LOCUS       XM_047441625            6176 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DEP domain containing 5, GATOR1 subcomplex
            subunit (DEPDC5), transcript variant X3, mRNA.
ACCESSION   XM_047441625
VERSION     XM_047441625.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000022.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
     gene            1..6176
                     /gene="DEPDC5"
                     /gene_synonym="DEE111; DEP.5; FFEVF; FFEVF1; FPEVF"
                     /note="DEP domain containing 5, GATOR1 subcomplex subunit;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 42 ESTs, 177 long SRA reads, 2 Proteins,
                     and 96% coverage of the annotated genomic feature by
                     RNAseq alignments, including 18 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:9681"
                     /db_xref="HGNC:HGNC:18423"
                     /db_xref="MIM:614191"
     CDS             90..4640
                     /gene="DEPDC5"
                     /gene_synonym="DEE111; DEP.5; FFEVF; FFEVF1; FPEVF"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform X2"
                     /protein_id="XP_047297581.1"
                     /db_xref="GeneID:9681"
                     /db_xref="HGNC:HGNC:18423"
                     /db_xref="MIM:614191"
                     /translation="MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHP
                     NDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
                     TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDT
                     RVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTV
                     VLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKK
                     LFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSV
                     VITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSR
                     LGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE
                     NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPS
                     RTLPTEEVRSQASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQ
                     RDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVG
                     MNPRTQNKDSLEDSVSTSPDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQND
                     YTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVP
                     PPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQ
                     IHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWR
                     TRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHR
                     SDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQA
                     AVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTA
                     TPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSS
                     TLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQK
                     MLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR
                     KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVP
                     EQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHR
                     KATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETY
                     WDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQ
                     QRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCI
                     NRDNRLVTFWTSCLEKMHASAP"
ORIGIN      
        1 ggagccaccg gagcggcgcg ggttctcagg gaggcaagat gacttctctg ccccaagctt
       61 ggaacagcta aagggaaaaa cagtgcaaga tgagaacaac aaaggtctac aaactcgtca
      121 tccacaagaa gggctttggg ggcagtgatg atgagctagt tgtgaacccc aaagtgttcc
      181 ctcacatcaa gcttggagac attgtagaga ttgcacaccc caacgatgaa tacagccctc
      241 tgcttttgca ggtcaagtct cttaaggaag atttacagaa ggaaactatc agtgtggacc
      301 agactgtgac tcaagtgttc cggctgagac cttatcagga tgtctatgtt aatgtcgtag
      361 accctaagga tgtgaccctt gacctagtgg aattaacttt taaggatcag tatattggcc
      421 gtggggatat gtggcgacta aagaaaagtt tggtcagcac atgtgcctat atcacccaga
      481 aggtggagtt tgctggcatc agagcacagg ctggtgaact gtgggttaag aatgagaagg
      541 tcatgtgtgg ctacatcagt gaagatacca gggtggtgtt tcgttctacg tcggctatgg
      601 tttacatatt tattcagatg agctgtgaaa tgtgggattt tgatatttat ggggatttgt
      661 attttgagaa agctgtgaat ggtttccttg ctgatctatt taccaagtgg aaggagaaga
      721 actgtagtca tgaagtgaca gtggtcctgt tttctagaac tttctatgat gcaaaatctg
      781 ttgatgaatt tcctgaaata aaccgagcct caattcgaca ggatcacaag gggagattct
      841 atgaagactt ttacaaagtg gtggtgcaga atgagagaag agaagaatgg acttcacttc
      901 tcgtaaccat taaaaaactc ttcatccagt atccagtgtt ggtgcgactg gaacaggcag
      961 agggctttcc tcaaggagat aattctacct cagcacaagg aaactacctg gaggccatca
     1021 atctgtcatt caatgtgttt gataagcact acatcaaccg caactttgac cgaactgggc
     1081 agatgtcagt ggtgatcacg cccggggtgg gtgtctttga agtggaccgc ctactcatga
     1141 tcctgaccaa gcagcggatg atagataatg gaattggtgt ggatttggtg tgcatgggag
     1201 agcaaccgtt acatgctgtc ccattgttca agctccataa tcggagtgct ccccgtgatt
     1261 ctcgtctggg cgatgactat aatatccctc actggataaa ccacagtttc tacacatcca
     1321 aaagccagct cttttgtaat agtttcaccc cacgaataaa actggcagga aagaagcccg
     1381 cctctgagaa agcaaaaaat ggccgtgata catctctcgg gagtccaaaa gaatctgaga
     1441 acgcccttcc catccaagta gattatgacg cctatgacgc tcaagtgttc aggctgcccg
     1501 gcccatcccg ggcccagtgc ctcaccacct gcagatctgt gcgagagcga gagagtcaca
     1561 gtcgaaagag tgccagctcc tgtgatgttt catccagccc ttccctacca agccgcacac
     1621 tgcccactga ggaagtgagg agccaggctt ctgacgacag ctccctaggc aagagtgcca
     1681 acatcctgat gatcccacac ccccacctgc accagtatga agtcagcagc tccttgggat
     1741 acaccagcac tcgagatgtc ctggagaaca tgatggagcc accacagcga gactccagtg
     1801 caccagggag gtttcacgtt ggcagtgcag aatccatgct gcatgttcga cctggtggat
     1861 acacgcccca gagagcactg attaacccct tcgctccctc tcggatgccc atgaagctta
     1921 cgtccaacag aaggcgctgg atgcacactt ttcctgtggg tatgaatcct aggacccaga
     1981 ataaggattc tctagaggac agtgtttcta cctctccaga cccaatgcca ggcttctgtt
     2041 gcacagttgg agtggactgg aagtctctca ctactccggc gtgcctcccc cttaccaccg
     2101 actacttccc tgaccgccag ggcctgcaga atgactacac agagggctgt tatgatctcc
     2161 ttccagaagc agacatcgac aggagggacg aagatggtgt gcagatgaca gcccagcagg
     2221 tatttgaaga gtttatttgc caacgtctca tgcagggcta ccaaatcata gtgcagccca
     2281 agacacagaa acccaatcct gctgtcccgc ccccgctgag cagtagccca ctctatagcc
     2341 gaggccttgt gtcccgaaac cgccctgagg aggaggacca gtattggctg agtatgggca
     2401 gaacgttcca caaagtgacg ctgaaggata agatgatcac agtgacgcga taccttccca
     2461 agtatcctta tgaatctgcc cagatccact acacctacag cctctgtcct tcccactcag
     2521 actcagagtt cgtctcctgc tgggtggaat tctcccacga acggctggag gagtacaagt
     2581 ggaattactt agatcagtat atctgttctg ccggctctga agacttcagc ttaattgagt
     2641 ccctgaagtt ctggaggacc cgcttcctgc tgctgccagc ctgtgtcacc gccaccaagc
     2701 gcatcacgga gggggaggcc cactgcgaca tctatgggga caggccccgt gcagacgagg
     2761 acgagtggca actcctggat ggttttgtcc gctttgtgga gggcttgaat cgcattcgca
     2821 ggcggcatcg ctcggatcgc atgatgcgga aagggaccgc catgaaaggc ttgcagatga
     2881 ctgggcccat ttccacgcat tctctggagt caactgcacc cccagtgggg aagaagggaa
     2941 cctcagctct ctctgccctg ttggagatgg aggccagtca gaagtgcctg ggagaacagc
     3001 aggcagctgt gcatggtggg aagagctccg cccagtcagc cgagagcagc agcgttgcca
     3061 tgactcccac ctacatggac agcccacgaa aggacggggc cttctttatg gagtttgtcc
     3121 gcagcccacg cacagcatcg tccgccttct accctcaggt atctgtggac caaacagcca
     3181 ctcctatgtt ggacggcacc agtttgggca tatgcacagg ccaatccatg gacagaggca
     3241 acagccagac ctttgggaac tcccagaaca taggagaaca gggctactcc tccacaaact
     3301 ccagtgacag cagctctcag cagctggtgg caagctcctt gacctcatcc tctaccctga
     3361 cagagatcct ggaagccatg aagcacccct cgacaggagt ccagctgctc tctgaacaga
     3421 agggcctctc accgtactgc ttcatcagcg cggaggtggt acactggttg gtgaaccacg
     3481 tggaggggat ccagacacag gcgatggcca ttgacatcat gcagaaaatg ctggaagagc
     3541 agctcatcac acatgcatct ggcgaagcct ggcggacctt catctacggc ttctatttct
     3601 acaagatagt aacggacaaa gagcccgacc gagtggccat gcagcagccc gccaccacct
     3661 ggcacacagc aggagtggac gacttcgcca gcttccagcg caagtggttt gaggtggcct
     3721 ttgtggcaga agagctcgtg cactctgaga ttcctgcctt tctcctgccc tggctgccta
     3781 gccggccagc ctcctatgca agtaggcaca gctcctttag ccgaagtttt ggaggacgga
     3841 gccaggcggc agcactttta gctgccactg tcccagagca gaggactgtg accctggatg
     3901 ttgacgtgaa caaccgcaca gaccggctgg agtggtgcag ctgttattac catggcaact
     3961 tttctctgaa tgcagccttt gagatcaagc tgcactggat ggcggtgacc gcagcagtac
     4021 tcttcgagat ggtccaaggt tggcatcgga aagccacctc ctgtggcttc ttgttagtcc
     4081 cagttttgga ggggcctttt gcactgccca gttacctgta tggcgacccc cttcgtgccc
     4141 agctcttcat cccactcaac atcagctgct tgctcaagga gggcagcgag cacctgtttg
     4201 atagctttga acccgaaacg tactgggatc gaatgcacct cttccaggaa gccattgcac
     4261 acaggtttgg gtttgtacaa gataaatatt ctgcctctgc ttttaacttc cctgctgaga
     4321 acaagcctca gtatatccac gttacaggaa cagtgtttct gcagctgccc tactccaagc
     4381 gcaagttctc agggcagcag cggcggcggc ggaactccac cagctccacc aaccagaaca
     4441 tgttctgcga ggagcgggtc ggctacaact gggcctacaa caccatgctc accaaaacat
     4501 ggcgctccag cgccacaggg gatgaaaagt ttgctgatcg gctgctgaag gacttcacgg
     4561 acttctgcat caaccgtgac aaccggctgg tcacgttctg gacaagttgc ctggagaaga
     4621 tgcatgccag tgccccgtga ggccaggctg cacctgtgct gggggaaggt gggtgagcca
     4681 ctgccctcaa acccggggcg gaggattcca ggcaggctct aggagtcagg tgtccgtttg
     4741 ctgctatcag tgagtggggg ccattgtttt ttgtttgttt gtttgtttgt ttgtttgttt
     4801 ttggccccca cgacaagtct tctactctag aagaaagact ttggaagcag ctgctgctgc
     4861 tgccaccact cctgtcagca agtgctcaga gcaggtggga ggcacagatt gtccgtggga
     4921 gggctccagt gtctgggaag agggcaggcg gcccccatga atgtcctcgg aagggggtgg
     4981 ctcctggtag catccttttc cttcaccatc tatgggatat taggggcaga atctgccact
     5041 tcttgcccag gagtgtgcac agatgtaaga taattttgtg aaataatgta ccatagactc
     5101 tcaccaactg tatatacctg tacatatcag aagcaaataa agagctccac gtgcatcatt
     5161 tctttcccca cccagttccc cacagaagca gtcccatcct gggctgggca gttgtgccag
     5221 gtggccgggg tcatggcagt caatgaagtg gtcacagatg gtgagagggc ttcagaattc
     5281 actggcttag agtctggctg ggagtttatt gagagatttc tttcataggc cactgggcag
     5341 gagcaaggat ggttccagtg aggacagtga gcaggcagta taacttacaa ggtaactgca
     5401 ggctcatgct gtcagaatga atcttgctaa atgggtgagc tcagctctgg gacgcagata
     5461 tgatggcatt ctgaaaaaaa tcaaaggaaa cattttgtag actctaactt aggttttttt
     5521 tgttgttgtt ttttttgttg ttttttttga cacagttttc actcttgttg cccaggctgg
     5581 agtgcaatgg tgtgatctca gctcactaca acctctgcct cctgggttca agcgattctc
     5641 ctgtctcggc ctcccgagta gctgggatta caggcacctg ccaccatacc aggctaattt
     5701 tttgtatttt aagtagagat ggggtttcac catgttggcc aggctggtct tgaactcctc
     5761 acctcaggcg atccacccac ctcagcctcc caaagtgctg ggattacagg tgtgagccac
     5821 catgcccggc ctaacttaga tttgctgaga taagactcag cttggtgctt cacctcagca
     5881 ccctgcctta agctactcag ggcagttcag gagctgtggg tcagagggga gaatccgaca
     5941 gtgactgcca cttcttgctg tgccatctca ccacgtggag ttcatcacaa gctctgttga
     6001 tttgcctcct caatggcttt gcatccattc tcttcttccc aggccctgag ctgccactca
     6061 gtccagcctt cctttgtctt tctcttagat ccccaggaaa accttctaat ttgtctctgc
     6121 tttcactcca cttgtcagtc agtcttttta taaaaccact gtgattttgc ccacca
//
