LOCUS       NM_018369               2504 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens DEP domain containing 1B (DEPDC1B), transcript variant
            1, mRNA.
ACCESSION   NM_018369
VERSION     NM_018369.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2504)
  AUTHORS   Zhao,R., Ning,X., Lu,H., Xu,W., Ma,J., Cheng,J. and Ma,R.
  TITLE     XTP8 Promotes Ovarian Cancer Progression by Activating
            AKT/AMPK/mTOR Pathway to Regulate EMT
  JOURNAL   Cell Biochem Biophys 82 (2), 945-957 (2024)
   PUBMED   38717641
  REMARK    GeneRIF: XTP8 Promotes Ovarian Cancer Progression by Activating
            AKT/AMPK/mTOR Pathway to Regulate EMT.
REFERENCE   2  (bases 1 to 2504)
  AUTHORS   Zhao,R., Song,N., Ning,X., Chen,X. and Ma,R.
  TITLE     ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in
            ovarian cancer cells
  JOURNAL   Reproduction 168 (1), e230484 (2024)
   PUBMED   38614125
  REMARK    GeneRIF: ZNF146 regulates cell cycle progression via TFDP1 and
            DEPDC1B in ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2504)
  AUTHORS   Zuo,X., Wang,D., Tao,C., Dou,X., Zhao,Z., Zhang,J., Huang,S.,
            Li,Y., Zhang,X., Bu,Y. and Wang,Y.
  TITLE     DEPDC1B is a Novel Direct Target of B-Myb and Contributes to
            Malignant Progression and Immune Infiltration in Lung
            Adenocarcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 204 (2024)
   PUBMED   38940035
  REMARK    GeneRIF: DEPDC1B is a Novel Direct Target of B-Myb and Contributes
            to Malignant Progression and Immune Infiltration in Lung
            Adenocarcinoma.
REFERENCE   4  (bases 1 to 2504)
  AUTHORS   Fei,H., Shi,X., Li,S., Li,Y., Yin,X., Wu,Z., Wang,W., Shi,H. and
            Li,R.
  TITLE     DEPDC1B enhances malignant phenotypes of multiple myeloma through
            upregulating CCNB1 and inhibiting p53 signaling pathway
  JOURNAL   Tissue Cell 86, 102263 (2024)
   PUBMED   37979396
  REMARK    GeneRIF: DEPDC1B enhances malignant phenotypes of multiple myeloma
            through upregulating CCNB1 and inhibiting p53 signaling pathway.
REFERENCE   5  (bases 1 to 2504)
  AUTHORS   Wang,Q., Chen,F., Yang,N., Xu,L., Yu,X., Wu,M. and Zhou,Y.
  TITLE     DEPDC1B-mediated USP5 deubiquitination of beta-catenin promotes
            breast cancer metastasis by activating the wnt/beta-catenin pathway
  JOURNAL   Am J Physiol Cell Physiol 325 (4), C833-C848 (2023)
   PUBMED   37642235
  REMARK    GeneRIF: DEPDC1B-mediated USP5 deubiquitination of beta-catenin
            promotes breast cancer metastasis by activating the
            wnt/beta-catenin pathway.
REFERENCE   6  (bases 1 to 2504)
  AUTHORS   Wu,D., Zhu,X., Jimenez-Cowell,K., Mold,A.J., Sollecito,C.C.,
            Lombana,N., Jiao,M. and Wei,Q.
  TITLE     Identification of the GTPase-activating protein DEP domain
            containing 1B (DEPDC1B) as a transcriptional target of Pitx2
  JOURNAL   Exp Cell Res 333 (1), 80-92 (2015)
   PUBMED   25704760
  REMARK    GeneRIF: Pitx2-mediated repression of Depdc1b expression
            contributes to the regulation of multiple molecular pathways, such
            as Rho GTPase signaling.
REFERENCE   7  (bases 1 to 2504)
  AUTHORS   Marchesi,S., Montani,F., Deflorian,G., D'Antuono,R., Cuomo,A.,
            Bologna,S., Mazzoccoli,C., Bonaldi,T., Di Fiore,P.P. and
            Nicassio,F.
  TITLE     DEPDC1B coordinates de-adhesion events and cell-cycle progression
            at mitosis
  JOURNAL   Dev Cell 31 (4), 420-433 (2014)
   PUBMED   25458010
REFERENCE   8  (bases 1 to 2504)
  AUTHORS   Su,Y.F., Liang,C.Y., Huang,C.Y., Peng,C.Y., Chen,C.C., Lin,M.C.,
            Lin,R.K., Lin,W.W., Chou,M.Y., Liao,P.H. and Yang,J.J.
  TITLE     A putative novel protein, DEPDC1B, is overexpressed in oral cancer
            patients, and enhanced anchorage-independent growth in oral cancer
            cells that is mediated by Rac1 and ERK
  JOURNAL   J Biomed Sci 21 (1), 67 (2014)
   PUBMED   25091805
  REMARK    GeneRIF: proliferation was linked to a novel DEPDC1B-Rac1-ERK1/2
            signaling axis in oral cancer cell lines.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2504)
  AUTHORS   Yang,Y., Liu,L., Cai,J., Wu,J., Guan,H., Zhu,X., Yuan,J. and Li,M.
  TITLE     DEPDC1B enhances migration and invasion of non-small cell lung
            cancer cells via activating Wnt/beta-catenin signaling
  JOURNAL   Biochem Biophys Res Commun 450 (1), 899-905 (2014)
   PUBMED   24971537
  REMARK    GeneRIF: Taken together, our data demonstrate that DEPDC1B might
            confer metastasis-related malignant phenotype to NSCLC in a
            Wnt/beta-catenin dependent manner, providing new insights in
            developing novel anti-NSCLC strategies.
            Erratum:[Biochem Biophys Res Commun. 2021 Sep 3;568:195. doi:
            10.1016/j.bbrc.2021.07.010.. PMID: 34272055]
REFERENCE   10 (bases 1 to 2504)
  AUTHORS   Niu,N., Qin,Y., Fridley,B.L., Hou,J., Kalari,K.R., Zhu,M., Wu,T.Y.,
            Jenkins,G.D., Batzler,A. and Wang,L.
  TITLE     Radiation pharmacogenomics: a genome-wide association approach to
            identify radiation response biomarkers using human lymphoblastoid
            cell lines
  JOURNAL   Genome Res 20 (11), 1482-1492 (2010)
   PUBMED   20923822
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association and gene-environment interaction. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC299445.1, AK290684.1, BC010904.1 and AA830503.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018369.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019075.1, AF303178.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265036.10/ ENSP00000265036.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DC299445.1         1-5
            6-1934              AK290684.1         1-1929
            1935-2501           BC010904.1         1003-1569
            2502-2504           AA830503.1         13-15               c
FEATURES             Location/Qualifiers
     source          1..2504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..2504
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /note="DEP domain containing 1B"
                     /db_xref="GeneID:55789"
                     /db_xref="HGNC:HGNC:24902"
                     /db_xref="MIM:616073"
     exon            1..121
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1663
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer cell 3; HBxAg transactivated protein 1; DEP
                     domain-containing protein 1B; HBV XAg-transactivated
                     protein 8; HBV X-transactivated gene 8 protein"
                     /codon_start=1
                     /product="DEP domain-containing protein 1B isoform 1"
                     /protein_id="NP_060839.2"
                     /db_xref="CCDS:CCDS3977.1"
                     /db_xref="GeneID:55789"
                     /db_xref="HGNC:HGNC:24902"
                     /db_xref="MIM:616073"
                     /translation="MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCF
                     TAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRH
                     LYRFPPSSPLKPYPKKPPNQKDVIKFPEWNDLPPGTSQENIPVRPVVMNSEMWYKRHS
                     IAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFII
                     HNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNCSDLKQPMYLGFEKDVFKTIA
                     DYYGHLKEPLLTFHLFDAFVSVLGLLQKEKVAVEAFQICCLLLPPENRRKLQLLMRMM
                     ARICLNKEMPPLCDGFGTRTLMVQTFSRCILCSKDEVDLDELLAARLVTFLMDNYQEI
                     LKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQISPEEFEYQRSYGSQE
                     PLAALLEEVITDAKLSNKEKKKKLKQFQKSYPEVYQERFPTPESAALLFPEKPKPKPQ
                     LLMWALKKPFQPFQRTRSFRM"
     exon            122..387
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..523
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..651
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..782
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..830
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..971
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1138
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1315
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1501
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..2504
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2504
                     /gene="DEPDC1B"
                     /gene_synonym="BRCC3; XTP1"
                     /note="major polyA site"
ORIGIN      
        1 gattcaaact gctgctcctc cggctggcgg ggatcagcgc tggcgcggct gcggccgctg
       61 ctgcctacgc gccatggagc atcgcatcgt ggggcccggg ccgtaccgag ctaccaggct
      121 gtggaatgag accgtggagc tttttcgtgc taagatgccg ttacggaaac atcgctgtcg
      181 tttcaagagc tatgagcatt gtttcacagc ggccgaagct gtggattggc tgcatgagct
      241 gctgaggtgc agtcaaaact tcggccctga agtgacccgc aaacaaacgg tccagctgct
      301 aaaaaaattc ctgaagaatc acgttattga agacatcaag ggaaaatggg gtgaggaaga
      361 ttttgaagac aatcgtcact tatacagatt tcctccttct tcacccctga aaccatatcc
      421 aaagaagccc ccaaaccaaa aggatgttat taaatttcca gaatggaatg atctcccacc
      481 aggcacttca caagagaaca tcccagtgag gccagttgtg atgaattctg agatgtggta
      541 caagcgtcac agtattgcaa ttggagaggt gccagcttgc cgtcttgtcc accgcagaca
      601 gctgacagag gccaatgtag aagagatatg gaagtctatg acattatcat acttacagaa
      661 aattcttggc ctggattcct tagaagaagt tttagacgtc aaacttgtca attcgaagtt
      721 catcatccat aatgtatata gtgttagcaa gcagggagtt gttattcttg atgacaagtc
      781 aaaagaactt cctcattggg tgctgtcagc tatgaagtgt ttggcaaatt ggcccaactg
      841 ttctgatttg aagcagccta tgtacttggg atttgaaaaa gatgtcttta aaaccatagc
      901 tgattactat ggtcacttga aagagcctct acttacattt catctttttg atgcttttgt
      961 cagtgtactg ggtttgttac agaaggagaa agtggcagtt gaagcatttc agatttgctg
     1021 ccttctccta cctcctgaaa ataggagaaa gttacagcta ttgatgagga tgatggcaag
     1081 gatttgctta aacaaagaga tgccacccct gtgtgatggc tttggtaccc gaacactgat
     1141 ggttcagaca ttttcccgtt gcatcttgtg ttccaaggat gaagtggact tggatgagtt
     1201 attagctgct agattggtaa cgtttctgat ggacaattac caggaaattc tgaaagtccc
     1261 tttggccttg cagacctcta tagaggagcg tgtggctcat ctacgaagag tccagataaa
     1321 atacccagga gctgatatgg atatcacttt atctgctcca tcattttgcc gtcaaattag
     1381 tccagaggaa tttgaatatc aaagatcata tggctctcag gaacctctgg cagccttgtt
     1441 ggaggaagtc ataacagatg ccaaactctc caacaaagag aaaaagaaga aactgaagca
     1501 gtttcagaaa tcctatcctg aagtctatca agaacgattt cctacaccag aaagtgcagc
     1561 acttctgttt cctgaaaaac ccaaaccgaa accacagctg ctaatgtggg cactaaagaa
     1621 gcctttccaa ccatttcaaa gaactagaag ttttcgaatg taataatact tccacagcaa
     1681 caggtgctag agaccactgt tgttgttttg agtgaatggt ggttaggaga aagactttgg
     1741 tggtggaaga aagaaaagca taaaacaaag actactgaaa tatagataaa gattgcctta
     1801 gtttttaaaa atgtttggcc attagtattt ttataaaact caatgctagt tttaaagtgt
     1861 ataaattggt taaaatttat gagtcaaata tatagtgata atgttaacat gtttgtaatt
     1921 gctacagaat ttaagggtat ttttatctct gtgctttctt tttcatggtg tttattaaat
     1981 aattgtgtat atacatccta gctactgata tctttattat agccttaaga cttaatttta
     2041 agtcttaaaa atagcgtgta tacttgaata agaaagacac tgggtactgt tactgtgatg
     2101 ctattgactt agtagccaat tatcatttct cctgtataaa ttccagtttt tattgctgca
     2161 cataaatttt ttaatgtctt atattgtgat agctatgtct tttattgcag atttattgga
     2221 tgttatgaca gattttacta aagctagtgt ttttataaca tatatattag ttgatgttta
     2281 cctataagtg gagtagattt tcatctgcct gcaatggtat aatttcagtc ttagctaaaa
     2341 atggaaagtt gaactggata aattctttgg gtacccttag acctctgatt ctaagtcaaa
     2401 tgcaaatggg ttaaataaaa tgagactact tcctttataa atatattttc atccttttga
     2461 aagtaagtga aatgtaaata aacttatttt ttttaaaaat gcca
//
