LOCUS       XM_047428430            8969 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DENN domain containing 5B (DENND5B),
            transcript variant X19, mRNA.
ACCESSION   XM_047428430
VERSION     XM_047428430.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..8969
                     /gene="DENND5B"
                     /note="DENN domain containing 5B; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 27 ESTs, 892 long SRA reads, 1 Protein, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 30 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
     CDS             305..3592
                     /gene="DENND5B"
                     /codon_start=1
                     /product="DENN domain-containing protein 5B isoform X18"
                     /protein_id="XP_047284386.1"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
                     /translation="MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGE
                     NFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSF
                     IITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLAS
                     SLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQ
                     QPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFE
                     LLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASL
                     LHFLDAPVPYLMGLQSKEGTDRSKLELPQEASFLSDQPEPYLPFLSRFIETQMFATFI
                     DNKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLM
                     KMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERL
                     RQHSEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRM
                     KTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALW
                     SHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKT
                     DVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSL
                     NAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNL
                     LEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGID
                     DGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQ
                     EGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNVFI
                     WDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILV
                     CLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDFTIVLEGS
                     LIKGVDV"
ORIGIN      
        1 agacgcggcg gctctcagct cgcgagcgca gctgcggctg cgagggcctc tcaggccgac
       61 actccccccg cgcccctccc ccacccggcc gggctccgga cccgccgcgc gcgagcccgc
      121 ggccgcttcc cccgcgccga gcgaggaggc aggctgcggc ggcgagaggc ggctgcgcgg
      181 ccatgggcgc gccagtgtcg ccctagggcg ggcgcacaga ccacagccgg agcggtggtg
      241 gcagcctccg cagaaagcct tcccgggcgg cggcggcggc ggcccctgga gcagcgcggc
      301 cgggatgagc gggagctgcg cggcgcccgg cccgggctcg ggctcctccc cggccgcctg
      361 ccgcttcgcg cactacttcg tgctgtgcgg gatcgacgcg gacagcgggc tggagcctga
      421 cgagctggcg ggcgaaaatt ttgaccagag tcctttgaga agaacattca aatccaaagt
      481 tctcgcccac tatcctcaga atatagaatg gaaccctttt gatcaagatg cggtgaacat
      541 gttgtgcatg cctaaagggc tatctttcag gacacaaacg gacaataaag acccccagtt
      601 tcactcattt ataattacca gggaagatgg ttctcgcacc tatggttttg ttctcacttt
      661 ttatgaagaa gttacaagta agcaaatctg cacagcaatg cagacacttt accagatgca
      721 caacgctgag cattacagca gtgtgtatgc ttcatcttcc tgcagtatgg actcattggc
      781 aagtagtctt gatgaaggag atacaacttc ccttttgaaa ctccagcgat acaactccta
      841 tgatattagc agagacaccc tgtatgtttc aaaaagtata tgcttgatca caccgttacc
      901 attcatgcag gcctgcaaga aattccttat ccagctttac aaggctgtta cctcacagca
      961 gccaccaccc ttgccacttg aaagctatat ccacaatatt ctttatgaag taccccttcc
     1021 acctccaggg aggtcactga aattttatgg tgtttatgaa cctgtcatct gccagaggcc
     1081 tgggcccagt gaactccccc tctctgatta cccccttcgg gaggcatttg agctcctggg
     1141 attagagaac ctggtgcagg tgtttacctg tgttctttta gagatgcaaa tccttctcta
     1201 ctcacaagat tatcaacgcc tgatgactgt ggcagaaggc atcaccacac ttttgttccc
     1261 atttcaatgg caacatgttt atgtgcccat tctacctgct tctctgctac attttcttga
     1321 tgctcctgtc ccttatctga tgggccttca gtcaaaagaa ggaactgacc gttctaaact
     1381 agaacttcct caagaggctt cctttctgtc tgaccagcct gagccttacc tgccatttct
     1441 ttcacgcttc attgaaacac agatgtttgc cacctttatt gataataaaa ttatgtctca
     1501 gtgggaagag aaagatcctt tgcttcgggt ctttgacact cggattgata agataaggct
     1561 gtataatgta agggcaccca ccttgcggac atctatatat cagaaatgca gcactttaaa
     1621 agaagcagcc caatcaattg agcagagact gatgaaaatg gatcacactg caatccaccc
     1681 acatctactt gatatgaaaa ttggtcaagg caaatatgag caggggttct ttccaaagtt
     1741 acagtccgat gtcttggcaa caggaccaac cagtaacaat cgctgggtaa gtcggagtgc
     1801 cactgcacag cgcaggaaag aacgccttcg ccagcattct gagcatgttg ggctggacaa
     1861 cgacttgagg gagaaatata tgcaagaggc acgaagttta ggaaaaaacc tgaggcaacc
     1921 caaactgtca gacctctctc ctgcagttat tgcacagacc aactgtaaat tcgtagaagg
     1981 cttattaaaa gaatgtagaa tgaagacaaa gcgcatgttg gtggagaaga tgggacatga
     2041 agcggtggaa cttggccatg gagaagcaaa catcaccggc ctggaggaga acaccttgat
     2101 cgccagcctt tgtgacctgc tggagaggat atggagccat ggcttgcagg tcaagcaggg
     2161 gaagtcggct ttgtggtcac atttaattca atttcaggac agagaagaga aacaagagca
     2221 ccttgcagaa tcaccagttg ccctcggacc agaaagaaga aaatctgact caggagttat
     2281 gttgccaacg ctcagggtct ctcttattca ggacatgagg catattcaaa acatgagtga
     2341 gatcaagact gatgttggac gagctcgggc gtggataaga ctgtctctag aaaagaagct
     2401 cttgtcccag catcttaagc agttgctttc taaccaacca ctcaccaaga agctttataa
     2461 gcgatatgct tttctacgtt gcgaagaaga aagagagcag tttctttacc accttctttc
     2521 tctcaatgct gtggactatt tctgcttcac cagtgtgttc accactatca tgattccgta
     2581 taggtcagtg atcatcccaa tcaaaaagct gagcaatgca ataatcacat caaacccttg
     2641 gatctgtgta tcaggagagc tgggagacac aggagtaatg cagattccca aaaacctcct
     2701 cgaaatgacc tttgagtgcc agaacttggg gaagctgacc actgttcaga ttggtcacga
     2761 taactcagga ctgttagcca aatggctagt ggattgtgtc atggtcagaa atgaaatcac
     2821 aggacataca tacagattcc catgtgggcg gtggctgggg aaaggcattg atgatgggag
     2881 cctggagaga attcttattg gagagttgat gacatcagca tcagatgaag atctagtaaa
     2941 gcagtgtcgg actccacccc agcagaagtc acccaccacg gctaggagat tgagcatcac
     3001 ttcactgaca ggaaaaaaca acaaacccaa tgctgggcag atacaagaag gaattggaga
     3061 agctgtgaac aatattgtga aacattttca taaacctgaa aaagagagag gaagcctcac
     3121 cgtgttgctg tgtggagaaa atggcctggt tgcagccctt gagcaagttt tccaccatgg
     3181 gttcaaatct gcccgcatct ttcacaagaa tgtcttcatc tgggacttca tagagaaagt
     3241 ggttgcttat tttgaaacaa ctgaccagat tctagataat gaagatgatg tccttattca
     3301 gaaatcatcc tgcaaaacct tctgccacta cgtaaatgct attaatactg cacccaggaa
     3361 cattgggaag gatggcaaat tccagatttt agtttgcctt ggaacaaggg atcgcctgct
     3421 cccacagtgg attccattgt tagctgagtg tcctgccatc actcgaatgt atgaagagag
     3481 cgctctcctg cgagaccgca tgactgtcaa ctcccttatc cgaattctgc agaccattca
     3541 ggacttcacc atagtcctag aaggatcact catcaaagga gtggatgtgt aacccaactg
     3601 gctagaaact ctcagtccaa accttgctcc ttccccaact aggggaccga tttggacttg
     3661 tctgacagta gtgagtcact gcaggggcag ccaaacatat gccccatttg gaacaatcct
     3721 cactctacag acaaggcaaa atgttgtatt gtagttcatt tgaacctgga atttagtata
     3781 aaatagagta ttttcatgtg ttagatgtgt gtaaatatgc tatcttcttt aagaaattat
     3841 attactctaa taagatgctt ttcttagatt gaatattcct gtgacttaaa ataagtagct
     3901 taaaaatgtt gggggttggg gggaagagtg gtgctagcca ggaagaagcc agtaaacatg
     3961 taaatatagt gcaacccagt cgggcttttt tttttctcca ggtatcacaa agaaacccag
     4021 aatgcattgt tatgtagtag ccatccatct tggagtctga tcctttgtat tgtggatgca
     4081 cacagcttta cctactgtac tggtagtctt cacttctatc ttttaagtta caaactgttt
     4141 tatatatttg aatcgctagt cacttttcca gtcttttgga aaaaaatttc agtccgcaca
     4201 agatgatata attggagtat tttaaacact agaccccagg agcttggctg aactggaaag
     4261 agaacataca aagctctgag aaatgtgttc aattgtggga ttataacttc tttacacttc
     4321 ggaaagatta gcctagacta acttcattct tggcattttt attcttgtta tttgaggtac
     4381 tttgggaaga tgtgaatttc agtgttagat tcatagtgat aagaactgca aacagcaatt
     4441 tgattctgta cttttaattt ggccatctaa actgtgcagt ggtctacctc ttaaggataa
     4501 ccatgagccc tgtctttgtt agggtctaat cacccacctc tccagggccc atcccccctc
     4561 gggaaatgga aggaatgtct aaggaggagg agggctgtgt gtggcttgga atgtttttgt
     4621 gaaagcattt gttgaccatg ataatgcaaa taacagaagg agagagagaa tgaacccttt
     4681 ctgggtgttt cagggcaagc tttacgttcc tttgtaggaa ggggagtaat aatgtaaaac
     4741 aactgaccca gagaagctaa aagccactgg cagcacaggc tgacaaaatg gaagcaaagc
     4801 aagaggtggc aacaattttg aaagaccaaa agttgtgagt aactttccag tttgatagtt
     4861 tataaagaag ttaagtaaat gtagtattgg ctagttactg taagtcctca tcttctggta
     4921 ggtcctgtaa ctctaattag gcatttgtac atttttagca gcaaaattgc ctcagcagag
     4981 ctcccagttt tattcccagt tgtggctgaa aagcaaagcc atggcatcag tatccttgtg
     5041 caatcggagg ttgctgggct ttcaccacct gtgttgttaa ccttatttcc tggaggaaga
     5101 aacagatgaa acaagtgcct aactcccttt atcaaacaca gccaaggaca gcctctttta
     5161 acatgtgact tcatacttga ggaaaaggag agttgacagc tgtatttaaa aacccatgga
     5221 gccgggtgcg gtggctcacg cctatgatcc cagcactttg ggaggccgag gcaggcggat
     5281 cacaaggtca ggagattgag accctcctgg ctaacaccgt gaaaccccgt ctctactaaa
     5341 aatacaaaaa attagccggg cgtggtggcg ggtgcctgta caggaggctg aggcaggaga
     5401 atggcgtgaa cccgcgaggc ggagcttgca gtaagctgag atcgcgccac tgccctccag
     5461 cctgggcaac agagcaagac tccatctcaa aaaataaata gataaaaata aaaacccatg
     5521 gaaatggttt aagaaaatgg ttctgggtac accagaaatt tgtttgcctg aagctaaagt
     5581 gtgtctacaa tggtacagct cttccaggga catgggaagt ttatcgtggg agatatccag
     5641 aacctgtttt acactgggct cctactgtgt ttggtgatca gaaactatag aggggtccaa
     5701 cccaggattt catgtttgta tcttcataag gccatgctcc tgacaggtct aggcaacctg
     5761 ggggatgact taggttaatg tgctaggatt gacacacctc atccagcctt cttactttgt
     5821 ggatgggaac acttaaggaa tagagagatt aaatcttaca cttaccccac agctggttac
     5881 tgacaacaca agctctagaa ttcatgtttg tttgtttgtt ttatttcacc aggctgcatg
     5941 agactgacct tccggcattc ttactaatag tctttctatt atactattgg atctttattc
     6001 atccacctat acaagtagga aataaggatg aatattcatt tagaagaatt aatattcata
     6061 ttaacacatt gctctcagat tattgggaat taacatcttg taaaaactgg gagcaggcca
     6121 ggtacggtgg ctaacgcctg taatcctgac actttgggag tctgaggcgg gtggttcatc
     6181 tgaggtcagt cgggagttca agaccagact ggccaacatg gtgaaacccc gtctctacta
     6241 aaaaaaaaaa atagacaaaa attagcgggg gggtggtggc agggcctgta attccagcta
     6301 ctcaggaggc tgaagcagga gaatcgttta aacacaggag gtggaggttg cagtgagccg
     6361 agattgtgcc actgcactcc aacctgggtg acaagagcga gactccgtct caaaaaaaaa
     6421 aaaagaaaaa aactgcagcc aaagttggat ttgcggccta tgaataaaac cattacttta
     6481 aaaagtaata cccccaaaaa agttacacct gaagtttcat cttcatgcct ttgtgtaata
     6541 ttactataat ggtgaaatga tgatttaaaa aaaacacatc agaactgaca catcctcttg
     6601 gatgatgggt ccttcagtca ccttgtgagc ccatgtactt attccgttga tacagcctgt
     6661 gctataaaca tgtggggccc tccttgtgtg agctgcttga atggccagta cccccattct
     6721 tttgaatatt cccaatggca gtcaatcttg gcctttaaga ataaatttaa atatttggaa
     6781 atagtcctta ggatccaagt ttgatcaatg aaaaggatgc ttaagctgag tttggggtca
     6841 cataagaagt gcagttataa agaaataaga catgttgggc atggcagtac acacctgtag
     6901 tcccagctgc ttgggaagcc aaggcaggag gatcacttca acccaggagt ttgagtccag
     6961 cctgggtaac atagggaaac cccatctcaa aaaaacaaaa caaaggactt agtttttatg
     7021 tggctcataa gtgtctctaa gttataccaa aagtttgagc acaacagtag tagcagaatg
     7081 cttagaataa atgcttgact tttaagctga cttttggaag gaccataccc acatagaggc
     7141 atcttttctg ctgtggtaat tttttaaatt aatacattgc tttaggatta catctcaaag
     7201 taaataaaaa aatcaatatt taatttgttt ttttcctgca aataaattaa atgctgggac
     7261 cataatgatt atttttgcat agtaatagct ggtgaagaag ttgttttaaa attaaattgc
     7321 caaaagtatt acctcttgaa aaatttattt tcccaaagtt tttcatatgt catgaaaccc
     7381 ctaatcttga cctttatgac acagtggcat tacactgatg ttggaagcat gtgtgagatc
     7441 tgtgccctgg tcgggagtca tatgccttaa aaatgactgc gagtcagtgt gaagtagtat
     7501 aaagtggagt cctacgtggg aaaaagcagg ctactgagga caaaaacctc ccaaccctcc
     7561 ccaccttgtt ttccactggg aatgagaatt tgatatgaga aacttcaacc ttgcagaagt
     7621 gtggatttcc ctctgaaatt taaatgtttc acacattttt gtaccttttg taaccttgtg
     7681 gtatttactt tcacatggct ttttaaaaaa ttattttaat gaacttctat cacactatat
     7741 gaatgatatg ggggaaatac tgaactgctc atatttcctt ttttggcaat aaagcactgt
     7801 tatatgtaaa tgtaagtgaa aaagaggttc aagactatac aacagcttat gtgtagtata
     7861 tgttgacatc cctaaggtat tttgaaacat gaggtgacag acaaggacct caaatttcca
     7921 gggaaatatt tatttcacaa cattaggagt gtagctcttc ataatgaaat atcttctttc
     7981 tgctaaagat tacaattttt catttaggga actgtgaata ttttctgtga ggtttacaga
     8041 aactagtgta tccttttcac tatgttgaaa agacaatctg aactttagct atttatattt
     8101 cagtattaac acaccttcac tgattgagag tcttgagccc ttctctactt ttataaagtg
     8161 aatcctattt ccaagtcatc catgtctttt gaagtctgtt tcttatataa gtatttatta
     8221 ctttactgtt tagcataaat aggagacaga aaaggataat aaactactag gtcctttatt
     8281 cctattaaaa taaatttata aatcccttga atcaactgaa ttctaagctt tttgaagagg
     8341 ttgctgatgt agtgtgatca aaagaatcta aggagaacct cctctccaaa atctgattgg
     8401 agctgttcac cctctcaagg acaagataaa gattgacttc agagatatat cacatcaagc
     8461 tagaggaaaa aaaaaaaacc tcaaataaaa tttttcctca ttcgaaggga tccagggtat
     8521 ccttgggtta tgtaggaggg aatcatattt gttctaattt acctgaatgt acttgtgtgt
     8581 gaatccaatc ttgattctaa acaccaaatc ttgtcaacag tagagaagta tagtaaggag
     8641 ttcctgttgt caatcaaatg agggtgtgaa acatttagaa tgctctgtgt tacacttgaa
     8701 ccatgtataa atgtaacctg tgtatctttt ttttaattag cttttctgaa tttaaattat
     8761 attgtttttc tttgtattgt tagcaaaatg catcagaact ggattttttt tctcatctga
     8821 acataatata aaatttgaaa gagtattgtg atattaagca ctttaacata catatcagac
     8881 aaactgacgt gggtttttca ggtttgggag tacatttaaa tatgactttt catgctttgt
     8941 tctttacaaa taaaactgtg ggattgata
//
