LOCUS       NM_001386035            7904 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens DENN domain containing 4C (DENND4C), transcript
            variant 13, mRNA.
ACCESSION   NM_001386035
VERSION     NM_001386035.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7904)
  AUTHORS   Yang,B., Wang,J., Qiao,J., Zhang,Q., Liu,Q., Tan,Y., Wang,Q.,
            Sun,W., Feng,W., Li,Z., Wang,C., Yang,S. and Cui,L.
  TITLE     Circ DENND4C inhibits pyroptosis and alleviates
            ischemia-reperfusion acute kidney injury by exosomes secreted from
            human urine-derived stem cells
  JOURNAL   Chem Biol Interact 391, 110922 (2024)
   PUBMED   38412628
  REMARK    GeneRIF: Circ DENND4C inhibits pyroptosis and alleviates
            ischemia-reperfusion acute kidney injury by exosomes secreted from
            human urine-derived stem cells.
REFERENCE   2  (bases 1 to 7904)
  AUTHORS   Liu,S., Yuan,L., Li,J., Liu,Y., Wang,H. and Ren,X.
  TITLE     circDENND4C, a novel serum marker for epithelial ovarian cancer,
            acts as a tumor suppressor by downregulating miR-200b/c
  JOURNAL   Ann Med 55 (1), 908-919 (2023)
   PUBMED   36896567
  REMARK    GeneRIF: circDENND4C, a novel serum marker for epithelial ovarian
            cancer, acts as a tumor suppressor by downregulating miR-200b/c.
REFERENCE   3  (bases 1 to 7904)
  AUTHORS   Zhang,Z.J., Zhang,Y.H., Qin,X.J., Wang,Y.X. and Fu,J.
  TITLE     Circular RNA circDENND4C facilitates proliferation, migration and
            glycolysis of colorectal cancer cells through miR-760/GLUT1 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2387-2400 (2020)
   PUBMED   32196590
  REMARK    GeneRIF: Circular RNA circDENND4C facilitates proliferation,
            migration and glycolysis of colorectal cancer cells through
            miR-760/GLUT1 axis.
REFERENCE   4  (bases 1 to 7904)
  AUTHORS   Ren,S., Liu,J., Feng,Y., Li,Z., He,L., Li,L., Cao,X., Wang,Z. and
            Zhang,Y.
  TITLE     Knockdown of circDENND4C inhibits glycolysis, migration and
            invasion by up-regulating miR-200b/c in breast cancer under hypoxia
  JOURNAL   J Exp Clin Cancer Res 38 (1), 388 (2019)
   PUBMED   31488193
  REMARK    GeneRIF: circDENND4C silence suppresses glycolysis, migration and
            invasion in breast cancer cells under hypoxia by increasing
            miR-200b and miR-200c.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7904)
  AUTHORS   Sano,H., Peck,G.R., Kettenbach,A.N., Gerber,S.A. and Lienhard,G.E.
  TITLE     Insulin-stimulated GLUT4 protein translocation in adipocytes
            requires the Rab10 guanine nucleotide exchange factor Dennd4C
  JOURNAL   J Biol Chem 286 (19), 16541-16545 (2011)
   PUBMED   21454697
  REMARK    GeneRIF: Insulin-stimulated GLUT4 protein translocation in
            adipocytes requires the Rab10 guanine nucleotide exchange factor
            Dennd4C
REFERENCE   6  (bases 1 to 7904)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   7  (bases 1 to 7904)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 7904)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 7904)
  AUTHORS   Semova,N., Kapanadze,B., Corcoran,M., Kutsenko,A., Baranova,A. and
            Semov,A.
  TITLE     Molecular cloning, structural analysis, and expression of a human
            IRLB, MYC promoter-binding protein: new DENN domain-containing
            protein family emerges
  JOURNAL   Genomics 82 (3), 343-354 (2003)
   PUBMED   12906859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161909.20 and AL391834.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4433900.1,
                                           SRR11853567.30080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL161909.20        45475-45615
            142-463             AL161909.20        90940-91261
            464-716             AL161909.20        101551-101803
            717-786             AL161909.20        103378-103447
            787-959             AL161909.20        105486-105658
            960-1026            AL161909.20        112838-112904
            1027-1085           AL161909.20        114011-114069
            1086-1230           AL161909.20        114969-115113
            1231-1406           AL161909.20        120134-120309
            1407-1507           AL161909.20        131199-131299
            1508-1726           AL161909.20        131403-131621
            1727-1872           AL391834.8         3855-4000
            1873-1908           AL391834.8         5432-5467
            1909-2039           AL391834.8         5557-5687
            2040-2172           AL391834.8         7523-7655
            2173-2379           AL391834.8         11471-11677
            2380-2508           AL391834.8         14470-14598
            2509-2653           AL391834.8         15763-15907
            2654-2800           AL391834.8         16179-16325
            2801-2923           AL391834.8         20485-20607
            2924-3070           AL391834.8         22126-22272
            3071-4236           AL391834.8         25414-26579
            4237-4414           AL391834.8         30195-30372
            4415-4524           AL391834.8         31566-31675
            4525-4700           AL391834.8         31983-32158
            4701-4883           AL391834.8         36465-36647
            4884-5079           AL391834.8         37458-37653
            5080-5325           AL391834.8         39737-39982
            5326-5443           AL391834.8         41339-41456
            5444-5594           AL391834.8         49330-49480
            5595-5659           AL391834.8         51249-51313
            5660-7904           AL391834.8         51530-53774
FEATURES             Location/Qualifiers
     source          1..7904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..7904
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="DENN domain containing 4C"
                     /db_xref="GeneID:55667"
                     /db_xref="HGNC:HGNC:26079"
     exon            1..141
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            142..463
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            464..716
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            717..786
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            787..959
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1026
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             976..5796
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="isoform 8 is encoded by transcript variant 13; DENN
                     domain-containing protein 4C; DENN/MADD domain containing
                     4C; DENN/MADD domain containing 4A pseudogene"
                     /codon_start=1
                     /product="DENN domain-containing protein 4C isoform 8"
                     /protein_id="NP_001372964.1"
                     /db_xref="GeneID:55667"
                     /db_xref="HGNC:HGNC:26079"
                     /translation="MQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTL
                     LMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPL
                     SLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKP
                     CKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFM
                     ASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRF
                     IEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHT
                     VFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITKSPPL
                     MAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQ
                     AYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGY
                     YNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISALQNVTG
                     GSDGDTVSHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSSTGGQSDQGYGSKDELIK
                     DDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIV
                     KVPSGIFDVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKHFPER
                     SCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIARTHSFE
                     NVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESL
                     LSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTGGKTP
                     DSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALER
                     RSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSS
                     PHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEE
                     ETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPT
                     GEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEI
                     MAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLA
                     NESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISS
                     VPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPP
                     PVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLP
                     GLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKK
                     SSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLV
                     SLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI"
     exon            1027..1085
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1230
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1406
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1507
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1726
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1872
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1908
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2039
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2172
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2379
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2508
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2653
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2800
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2923
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3070
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..4236
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4414
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4524
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4700
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4883
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..5079
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5080..5325
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5326..5443
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5444..5594
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5659
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5660..7904
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7738..7743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="hexamer: AATGAA"
     polyA_site      7762
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="major polyA site"
     regulatory      7869..7874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="hexamer: ATTAAA"
     polyA_site      7904
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
ORIGIN      
        1 agaccggact gaggcggcgg cggccgctgg agctagtccc ccgccctgcc ctgccgagcg
       61 cgcccagtcc gcgaatccgg tgctttcttg ccccaggaag aagccgtgtc ggggctgcgc
      121 tgacagagga gcaggcagca gaaaatacag tagcagccat gatagaagac aaaggaccaa
      181 gagtgacaga ctactttgtc gtagctggtc tcactgacac atctactctt ttggatcaag
      241 aaataaatcg tttagatact aagtcaactg gacctaaagc tccaattaca gacattgcca
      301 ttattatcaa atcagctgga gaaacagtac ctgaaggtta cacctgtgta gaagccactc
      361 catcagctct ccaagcaaac ttgaactatg gaagtctgaa aagcccagaa cttttcctct
      421 gttataagag agggagagat aaaccaccgc ttacagatat tggagttcta tatgaaggga
      481 aagaacggct tattccagga tgtgaagtga tcctagccac accctatggt cgctgtgcca
      541 atgtcaacaa tagttcaact acttcacaaa gaatctttat cacttatcga agggctcctc
      601 cagttcgacc ccagaattcc ttggctgtaa ctgatatctg tgttattgta accagtaaag
      661 gagaaactcc tcctcatacc ttctgcaaag ttgacaaaaa cttaaattgt ggaatgtggg
      721 gttccagcgt gtttctgtgt tataagaagt ctgtacctgc ttcaaatgca atagcatata
      781 aggctggttt aatttttaga tatccagaag aggactatga gtcatttcca ctctcagaat
      841 cagatgtacc tcttttctgc cttcctatgg gagctactat tgagtgctgg gatcctgaaa
      901 ccaaatatcc acttccagtt ttttcaactt ttgtcttgac aggttcttca gccaaaaagg
      961 cacatttcac attttatgca aaacatccct tttccttcac cacaaagacc gagaatcctt
     1021 gtccagctgt cagtccatga tgcattaata ttatcacagc cagtttctac acctttacca
     1081 ctaagtggag ccaactttag caccttgcta atgaatctgg gtcctgagaa ttgtgcaaca
     1141 ctgctgctct ttgttttact tgagagtaaa attctgctgc attctcttag gccagctgtc
     1201 ttgactgggg tagctgaagc tgttgtagct atgatctttc catttcagtg gcaatgccca
     1261 tatattcccc tttgtcctct ttcactggct gcagtgctta gtgcaccttt accatttata
     1321 gttggagttg actcaaggta ttttgatctt catgacccac cacaagatgt tgtttgcatt
     1381 gacttggata cgaacatgtt atatgtatca gatgaaaaga agaacatgaa ctggaagcaa
     1441 cttcccaaaa agccgtgcaa aaatctactt agcaccttaa agaaattgta tccccagctg
     1501 tcttcagttc accaaaaaac tcaagaaggc tcagcgattg acatgactcc aattgaagca
     1561 gatttctcct ggcaaaagaa gatgacacag cttgagatgg aaattcaaga ggcatttttg
     1621 cgctttatgg cgtctatttt aaaaggatat agaacatatc tcagaccaat cacagaggct
     1681 ccttcaaata aagccacagc tgctgattca ttgtttgacc gacagggatt tttaaaaagt
     1741 cgagatcgtg cctatgcaaa attctatacc cttttatcca aaacacagat ttttattcgt
     1801 ttcattgaag aatgcagttt tgtaagtgat aaagatactg gattagcatt ttttgatgac
     1861 tgcatagaaa agttgtttcc tgataaaggc acagagaaaa cagataaggt tgattttgat
     1921 tcagcagaag ataccagatt gatagaacta gatgattcac agaaaagtga gcatactgta
     1981 tttataatgc cgccagagcc acctcctgat gatggaaagg acctgtcacc aaagtacagt
     2041 tacaaatact ttccaagact ggaccttaag ctttttgaca gaccgcagga gttgaaactt
     2101 tgttttagta gacaccctac tgggaatagc attacaaaga gtccacctct catggctaag
     2161 agaactaaac aggaaataaa aacagctcat aaattggcga agagatgtta tacaaatcca
     2221 ccacagtggg ccaagtgtct gtttagtcat tgttacagtt tatggtttat ttgtcttccg
     2281 gcctatgtta gagtttctca tcctaaagtc agagcacttc agcaggcata tgatgtactt
     2341 attaagatga ggaaaacaga tgtggatccc ttagatgagg tgtgctatcg agtagtgatg
     2401 cagctttgtg gactttgggg tcatcctgtt ttagcagtga gagtcttatt tgaaatgaaa
     2461 actgctagga taaagcctaa tgctattact tatggttatt ataataaggt agtcttggag
     2521 agcccgtggc ctagcagtac ccgcagtggt attttcttat ggacgaaggt acggaatgtg
     2581 gtacgtggct tggcacagtt taggcagccg cttaaaaaga ctgtgcaaag gtcacaggtc
     2641 tcctcaatat cagctcttca aaatgtcaca ggtggaagtg atggggacac ggtgagccac
     2701 ggtagtgtgg atagttctaa tgatgctaac aatggggagc acacagtctt cgtcagagat
     2761 ttaatcaggc ttgagtccat tgataatcac tctagcacag gtggtcagtc tgaccaagga
     2821 tacgggtcta aggatgaact tataaaggat gatgcagaaa ttcatgtgcc tgaagaacag
     2881 gcagcaagag aattgataac taaaacaaaa atgcaaacag aagaggtgtg tgatgcctct
     2941 gctattgtgg caaaacattc acaacctagt ccagagcctc acagtcctac tgaacctcct
     3001 gcatggggca gcagtattgt gaaagttccg tctggtatat ttgatgtcaa cagcaggaaa
     3061 agtagcactg gtagtatatc aaatgtgctg ttttctactc aagatccagt tgaagatgca
     3121 gtctttggcg aagctactaa tctcaagaag aatggtgata gaggagaaaa aagacaaaag
     3181 cattttcctg agaggagttg tagttttagt tctgaaagtc gagcaggaat gttgcttaag
     3241 aagagtagtt tggattcgaa ttcaagtgaa atggctatca tgatgggagc agatgccaag
     3301 attctcacag cagcattgac atgtcctaag acttctctac ttcatattgc aagaacccat
     3361 agctttgaga atgttagctg tcacctacct gatagtagga cttgtatgtc tgaaagcact
     3421 tggaatcctg agcacagatc atctccggtg ccagagatgc ttgaggaaag ccaagaactc
     3481 cttgagcctg tggttgatga cgtacctaaa actactgcaa cagtagatac atatgagagt
     3541 ctactaagtg atagtaacag taatcagtcc agagacttga aaacagtatc caaagatctg
     3601 aggaataaga gaagtagttt atatggtatt gctaaggtgg ttcagaggga agatgttgaa
     3661 actggactag atcctttgtc tcttttagcc actgaatgta caggaggaaa aactcctgat
     3721 tctgaagata agttgttttc tccagttatt gcacgtaatc tggctgatga aatagaaagc
     3781 tatatgaacc taaaaagtcc cctaggtagt aaatcttcta gtatggaatt acacagagag
     3841 gaaaacagag agtctggcat gactactgca tttattcatg ctctagagag gagatcaagc
     3901 ctacctttag atcatggttc accagcacag gaaaatcctg aaagtgaaaa gagctcacct
     3961 gcagtgtcca ggtctaaaac ttttactggg cgtttcaagc agcaaacccc ctctcgaact
     4021 cataaagaac gttcaacttc tttgtcagca ctggtgcgtt cttcgccaca tggctcgttg
     4081 ggttctgtag taaattcttt gtcagggcta aagctggata atatactctc agggcccaag
     4141 atagatgtcc tgaaatctgg tatgaaacaa gcagcgacag tagccagtaa gatgtgggta
     4201 gctgttgcgt ctgcctacag ctactcagat gatgaggaag aaactaatag agactacagc
     4261 ttcccagctg gcctagaaga ccatattttg ggggagaata tatcgcctaa cacaagtatc
     4321 tcagggttgg tccccagtga acttacccag agcaacacaa gtcttggcag tagcagcagt
     4381 agtggagatg taggaaaact gcattatcca acaggtgaag ttccatttcc aagaggcatg
     4441 aaagggcaag actttgaaaa atcagatcat ggttcttctc aaaataccag catgtctagc
     4501 atctatcaga attgtgcaat ggaggttttg atgtccagtt gttcacagtg tagagcttgt
     4561 ggagctttag tttatgatga agaaattatg gctggatgga cagcagatga ctcaaatttg
     4621 aatacagctt gtccattctg taaaagcaac ttcttgcctc ttctcaatat agaattcaaa
     4681 gatttgagag gttctgcaag ctttttcctg aaaccaagta cctctggtga cagtttacaa
     4741 agtggaagca ttccattggc aaatgaatcc ttggagcaca aacctgtatc cagtttagca
     4801 gaacctgact tgatcaactt tatggacttc ccaaaacata accagatcat aactgaagaa
     4861 acaggctctg cagttgaacc aagtgatgaa ataaagagag ccagtggaga tgtccaaact
     4921 atgaaaattt catctgtgcc taatagttta tcaaagcgaa atgtgtcttt gactcgaagt
     4981 cacagtgttg gaggcccatt gcagaatatt gactttaccc agcgaccgtt tcatggcatc
     5041 tcaacagtta gtcttccaaa tagtctgcag gaagttgtgg atcctttagg aaaaagaccc
     5101 aatcctcccc ctgtttctgt gccctacttg agtcctctag tactccgtaa agaacttgaa
     5161 tctttgctag aaaatgaagg tgatcaggtg attcatacat cttctttcat caatcaacat
     5221 ccaatcattt tctggaacct cgtttggtat ttcagacgtt tggaccttcc tagtaacttg
     5281 ccaggactta tcctcacatc tgaacattgt aatgaaggtg tacagcttcc tctgtcatct
     5341 ctgtcccagg atagcaaact tgtgtatatt cagctgttat gggataatat caaccttcat
     5401 caggaaccaa gagaacctct gtatgtctca tggaggaatt ttaattctga aaagaaatca
     5461 tctctcctgt cagaggaaca acaagaaaca agcactttag tagaaaccat caggcagagt
     5521 attcagcaca ataatgttct taaacccatc aacctacttt cacagcaaat gaagccaggc
     5581 atgaaaagac aaaggagttt atacagagaa atcctcttct tatcattagt gtctctagga
     5641 agagagaata ttgatattga ggcatttgac aatgaatatg gaattgcata caatagtctg
     5701 tcttcagaga ttcttgaaag gttgcagaaa attgatgctc caccaagtgc cagtgtcgag
     5761 tggtgcagga agtgttttgg agcgcctctc atttaaatag agattcacta gaatgttgac
     5821 acacaaggct tggggattag atttcatctg gaaacattca agtttttttt tccaaatcgt
     5881 aagaactggt gaatacggaa ttgaagtaac tcttggggac aatatataat gaattatgat
     5941 tcatattgca ttaccttgaa atatgaagtg ccatttgaat gtcccagggc ttattaatat
     6001 tgaagatttt caacccctga actgcttttc tgcctctgtg gaaaactact ttgggattct
     6061 tcagtatttg tagtagtttg atagaaataa tgaggaacca tattcattct aggcattgtt
     6121 tatatttgaa gttactgagt ttgaggaatg gcaaattaaa tttgcctaac ccccaaaaca
     6181 aatgaaatat ctcaattata aaagcaacat ggccgggcac ggtggctcag gcctgtaatc
     6241 ccagcacttt gggaggctga gcaaggtggg tggatcactt gaggccagga gttcgagacc
     6301 agcctggcca acacggtgag accctgtctt tactaaaaat acaaaaatta gccaggcgca
     6361 ccactgtagt cccagctact caggctgagg caggagaatc gcttgaactg aggcagaggc
     6421 tacagtgagt ggagatcacg ccactgcaac tccagcttgg gtgacagagt gagaccgtct
     6481 caaaaaaaaa aaaaaaaaaa aaagagagca acatatttgt gtaagtttgt atatgtgtag
     6541 ggctgtgtag gtatgtgtat atacagccat attctaagtg tatatttatt aaaatagatt
     6601 gcatgttgca atacggtttt ctgaaagggg tctcattgac tattaaataa atgactacta
     6661 ctaaacttgt ctgtagtcat taatcttaaa attacctgaa aatctgatga cagctgcctt
     6721 ccctaacttt aatgtattag gttggcacaa aattaattgt agtttttgcc actattaatg
     6781 gcaaaaaccg caattatttt tgtaccaaca taatacacct ttcatattat gtattatctt
     6841 gcttaatggg ttttatcttg attatccagt tacttccatc ctcttcccaa tgttaatttg
     6901 caatagtttt aaaatgggaa caaatgaatc aatcatcaga tagttaaaat gaaattaaat
     6961 cagctgccta ataatttatg gaattcattg gaatgtgctt aaaatgctaa agtgtatgtc
     7021 attgaacatg aaatcttttt tcaggcacat acattgttgg tattgatgac tttttaaaac
     7081 ctgtgggata aacttgcact gcacacggaa gttttattct tgtatattta gatttgtatg
     7141 cttgtgagta aaaatgtgca tttgtaaata ctgtgttttt aggttgaatc aattaagtct
     7201 taaaactgta aatttattaa gcttgttgcc agtaggttta agaaaatcat gatctcacat
     7261 gcctcacttt gacatttatc atgcctttta ttaaaaatat cccttaggaa cagtaagttt
     7321 gccttaactc tctgcatggt ttaaaaagcc attggttttg tgtgtgttta cagtaattat
     7381 gcagatgact aaatgagttg acacagtaaa attacttcca tatggtacag taacaaccta
     7441 actcccttct acctgatgta accatttaca aattatagtt attgtaccag tctttcaaca
     7501 tttcagggtt aatctgacct atgcagaatt ctagtgtgaa tttattgtga aaatgctaaa
     7561 tgaaacaatt tgtcagaaat tatgtacaat tttcattacc ttcaaaatgg atcttttgca
     7621 ctgtctgaga gtatatattt ttgcaactca agacttggta ctagttttaa tacttaacac
     7681 ttactgaccc aacagaagtt tggaattacc ttgcatataa aaattgaggt tgaataaaat
     7741 gaaaaattgt tgttttctgt tacattaagc ctcttgaaat ctgtaatctt tagaatccca
     7801 atattttgtt ttttccattc cttcactcgt aacttgaact caagttttca cttactgacg
     7861 cgcttcccat taaaaaaaat ctgtaaagat ctctaccttg aaaa
//
