LOCUS       NM_144973               9506 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens DENN domain containing 5B (DENND5B), transcript
            variant 1, mRNA.
ACCESSION   NM_144973
VERSION     NM_144973.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9506)
  AUTHORS   Scala,M., Tomati,V., Ferla,M., Lena,M., Cohen,J.S., Fatemi,A.,
            Brokamp,E., Bican,A., Phillips,J.A. 3rd, Koziura,M.E.,
            Nicouleau,M., Rio,M., Siquier,K., Boddaert,N., Musante,I.,
            Tamburro,S., Baldassari,S., Iacomino,M., Scudieri,P.,
            Rosenfeld,J.A., Bellus,G., Reed,S., Al Saif,H., Russo,R.S.,
            Walsh,M.B., Cantagrel,V., Crunk,A., Gustincich,S., Ruggiero,S.M.,
            Fitzgerald,M.P., Helbig,I., Striano,P., Severino,M., Salpietro,V.,
            Pedemonte,N. and Zara,F.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     De novo variants in DENND5B cause a neurodevelopmental disorder
  JOURNAL   Am J Hum Genet 111 (3), 529-543 (2024)
   PUBMED   38387458
  REMARK    GeneRIF: De novo variants in DENND5B cause a neurodevelopmental
            disorder.
REFERENCE   2  (bases 1 to 9506)
  AUTHORS   Gordon,S.M., Neufeld,E.B., Yang,Z., Pryor,M., Freeman,L.A., Fan,X.,
            Kullo,I.J., Biesecker,L.G. and Remaley,A.T.
  TITLE     DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass
  JOURNAL   Sci Rep 9 (1), 3597 (2019)
   PUBMED   30837651
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9506)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022080.37, AI762929.1, BF513808.1, BC020855.1, AB209341.1,
            AC068792.31 and BM676905.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144973.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389082.10/ ENSP00000373734.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC022080.37        141417-141534       c
            119-186             AI762929.1         1-68
            187-267             BF513808.1         68-148
            268-472             AI762929.1         150-354
            473-1879            BC020855.1         25-1431
            1880-4532           AB209341.1         392-3044
            4533-9257           AC068792.31        64419-69143
            9258-9506           BM676905.1         22-270              c
FEATURES             Location/Qualifiers
     source          1..9506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..9506
                     /gene="DENND5B"
                     /note="DENN domain containing 5B"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
     exon            1..431
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..4129
                     /gene="DENND5B"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 5B; rab6IP1-like protein;
                     DENN/MADD domain containing 5B"
                     /codon_start=1
                     /product="DENN domain-containing protein 5B isoform 1"
                     /protein_id="NP_659410.3"
                     /db_xref="CCDS:CCDS44857.1"
                     /db_xref="GeneID:160518"
                     /db_xref="HGNC:HGNC:28338"
                     /db_xref="MIM:617279"
                     /translation="MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGE
                     NFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSF
                     IITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLAS
                     SLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQ
                     QPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFE
                     LLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASL
                     LHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDF
                     IQELSEVLVQFGIPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKG
                     NETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFAN
                     RFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQM
                     FATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSI
                     EQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQR
                     RKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLL
                     KECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQG
                     KSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNM
                     SEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLY
                     HLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQ
                     IPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWL
                     GKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPN
                     AGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFH
                     KNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGK
                     FQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDFTI
                     VLEGSLIKGVDV"
     exon            432..541
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            542..1208
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1396
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1933
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2165
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2316
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2410
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2542
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2695
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2774
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2856
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2985
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3107
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3253
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3372
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3560
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3643
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3770
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3945
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..9506
                     /gene="DENND5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9486..9491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND5B"
                     /note="hexamer: AATAAA"
     polyA_site      9506
                     /gene="DENND5B"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggcg gctctcagct cgcgagcgca gctgcggctg cgagggcctc tcaggccgac
       61 actccccccg cgcccctccc ccacccggcc gggctccgga cccgccgcgc gcgagcccgc
      121 ggccgcttcc cccgcgccga gcgaggaggc aggctgcggc ggcgagaggc ggctgcgcgg
      181 ccatgggcgc gccagtgtcg ccctagggcg ggcgcacaga ccacagccgg agcggtggtg
      241 gcagcctccg cagaaagcct tcccgggcgg cggcggcggc ggcccctgga gcagcgcggc
      301 cgggatgagc gggagctgcg cggcgcccgg cccgggctcg ggctcctccc cggccgcctg
      361 ccgcttcgcg cactacttcg tgctgtgcgg gatcgacgcg gacagcgggc tggagcctga
      421 cgagctggcg ggcgaaaatt ttgaccagag tcctttgaga agaacattca aatccaaagt
      481 tctcgcccac tatcctcaga atatagaatg gaaccctttt gatcaagatg cggtgaacat
      541 gttgtgcatg cctaaagggc tatctttcag gacacaaacg gacaataaag acccccagtt
      601 tcactcattt ataattacca gggaagatgg ttctcgcacc tatggttttg ttctcacttt
      661 ttatgaagaa gttacaagta agcaaatctg cacagcaatg cagacacttt accagatgca
      721 caacgctgag cattacagca gtgtgtatgc ttcatcttcc tgcagtatgg actcattggc
      781 aagtagtctt gatgaaggag atacaacttc ccttttgaaa ctccagcgat acaactccta
      841 tgatattagc agagacaccc tgtatgtttc aaaaagtata tgcttgatca caccgttacc
      901 attcatgcag gcctgcaaga aattccttat ccagctttac aaggctgtta cctcacagca
      961 gccaccaccc ttgccacttg aaagctatat ccacaatatt ctttatgaag taccccttcc
     1021 acctccaggg aggtcactga aattttatgg tgtttatgaa cctgtcatct gccagaggcc
     1081 tgggcccagt gaactccccc tctctgatta cccccttcgg gaggcatttg agctcctggg
     1141 attagagaac ctggtgcagg tgtttacctg tgttctttta gagatgcaaa tccttctcta
     1201 ctcacaagat tatcaacgcc tgatgactgt ggcagaaggc atcaccacac ttttgttccc
     1261 atttcaatgg caacatgttt atgtgcccat tctacctgct tctctgctac attttcttga
     1321 tgctcctgtc ccttatctga tgggccttca gtcaaaagaa ggaactgacc gttctaaact
     1381 agaacttcct caagaggcta atttgtgttt tgtggacatt gacaaccatt ttattgagtt
     1441 gcctgaagaa tttccacagt tccccaataa agtggatttt atccaagaac tctctgaggt
     1501 tcttgttcaa tttgggatcc ctcctgaggg cagcctacat tgcagtgaga gtaccagcaa
     1561 actgaagaat atggttctga aagacttggt caatgacaaa aagaacggca atgtctgtac
     1621 taataacatc agcatgtatg agttactgaa gggcaatgaa accatagccc gcttgcaggc
     1681 tctggccaag cgtactggtg tggctgtgga aaaaatggac ctctctgctt ctctgggtga
     1741 aaaagacaag gatttaaaac tgcattgtga agaggcagaa ctaagggact accagctcaa
     1801 tgtacagctc cgagaggtct ttgctaaccg ttttacacag atgtttgcag attacgaagc
     1861 atttgtcatt cagactgccc aggacatgga atcctggctg accaaccggg aacagatgca
     1921 gaactttgac aaagcttcct ttctgtctga ccagcctgag ccttacctgc catttctttc
     1981 acgcttcatt gaaacacaga tgtttgccac ctttattgat aataaaatta tgtctcagtg
     2041 ggaagagaaa gatcctttgc ttcgggtctt tgacactcgg attgataaga taaggctgta
     2101 taatgtaagg gcacccacct tgcggacatc tatatatcag aaatgcagca ctttaaaaga
     2161 agcagcccaa tcaattgagc agagactgat gaaaatggat cacactgcaa tccacccaca
     2221 tctacttgat atgaaaattg gtcaaggcaa atatgagcag gggttctttc caaagttaca
     2281 gtccgatgtc ttggcaacag gaccaaccag taacaatcgc tgggtaagtc ggagtgccac
     2341 tgcacagcgc aggaaagaac gccttcgcca gcattctgag catgttgggc tggacaacga
     2401 cttgagggag aaatatatgc aagaggcacg aagtttagga aaaaacctga ggcaacccaa
     2461 actgtcagac ctctctcctg cagttattgc acagaccaac tgtaaattcg tagaaggctt
     2521 attaaaagaa tgtagaatga agacaaagcg catgttggtg gagaagatgg gacatgaagc
     2581 ggtggaactt ggccatggag aagcaaacat caccggcctg gaggagaaca ccttgatcgc
     2641 cagcctttgt gacctgctgg agaggatatg gagccatggc ttgcaggtca agcaggggaa
     2701 gtcggctttg tggtcacatt taattcaatt tcaggacaga gaagagaaac aagagcacct
     2761 tgcagaatca ccagttgccc tcggaccaga aagaagaaaa tctgactcag gagttatgtt
     2821 gccaacgctc agggtctctc ttattcagga catgaggcat attcaaaaca tgagtgagat
     2881 caagactgat gttggacgag ctcgggcgtg gataagactg tctctagaaa agaagctctt
     2941 gtcccagcat cttaagcagt tgctttctaa ccaaccactc accaagaagc tttataagcg
     3001 atatgctttt ctacgttgcg aagaagaaag agagcagttt ctttaccacc ttctttctct
     3061 caatgctgtg gactatttct gcttcaccag tgtgttcacc actatcatga ttccgtatag
     3121 gtcagtgatc atcccaatca aaaagctgag caatgcaata atcacatcaa acccttggat
     3181 ctgtgtatca ggagagctgg gagacacagg agtaatgcag attcccaaaa acctcctcga
     3241 aatgaccttt gagtgccaga acttggggaa gctgaccact gttcagattg gtcacgataa
     3301 ctcaggactg ttagccaaat ggctagtgga ttgtgtcatg gtcagaaatg aaatcacagg
     3361 acatacatac agattcccat gtgggcggtg gctggggaaa ggcattgatg atgggagcct
     3421 ggagagaatt cttattggag agttgatgac atcagcatca gatgaagatc tagtaaagca
     3481 gtgtcggact ccaccccagc agaagtcacc caccacggct aggagattga gcatcacttc
     3541 actgacagga aaaaacaaca aacccaatgc tgggcagata caagaaggaa ttggagaagc
     3601 tgtgaacaat attgtgaaac attttcataa acctgaaaaa gagagaggaa gcctcaccgt
     3661 gttgctgtgt ggagaaaatg gcctggttgc agcccttgag caagttttcc accatgggtt
     3721 caaatctgcc cgcatctttc acaagaatgt cttcatctgg gacttcatag agaaagtggt
     3781 tgcttatttt gaaacaactg accagattct agataatgaa gatgatgtcc ttattcagaa
     3841 atcatcctgc aaaaccttct gccactacgt aaatgctatt aatactgcac ccaggaacat
     3901 tgggaaggat ggcaaattcc agattttagt ttgccttgga acaagggatc gcctgctccc
     3961 acagtggatt ccattgttag ctgagtgtcc tgccatcact cgaatgtatg aagagagcgc
     4021 tctcctgcga gaccgcatga ctgtcaactc ccttatccga attctgcaga ccattcagga
     4081 cttcaccata gtcctagaag gatcactcat caaaggagtg gatgtgtaac ccaactggct
     4141 agaaactctc agtccaaacc ttgctccttc cccaactagg ggaccgattt ggacttgtct
     4201 gacagtagtg agtcactgca ggggcagcca aacatatgcc ccatttggaa caatcctcac
     4261 tctacagaca aggcaaaatg ttgtattgta gttcatttga acctggaatt tagtataaaa
     4321 tagagtattt tcatgtgtta gatgtgtgta aatatgctat cttctttaag aaattatatt
     4381 actctaataa gatgcttttc ttagattgaa tattcctgtg acttaaaata agtagcttaa
     4441 aaatgttggg ggttgggggg aagagtggtg ctagccagga agaagccagt aaacatgtaa
     4501 atatagtgca acccagtcgg gctttttttt ttctccaggt atcacaaaga aacccagaat
     4561 gcattgttat gtagtagcca tccatcttgg agtctgatcc tttgtattgt ggatgcacac
     4621 agctttacct actgtactgg tagtcttcac ttctatcttt taagttacaa actgttttat
     4681 atatttgaat cgctagtcac ttttccagtc ttttggaaaa aaatttcagt ccgcacaaga
     4741 tgatataatt ggagtatttt aaacactaga ccccaggagc ttggctgaac tggaaagaga
     4801 acatacaaag ctctgagaaa tgtgttcaat tgtgggatta taacttcttt acacttcgga
     4861 aagattagcc tagactaact tcattcttgg catttttatt cttgttattt gaggtacttt
     4921 gggaagatgt gaatttcagt gttagattca tagtgataag aactgcaaac agcaatttga
     4981 ttctgtactt ttaatttggc catctaaact gtgcagtggt ctacctctta aggataacca
     5041 tgagccctgt ctttgttagg gtctaatcac ccacctctcc agggcccatc ccccctcggg
     5101 aaatggaagg aatgtctaag gaggaggagg gctgtgtgtg gcttggaatg tttttgtgaa
     5161 agcatttgtt gaccatgata atgcaaataa cagaaggaga gagagaatga accctttctg
     5221 ggtgtttcag ggcaagcttt acgttccttt gtaggaaggg gagtaataat gtaaaacaac
     5281 tgacccagag aagctaaaag ccactggcag cacaggctga caaaatggaa gcaaagcaag
     5341 aggtggcaac aattttgaaa gaccaaaagt tgtgagtaac tttccagttt gatagtttat
     5401 aaagaagtta agtaaatgta gtattggcta gttactgtaa gtcctcatct tctggtaggt
     5461 cctgtaactc taattaggca tttgtacatt tttagcagca aaattgcctc agcagagctc
     5521 ccagttttat tcccagttgt ggctgaaaag caaagccatg gcatcagtat ccttgtgcaa
     5581 tcggaggttg ctgggctttc accacctgtg ttgttaacct tatttcctgg aggaagaaac
     5641 agatgaaaca agtgcctaac tccctttatc aaacacagcc aaggacagcc tcttttaaca
     5701 tgtgacttca tacttgagga aaaggagagt tgacagctgt atttaaaaac ccatggagcc
     5761 gggtgcggtg gctcacgcct atgatcccag cactttggga ggccgaggca ggcggatcac
     5821 aaggtcagga gattgagacc ctcctggcta acaccgtgaa accccgtctc tactaaaaat
     5881 acaaaaaatt agccgggcgt ggtggcgggt gcctgtacag gaggctgagg caggagaatg
     5941 gcgtgaaccc gcgaggcgga gcttgcagta agctgagatc gcgccactgc cctccagcct
     6001 gggcaacaga gcaagactcc atctcaaaaa ataaatagat aaaaataaaa acccatggaa
     6061 atggtttaag aaaatggttc tgggtacacc agaaatttgt ttgcctgaag ctaaagtgtg
     6121 tctacaatgg tacagctctt ccagggacat gggaagttta tcgtgggaga tatccagaac
     6181 ctgttttaca ctgggctcct actgtgtttg gtgatcagaa actatagagg ggtccaaccc
     6241 aggatttcat gtttgtatct tcataaggcc atgctcctga caggtctagg caacctgggg
     6301 gatgacttag gttaatgtgc taggattgac acacctcatc cagccttctt actttgtgga
     6361 tgggaacact taaggaatag agagattaaa tcttacactt accccacagc tggttactga
     6421 caacacaagc tctagaattc atgtttgttt gtttgtttta tttcaccagg ctgcatgaga
     6481 ctgaccttcc ggcattctta ctaatagtct ttctattata ctattggatc tttattcatc
     6541 cacctataca agtaggaaat aaggatgaat attcatttag aagaattaat attcatatta
     6601 acacattgct ctcagattat tgggaattaa catcttgtaa aaactgggag caggccaggt
     6661 acggtggcta acgcctgtaa tcctgacact ttgggagtct gaggcgggtg gttcatctga
     6721 ggtcagtcgg gagttcaaga ccagactggc caacatggtg aaaccccgtc tctactaaaa
     6781 aaaaaaaata gacaaaaatt agcggggggg tggtggcagg gcctgtaatt ccagctactc
     6841 aggaggctga agcaggagaa tcgtttaaac acaggaggtg gaggttgcag tgagccgaga
     6901 ttgtgccact gcactccaac ctgggtgaca agagcgagac tccgtctcaa aaaaaaaaaa
     6961 agaaaaaaac tgcagccaaa gttggatttg cggcctatga ataaaaccat tactttaaaa
     7021 agtaataccc ccaaaaaagt tacacctgaa gtttcatctt catgcctttg tgtaatatta
     7081 ctataatggt gaaatgatga tttaaaaaaa acacatcaga actgacacat cctcttggat
     7141 gatgggtcct tcagtcacct tgtgagccca tgtacttatt ccgttgatac agcctgtgct
     7201 ataaacatgt ggggccctcc ttgtgtgagc tgcttgaatg gccagtaccc ccattctttt
     7261 gaatattccc aatggcagtc aatcttggcc tttaagaata aatttaaata tttggaaata
     7321 gtccttagga tccaagtttg atcaatgaaa aggatgctta agctgagttt ggggtcacat
     7381 aagaagtgca gttataaaga aataagacat gttgggcatg gcagtacaca cctgtagtcc
     7441 cagctgcttg ggaagccaag gcaggaggat cacttcaacc caggagtttg agtccagcct
     7501 gggtaacata gggaaacccc atctcaaaaa aacaaaacaa aggacttagt ttttatgtgg
     7561 ctcataagtg tctctaagtt ataccaaaag tttgagcaca acagtagtag cagaatgctt
     7621 agaataaatg cttgactttt aagctgactt ttggaaggac catacccaca tagaggcatc
     7681 ttttctgctg tggtaatttt ttaaattaat acattgcttt aggattacat ctcaaagtaa
     7741 ataaaaaaat caatatttaa tttgtttttt tcctgcaaat aaattaaatg ctgggaccat
     7801 aatgattatt tttgcatagt aatagctggt gaagaagttg ttttaaaatt aaattgccaa
     7861 aagtattacc tcttgaaaaa tttattttcc caaagttttt catatgtcat gaaaccccta
     7921 atcttgacct ttatgacaca gtggcattac actgatgttg gaagcatgtg tgagatctgt
     7981 gccctggtcg ggagtcatat gccttaaaaa tgactgcgag tcagtgtgaa gtagtataaa
     8041 gtggagtcct acgtgggaaa aagcaggcta ctgaggacaa aaacctccca accctcccca
     8101 ccttgttttc cactgggaat gagaatttga tatgagaaac ttcaaccttg cagaagtgtg
     8161 gatttccctc tgaaatttaa atgtttcaca catttttgta ccttttgtaa ccttgtggta
     8221 tttactttca catggctttt taaaaaatta ttttaatgaa cttctatcac actatatgaa
     8281 tgatatgggg gaaatactga actgctcata tttccttttt tggcaataaa gcactgttat
     8341 atgtaaatgt aagtgaaaaa gaggttcaag actatacaac agcttatgtg tagtatatgt
     8401 tgacatccct aaggtatttt gaaacatgag gtgacagaca aggacctcaa atttccaggg
     8461 aaatatttat ttcacaacat taggagtgta gctcttcata atgaaatatc ttctttctgc
     8521 taaagattac aatttttcat ttagggaact gtgaatattt tctgtgaggt ttacagaaac
     8581 tagtgtatcc ttttcactat gttgaaaaga caatctgaac tttagctatt tatatttcag
     8641 tattaacaca ccttcactga ttgagagtct tgagcccttc tctactttta taaagtgaat
     8701 cctatttcca agtcatccat gtcttttgaa gtctgtttct tatataagta tttattactt
     8761 tactgtttag cataaatagg agacagaaaa ggataataaa ctactaggtc ctttattcct
     8821 attaaaataa atttataaat cccttgaatc aactgaattc taagcttttt gaagaggttg
     8881 ctgatgtagt gtgatcaaaa gaatctaagg agaacctcct ctccaaaatc tgattggagc
     8941 tgttcaccct ctcaaggaca agataaagat tgacttcaga gatatatcac atcaagctag
     9001 aggaaaaaaa aaaaacctca aataaaattt ttcctcattc gaagggatcc agggtatcct
     9061 tgggttatgt aggagggaat catatttgtt ctaatttacc tgaatgtact tgtgtgtgaa
     9121 tccaatcttg attctaaaca ccaaatcttg tcaacagtag agaagtatag taaggagttc
     9181 ctgttgtcaa tcaaatgagg gtgtgaaaca tttagaatgc tctgtgttac acttgaacca
     9241 tgtataaatg taacctgtgt atcttttttt taattagctt ttctgaattt aaattatatt
     9301 gtttttcttt gtattgttag caaaatgcat cagaactgga ttttttttct catctgaaca
     9361 taatataaaa tttgaaagag tattgtgata ttaagcactt taacatacat atcagacaaa
     9421 ctgacgtggg tttttcaggt ttgggagtac atttaaatat gacttttcat gctttgttct
     9481 ttacaaataa aactgtggga ttgata
//
