LOCUS       NM_007021               2120 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens DEPP autophagy regulator 1 (DEPP1), mRNA.
ACCESSION   NM_007021
VERSION     NM_007021.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Kuwahara,M., Akasaki,Y., Kurakazu,I., Sueishi,T., Toya,M.,
            Uchida,T., Tsutsui,T., Hirose,R., Tsushima,H., Teramura,T. and
            Nakashima,Y.
  TITLE     C10orf10/DEPP activates mitochondrial autophagy and maintains
            chondrocyte viability in the pathogenesis of osteoarthritis
  JOURNAL   FASEB J 36 (2), e22145 (2022)
   PUBMED   34997944
  REMARK    GeneRIF: C10orf10/DEPP activates mitochondrial autophagy and
            maintains chondrocyte viability in the pathogenesis of
            osteoarthritis.
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Klee,K., Storti,F., Maggi,J., Todorova,V., Karademir,D., Berger,W.,
            Samardzija,M. and Grimm,C.
  TITLE     The Expression of Decidual Protein Induced by Progesterone (DEPP)
            is Controlled by Three Distal Consensus Hypoxia Responsive Element
            (HRE) in Hypoxic Retinal Epithelial Cells
  JOURNAL   Genes (Basel) 11 (1), 111 (2020)
   PUBMED   31963726
  REMARK    GeneRIF: The Expression of Decidual Protein Induced by Progesterone
            (DEPP) is Controlled by Three Distal Consensus Hypoxia Responsive
            Element (HRE) in Hypoxic Retinal Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2120)
  AUTHORS   Salcher,S., Hermann,M., Kiechl-Kohlendorfer,U., Ausserlechner,M.J.
            and Obexer,P.
  TITLE     C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of
            FOXO3-induced autophagy
  JOURNAL   Mol Cancer 16 (1), 95 (2017)
   PUBMED   28545464
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2120)
  AUTHORS   Salcher,S., Hagenbuchner,J., Geiger,K., Seiter,M.A., Rainer,J.,
            Kofler,R., Hermann,M., Kiechl-Kohlendorfer,U., Ausserlechner,M.J.
            and Obexer,P.
  TITLE     C10ORF10/DEPP, a transcriptional target of FOXO3, regulates
            ROS-sensitivity in human neuroblastoma
  JOURNAL   Mol Cancer 13, 224 (2014)
   PUBMED   25261981
  REMARK    GeneRIF: Knockdown of DEPP prevented the primary and secondary
            reactive oxygen species wave during FOXO3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2120)
  AUTHORS   Deng,J., Dong,Y., Li,C., Zuo,W., Meng,G., Xu,C. and Li,J.
  TITLE     Decreased expression of C10orf10 and its prognostic significance in
            human breast cancer
  JOURNAL   PLoS One 9 (6), e99730 (2014)
   PUBMED   24936657
  REMARK    GeneRIF: C10orf10 expression is frequently decreased in breast
            cancer tissues and is associated with shorter survival times.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2120)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2120)
  AUTHORS   Shin,D. and Anderson,D.J.
  TITLE     Isolation of arterial-specific genes by subtractive hybridization
            reveals molecular heterogeneity among arterial endothelial cells
  JOURNAL   Dev Dyn 233 (4), 1589-1604 (2005)
   PUBMED   15977181
  REMARK    GeneRIF: Expressed in endothelial cells of peripheral tissues, but
            not in atrial or ventricular endocardial cells of the heart,
            unexpected degree of molecular heterogeneity among arterial
            endothelial cells, up-regulated in subsets of endothelial cells.
REFERENCE   8  (bases 1 to 2120)
  AUTHORS   Watanabe,H., Nonoguchi,K., Sakurai,T., Masuda,T., Itoh,K. and
            Fujita,J.
  TITLE     A novel protein Depp, which is induced by progesterone in human
            endometrial stromal cells activates Elk-1 transcription factor
  JOURNAL   Mol Hum Reprod 11 (7), 471-476 (2005)
   PUBMED   16123073
  REMARK    GeneRIF: Depp modulates the effects of progesterone during
            decidualization and in the decidua by affecting gene expression.
REFERENCE   9  (bases 1 to 2120)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 2120)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB030770.1 and AL353801.13.
            
            On May 17, 2019 this sequence version replaced NM_007021.3.
            
            Summary: The expression of this gene is induced by fasting as well
            as by progesterone. The protein encoded by this gene contains a
            t-synaptosome-associated protein receptor (SNARE) coiled-coil
            homology domain and a peroxisomal targeting signal. Production of
            the encoded protein leads to phosphorylation and activation of the
            transcription factor ELK1. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002191.1, AL136653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298295.4/ ENSP00000298295.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               DB030770.1         104-587
            485-1987            AL353801.13        151628-153130       c
            1988-2120           AL353801.13        151495-151627       c
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..2120
                     /gene="DEPP1"
                     /gene_synonym="C10orf10; DEPP; FIG; Fseg"
                     /note="DEPP autophagy regulator 1"
                     /db_xref="GeneID:11067"
                     /db_xref="HGNC:HGNC:23355"
                     /db_xref="MIM:611309"
     exon            1..192
                     /gene="DEPP1"
                     /gene_synonym="C10orf10; DEPP; FIG; Fseg"
                     /inference="alignment:Splign:2.1.0"
     exon            193..2120
                     /gene="DEPP1"
                     /gene_synonym="C10orf10; DEPP; FIG; Fseg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPP1"
                     /gene_synonym="C10orf10; DEPP; FIG; Fseg"
                     /note="hexamer: ATTAAA"
     polyA_site      1987
                     /gene="DEPP1"
                     /gene_synonym="C10orf10; DEPP; FIG; Fseg"
                     /note="major polyA site"
ORIGIN      
        1 acactgctca gggaagagcc tgctacggtg gactgtgaga ctcagtgcac tgtcctcctc
       61 ccagcgaccc cacgctggac cccctgccgg accctccacc cttcggcccc caagcttccc
      121 aggggcttcc tttggactgg actgtccctg ctcatccatt ctcctgccac ccccagacct
      181 cctcagctcc aggttgccac ctcctctcgc cagagtgatg aggtcccggc ttctgctctc
      241 cgtggcccat ctgcccacaa ttcgggagac cacggaggag atgctgcttg ggggtcctgg
      301 acaggagccc ccaccctctc ctagcctgga tgactacgtg aggtctatat ctcgactggc
      361 acagcccacc tctgtgctgg acaaggccac ggcccagggc caacccaggc caccccacag
      421 gccagcccag gcctgccgga agggccgccc tgctgtgtcc ctgcgagaca tcaccgcacg
      481 tttcagtggc cagcagccca cactgcccat ggctgatact gtggaccccc tggactggct
      541 ttttggggag tcccaggaaa agcagccaag ccagagggac ctgccaagga ggactggccc
      601 ctctgctggc ctctggggtc cacatagaca gatggacagc agcaagccca tgggggcccc
      661 cagagggagg ctctgtgaag ccaggatgcc tgggcattcc ctggcaagac caccgcagga
      721 tgggcagcag agctctgacc taagaagctg gacttttggg cagtctgccc aagccatggc
      781 ctcccgccac cgcccccgcc ccagcagtgt cctcagaaca ctctactcgc acctcccggt
      841 gatccatgaa ctctgacccc tccccagtaa aggcttctgt agagagcatg ctgggtctgc
      901 atctcctctc gtctcctcca tggtggtcac tgcccctggc aggtctctga aagggaaatg
      961 cttttctgca gaggcccctg cttgggcagt tcacagtgag accgaccccc tctgaatatg
     1021 ataacagcct gtttcacatg aggagatgtt accaatcccg ttcgctctga cccttgctgg
     1081 ctgatcacct tgagcaactt acttaacatc tgtgttcctc agtttctcat gggtaatata
     1141 gggataatta ctggcacctg cctcccaggc cattctgacg tgtaaccgca tataggagcc
     1201 cactggctga gtagctacca tcatcgctgg tggggaaact ggtggtaggg gtgtgagggt
     1261 agtgggggtg tcagcccccc aggtgtttca gaacaaggcc tcgggcactc ccaagtctgc
     1321 ctcttggctc ccaccctcaa agcccatgtt ctgtgaggcc caagagaaca catggagtct
     1381 tagcaaatgc actaatgtat tccgggggac tgtcacctgg caccactggg gcactctgct
     1441 ggctacaact catacgtcct gtggtggcat tgggagagtt cccccatgat gagggccaag
     1501 atagaatctg taccactcag tgctaccatc cccaccccta caccacttcc acacaggggc
     1561 ctcatggcat ggtcagggtc ccagctgtgg gtgagagcag ggcactgtcc agctgtccac
     1621 tggggaagtc aagatgtcct aaggcccagg tcagggcatc tggagtctga aggaccctag
     1681 ttcctagagg catctggcag caagaaggtg aggcatcagg gaacgggaat caggctggga
     1741 ctgatcagag gtgaagggac agagagagga gaggaggaag attgagctgg gggcaacagc
     1801 caagctcacc tgggcaggtc tctgccacct ccttgctctg tgagctgtca gtctaggtta
     1861 ttctcttttt ttgtggctat ttttaattgc tttggatttg ttaaatgttt tctgtcttct
     1921 gttaagtgtg ttttctctgg agatagaatg taaaccatat taaaaggaaa aagtttcaga
     1981 caagcaatta cccagtttcc ttatctataa aatggggaca tcagcaatgt tcttcacacc
     2041 ctgcaagggc tgggaatctg cgcatgtgaa cttggagctg catttatgag cactgtagac
     2101 aaatgtttgt atctgtcaca
//
