LOCUS       NM_001364818            3324 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens DEP domain containing 4 (DEPDC4), transcript variant
            5, mRNA.
ACCESSION   NM_001364818 XM_017018781
VERSION     NM_001364818.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Consonni,S.V., Maurice,M.M. and Bos,J.L.
  TITLE     DEP domains: structurally similar but functionally different
  JOURNAL   Nat Rev Mol Cell Biol 15 (5), 357-362 (2014)
   PUBMED   24739740
  REMARK    Review article
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Hawthorne,F., Feng,S., Metlapally,R., Li,Y.J., Tran-Viet,K.N.,
            Guggenheim,J.A., Malecaze,F., Calvas,P., Rosenberg,T., Mackey,D.A.,
            Venturini,C., Hysi,P.G., Hammond,C.J. and Young,T.L.
  TITLE     Association mapping of the high-grade myopia MYP3 locus reveals
            novel candidates UHRF1BP1L, PTPRR, and PPFIA2
  JOURNAL   Invest Ophthalmol Vis Sci 54 (3), 2076-2086 (2013)
   PUBMED   23422819
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026110.42.
            
            On Sep 25, 2020 this sequence version replaced NM_001364818.1.
            
            Transcript Variant: This variant (5), as well as variant 9, encodes
            isoform 4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.478915.1,
                                           SRR14372079.340361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550587.6/ ENSP00000448385.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC026110.42        102658-102817
            161-557             AC026110.42        105844-106240
            558-703             AC026110.42        107328-107473
            704-881             AC026110.42        113511-113688
            882-1108            AC026110.42        116022-116248
            1109-1251           AC026110.42        117201-117343
            1252-1377           AC026110.42        117436-117561
            1378-1456           AC026110.42        120759-120837
            1457-1540           AC026110.42        127168-127251
            1541-3324           AC026110.42        127892-129675
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..3324
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="DEP domain containing 4"
                     /db_xref="GeneID:120863"
                     /db_xref="HGNC:HGNC:22952"
     exon            1..160
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1494
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="isoform 4 is encoded by transcript variant 5; DEP
                     domain-containing protein 4"
                     /codon_start=1
                     /product="DEP domain-containing protein 4 isoform 4"
                     /protein_id="NP_001351747.1"
                     /db_xref="CCDS:CCDS91741.1"
                     /db_xref="GeneID:120863"
                     /db_xref="HGNC:HGNC:22952"
                     /translation="MVPGEEPARELMAVLLTPRFRRLVSQNELPGPGLNGPSSRNRRD
                     GFCRKRRTGCSGPFQATQLWDGIIHSLQAQVEIKRRRHHLQTYKDCFTGSDAVDVVLS
                     HLMQNTCLSSNDISCLKGVHLCQVLMNHKVFEPVGMKKLFKKEKELEFEDSNISLYRF
                     LGNKSSYDCCKRQKDAENEFNETLRPGYEMISNPLAQEIGEERIEELIHTINGNPALC
                     PNITVQKPFLRLSKEDVWKEQTLLCLLQLIHLPFLDNILEPPVKTQNLQLNKEEDLVI
                     TNTCLDRELIPSLCLPEIDNWLNAAIECLEYFPDQLIVTVSQQLMQNRNEETRLNSQK
                     KILFDVIAKYYAQERDCLLTDEYFDIHSGIIELLENEKRAEALEATQLYLRLLLLNIR
                     EELRRLLTFMAMASEPNAYKLQKQYDNKTVVLKTLAKSVLQAKSLLKVRAEQLVWFPL
                     EYHSELFKTPVTLLDLVSKKLKKLLHGEDADAISGMAENNSYTSTA"
     exon            161..557
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..703
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            704..881
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1108
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1251
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1377
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1456
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1540
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..3324
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="hexamer: AAGAAA"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="hexamer: TATAAA"
     polyA_site      1754
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="major polyA site"
     polyA_site      1778
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="major polyA site"
     regulatory      2108..2113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="major polyA site"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="hexamer: AATAAA"
     polyA_site      3324
                     /gene="DEPDC4"
                     /gene_synonym="DEP.4"
                     /note="major polyA site"
ORIGIN      
        1 gctatggtgc caggggagga gccagcgcgc gagcttatgg cggttctttt gactccgagg
       61 ttccgtagac ttgtcagtca gaacgagctt ccgggcccag ggctgaacgg gccaagttcc
      121 aggaaccgta gagatggctt ctgccggaaa aggaggacag gatgctctgg tccttttcaa
      181 gctactcagc tatgggatgg tattattcac tctcttcagg cccaagtgga aataaaaaga
      241 aggaggcatc atttacagac atacaaagac tgtttcactg gttctgatgc tgtcgatgtg
      301 gtcttaagtc atcttatgca aaacacgtgc ctaagtagca atgacatctc ttgtcttaaa
      361 ggggttcatc tttgccaagt tctaatgaat cacaaagtat ttgaaccagt aggaatgaag
      421 aagcttttca aaaaagaaaa ggaattagaa tttgaagatt ccaacattag tctctacagg
      481 tttctaggca ataaatcatc ttacgattgt tgcaaaagac aaaaggatgc tgagaatgag
      541 ttcaatgaaa ccttgagacc aggatatgaa atgatttcaa atcctctagc acaggagatt
      601 ggtgaggaaa gaattgagga acttattcat acaataaatg ggaatccagc tttatgtcca
      661 aatatcacag ttcagaaacc ttttctccgg ctttcaaaag aagatgtttg gaaagaacaa
      721 acattattat gtcttcttca attgattcac cttccattct tggacaatat tttggagcct
      781 ccagttaaaa cacaaaatct tcaactaaac aaagaggaag atcttgttat cactaacact
      841 tgcctagaca gagaacttat tccaagctta tgtctacctg aaatcgataa ctggcttaat
      901 gcagcaattg aatgcttgga gtatttccct gaccagttaa tagttacagt tagtcagcag
      961 ttaatgcaaa acagaaatga agagacaaga ttgaacagtc agaagaagat actctttgat
     1021 gtcatagcaa aatactatgc tcaagagaga gattgcctat taactgatga gtattttgat
     1081 attcattcag gaattattga acttttagaa aatgagaaaa gagcagaagc acttgaagca
     1141 acacaactat atctaagatt gctgttgctg aacattagag aagaattacg acggctactt
     1201 acttttatgg caatggcatc agagcccaat gcctacaagt tgcaaaaaca gtatgataat
     1261 aaaacagtgg tcctgaaaac tcttgccaaa tcagttttgc aagccaaatc attattaaaa
     1321 gtgcgggcag aacaactggt ctggtttcca ctggagtacc actctgagct cttcaagaca
     1381 ccagttactt tattggatct ggttagtaag aaacttaaga agcttctaca tggagaagat
     1441 gcagatgcca tatcaggtat ggctgaaaat aacagctaca catctacagc ttaggatact
     1501 ggagatttaa tgagaaaaag taccaaaagg ttgacacatg gctttacgtt ttgccaaccc
     1561 ttgacataca aggagtttga aaagcagaag ggaaggacaa ttcagtatct acaccagttg
     1621 gctcttgaga ttaatagtaa ccccagcatc tctctgaaac gaaaaaagaa attaattaag
     1681 gaatttcaaa aacaccatcc agaagctttg aattaacatt tctgatacaa gaaactacaa
     1741 tttgtaaata taaacaattc tctggtggtt ttctcaaatt gccatactta cacttcagag
     1801 aaagcataat ctcaaaggat tttaagtgtt ttatttttta tttttatttt gtagagacag
     1861 gggtcctatt atgttgccca ggctggtctc gaactcctgg cctcaagtca tcctcctgcc
     1921 ttggcctctt aaagtgctgg gattataggc atgagtcact gtacttggcc attattttat
     1981 ttttataaaa tattactttt aatttaatca tgcttaaaat atgttaagga agtttttaac
     2041 tttaagaagg aatacaagtt agccttcatg tttgctgatt cacttaatta tgctgctaaa
     2101 atcacttaat aaatgtgctg ctattattag ggatctagta cagttaattt cctttttttt
     2161 ccacaggaaa ggagcttttc atacacaagc tctctgaaga aagcatgcat tttccttagt
     2221 atatgattat tttcaagcaa cccccttaac ctgctgtaac ttaaataact gtgaatcatt
     2281 gaaataggga aagatgcata aagtagttgt tttgttttgt tttgttttgt ttttgaaatg
     2341 gagtcttgct ctgtcccagg ctggagtgca gtggcaccat ctcacctcac tgcaacctct
     2401 gcctcctggg ttcaagcaat tctccctgcc tcagcctccc gagtagctgg gattataggt
     2461 acctgccact atgcccggct aatttttgta gttttagtag agacagtgtt tcgccatgtt
     2521 ggccaggcta gtcttgaact cctgacctca ggtgatctgc ccaccttagc ctcccaaggt
     2581 gctgggatta caggcgtgag ccaccacacc cggccacatg aagtagattt aaaaggccac
     2641 aaattaaaaa ttcgtaaaca tcaaaactgt gatttctctc tctaattctt cttcagtcca
     2701 tattttatgg ttatcttctt tccttctcat tctttctctg ctccttcctt ttctttcctc
     2761 tttctctctc tctttccagc tctttcactt ttttcttgcc tgcttctctc tctttctttg
     2821 ttttaaattg gttagttcac tctatggcat cattccctaa tgtagcagag gttacagatt
     2881 caatacctat gggaagtttt acacagaaaa attcttatgg gccaaccttg gtggcccatg
     2941 cctgtagtcc cggcactttt gggaggccag ggagagggga ttgctttaag tccaggagtt
     3001 caagaccagc ctgagtaata gtgagaccct gcccctatct ctacaaaaac tacaaaaaaa
     3061 aaatttagcc aggtgtggca gcccacacct atagtcccag ctactcagga ggctgaggtg
     3121 ggaggatctc ttgagcccag gagttttagg ctgcagtgag ctatgattgc accactgtac
     3181 tgcagcctgg gcaataaagg aagcctgtct caaaaaaaag aaggaaaaaa gtattttgtg
     3241 gtcatcttaa tttatattgt tgatcacagg gaaacagaag cataattaat taaattcttg
     3301 aaaaaataaa ctatattaga caga
//
