            Roger,A.J.
  TITLE     Phylogenetic analyses of diplomonad genes reveal frequent lateral
            gene transfers affecting eukaryotes
  JOURNAL   Curr Biol 13 (2), 94-104 (2003)
   PUBMED   12546782
REFERENCE   9  (bases 1 to 1644)
  AUTHORS   Sgarrella,F., Poddie,F.P., Meloni,M.A., Sciola,L., Pippia,P. and
            Tozzi,M.G.
  TITLE     Channelling of deoxyribose moiety of exogenous DNA into
            carbohydrate metabolism: role of deoxyriboaldolase
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 117 (2), 253-257 (1997)
   PUBMED   9226884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041328.1 and CB851336.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015954.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.189350.1,
                                           SRR1660805.19903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428559.7/ ENSP00000416583.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1545              BC041328.1         161-1705
            1546-1644           CB851336.1         18-116              c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..1644
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /note="deoxyribose-phosphate aldolase"
                     /db_xref="GeneID:51071"
                     /db_xref="HGNC:HGNC:24269"
                     /db_xref="MIM:619668"
     exon            1..83
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1009
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /EC_number="4.1.2.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative deoxyribose-phosphate aldolase;
                     deoxyriboaldolase; phosphodeoxyriboaldolase;
                     2-deoxy-D-ribose 5-phosphate aldolase;
                     2-deoxyribose-5-phosphate aldolase homolog;
                     deoxyribose-phosphate aldolase (putative)"
                     /codon_start=1
                     /product="deoxyribose-phosphate aldolase isoform 1"
                     /protein_id="NP_057038.2"
                     /db_xref="CCDS:CCDS44838.1"
                     /db_xref="GeneID:51071"
                     /db_xref="HGNC:HGNC:24269"
                     /db_xref="MIM:619668"
                     /translation="MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQA
                     AWLLKAVTFIDLTTLSGDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVY
                     PARVCDAVKALKAAGCNIPVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINR
                     SLVLTGQWEALYDEIRQFRKACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIK
                     TSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEEL
                     GDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHDLPMS"
     exon            84..181
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            182..329
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            330..425
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            426..560
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            561..689
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            690..802
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            803..952
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1644
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /note="hexamer: ATTAAA"
     polyA_site      1545
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /note="major polyA site"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
                     /note="hexamer: ATTAAA"
     polyA_site      1644
                     /gene="DERA"
                     /gene_synonym="CGI-26; DEOC"
ORIGIN      
        1 gcggcgcaga ggcgggcgcc taccagccgg cagctccgga gctgcccgcg ccatgtccgc
       61 gcacaatcgg ggcaccgagc tcgaccttag ctggatctcc aaaatacaag tgaatcaccc
      121 ggcagttctg aggcgtgcgg aacaaatcca ggctcgcaga accgtgaaaa aggagtggca
      181 ggctgcttgg ctcctgaaag ctgttacctt tatagatctt actacacttt caggtgatga
      241 tacatcttcc aacattcaaa ggctctgtta taaagccaaa tacccaatcc gggaagatct
      301 cttaaaagct ttaaatatgc atgataaagg cattactaca gccgccgttt gtgtttatcc
      361 cgcccgggtg tgtgatgctg taaaagcact caaggctgca ggctgtaata tccctgtggc
      421 atcagtggcc gctggatttc cagctggaca gactcatttg aagacacgat tagaagagat
      481 cagattggct gtggaagatg gagctacaga aatcgacgtg gtaattaaca gaagcttggt
      541 gctgacaggc cagtgggaag ccctgtatga tgagattcgt cagtttcgca aggcctgtgg
      601 ggaggctcat cttaaaacta tattagcgac aggagaactt ggaactctta ctaatgtcta
      661 taaagccagt atgatagcaa tgatggcagg atcagatttt attaagacct ctactggaaa
      721 agaaacagta aatgccacct tcccggtagc tatagtaatg ctgcgggcca ttagagattt
      781 cttctggaaa actggaaaca agatagggtt taaaccagca ggaggcatcc gcagtgcaaa
      841 ggattccctt gcttggctct ctcttgtaaa ggaggagctt ggagatgagt ggctgaagcc
      901 agaactcttt cgaataggtg ccagtactct gctctcggac attgagaggc agatttacca
      961 tcatgtgact ggaagatatg cagcttatca tgatcttcca atgtcttaaa tcagtcacca
     1021 gttccagaaa agttctttac gacaatgttt aaaaattatt tttctacgta attgctaaaa
     1081 ttatttaatt aaaaaattgg gcagtaggta actggcattc ctctctttaa aatttctacc
     1141 gaacttaatg gaatggaaaa agcaaactca tccacatgtg gtactcattt caggcacatc
     1201 tgaaatgatc ttaattacta gaagatctgc actattaact ttgtgaagag tttctcctaa
     1261 aaactttaag taaaatgtta atggtagctt tgataacatc aaattctaag ggagaaaaaa
     1321 acaatattaa accgcccaag cagtgtgccc tagcagagga aaatgcaaca tctcgcaagc
     1381 gctgctgtaa cgacttcagg agtcactgat tcagcactaa tttcctgctg tgaaaactca
     1441 tctttcattt ttgccgtgga taggcgcttt tattaattgt tgtcctaatg aaatttctga
     1501 cattgtcata tacaacgatg aatatcatta aaatttttaa aataataaag ttcctatagt
     1561 ttattttttt aaaaaactta aaaattgtta caatacataa tgaaaaaata atccattaaa
     1621 cataaaaaga ggtttgatca gtga
//
