LOCUS       NM_001001794            4891 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens DENN domain containing 6B (DENND6B), mRNA.
ACCESSION   NM_001001794
VERSION     NM_001001794.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4891)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4891)
  AUTHORS   Linford,A., Yoshimura,S., Nunes Bastos,R., Langemeyer,L.,
            Gerondopoulos,A., Rigden,D.J. and Barr,F.A.
  TITLE     Rab14 and its exchange factor FAM116 link endocytic recycling and
            adherens junction stability in migrating cells
  JOURNAL   Dev Cell 22 (5), 952-966 (2012)
   PUBMED   22595670
REFERENCE   3  (bases 1 to 4891)
  AUTHORS   Marat,A.L., Dokainish,H. and McPherson,P.S.
  TITLE     DENN domain proteins: regulators of Rab GTPases
  JOURNAL   J Biol Chem 286 (16), 13791-13800 (2011)
   PUBMED   21330364
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031069.1, AA864612.1 and CR932344.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001001794.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.133591.1, BC031069.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413817.8/ ENSP00000391524.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1868              BC031069.1         49-1916
            1869-1958           AA864612.1         24-113              c
            1959-4891           CR932344.3         855-3787            c
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..4891
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /note="DENN domain containing 6B"
                     /db_xref="GeneID:414918"
                     /db_xref="HGNC:HGNC:32690"
                     /db_xref="MIM:620562"
     exon            1..201
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1782
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /note="protein FAM116B; family with sequence similarity
                     116, member B; DENN domain-containing protein 6B;
                     DENN/MADD domain containing 6B"
                     /codon_start=1
                     /product="protein DENND6B"
                     /protein_id="NP_001001794.3"
                     /db_xref="CCDS:CCDS46732.1"
                     /db_xref="GeneID:414918"
                     /db_xref="HGNC:HGNC:32690"
                     /db_xref="MIM:620562"
                     /translation="MDALLGTGPRRARGCLGAAGPTSSGRAARTPAAPWARFSAWLEC
                     VCVVTFDLELGQALELVYPNDFRLTDKEKSSICYLSFPDSHSGCLGDTQFSFRMRQCG
                     GQRSPWHADDRHYNSRAPVALQREPAHYFGYVYFRQVKDSSVKRGYFQKSLVLVSRLP
                     FVRLFQALLSLIAPEYFDKLAPCLEAVCSEIDQWPAPAPGQTLNLPVMGVVVQVRIPS
                     RVDKSESSPPKQFDQENLLPAPVVLASVHELDLFRCFRPVLTHMQTLWELMLLGEPLL
                     VLAPSPDVSSEMVLALTSCLQPLRFCCDFRPYFTIHDSEFKEFTTRTQAPPNVVLGVT
                     NPFFIKTLQHWPHILRVGEPKMSGDLPKQVKLKKPSRLKTLDTKPGLYTAYTAHLHRD
                     KALLKRLLKGVQKKRPSDVQSALLRRHLLELTQSFIIPLEHYMASLMPLQKSITPWKT
                     PPQIQPFSQDDFLRSLEHAGPQLTCILKGDWLGLYRRFFKSPHFDGWYRQRHKEMALK
                     LEALHLEAICEANIETWMKDKSEVEVVDLVLKLREKLVRAQGHQLPVKEATLQRAQLY
                     IETVIGSLPKDLQAVLCPP"
     exon            202..240
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            241..283
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            284..396
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            397..477
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            478..583
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            584..663
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            664..726
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            727..782
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            783..905
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1001
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1096
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1162
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1227
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1317
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1371
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1481
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1584
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1659
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..4891
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /note="hexamer: AGTAAA"
     polyA_site      1958
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /note="major polyA site"
     regulatory      4867..4872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
                     /note="hexamer: ATTAAA"
     polyA_site      4891
                     /gene="DENND6B"
                     /gene_synonym="AFI1B; FAM116B"
ORIGIN      
        1 ccccggcaac ccgcggccgc cgccatggac gcgctgttgg gcacagggcc tcgccgggct
       61 cgcggctgcc tgggcgcggc tggacccacg tcttcaggtc gcgcggcgcg gaccccggcg
      121 gcgccctggg cgcgcttctc cgcctggctg gagtgtgtgt gcgtggtcac cttcgacctg
      181 gagctgggcc aggcgctgga gctggtgtat ccgaacgact tccggctcac agacaaggag
      241 aaaagcagca tctgctacct gtcttttccc gactcgcact caggctgcct tggagacact
      301 cagttcagct tccgcatgcg ccagtgtgga gggcagagga gcccctggca tgccgacgac
      361 aggcactaca acagcagggc ccctgtggca ctgcagaggg agccggcaca ctacttcggc
      421 tacgtgtact tcaggcaggt gaaggacagc tctgtgaaga ggggctactt ccagaagtct
      481 ttggtgctgg tgtcccgctt gccctttgtc cggctgttcc aagcgctgct aagcctcatc
      541 gcccccgagt actttgacaa gctggcgccc tgcctggaag cagtgtgcag tgagatcgac
      601 cagtggccgg cgcctgcacc tgggcagacc ctgaacctac ctgtcatggg cgttgttgtc
      661 caggtgcgca tcccatccag ggtggacaag tccgagtcca gtcctccgaa gcagtttgac
      721 caagagaacc tgctgccagc cccagtggtt cttgctagcg tccacgagct ggacctgttc
      781 aggtgcttcc ggcctgtgct gactcatatg cagacactgt gggagctcat gctcctcggg
      841 gagcccctgc tagtcctggc accctcgccc gacgtgtcct cggagatggt gctggccttg
      901 accagctgcc tgcagcccct caggttctgc tgcgacttcc gtccctactt caccatccat
      961 gacagcgagt tcaaggagtt caccacacgc acgcaggccc caccaaacgt ggtcctggga
     1021 gtcacaaacc ctttctttat caaaacactc cagcactggc cccacatcct ccgagtcggg
     1081 gagcccaaga tgtcaggaga cctgcctaag caagtcaagc tgaaaaagcc ttcaaggttg
     1141 aagaccctgg acaccaagcc aggcctctac accgcttaca cggcccacct ccaccgcgac
     1201 aaggcgctgc tcaaacggct gctcaagggc gtgcagaaga agcggccgtc agatgtgcag
     1261 agcgccctgc tgcggcggca cctcctggag ctcacccaga gcttcatcat ccccctggag
     1321 cactacatgg ccagcctcat gcccctgcag aagagcatca cgccctggaa gactcccccc
     1381 cagatccagc ccttcagcca ggatgacttc ctgcgtagcc tggagcatgc tgggccccag
     1441 ctcacctgca tcctcaaggg cgactggctg ggtctctaca ggcggttttt caagtccccc
     1501 cattttgatg gctggtaccg gcagcggcac aaggagatgg ccctgaagct ggaggccctg
     1561 cacctggagg ctatctgtga ggcgaacatc gagacctgga tgaaagacaa gtccgaggtg
     1621 gaggtcgtgg acctggtcct gaaacttcgt gagaagctgg tgcgggctca gggccaccag
     1681 ctccctgtga aggaggctac gctgcagcgg gcacagctgt acatcgagac ggtcatcggc
     1741 tccctgccca aagacctgca ggctgtcttg tgccctccct agaacaaagc caagggccac
     1801 ggtcccaggg ccctaggtct gcctgagcct cccactcccc agtggtggcg gcactgggcc
     1861 aagcacacgc tccccttcct tggccccccg cccagactgc aggctcccct tcctgcacca
     1921 ccattgtctc agcagtaaag gcgacatttg gaaccacagc atggccttga ccataggggt
     1981 tcctcgcagg cagagccttg cctcctcctg ggtcccacct ggcctctgca gaccttaggc
     2041 tgggacgggg gcggggacag gctgggagcc cttgctgatg tgggtgcgtc taccgtctgc
     2101 ccctcccggt gcccatctgt tggcccccga cccccctgcg ctgtgtgtga tgcttccctc
     2161 agcccaacag gctgcccagg acaggaggga ccctctcctg acacagcccc cgtcttgtct
     2221 ggggatggga ggctattttg catatagtca tcaacttgag aaagggagag accactttgc
     2281 agtgtgaaga gctctgctca ccacccctgg tgctcctctg gacacccacc tgcttggggc
     2341 tgtggtttgt tgggaggtag gggttgggca gggggctgtg tgcagcccag cacctctgct
     2401 aggagagctg gctcagcctg gctctcggag agccacagca ccttcctggc tcccagtcct
     2461 ggagccccca ccaggcacca gctccgtgcg tcccttctgg gaggtggaca gggctcctgt
     2521 tgtccaagtg tgtccgtcca tcccccacat gcagcccaag gggctctgga cttcggcctg
     2581 accctgcctc tggctggagc ctgcatgtct ccctttcctt ggtaaggggt gaacgtccct
     2641 aagagccacc tctgggttgt atgctccccc cgtgacacct gcaggcactg aggccggtga
     2701 ggtacggtgt tgaccctgca cagcacacag tgacggtact gtcagggctc cggacagcca
     2761 agccctgctc agcatcacgc actgtgtgcc cgggagcagg tcccctgacc actcagaccc
     2821 tcagactcct catctgagcg agccagccat gcagatgccc gacagggtgc tgggagggcc
     2881 actcatggag actgggcttt gtaccctgtg aggccgggcg ggtgctggcc aggggacaca
     2941 gggctggggg agggactttt tctttttttt tctttttgaa atggagtctc gctctgttgc
     3001 ccaggctgga gtgcagtggc atgatctcgg ctcactgcaa gctctgcctc ccgggttcac
     3061 gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcacccac cactgcgctt
     3121 ggttaatttt ttgtatttgt agtagagaca gggtttcacc atgttagcca ggatggtctc
     3181 gatctcctga cctcgtaatc cgcccgcctc ggcctcccaa cgtgctagga ttacaggcat
     3241 gagccaccgc gcccggccgg gacttttctt tttcttctga ggcccccatt cagtccgagg
     3301 aatgtagcct tcattcagcg caacgtactg tttgtgttct cattggtgct ctcagacctc
     3361 cagccaggtg gtggagagcg agcactgcca gccacttcag tgcaggatgt gactgagcca
     3421 caaggacagc ggggtcaggt gtccgggcgc caggtagttc tcagaacttg gtacatgtca
     3481 acttgtccag cccaactgca gcccaggaca gcctgtccct gttcccattc tacagacaag
     3541 acgcggaggc agccgggagg gtgaccaagg ggagctgtta agccccagat gtctggtgca
     3601 gggtccaagg atgtgaccac atgaaacaga acacatagag gccgaggtgg caaacctgtt
     3661 ctgtggcagg gacaagccgg ggacccgagg gtgagaaagg tcctggcccc aaatgcagct
     3721 tgggcctcct gactgtagca cagggggacc agcctcccca ctgagggctt ggtctctaga
     3781 gggtctgcag agatgctggc acctcttgtg tgggcagctt gaatgctgac ctccataaga
     3841 tggggcctgg ggggccagta caggccctgc catcagctgc cctccaccag ggccctctgc
     3901 aaaagcctta tgctggtgac cagccccctg aggaccacca cttcaaggtg tcggggcagc
     3961 ttgggaagac aacccacctc tctcacaact gtgaccccac tttggggagc gcaccccaag
     4021 gaccgtggca gcatgtgctt ccccacagca cagtctcgcc tcacttggct ttctgagggc
     4081 tgccgcacag cacagagggc tgcagaccca catggctgca ggggaggggc ttcaggctgg
     4141 tctctgagga gcccccaggg accctggcca ctgtgtatcc agaaatgcac aagcagattt
     4201 ccctggaggg ctctggtgag gccacatagt ggcgtgtgaa gggggaactt gaggggggaa
     4261 ccgggctggg tggccagcat tgccctgggc agaagctaag gctaaggtgg ggggtagtgt
     4321 cccagcccct cttcctcagg gcctgtcccc acctgtgcag aagaggcctg gggtggaatg
     4381 tggcctgggg tggatgggtg ggggctgggc gtggagacct gccagctcca tctgtccgga
     4441 tgcctcttgt ggccccccca gtgtcagggc cgctctgagt tggctgagcc tctgtccagg
     4501 gctaggccat ggccctcccc gccccacgca ctccaggcca ggggcagtca gtgaagaggc
     4561 aggaaggtcc agacagctct acccctggcc agagtgccag cccccgcagg caagagggct
     4621 tgctgggcag aacttagttg gcgagggtga ggactgctgt ggtcacaggc ctcccgaagg
     4681 acagggacca cagaacctag agggtgggaa gggctgggag caggtctgga gtggggctcg
     4741 gggctgaggg tgcacacagg gggcctgctc agggacagga aggacagctg ctcaccctca
     4801 agcttcctgc tggctattta aagactccct tttagtctag aacagtggcc ttcccacagt
     4861 tttggtatta aaatgtcctt ttgtgactgg a
//
