LOCUS       NM_022783               2569 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DEP domain containing MTOR interacting protein
            (DEPTOR), transcript variant 1, mRNA.
ACCESSION   NM_022783
VERSION     NM_022783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Yin,S., Liu,H., Zhou,Z., Xu,X., Wang,P., Chen,W., Deng,G., Wang,H.,
            Yu,H., Gu,L., Huo,M., Li,M., Zeng,L., He,Y. and Zhang,C.
  TITLE     PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated
            Glycolysis in Gastric Cancer
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301190 (2023)
   PUBMED   37469018
  REMARK    GeneRIF: PUM1 Promotes Tumor Progression by Activating
            DEPTOR-Meditated Glycolysis in Gastric Cancer.
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Ma,G., Sun,Y., Cai,F., Zhang,M., Liang,H., Deng,J., Zhang,R. and
            Zhang,L.
  TITLE     DEPTOR as a novel prognostic marker inhibits the proliferation via
            deactivating mTOR signaling pathway in gastric cancer cells
  JOURNAL   Exp Cell Res 427 (1), 113598 (2023)
   PUBMED   37054772
  REMARK    GeneRIF: DEPTOR as a novel prognostic marker inhibits the
            proliferation via deactivating mTOR signaling pathway in gastric
            cancer cells.
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Zhang,S., You,X., Zheng,Y., Shen,Y., Xiong,X. and Sun,Y.
  TITLE     The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor
            cascade in lung cancer cells
  JOURNAL   J Clin Invest 133 (4), e162434 (2023)
   PUBMED   36548081
  REMARK    GeneRIF: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor
            suppressor cascade in lung cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Guo,J., Yu,J., Mu,M., Chen,Z., Xu,Z., Zhao,C., Yang,K., Zheng,J.,
            Qin,X., Zhao,W. and Sun,X.
  TITLE     DFNA5 inhibits colorectal cancer proliferation by suppressing the
            mTORC1/2 signaling pathways via upregulation of DEPTOR
  JOURNAL   Cell Cycle 21 (20), 2165-2178 (2022)
   PUBMED   35923131
  REMARK    GeneRIF: DFNA5 inhibits colorectal cancer proliferation by
            suppressing the mTORC1/2 signaling pathways via upregulation of
            DEPTOR.
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Vega,M., Chen,Y., Shi,Y., Gera,J. and Lichtenstein,A.
  TITLE     Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT
            phosphorylation in multiple myeloma cells, is dependent on
            ERK1-mediated phosphorylation
  JOURNAL   J Biol Chem 298 (4), 101750 (2022)
   PUBMED   35216969
  REMARK    GeneRIF: Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT
            phosphorylation in multiple myeloma cells, is dependent on
            ERK1-mediated phosphorylation.
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Mparmpakas,D., Zachariades,E., Goumenou,A., Gidron,Y. and
            Karteris,E.
  TITLE     Placental DEPTOR as a stress sensor during pregnancy
  JOURNAL   Clin Sci (Lond) 122 (7), 349-359 (2012)
   PUBMED   21992080
  REMARK    GeneRIF: These novel findings are indicative of a higher order of
            complexity of DEPTOR signalling in the human placenta that is
            affected by maternal stress.
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Pei,L., Xie,P., Zhou,E., Yang,Q., Luo,Y. and Tang,Z.
  TITLE     Overexpression of DEP domain containing mTOR-interacting protein
            correlates with poor prognosis in differentiated thyroid carcinoma
  JOURNAL   Mol Med Rep 4 (5), 817-823 (2011)
   PUBMED   21643629
  REMARK    GeneRIF: DEPTOR is a novel prognostic marker for differentiated
            thyroid carcinoma.
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Boyd,K.D., Walker,B.A., Wardell,C.P., Ross,F.M., Gregory,W.M.,
            Davies,F.E. and Morgan,G.J.
  TITLE     High expression levels of the mammalian target of rapamycin
            inhibitor DEPTOR are predictive of response to thalidomide in
            myeloma
  JOURNAL   Leuk Lymphoma 51 (11), 2126-2129 (2010)
   PUBMED   20858096
  REMARK    GeneRIF: High expression levels of DEPTOR are predictive of
            response to thalidomide in myeloma.
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Peterson,T.R., Laplante,M., Thoreen,C.C., Sancak,Y., Kang,S.A.,
            Kuehl,W.M., Gray,N.S. and Sabatini,D.M.
  TITLE     DEPTOR is an mTOR inhibitor frequently overexpressed in multiple
            myeloma cells and required for their survival
  JOURNAL   Cell 137 (5), 873-886 (2009)
   PUBMED   19446321
  REMARK    GeneRIF: DEPTOR is highly overexpressed in a subset of multiple
            myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations.
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005717.3, AK023916.1 and AC091563.9.
            
            On Nov 22, 2018 this sequence version replaced NM_022783.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.847676.1,
                                           SRR1803615.133642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286234.6/ ENSP00000286234.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AP005717.3         104277-104425
            150-1966            AK023916.1         1-1817
            1967-2569           AC091563.9         138759-139361
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..2569
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="DEP domain containing MTOR interacting protein"
                     /db_xref="GeneID:64798"
                     /db_xref="HGNC:HGNC:22953"
                     /db_xref="MIM:612974"
     exon            1..247
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1355
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="isoform 1 is encoded by transcript variant 1; DEP
                     domain containing 6; DEP domain-containing
                     mTOR-interacting protein; DEP domain-containing protein 6"
                     /codon_start=1
                     /product="DEP domain-containing mTOR-interacting protein
                     isoform 1"
                     /protein_id="NP_073620.2"
                     /db_xref="CCDS:CCDS6331.1"
                     /db_xref="GeneID:64798"
                     /db_xref="HGNC:HGNC:22953"
                     /db_xref="MIM:612974"
                     /translation="MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRL
                     HEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVC
                     DEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVK
                     YERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFR
                     MNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAV
                     RRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIV
                     GDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLI
                     LTGPRTIVMEVMEELEC"
     exon            248..426
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            427..550
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            551..729
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            730..915
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1050
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1121
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1226
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2569
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="hexamer: ATTAAA"
     polyA_site      2172
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="major polyA site"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="hexamer: GATAAA"
     polyA_site      2246
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
     regulatory      2545..2550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
                     /note="hexamer: AATAAA"
     polyA_site      2569
                     /gene="DEPTOR"
                     /gene_synonym="DEP.6; DEPDC6; hDEPTOR"
ORIGIN      
        1 agtcagagca gcggagctgc cccgaacaaa gatggcgcgg gaagcgtctg tgagggcaga
       61 ctgatccgag cacccaaacc ctcggcggac agcggagcca gtggtagccg cacggcccta
      121 aaaccatgga ggagggcggc agcactggca gtgctggcag tgacagcagc accagcggga
      181 gtggcggggc gcagcaaagg gagctggagc gcatggctga ggtcttggtc accggggaac
      241 agctacggct caggctgcac gaagaaaagg ttattaaaga tagacgtcat catctcaaga
      301 cctacccaaa ctgttttgtc gcaaaagaac tgattgactg gctgattgaa cacaaagagg
      361 cttctgacag agagacggca attaaactca tgcagaaatt agcagaccgg ggcattattc
      421 accatgtgtg tgatgagcat aaggaattca aggatgtcaa actcttctac cgctttagaa
      481 aggatgacgg caccttccca ttggataatg aagtgaaggc ctttatgaga ggacagaggc
      541 tatatgaaaa gctgatgagc cctgaaaaca cactcctgca gcccagggag gaggaagggg
      601 tcaagtatga gcgcaccttc atggcatctg aattcctgga ctggctggtt caggaaggtg
      661 aggccaccac gaggaaagag gcagagcagc tttgccaccg gcttatggag catggcatca
      721 tccagcatgt gtccaacaag cacccatttg tggacagcaa tcttctctac cagttcagaa
      781 tgaacttccg gcggaggcga agactgatgg agctgctcaa tgaaaagtcc ccctcctccc
      841 aggaaactca tgacagtccc ttctgcctga ggaagcagag ccatgacaat cggaaatcta
      901 ccagctttat gtcagtgagc cccagcaagg agatcaagat cgtgtctgca gtgaggagaa
      961 gcagcatgag cagctgtggc agcagcggct acttcagcag cagccccacc ctcagcagca
     1021 gcccccctgt gctctgcaac cccaagtccg tgctgaagag acctgtcacc tctgaggaac
     1081 tccttactcc cggggctccg tatgcaagga agacattcac gattgttggt gacgcggttg
     1141 gctggggttt tgtggtgcga ggaagtaagc catgccacat ccaggctgta gaccccagtg
     1201 gccctgcagc cgcagcagga atgaaggtct gtcagtttgt cgtctctgtc aacgggctca
     1261 atgtcctgca tgtagactac cggaccgtga gcaatctgat tctgacgggc ccacggacga
     1321 ttgtcatgga agtcatggag gagttagagt gctgagctcc tgggcctccc agccctccag
     1381 tggcctgtgg gtgagggaag ccagaatgac acaaagcaat gcaaagacaa gattgccatg
     1441 caaatggatg gttttggaca tacgagtctt ctccgcacat acatgtctaa agttgagttt
     1501 tatacactga atgtggaaga accgggtatc atatcttttt taaaaaatgt cagtgtagaa
     1561 aacatttggg aaaccatttt cctacatgat agaactgcct tactagattt ctatttgtag
     1621 ctctcattca ttgtttttta tcttagtttg cagaaaggtg ttgaaatgct tctctagccc
     1681 aaacagcgac atgctaaagt ccccttcttc agagtcaata gagtagttgt taaaggtttt
     1741 aaattgtact ttctccaaaa ttagcatgca gctatttaat agggaatcta gatttcacca
     1801 agattcaaat caaagcaaca tttaaaggaa taagacctgt tcactagcat tttcaagggg
     1861 gttctaaagc attcaagtgc ttaaaagcca taaaaaatga cttcttaatt cctgccttta
     1921 gtgtcaactt ttaagttaat acaggtttca attgtggcat taggaaaaaa aaaaaccttg
     1981 tgatgctatg gttgggggta gttagggaga gactacatga aattgtgtgc ccctattttc
     2041 tttctgatcc taaatcattt tgttttataa atcagctata gcatctttct agaattaatc
     2101 ctgaatatgt tgaatgttaa aatagagaag tttgtatata cacataatta aaaatcaacc
     2161 cttctggcaa gatttcactt tgaaggtgtc tgtttttaag ggaaggctaa aactttgctg
     2221 atatgtgata aaacttgaac tctaaattgc ctccttagcc tgaattttta ctagctttct
     2281 agtgtaacat attctaagga catgacatgc tgcttatttg gggggattat ttttcaccaa
     2341 aatgatcatc ttgtgttgta acttttcagc tcacttgtat atacgcacgt tttcattttt
     2401 ggtctagaaa atagtgcatt ttggggctca gcgtgcagag gaaattcctc aaagtgccaa
     2461 attaggcagt caggaaatac taaattcttc attccaaata atggatctga atgatgacgt
     2521 taatttttta tcatgcatta acaaaataaa atatgagaat tgtaccaca
//
