LOCUS       NM_152678               4646 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DENN domain containing 6A (DENND6A), mRNA.
ACCESSION   NM_152678 XM_941559
VERSION     NM_152678.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4646)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4646)
  AUTHORS   So,J., Pasculescu,A., Dai,A.Y., Williton,K., James,A., Nguyen,V.,
            Creixell,P., Schoof,E.M., Sinclair,J., Barrios-Rodiles,M., Gu,J.,
            Krizus,A., Williams,R., Olhovsky,M., Dennis,J.W., Wrana,J.L.,
            Linding,R., Jorgensen,C., Pawson,T. and Colwill,K.
  TITLE     Integrative analysis of kinase networks in TRAIL-induced apoptosis
            provides a source of potential targets for combination therapy
  JOURNAL   Sci Signal 8 (371), rs3 (2015)
   PUBMED   25852190
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4646)
  AUTHORS   Linford,A., Yoshimura,S., Nunes Bastos,R., Langemeyer,L.,
            Gerondopoulos,A., Rigden,D.J. and Barr,F.A.
  TITLE     Rab14 and its exchange factor FAM116 link endocytic recycling and
            adherens junction stability in migrating cells
  JOURNAL   Dev Cell 22 (5), 952-966 (2012)
   PUBMED   22595670
  REMARK    GeneRIF: FAM116 and Rab14 therefore define an endocytic recycling
            pathway needed for ADAM protease trafficking and regulation of
            cell-cell junctions.
REFERENCE   4  (bases 1 to 4646)
  AUTHORS   Marat,A.L., Dokainish,H. and McPherson,P.S.
  TITLE     DENN domain proteins: regulators of Rab GTPases
  JOURNAL   J Biol Chem 286 (16), 13791-13800 (2011)
   PUBMED   21330364
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040291.1, AK074156.1, AC114480.2 and AA605125.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152678.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040291.1, AK074156.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311128.10/ ENSP00000311401.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              BC040291.1         1-1087
            1088-2010           AK074156.1         1087-2009
            2011-4369           AC114480.2         62873-65231         c
            4370-4646           AA605125.1         22-298              c
FEATURES             Location/Qualifiers
     source          1..4646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..4646
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /note="DENN domain containing 6A"
                     /db_xref="GeneID:201627"
                     /db_xref="HGNC:HGNC:26635"
                     /db_xref="MIM:620561"
     exon            1..296
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1886
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /note="protein FAM116A; family with sequence similarity
                     116, member A; DENN domain-containing protein 6A;
                     DENN/MADD domain containing 6A"
                     /codon_start=1
                     /product="protein DENND6A"
                     /protein_id="NP_689891.1"
                     /db_xref="CCDS:CCDS33773.1"
                     /db_xref="GeneID:201627"
                     /db_xref="HGNC:HGNC:26635"
                     /db_xref="MIM:620561"
                     /translation="MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEE
                     DDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFP
                     DSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVR
                     DKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPV
                     PGKTLHLPIMGVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFC
                     PVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDS
                     EFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNL
                     KTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIP
                     LERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHF
                     LKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLL
                     QADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT"
     exon            297..335
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            336..378
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            379..491
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            492..572
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            573..678
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            679..758
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            759..821
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            822..877
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1000
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1096
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1191
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1257
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1322
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1412
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1466
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1576
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1679
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1754
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..4646
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4622..4627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /note="hexamer: ATTAAA"
     polyA_site      4646
                     /gene="DENND6A"
                     /gene_synonym="AFI1A; FAM116A"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcgctc tgcggcgcgg tccgctgtgg aggcggcgcg aacggtcagg gggcggccga
       61 tggctttgag gggccctgcg ggcttggggc ccggctctcg aaggccgttg gacgaagcgg
      121 tggcaggggc cgagggccgc gaggcgccgg cccttgtggc ggcgggaggc gcgccagagg
      181 acgatgaaga ggacgatggc cgtggccggg gcctgctgcg ctgggacagc ttctccgcct
      241 ggctgcactg cgtgtgtgtg gtgggcttcg acctggagct gggccaggcc gtggaggtaa
      301 tttatcctca gcattccaaa cttactgaca gagaaaaaac caatatttgc tatttgtctt
      361 ttccagattc aaattcaggt tgtcttggag atacccagtt ttgttttaga tttcgacagt
      421 cttctgggag gagggtgtcg ctgcattgtc tcctggatca atttgacaaa gatttaccag
      481 tttacttaaa gaaggatcct gcttattttt atggatatgt gtatttccga caagttcgag
      541 ataaaactct aaaaagaggc tactttcaga agtccttggt tttgatcagc aaactacctt
      601 atattcattt ttttcacact gtgctcaaac agatagcacc agagtatttt gaaaagaatg
      661 aaccttattt ggaagcagct tgtaatgatg ttgatcgatg gcctgcccca gtgccaggga
      721 aaacattaca cctgccaatc atgggggtgg taatgaaggt acggattccc acatgtcatg
      781 acaagcctgg gacaactcaa atagtgcagt taactcagca ggtggacaca aatatatctg
      841 ttattttacc tactgttcat gaggtggata ttttcaggtg tttctgccca gttttccttc
      901 atagtcagat gctctgggag ctggtgctgt tgggggagcc ccttgtggtt atggcgccat
      961 caccatcgga atcatcagag actgtattgg cacttgttaa ctgtatttct ccattaaagt
     1021 acttcagtga tttccgacct tatttcacta ttcatgatag tgaattcaaa gaatatacta
     1081 cccgtaccca agctccgccc tcagttatat taggagtaac caaccctttt tttgctaaga
     1141 cactccagca ctggccacac attattcgaa taggagacct taaacctaca ggtgaaattc
     1201 ctaagcaggt taaagtgaaa aaactgaaga atctaaagac tctggattcc aaacctggag
     1261 tttatacttc atataagcca tatttaaata gagatgaaga gatcataaaa caattacaga
     1321 agggtgtaca acagaaacgt ccttctgagg ctcaaagtgt tattcttcga cgctattttt
     1381 tggaactgac acaaagtttc atcattccat tagaaagata tgtggcaagc ttgatgcctt
     1441 tgcagaaaag tatttcccca tggaagagtc cacctcaatt aagacagttt cttccagaag
     1501 aatttatgaa aacacttgag aaaacaggac ctcagctaac ctctagaata aaaggcgatt
     1561 ggattggact ttaccggcat ttcctaaagt ctccaaattt tgatggctgg tttaagaccc
     1621 ggaggaagga aatgacccaa aaattggagg cactccatct agaagctctt tgtgaagagg
     1681 acttacttct ctggatccag aaacacacag aagtagaaac agtagacctt gtcttgaagc
     1741 tgaaaaataa gctgttgcag gctgatcgag agcacttacc tgtgaaacct gacactatgg
     1801 aaaagttacg gacacacata gatgccatta tcttagcatt gccagaggac ttgcaaggca
     1861 tactgctcaa aacgggcatg acatgatatt tgccaagatt ttccagccaa aaaggattat
     1921 gcatcatgaa gcatactgac atttcaacca gacgcacaaa ggagatctct cagtggcagc
     1981 ggagtggaaa attgccatga atgctagtta cagggtagaa agactgtatt gtataaacag
     2041 acctttttag tgcattactt tttaaagtgg atatctgtgg tggttccact ttaatactga
     2101 aacaccgaaa ggcatttcta tatttttaat catgttctaa agtgctctta tgagagactt
     2161 gtgggccatc agtattagtg atttcatact gcagtgctgg cattgcagat atttttttaa
     2221 attggtgctg ctttgcccaa tcatgttaaa actcaggggg atataaaaat aacattcaca
     2281 ctggctatct tcttaagaac agaaagactg aactgtccta tggttagaag gaattgatgc
     2341 ttatgtagtg ccttctgttg tcctacatgt ttcacagttc agctgctagt cttgaagctt
     2401 ttccttagct tcattatgat acgtaatttt ataaggtatt ctgttgagtg atcattgttt
     2461 aaaaaaaaag tttcttgcta cccattgtgt ttattaatag acatgatggg tttttttcag
     2521 ttgtcatata gattttcatt attttccctt ccattttcaa aatttaatgt taccagtttc
     2581 tccaaagaca agaaggcatc tagtattaat gatggaagag tttattttct cttacccttt
     2641 actaatttaa acattaggct gggtgtggtg gctcacgcct gtaatcctag cactttggga
     2701 ggccaaggtg gacaggtcac ttaaggtcga gagtccaaga ccagcctggc caacatggtg
     2761 aaaccccgtc tctagtaaaa atacaaaaat tagccaggca tggtggcacg cgcctgtaat
     2821 cccagctact tgggaggctg agatgtgaga atcacttgaa cctgggaggc ggaggttgca
     2881 gtgagctgag attacacccc tggactccag cttgggtgac acagtgagac tgtgtctcaa
     2941 caaaaataaa aaattaaata aatactaatt taaatattat taaatgttta aactaatgaa
     3001 cttggctgct tttcaaagac attttaatta taaatctcat aatcagctat ttttttaaac
     3061 tgaactattc ttatttcaaa ggcattcatg agttttttat gtgatactta tttgagtgat
     3121 gataagattg atttctggca ttatttgttt ggtagcgttt tatttttccc aacattaatg
     3181 tttcttaaaa cacttttcct actattgttt gacatgggaa ctttcgcctg agtcactgtc
     3241 atggttagct tttgttgttg ttgtttttgt ttctgttttg tttaaacaat actaccttgc
     3301 caaaaataga agaatgtgat ttggtagagt agggttgttt ggtttgtgtt tgaataagag
     3361 tatcctacag aagccacttt tttttttttt gagatggagt tttgctcttg ttgcccaggc
     3421 tggagtgcaa tggcgcaatc tcggctgact gcaacctcca cctcccgggt gcaagtgatt
     3481 gtcctgcctc agcctcctga gtagctggga ttacaggtat gtgccaccac gcctggctaa
     3541 ttttgtattt ttagtagaga tggggtttct ccatgttggt caggctggtc tcaaactccc
     3601 gacctcaggt gatccgcccg cctcggcctc ccaaagtgct gggattacag gtgtgagcca
     3661 ccgcacctgg ccagaagcca ctaactaaaa taggcacaca tgacacagca tgtggttaat
     3721 agctgtgtct tgaattatcc tctaaataac caaatttagt tgtatgtatt tgtaaaggat
     3781 atggcttcag aagctatctt ttgttctctg tcgatataac tcttaagggc attcctgacc
     3841 caagaaagac tccttgcgtt tgtaactgtg gtctaatacc caaatgtgcc ctgttcttat
     3901 ggatacagtc tcttgaagca tacctcaaag tcatagagag aatatggcat ttgaaagaaa
     3961 tcgtttgcct tggatcatat gagttatttt gtgaaacaac agctgacttt tcagaaaagg
     4021 agcaactact tttatatgct aaaagtattt cataactttc tgggaaacct tatttaggta
     4081 taaatggtca tcttattatt tttcaaaaag gtatatttta ataattgtac aatttatata
     4141 cagtttgtga ccagaatttg taagttgttg gtgtcatatc aaggatcttt taaattatgc
     4201 cactacagga tgtatcattt caagtctatt ttgcacagct aaacagtagc aaaagatgcc
     4261 aattagcatg ataatggtgt cttcattttt actgtattta actgaaacct aacacatgtt
     4321 gaaaaccata tcatacctag tttatctctt aatttcaaac tatgtacttg taaaaatgat
     4381 gtaaatttgc actgggaacc tgggaaagag tgactgataa tttttggtgc gtgattttta
     4441 gatttgtctt ttttttttta agaagaattt gttactatgt aaaccctgac attaaatgtt
     4501 ttatctctac cagcatcagg aggaatcact gctttaaggg tattatgtaa tgcctagtgc
     4561 cttctattta cagtgaaaaa gaggttttgt gaaggcattt atggtcatta ccaaaaacta
     4621 aattaaaggc cttggatttt aaagca
//
