LOCUS       XM_047428415            9512 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens DENN domain containing 5B (DENND5B),
            transcript variant X1, mRNA.
ACCESSION   XM_047428415
VERSION     XM_047428415.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..9512
                     /gene="DENND5B"
                     /note="DENN domain containing 5B; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 20 ESTs, 904 long SRA reads, 1 Protein, and 94%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
     CDS             95..4135
                     /gene="DENND5B"
                     /codon_start=1
                     /product="DENN domain-containing protein 5B isoform X1"
                     /protein_id="XP_047284371.1"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
                     /translation="MGTHHHAQLIFVFLVEMRFHHVDQAGLELLTSSNSPASASRSAE
                     ITVVSQHAQPGFLYQWLEADRHGKSQGAANTTSGENFDQSPLRRTFKSKVLAHYPQNI
                     EWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTS
                     KQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISR
                     DTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPP
                     GRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLY
                     SQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRS
                     KLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSE
                     STSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDL
                     SASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESW
                     LTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVF
                     DTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQ
                     GKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREPSG
                     ELLVCQNSMAFWEWDQGPPPPARLPKKSFSECCLKYMQEARSLGKNLRQPKLSDLSPA
                     VIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDL
                     LERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTL
                     RVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRY
                     AFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPW
                     ICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNE
                     ITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARR
                     LSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALE
                     QVFHHGFKSARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVN
                     AINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVN
                     SLIRILQTIQDFTIVLEGSLIKGVDV"
ORIGIN      
        1 gctgaagtgc agtggcatga tctcagatca ctacaacctc cacctcttgg gttccagtaa
       61 ttctcctgcc tggccttcct gagtaactgg gattatgggc acccaccacc atgcccagct
      121 aatttttgta tttttagtag agatgaggtt tcaccatgtt gatcaggctg gtctcgaact
      181 cctgacctca agcaattcac ctgcctcggc ctcccgaagt gctgagatta cagttgtgag
      241 ccaacatgcc cagccaggat ttttgtacca atggctagaa gcagatcgtc atggcaagag
      301 ccaaggtgct gcaaatacga cttcaggcga aaattttgac cagagtcctt tgagaagaac
      361 attcaaatcc aaagttctcg cccactatcc tcagaatata gaatggaacc cttttgatca
      421 agatgcggtg aacatgttgt gcatgcctaa agggctatct ttcaggacac aaacggacaa
      481 taaagacccc cagtttcact catttataat taccagggaa gatggttctc gcacctatgg
      541 ttttgttctc actttttatg aagaagttac aagtaagcaa atctgcacag caatgcagac
      601 actttaccag atgcacaacg ctgagcatta cagcagtgtg tatgcttcat cttcctgcag
      661 tatggactca ttggcaagta gtcttgatga aggagataca acttcccttt tgaaactcca
      721 gcgatacaac tcctatgata ttagcagaga caccctgtat gtttcaaaaa gtatatgctt
      781 gatcacaccg ttaccattca tgcaggcctg caagaaattc cttatccagc tttacaaggc
      841 tgttacctca cagcagccac cacccttgcc acttgaaagc tatatccaca atattcttta
      901 tgaagtaccc cttccacctc cagggaggtc actgaaattt tatggtgttt atgaacctgt
      961 catctgccag aggcctgggc ccagtgaact ccccctctct gattaccccc ttcgggaggc
     1021 atttgagctc ctgggattag agaacctggt gcaggtgttt acctgtgttc ttttagagat
     1081 gcaaatcctt ctctactcac aagattatca acgcctgatg actgtggcag aaggcatcac
     1141 cacacttttg ttcccatttc aatggcaaca tgtttatgtg cccattctac ctgcttctct
     1201 gctacatttt cttgatgctc ctgtccctta tctgatgggc cttcagtcaa aagaaggaac
     1261 tgaccgttct aaactagaac ttcctcaaga ggctaatttg tgttttgtgg acattgacaa
     1321 ccattttatt gagttgcctg aagaatttcc acagttcccc aataaagtgg attttatcca
     1381 agaactctct gaggttcttg ttcaatttgg gatccctcct gagggcagcc tacattgcag
     1441 tgagagtacc agcaaactga agaatatggt tctgaaagac ttggtcaatg acaaaaagaa
     1501 cggcaatgtc tgtactaata acatcagcat gtatgagtta ctgaagggca atgaaaccat
     1561 agcccgcttg caggctctgg ccaagcgtac tggtgtggct gtggaaaaaa tggacctctc
     1621 tgcttctctg ggtgaaaaag acaaggattt aaaactgcat tgtgaagagg cagaactaag
     1681 ggactaccag ctcaatgtac agctccgaga ggtctttgct aaccgtttta cacagatgtt
     1741 tgcagattac gaagcatttg tcattcagac tgcccaggac atggaatcct ggctgaccaa
     1801 ccgggaacag atgcagaact ttgacaaagc ttcctttctg tctgaccagc ctgagcctta
     1861 cctgccattt ctttcacgct tcattgaaac acagatgttt gccaccttta ttgataataa
     1921 aattatgtct cagtgggaag agaaagatcc tttgcttcgg gtctttgaca ctcggattga
     1981 taagataagg ctgtataatg taagggcacc caccttgcgg acatctatat atcagaaatg
     2041 cagcacttta aaagaagcag cccaatcaat tgagcagaga ctgatgaaaa tggatcacac
     2101 tgcaatccac ccacatctac ttgatatgaa aattggtcaa ggcaaatatg agcaggggtt
     2161 ctttccaaag ttacagtccg atgtcttggc aacaggacca accagtaaca atcgctgggt
     2221 aagtcggagt gccactgcac agcgcaggaa agaacgcctt cgccagcatt ctgagcatgt
     2281 tgggctggac aacgacttga gggagccttc cggggaactt ttggtctgtc agaactccat
     2341 ggcattctgg gagtgggacc agggtccacc tcctcctgca cgacttccta aaaaatcctt
     2401 ctctgagtgc tgcctgaaat atatgcaaga ggcacgaagt ttaggaaaaa acctgaggca
     2461 acccaaactg tcagacctct ctcctgcagt tattgcacag accaactgta aattcgtaga
     2521 aggcttatta aaagaatgta gaatgaagac aaagcgcatg ttggtggaga agatgggaca
     2581 tgaagcggtg gaacttggcc atggagaagc aaacatcacc ggcctggagg agaacacctt
     2641 gatcgccagc ctttgtgacc tgctggagag gatatggagc catggcttgc aggtcaagca
     2701 ggggaagtcg gctttgtggt cacatttaat tcaatttcag gacagagaag agaaacaaga
     2761 gcaccttgca gaatcaccag ttgccctcgg accagaaaga agaaaatctg actcaggagt
     2821 tatgttgcca acgctcaggg tctctcttat tcaggacatg aggcatattc aaaacatgag
     2881 tgagatcaag actgatgttg gacgagctcg ggcgtggata agactgtctc tagaaaagaa
     2941 gctcttgtcc cagcatctta agcagttgct ttctaaccaa ccactcacca agaagcttta
     3001 taagcgatat gcttttctac gttgcgaaga agaaagagag cagtttcttt accaccttct
     3061 ttctctcaat gctgtggact atttctgctt caccagtgtg ttcaccacta tcatgattcc
     3121 gtataggtca gtgatcatcc caatcaaaaa gctgagcaat gcaataatca catcaaaccc
     3181 ttggatctgt gtatcaggag agctgggaga cacaggagta atgcagattc ccaaaaacct
     3241 cctcgaaatg acctttgagt gccagaactt ggggaagctg accactgttc agattggtca
     3301 cgataactca ggactgttag ccaaatggct agtggattgt gtcatggtca gaaatgaaat
     3361 cacaggacat acatacagat tcccatgtgg gcggtggctg gggaaaggca ttgatgatgg
     3421 gagcctggag agaattctta ttggagagtt gatgacatca gcatcagatg aagatctagt
     3481 aaagcagtgt cggactccac cccagcagaa gtcacccacc acggctagga gattgagcat
     3541 cacttcactg acaggaaaaa acaacaaacc caatgctggg cagatacaag aaggaattgg
     3601 agaagctgtg aacaatattg tgaaacattt tcataaacct gaaaaagaga gaggaagcct
     3661 caccgtgttg ctgtgtggag aaaatggcct ggttgcagcc cttgagcaag ttttccacca
     3721 tgggttcaaa tctgcccgca tctttcacaa gaatgtcttc atctgggact tcatagagaa
     3781 agtggttgct tattttgaaa caactgacca gattctagat aatgaagatg atgtccttat
     3841 tcagaaatca tcctgcaaaa ccttctgcca ctacgtaaat gctattaata ctgcacccag
     3901 gaacattggg aaggatggca aattccagat tttagtttgc cttggaacaa gggatcgcct
     3961 gctcccacag tggattccat tgttagctga gtgtcctgcc atcactcgaa tgtatgaaga
     4021 gagcgctctc ctgcgagacc gcatgactgt caactccctt atccgaattc tgcagaccat
     4081 tcaggacttc accatagtcc tagaaggatc actcatcaaa ggagtggatg tgtaacccaa
     4141 ctggctagaa actctcagtc caaaccttgc tccttcccca actaggggac cgatttggac
     4201 ttgtctgaca gtagtgagtc actgcagggg cagccaaaca tatgccccat ttggaacaat
     4261 cctcactcta cagacaaggc aaaatgttgt attgtagttc atttgaacct ggaatttagt
     4321 ataaaataga gtattttcat gtgttagatg tgtgtaaata tgctatcttc tttaagaaat
     4381 tatattactc taataagatg cttttcttag attgaatatt cctgtgactt aaaataagta
     4441 gcttaaaaat gttgggggtt ggggggaaga gtggtgctag ccaggaagaa gccagtaaac
     4501 atgtaaatat agtgcaaccc agtcgggctt ttttttttct ccaggtatca caaagaaacc
     4561 cagaatgcat tgttatgtag tagccatcca tcttggagtc tgatcctttg tattgtggat
     4621 gcacacagct ttacctactg tactggtagt cttcacttct atcttttaag ttacaaactg
     4681 ttttatatat ttgaatcgct agtcactttt ccagtctttt ggaaaaaaat ttcagtccgc
     4741 acaagatgat ataattggag tattttaaac actagacccc aggagcttgg ctgaactgga
     4801 aagagaacat acaaagctct gagaaatgtg ttcaattgtg ggattataac ttctttacac
     4861 ttcggaaaga ttagcctaga ctaacttcat tcttggcatt tttattcttg ttatttgagg
     4921 tactttggga agatgtgaat ttcagtgtta gattcatagt gataagaact gcaaacagca
     4981 atttgattct gtacttttaa tttggccatc taaactgtgc agtggtctac ctcttaagga
     5041 taaccatgag ccctgtcttt gttagggtct aatcacccac ctctccaggg cccatccccc
     5101 ctcgggaaat ggaaggaatg tctaaggagg aggagggctg tgtgtggctt ggaatgtttt
     5161 tgtgaaagca tttgttgacc atgataatgc aaataacaga aggagagaga gaatgaaccc
     5221 tttctgggtg tttcagggca agctttacgt tcctttgtag gaaggggagt aataatgtaa
     5281 aacaactgac ccagagaagc taaaagccac tggcagcaca ggctgacaaa atggaagcaa
     5341 agcaagaggt ggcaacaatt ttgaaagacc aaaagttgtg agtaactttc cagtttgata
     5401 gtttataaag aagttaagta aatgtagtat tggctagtta ctgtaagtcc tcatcttctg
     5461 gtaggtcctg taactctaat taggcatttg tacattttta gcagcaaaat tgcctcagca
     5521 gagctcccag ttttattccc agttgtggct gaaaagcaaa gccatggcat cagtatcctt
     5581 gtgcaatcgg aggttgctgg gctttcacca cctgtgttgt taaccttatt tcctggagga
     5641 agaaacagat gaaacaagtg cctaactccc tttatcaaac acagccaagg acagcctctt
     5701 ttaacatgtg acttcatact tgaggaaaag gagagttgac agctgtattt aaaaacccat
     5761 ggagccgggt gcggtggctc acgcctatga tcccagcact ttgggaggcc gaggcaggcg
     5821 gatcacaagg tcaggagatt gagaccctcc tggctaacac cgtgaaaccc cgtctctact
     5881 aaaaatacaa aaaattagcc gggcgtggtg gcgggtgcct gtacaggagg ctgaggcagg
     5941 agaatggcgt gaacccgcga ggcggagctt gcagtaagct gagatcgcgc cactgccctc
     6001 cagcctgggc aacagagcaa gactccatct caaaaaataa atagataaaa ataaaaaccc
     6061 atggaaatgg tttaagaaaa tggttctggg tacaccagaa atttgtttgc ctgaagctaa
     6121 agtgtgtcta caatggtaca gctcttccag ggacatggga agtttatcgt gggagatatc
     6181 cagaacctgt tttacactgg gctcctactg tgtttggtga tcagaaacta tagaggggtc
     6241 caacccagga tttcatgttt gtatcttcat aaggccatgc tcctgacagg tctaggcaac
     6301 ctgggggatg acttaggtta atgtgctagg attgacacac ctcatccagc cttcttactt
     6361 tgtggatggg aacacttaag gaatagagag attaaatctt acacttaccc cacagctggt
     6421 tactgacaac acaagctcta gaattcatgt ttgtttgttt gttttatttc accaggctgc
     6481 atgagactga ccttccggca ttcttactaa tagtctttct attatactat tggatcttta
     6541 ttcatccacc tatacaagta ggaaataagg atgaatattc atttagaaga attaatattc
     6601 atattaacac attgctctca gattattggg aattaacatc ttgtaaaaac tgggagcagg
     6661 ccaggtacgg tggctaacgc ctgtaatcct gacactttgg gagtctgagg cgggtggttc
     6721 atctgaggtc agtcgggagt tcaagaccag actggccaac atggtgaaac cccgtctcta
     6781 ctaaaaaaaa aaaatagaca aaaattagcg ggggggtggt ggcagggcct gtaattccag
     6841 ctactcagga ggctgaagca ggagaatcgt ttaaacacag gaggtggagg ttgcagtgag
     6901 ccgagattgt gccactgcac tccaacctgg gtgacaagag cgagactccg tctcaaaaaa
     6961 aaaaaaagaa aaaaactgca gccaaagttg gatttgcggc ctatgaataa aaccattact
     7021 ttaaaaagta atacccccaa aaaagttaca cctgaagttt catcttcatg cctttgtgta
     7081 atattactat aatggtgaaa tgatgattta aaaaaaacac atcagaactg acacatcctc
     7141 ttggatgatg ggtccttcag tcaccttgtg agcccatgta cttattccgt tgatacagcc
     7201 tgtgctataa acatgtgggg ccctccttgt gtgagctgct tgaatggcca gtacccccat
     7261 tcttttgaat attcccaatg gcagtcaatc ttggccttta agaataaatt taaatatttg
     7321 gaaatagtcc ttaggatcca agtttgatca atgaaaagga tgcttaagct gagtttgggg
     7381 tcacataaga agtgcagtta taaagaaata agacatgttg ggcatggcag tacacacctg
     7441 tagtcccagc tgcttgggaa gccaaggcag gaggatcact tcaacccagg agtttgagtc
     7501 cagcctgggt aacataggga aaccccatct caaaaaaaca aaacaaagga cttagttttt
     7561 atgtggctca taagtgtctc taagttatac caaaagtttg agcacaacag tagtagcaga
     7621 atgcttagaa taaatgcttg acttttaagc tgacttttgg aaggaccata cccacataga
     7681 ggcatctttt ctgctgtggt aattttttaa attaatacat tgctttagga ttacatctca
     7741 aagtaaataa aaaaatcaat atttaatttg tttttttcct gcaaataaat taaatgctgg
     7801 gaccataatg attatttttg catagtaata gctggtgaag aagttgtttt aaaattaaat
     7861 tgccaaaagt attacctctt gaaaaattta ttttcccaaa gtttttcata tgtcatgaaa
     7921 cccctaatct tgacctttat gacacagtgg cattacactg atgttggaag catgtgtgag
     7981 atctgtgccc tggtcgggag tcatatgcct taaaaatgac tgcgagtcag tgtgaagtag
     8041 tataaagtgg agtcctacgt gggaaaaagc aggctactga ggacaaaaac ctcccaaccc
     8101 tccccacctt gttttccact gggaatgaga atttgatatg agaaacttca accttgcaga
     8161 agtgtggatt tccctctgaa atttaaatgt ttcacacatt tttgtacctt ttgtaacctt
     8221 gtggtattta ctttcacatg gctttttaaa aaattatttt aatgaacttc tatcacacta
     8281 tatgaatgat atgggggaaa tactgaactg ctcatatttc cttttttggc aataaagcac
     8341 tgttatatgt aaatgtaagt gaaaaagagg ttcaagacta tacaacagct tatgtgtagt
     8401 atatgttgac atccctaagg tattttgaaa catgaggtga cagacaagga cctcaaattt
     8461 ccagggaaat atttatttca caacattagg agtgtagctc ttcataatga aatatcttct
     8521 ttctgctaaa gattacaatt tttcatttag ggaactgtga atattttctg tgaggtttac
     8581 agaaactagt gtatcctttt cactatgttg aaaagacaat ctgaacttta gctatttata
     8641 tttcagtatt aacacacctt cactgattga gagtcttgag cccttctcta cttttataaa
     8701 gtgaatccta tttccaagtc atccatgtct tttgaagtct gtttcttata taagtattta
     8761 ttactttact gtttagcata aataggagac agaaaaggat aataaactac taggtccttt
     8821 attcctatta aaataaattt ataaatccct tgaatcaact gaattctaag ctttttgaag
     8881 aggttgctga tgtagtgtga tcaaaagaat ctaaggagaa cctcctctcc aaaatctgat
     8941 tggagctgtt caccctctca aggacaagat aaagattgac ttcagagata tatcacatca
     9001 agctagagga aaaaaaaaaa acctcaaata aaatttttcc tcattcgaag ggatccaggg
     9061 tatccttggg ttatgtagga gggaatcata tttgttctaa tttacctgaa tgtacttgtg
     9121 tgtgaatcca atcttgattc taaacaccaa atcttgtcaa cagtagagaa gtatagtaag
     9181 gagttcctgt tgtcaatcaa atgagggtgt gaaacattta gaatgctctg tgttacactt
     9241 gaaccatgta taaatgtaac ctgtgtatct tttttttaat tagcttttct gaatttaaat
     9301 tatattgttt ttctttgtat tgttagcaaa atgcatcaga actggatttt ttttctcatc
     9361 tgaacataat ataaaatttg aaagagtatt gtgatattaa gcactttaac atacatatca
     9421 gacaaactga cgtgggtttt tcaggtttgg gagtacattt aaatatgact tttcatgctt
     9481 tgttctttac aaataaaact gtgggattga ta
//
