LOCUS       NM_001077242            1741 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant
            1, mRNA.
ACCESSION   NM_001077242
VERSION     NM_001077242.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Liao,Z., Wang,X., Wang,X., Li,L. and Lin,D.
  TITLE     DEPDC7 inhibits cell proliferation, migration and invasion in
            hepatoma cells
  JOURNAL   Oncol Lett 14 (6), 7332-7338 (2017)
   PUBMED   29344171
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Liao,Z., Wang,X., Lin,D. and Zou,Q.
  TITLE     Construction and Identification of the RNAi Recombinant Lentiviral
            Vector Targeting Human DEPDC7 Gene
  JOURNAL   Interdiscip Sci 9 (3), 350-356 (2017)
   PUBMED   27016254
  REMARK    GeneRIF: RNA interference (RNAi) recombinant lentiviral vector
            particle targeting DEPDC7 was constructed in order to knockdown its
            gene expression in human hepatocellular carcinoma cell line HepG2.
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Cordova-Palomera,A., Fatjo-Vilas,M., Palma-Gudiel,H.,
            Blasco-Fontecilla,H., Kebir,O. and Fananas,L.
  TITLE     Further evidence of DEPDC7 DNA hypomethylation in depression: A
            study in adult twins
  JOURNAL   Eur Psychiatry 30 (6), 715-718 (2015)
   PUBMED   25952135
  REMARK    GeneRIF: DEPDC7 hypomethylation in peripheral blood DNA may be
            associated with recent depressive symptomatology.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   D'Andrea,E.L., Ferravante,A., Scudiero,I., Zotti,T., Reale,C.,
            Pizzulo,M., De La Motte,L.R., De Maio,C., Mazzone,P., Telesio,G.,
            Vito,P. and Stilo,R.
  TITLE     The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing
            protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates
            NF-kappaB activation
  JOURNAL   PLoS One 9 (12), e116062 (2014)
   PUBMED   25541973
  REMARK    GeneRIF: The study identified the DEP domain-containing protein
            DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030970.1 and AJ245600.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001077242.1.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.391689.1, BC030970.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241051.8/ ENSP00000241051.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BC030970.1         15-45
            32-860              AJ245600.1         1-829
            861-1420            BC030970.1         875-1434
            1421-1741           AJ245600.1         1390-1710
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..1741
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /note="DEP domain containing 7"
                     /db_xref="GeneID:91614"
                     /db_xref="HGNC:HGNC:29899"
                     /db_xref="MIM:612294"
     exon            1..151
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1614
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /note="isoform 1 is encoded by transcript variant 1; DEP
                     domain-containing protein 7; novel 58.3 KDA protein;
                     dJ85M6.4 (novel 58.3 KDA protein)"
                     /codon_start=1
                     /product="DEP domain-containing protein 7 isoform 1"
                     /protein_id="NP_001070710.1"
                     /db_xref="CCDS:CCDS41632.1"
                     /db_xref="GeneID:91614"
                     /db_xref="HGNC:HGNC:29899"
                     /db_xref="MIM:612294"
                     /translation="MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIIN
                     TLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQAL
                     MDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADAL
                     FKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLP
                     LLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYL
                     PDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNG
                     KTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSK
                     AIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYI
                     YCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEH
                     FGD"
     exon            152..542
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..670
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..860
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1072
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1215
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1341
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1420
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1741
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="DEPDC7"
                     /gene_synonym="dJ85M6.4; TR2"
                     /note="major polyA site"
ORIGIN      
        1 acagttaaca gacgggcgct cagggagcta gggagctgtg aagctgctgg aggagttggc
       61 gtccggggag caagggccat ggccaccgtg caggagaagg ctgctgcgct gaacctctcg
      121 gctctccaca gccccgcgca caggcctccg ggtttcagtg tagctcagaa gccatttgga
      181 gccacgtatg tatggagcag catcataaac actcttcaaa cacaagtgga agtgaaaaaa
      241 cgaaggcacc gtttaaaacg acataatgac tgctttgttg gttcagaagc tgtggatgtc
      301 attttttctc acctaattca gaataagtat tttggtgatg tagatattcc tcgagccaaa
      361 gtggtgagag tgtgtcaagc gcttatggac tacaaagtat ttgaagcagt tccaaccaaa
      421 gtctttggaa aagacaaaaa acctacattt gaagatagta gttgcagcct ttatagattc
      481 accacaatac ctaaccaaga cagtcagtta ggcaaagaga acaaactata ttcacctgcc
      541 aggtatgcag atgcattatt taagtcatcc gatatcagat cagccagttt agaggacctg
      601 tgggaaaatc tgagtttaaa gcctgccaac tcccctcatg taaatatctc tgcaaccttg
      661 tctccacaag ttattaatga agtgtggcaa gaagaaacaa ttgggcgtct actacaactt
      721 gtagaccttc cacttcttga ctccttactg aaacagcaag aggctgtacc taaaattcct
      781 caacctaaga ggcagtccac catggtcaac agcagtaact atctggatcg agggattctc
      841 aaggcttata gtgactctca ggaagatgag tggctctcgg cagcaattga ctgtttagaa
      901 taccttccag accaaatggt ggtggaaata agcagaagct ttcctgagca accagaccga
      961 acagacttag tgaaagaact tctgtttgat gccattggca gatattacag tagtagggaa
     1021 cctctgttaa atcacttatc tgacgttcat aatggaattg cagaactctt agtgaatggg
     1081 aagacggaaa tagctttaga agctacccag ctccttctaa agcttttaga tttccaaaat
     1141 agagaagaat ttagaagact actgtatttc atggctgttg cagcaaatcc ttctgagttt
     1201 aaattacaga aagaaagtga caaccgaatg gttgtgaaaa ggatattctc aaaagctatt
     1261 gttgacaata aaaatttatc caaaggcaaa acagatcttc tggtactctt tttaatggat
     1321 catcagaaag atgtttttaa gattcctgga actctacata aaattgtaag tgttaagctt
     1381 atggccatac agaacggaag agatccaaat agagatgcag gatatattta ttgccagaga
     1441 attgatcaac gtgactattc caacaataca gagaagacaa ccaaagatga gctgttgaat
     1501 ttactaaaaa ctcttgatga ggattcaaaa ctttctgcca aagagaagaa aaaattgcta
     1561 ggtcaattct ataagtgtca cccagacatc tttattgagc attttggaga ctgagttttt
     1621 aatatctgta tataagttgt gtattttaag aataaattat gtatcctaaa tatccaatca
     1681 catttgtaag cgtggaagct ctaaatttga aactgtactt aataaaaatt tttttgtata
     1741 a
//
