LOCUS       NM_001114120            5299 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens DEP domain containing 1 (DEPDC1), transcript variant
            1, mRNA.
ACCESSION   NM_001114120
VERSION     NM_001114120.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5299)
  AUTHORS   Di,S.C., Chen,W.J., Yang,W., Zhang,X.M., Dong,K.Q., Tian,Y.J.,
            Sun,Y., Qian,C., Chen,J.X., Liu,Z.C., Gong,Z.X., Chu,J., Zhou,W.,
            Pan,X.W. and Cui,X.G.
  TITLE     DEPDC1 as a metabolic target regulates glycolysis in renal cell
            carcinoma through AKT/mTOR/HIF1alpha pathway
  JOURNAL   Cell Death Dis 15 (7), 533 (2024)
   PUBMED   39068164
  REMARK    GeneRIF: DEPDC1 as a metabolic target regulates glycolysis in renal
            cell carcinoma through AKT/mTOR/HIF1alpha pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5299)
  AUTHORS   Lv,M., Li,X., Yin,Z., Yang,H. and Zhou,B.
  TITLE     Comprehensive analysis and validation reveal DEPDC1 as a potential
            diagnostic biomarker associated with tumor immunity in
            non-small-cell lung cancer
  JOURNAL   PLoS One 19 (4), e0294227 (2024)
   PUBMED   38564630
  REMARK    GeneRIF: Comprehensive analysis and validation reveal DEPDC1 as a
            potential diagnostic biomarker associated with tumor immunity in
            non-small-cell lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5299)
  AUTHORS   Shen,L., Li,H., Liu,R., Zhou,C., Bretches,M., Gong,X., Lu,L.,
            Zhang,Y., Zhao,K., Ning,B., Yang,S.Y. and Zhang,A.
  TITLE     DEPDC1 as a crucial factor in the progression of human osteosarcoma
  JOURNAL   Cancer Med 12 (5), 5798-5808 (2023)
   PUBMED   36479633
  REMARK    GeneRIF: DEPDC1 as a crucial factor in the progression of human
            osteosarcoma.
REFERENCE   4  (bases 1 to 5299)
  AUTHORS   Yang,M., Zhang,H., Gao,S. and Huang,W.
  TITLE     DEPDC1 and KIF4A synergistically inhibit the malignant biological
            behavior of osteosarcoma cells through Hippo signaling pathway
  JOURNAL   J Orthop Surg Res 18 (1), 145 (2023)
   PUBMED   36849972
  REMARK    GeneRIF: DEPDC1 and KIF4A synergistically inhibit the malignant
            biological behavior of osteosarcoma cells through Hippo signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5299)
  AUTHORS   Huang,G., Chen,S., Washio,J., Paka Lubamba,G., Takahashi,N. and
            Li,C.
  TITLE     Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the
            Malignant Progression of Oral Squamous Cell Carcinoma via the
            WNT/beta-Catenin Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (3), 1992 (2023)
   PUBMED   36768316
  REMARK    GeneRIF: Glycolysis-Related Gene Analyses Indicate That DEPDC1
            Promotes the Malignant Progression of Oral Squamous Cell Carcinoma
            via the WNT/beta-Catenin Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5299)
  AUTHORS   Sendoel,A., Maida,S., Zheng,X., Teo,Y., Stergiou,L., Rossi,C.A.,
            Subasic,D., Pinto,S.M., Kinchen,J.M., Shi,M., Boettcher,S.,
            Meyer,J.N., Manz,M.G., Bano,D. and Hengartner,M.O.
  TITLE     DEPDC1/LET-99 participates in an evolutionarily conserved pathway
            for anti-tubulin drug-induced apoptosis
  JOURNAL   Nat Cell Biol 16 (8), 812-820 (2014)
   PUBMED   25064737
  REMARK    GeneRIF: DEPDC1 regulates vincristine-induced cell death by
            promoting JNK-dependent degradation of the BCL-2 family protein
            MCL1.
REFERENCE   7  (bases 1 to 5299)
  AUTHORS   Yuan,S.G., Liao,W.J., Yang,J.J., Huang,G.J. and Huang,Z.Q.
  TITLE     DEP domain containing 1 is a novel diagnostic marker and prognostic
            predictor for hepatocellular carcinoma
  JOURNAL   Asian Pac J Cancer Prev 15 (24), 10917-10922 (2014)
   PUBMED   25605201
  REMARK    GeneRIF: High DEPDC1 mRNA expression is associated with
            hepatocellular carcinoma/
REFERENCE   8  (bases 1 to 5299)
  AUTHORS   Kassambara,A., Schoenhals,M., Moreaux,J., Veyrune,J.L., Reme,T.,
            Goldschmidt,H., Hose,D. and Klein,B.
  TITLE     Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma,
            delays growth and induces mature plasma cell markers in malignant
            plasma cells
  JOURNAL   PLoS One 8 (4), e62752 (2013)
   PUBMED   23646139
  REMARK    GeneRIF: Inhibition of DEPDC1A, a bad prognostic marker in multiple
            myeloma, delays growth and induces mature plasma cell markers in
            malignant plasma cells.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5299)
  AUTHORS   Harada,Y., Kanehira,M., Fujisawa,Y., Takata,R., Shuin,T., Miki,T.,
            Fujioka,T., Nakamura,Y. and Katagiri,T.
  TITLE     Cell-permeable peptide DEPDC1-ZNF224 interferes with
            transcriptional repression and oncogenicity in bladder cancer cells
  JOURNAL   Cancer Res 70 (14), 5829-5839 (2010)
   PUBMED   20587513
  REMARK    GeneRIF: Coimmunoprecipitation and immunocytochemistry revealed
            that DEPDC1 interacted and colocalized with zinc finger
            transcription factor ZNF224, a known transcriptional repressor.
REFERENCE   10 (bases 1 to 5299)
  AUTHORS   Kanehira,M., Harada,Y., Takata,R., Shuin,T., Miki,T., Fujioka,T.,
            Nakamura,Y. and Katagiri,T.
  TITLE     Involvement of upregulation of DEPDC1 (DEP domain containing 1) in
            bladder carcinogenesis
  JOURNAL   Oncogene 26 (44), 6448-6455 (2007)
   PUBMED   17452976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB147703.1, AB281187.1 and BU588593.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001114120.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB281187.1, AK225735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456315.7/ ENSP00000412292.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB147703.1         140-144
            6-5225              AB281187.1         1-5220
            5226-5299           BU588593.1         264-337
FEATURES             Location/Qualifiers
     source          1..5299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5299
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /note="DEP domain containing 1"
                     /db_xref="GeneID:55635"
                     /db_xref="HGNC:HGNC:22949"
                     /db_xref="MIM:612002"
     exon            1..131
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2519
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /note="isoform a is encoded by transcript variant 1; cell
                     cycle control protein SDP35; DEP domain-containing protein
                     1A"
                     /codon_start=1
                     /product="DEP domain-containing protein 1A isoform a"
                     /protein_id="NP_001107592.1"
                     /db_xref="CCDS:CCDS44159.1"
                     /db_xref="GeneID:55635"
                     /db_xref="HGNC:HGNC:22949"
                     /db_xref="MIM:612002"
                     /translation="MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCF
                     TAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDNNQ
                     LFRFPATSPLKTLPRRYPELRKNNIENFSKDKDSIFKLRNLSRRTPKRHGLHLSQENG
                     EKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIP
                     QYIMYNMANTSKRGVVILQNKSDDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVF
                     RTIADYFLDLPEPLLTFEYYELFVNILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLN
                     NLNSFKSTECLLLSLLHREKNKEESDSTERLQISNPGFQERCAKKMQLVNLRNRRVSA
                     NDIMGGSCHNLIGLSNMHDLSSNSKPRCCSLEGIVDVPGNSSKEASSVFHQSFPNIEG
                     QNNKLFLESKPKQEFLLNLHSEENIQKPFSAGFKRTSTLTVQDQEELCNGKCKSKQLC
                     RSQSLLLRSSTRRNSYINTPVAEIIMKPNVGQGSTSVQTAMESELGESSATINKRLCK
                     STIELSENSLLPASSMLTGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMI
                     SRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEEVDLDELLAGRLVSFLMDHHQEI
                     LQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYSYCKQISAQEFDEQKVSTSQA
                     AIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEAALFGDKPTIKQP
                     MLILRKPKFRSLR"
     exon            132..397
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            398..554
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            674..804
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            805..852
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            853..993
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1845
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2018
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2195
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2381
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..5299
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5278..5283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /note="hexamer: ATTAAA"
     polyA_site      5299
                     /gene="DEPDC1"
                     /gene_synonym="DEP.8; DEPDC1-V2; DEPDC1A; SDP35"
                     /note="major polyA site"
ORIGIN      
        1 gtgccgagac tcgccactgc cgcggccgct gggcctgagt gtcgccttcg ccgccatgga
       61 cgccaccggg cgctgacaga cctatggaga gtcagggtgt gcctcccggg ccttatcggg
      121 ccaccaagct gtggaatgaa gttaccacat cttttcgagc aggaatgcct ctaagaaaac
      181 acagacaaca ctttaaaaaa tatggcaatt gtttcacagc aggagaagca gtggattggc
      241 tttatgacct attaagaaat aatagcaatt ttggtcctga agttacaagg caacagacta
      301 tccaactgtt gaggaaattt cttaagaatc atgtaattga agatatcaaa gggaggtggg
      361 gatcagaaaa tgttgatgat aacaaccagc tcttcagatt tcctgcaact tcgccactta
      421 aaactctacc acgaaggtat ccagaattga gaaaaaacaa catagagaac ttttccaaag
      481 ataaagatag catttttaaa ttacgaaact tatctcgtag aactcctaaa aggcatggat
      541 tacatttatc tcaggaaaat ggcgagaaaa taaagcatga aataatcaat gaagatcaag
      601 aaaatgcaat tgataataga gaactaagcc aggaagatgt tgaagaagtt tggagatatg
      661 ttattctgat ctacctgcaa accattttag gtgtgccatc cctagaagaa gtcataaatc
      721 caaaacaagt aattccccaa tatataatgt acaacatggc caatacaagt aaacgtggag
      781 tagttatact acaaaacaaa tcagatgacc tccctcactg ggtattatct gccatgaagt
      841 gcctagcaaa ttggccaaga agcaatgata tgaataatcc aacttatgtt ggatttgaac
      901 gagatgtatt cagaacaatc gcagattatt ttctagatct ccctgaacct ctacttactt
      961 ttgaatatta cgaattattt gtaaacattt tggttgtttg tggctacatc acagtttcag
     1021 atagatccag tgggatacat aaaattcaag atgatccaca gtcttcaaaa ttccttcact
     1081 taaacaattt gaattccttc aaatcaactg agtgccttct tctcagtctg cttcatagag
     1141 aaaaaaacaa agaagaatca gattctactg agagactaca gataagcaat ccaggatttc
     1201 aagaaagatg tgctaagaaa atgcagctag ttaatttaag aaacagaaga gtgagtgcta
     1261 atgacataat gggaggaagt tgtcataatt taatagggtt aagtaatatg catgatctat
     1321 cctctaacag caaaccaagg tgctgttctt tggaaggaat tgtagatgtg ccagggaatt
     1381 caagtaaaga ggcatccagt gtctttcatc aatcttttcc gaacatagaa ggacaaaata
     1441 ataaactgtt tttagagtct aagcccaaac aggaattcct gttgaatctt cattcagagg
     1501 aaaatattca aaagccattc agtgctggtt ttaagagaac ctctactttg actgttcaag
     1561 accaagagga gttgtgtaat gggaaatgca agtcaaaaca gctttgtagg tctcagagtt
     1621 tgcttttaag aagtagtaca agaaggaata gttatatcaa tacaccagtg gctgaaatta
     1681 tcatgaaacc aaatgttgga caaggcagca caagtgtgca aacagctatg gaaagtgaac
     1741 tcggagagtc tagtgccaca atcaataaaa gactctgcaa aagtacaata gaactttcag
     1801 aaaattcttt acttccagct tcttctatgt tgactggcac acaaagcttg ctgcaacctc
     1861 atttagagag ggttgccatc gatgctctac agttatgttg tttgttactt cccccaccaa
     1921 atcgtagaaa gcttcaactt ttaatgcgta tgatttcccg aatgagtcaa aatgttgata
     1981 tgcccaaact tcatgatgca atgggtacga ggtcactgat gatacatacc ttttctcgat
     2041 gtgtgttatg ctgtgctgaa gaagtggatc ttgatgagct tcttgctgga agattagttt
     2101 ctttcttaat ggatcatcat caggaaattc ttcaagtacc ctcttactta cagactgcag
     2161 tggaaaaaca tcttgactac ttaaaaaagg gacatattga aaatcctgga gatggactat
     2221 ttgctccttt gccaacttac tcatactgta agcagattag tgctcaggag tttgatgagc
     2281 aaaaagtttc tacctctcaa gctgcaattg cagaactttt agaaaatatt attaaaaaca
     2341 ggagtttacc tctaaaggag aaaagaaaaa aactaaaaca gtttcagaag gaatatcctt
     2401 tgatatatca gaaaagattt ccaaccacgg agagtgaagc agcacttttt ggtgacaaac
     2461 ctacaatcaa gcaaccaatg ctgattttaa gaaaaccaaa gttccgtagt ctaagataac
     2521 taactgaatt aaaaattatg taatacttgt ggaactttga taaatgaagc catatctgag
     2581 aatgtagcta ctcaaaagga agtctgtcat taataaggta tttctaaata aacacattat
     2641 gtaaggaagt gccaaaatag ttatcaatgt gagactctta ggaaactaac tagatctcaa
     2701 ttgagagcac ataacaatag atgataccaa atactttttg tttttaacac agctatccag
     2761 taaggctatc atgatgtgtg ctaaaatttt atttacttga attttgaaaa ctgagctgtg
     2821 ttagggatta aactataatt ctgttcttaa aagaaaattt atctgcaaat gtgcaagttc
     2881 tgagatatta gctaatgaat tagttgtttg gggttacttc tttgtttcta agtataagaa
     2941 tgtgaagaat atttgaaaac tcaatgaaat aattctcagc tgccaaatgt tgcactcttt
     3001 tatatattct ttttccactt ttgatctatt tatatatatg tatgtgtttt taaaatatgt
     3061 gtatatttta tcagatttgg ttttgcctta aatattatcc ccaattgctt cagtcattca
     3121 tttgttcagt atatatattt tgaattctag ttttcataat ctattagaag atggggatat
     3181 aaaagaagta taaggcaatc atatattcat tcaaaagata tttatttagc aactgctatg
     3241 tgcctttcgt tgttccagat atgcagagac aatgataaat aaaacatata atctcttcca
     3301 taaggtattt attttttaat caagggagat acacctatca gatgtttaaa ataacaacac
     3361 tacccactga aatcagggca tatagaatca ttcagctaaa gagtgacttc tatgatgatg
     3421 gaacaggtct ctaagctagt ggttttcaaa ctggtacaca ttagactcac ccgaggaatt
     3481 ttaaaacagc ctatatgccc agggcctaac ttacactaat taaatctgaa ttttggggat
     3541 gttgtatagg gattagtatt ttttttaatc taggtgattc caatattcag ccaactgtga
     3601 gaatcaatgg cctaaatgct ttttataaac atttttataa gtgtcaagat aatggcacat
     3661 tgactttatt ttttcattgg aagaaaatgc ctgccaagta taaatgactc tcatcttaaa
     3721 acaaggttct tcaggtttct gcttgattga cttggtacaa acttgaagca agttgccttc
     3781 taatttttac tccaagattg tttcatatct attccttaag tgtaaagaaa tatataatgc
     3841 atggtttgta ataaaatctt aatgtttaat gactgttctc atttctcaat gtaatttcat
     3901 actgtttctc tataaaatga tagtattcca tttaacatta ctgattttta ttaaaaacct
     3961 ggacagaaaa ttataaatta taaatatgac tttatcctgg ctataaaatt attgaaccaa
     4021 aatgaattct ttctaaggca tttgaatact aaaacgttta ttgtttatag atatgtaaaa
     4081 tgtggattat gttgcaaatt gagattaaaa ttatttgggg ttttgtaaca atataatttt
     4141 gcttttgtat tatagacaaa tatataaata ataaaggcag gcaactttca tttgcactaa
     4201 tgtacatgca attgagatta caaaatacat ggtacaatgc tttaataaca aactctgcca
     4261 gtcaggtttg aatcctactg tgctattaac tagctagtaa actcagacaa gttacttaac
     4321 ttctctaagc cccagttttg ttatctataa aatgaatatt ataatagtac ctctttttag
     4381 gattgcgagg attaagcagg ataatgcatg taaagtgtta gcacagtgtc tcacatagaa
     4441 taagcactct ataaatattt tactagaatc acctaggatt atagcactag aagagatctt
     4501 agcaaaaatg tggtcctttc tgttgctttg gacagacatg aaccaaaaca aaattacgga
     4561 caattgatga gccttattaa ctatcttttc attatgagac aaaggttctg attatgccta
     4621 ctggttgaaa ttttttaatc tagtcaagaa ggaaaatttg atgaggaagg aaggaatgga
     4681 tatcttcaga agggcttcgc ctaagctgga acatggatag attccattct aacataaaga
     4741 tctttaagtt caaatataga tgagttgact ggtagatttg gtggtagttg ctttctcggg
     4801 atataagaag caaaatcaac tgctacaagt aaagagggga tggggaaggt gttgcacatt
     4861 taaagagaga aagtgtgaaa aagcctaatt gtgggaatgc acaggtttca ccagatcaga
     4921 tgatgtctgg ttattctgta aattatagtt cttatcccag aaattactgc ctccaccatc
     4981 cctaatatct tctaattggt atcatataat gacccactct tcttatgtta tccaaacagt
     5041 tatgtggcat ttagtaatgg aatgtacatg gaatttccca ctgacttacc tttctgtcct
     5101 tgggaagctt aaactctgaa tcttctcatc tgtaaaatgt gaattaaagt atctacctaa
     5161 ctgagttgtg attgtagtga aagaaaggca atatatttaa atcttgaatt tagcaagccc
     5221 acgcttgatt tttatgtcct ttcctcttgc cttgtattga gtttaagatc tctactgatt
     5281 aaaactcttt tgctatcaa
//
