LOCUS       NM_001330640            8143 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens DENN domain containing 4C (DENND4C), transcript
            variant 3, mRNA.
ACCESSION   NM_001330640 XM_006716804
VERSION     NM_001330640.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8143)
  AUTHORS   Yang,B., Wang,J., Qiao,J., Zhang,Q., Liu,Q., Tan,Y., Wang,Q.,
            Sun,W., Feng,W., Li,Z., Wang,C., Yang,S. and Cui,L.
  TITLE     Circ DENND4C inhibits pyroptosis and alleviates
            ischemia-reperfusion acute kidney injury by exosomes secreted from
            human urine-derived stem cells
  JOURNAL   Chem Biol Interact 391, 110922 (2024)
   PUBMED   38412628
  REMARK    GeneRIF: Circ DENND4C inhibits pyroptosis and alleviates
            ischemia-reperfusion acute kidney injury by exosomes secreted from
            human urine-derived stem cells.
REFERENCE   2  (bases 1 to 8143)
  AUTHORS   Liu,S., Yuan,L., Li,J., Liu,Y., Wang,H. and Ren,X.
  TITLE     circDENND4C, a novel serum marker for epithelial ovarian cancer,
            acts as a tumor suppressor by downregulating miR-200b/c
  JOURNAL   Ann Med 55 (1), 908-919 (2023)
   PUBMED   36896567
  REMARK    GeneRIF: circDENND4C, a novel serum marker for epithelial ovarian
            cancer, acts as a tumor suppressor by downregulating miR-200b/c.
REFERENCE   3  (bases 1 to 8143)
  AUTHORS   Zhang,Z.J., Zhang,Y.H., Qin,X.J., Wang,Y.X. and Fu,J.
  TITLE     Circular RNA circDENND4C facilitates proliferation, migration and
            glycolysis of colorectal cancer cells through miR-760/GLUT1 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2387-2400 (2020)
   PUBMED   32196590
  REMARK    GeneRIF: Circular RNA circDENND4C facilitates proliferation,
            migration and glycolysis of colorectal cancer cells through
            miR-760/GLUT1 axis.
REFERENCE   4  (bases 1 to 8143)
  AUTHORS   Ren,S., Liu,J., Feng,Y., Li,Z., He,L., Li,L., Cao,X., Wang,Z. and
            Zhang,Y.
  TITLE     Knockdown of circDENND4C inhibits glycolysis, migration and
            invasion by up-regulating miR-200b/c in breast cancer under hypoxia
  JOURNAL   J Exp Clin Cancer Res 38 (1), 388 (2019)
   PUBMED   31488193
  REMARK    GeneRIF: circDENND4C silence suppresses glycolysis, migration and
            invasion in breast cancer cells under hypoxia by increasing
            miR-200b and miR-200c.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8143)
  AUTHORS   Sano,H., Peck,G.R., Kettenbach,A.N., Gerber,S.A. and Lienhard,G.E.
  TITLE     Insulin-stimulated GLUT4 protein translocation in adipocytes
            requires the Rab10 guanine nucleotide exchange factor Dennd4C
  JOURNAL   J Biol Chem 286 (19), 16541-16545 (2011)
   PUBMED   21454697
  REMARK    GeneRIF: Insulin-stimulated GLUT4 protein translocation in
            adipocytes requires the Rab10 guanine nucleotide exchange factor
            Dennd4C
REFERENCE   6  (bases 1 to 8143)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   7  (bases 1 to 8143)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 8143)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 8143)
  AUTHORS   Semova,N., Kapanadze,B., Corcoran,M., Kutsenko,A., Baranova,A. and
            Semov,A.
  TITLE     Molecular cloning, structural analysis, and expression of a human
            IRLB, MYC promoter-binding protein: new DENN domain-containing
            protein family emerges
  JOURNAL   Genomics 82 (3), 343-354 (2003)
   PUBMED   12906859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161909.20 and AL391834.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001330640.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.151817.1,
                                           SRR1803615.62765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434457.7/ ENSP00000473469.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL161909.20        45475-45615
            142-463             AL161909.20        90940-91261
            464-716             AL161909.20        101551-101803
            717-786             AL161909.20        103378-103447
            787-959             AL161909.20        105486-105658
            960-1198            AL161909.20        110790-111028
            1199-1265           AL161909.20        112838-112904
            1266-1324           AL161909.20        114011-114069
            1325-1469           AL161909.20        114969-115113
            1470-1645           AL161909.20        120134-120309
            1646-1746           AL161909.20        131199-131299
            1747-1965           AL161909.20        131403-131621
            1966-2111           AL391834.8         3855-4000
            2112-2147           AL391834.8         5432-5467
            2148-2278           AL391834.8         5557-5687
            2279-2411           AL391834.8         7523-7655
            2412-2618           AL391834.8         11471-11677
            2619-2747           AL391834.8         14470-14598
            2748-2892           AL391834.8         15763-15907
            2893-3039           AL391834.8         16179-16325
            3040-3162           AL391834.8         20485-20607
            3163-3309           AL391834.8         22126-22272
            3310-4475           AL391834.8         25414-26579
            4476-4653           AL391834.8         30195-30372
            4654-4763           AL391834.8         31566-31675
            4764-4939           AL391834.8         31983-32158
            4940-5122           AL391834.8         36465-36647
            5123-5318           AL391834.8         37458-37653
            5319-5564           AL391834.8         39737-39982
            5565-5682           AL391834.8         41339-41456
            5683-5833           AL391834.8         49330-49480
            5834-5898           AL391834.8         51249-51313
            5899-8143           AL391834.8         51530-53774
FEATURES             Location/Qualifiers
     source          1..8143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..8143
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="DENN domain containing 4C"
                     /db_xref="GeneID:55667"
                     /db_xref="HGNC:HGNC:26079"
     exon            1..141
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            142..463
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..6035
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="isoform 2 is encoded by transcript variant 3; DENN
                     domain-containing protein 4C; DENN/MADD domain containing
                     4C; DENN/MADD domain containing 4A pseudogene"
                     /codon_start=1
                     /product="DENN domain-containing protein 4C isoform 2"
                     /protein_id="NP_001317569.1"
                     /db_xref="CCDS:CCDS83349.1"
                     /db_xref="GeneID:55667"
                     /db_xref="HGNC:HGNC:26079"
                     /translation="MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPIT
                     DIAIIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIG
                     VLYEGKERLIPGCEVILATPYGRCANVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDI
                     CVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEE
                     DYESFPLSESDVPLFCLPMGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFY
                     EPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYK
                     LSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGAN
                     FSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIP
                     LCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQL
                     PKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAF
                     LRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQI
                     FIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQK
                     SEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITK
                     SPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVR
                     ALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAI
                     TYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISALQ
                     NVTGGSDGDTVSHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSSTGGQSDQGYGSKD
                     ELIKDDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWG
                     SSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKH
                     FPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIART
                     HSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDT
                     YESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTG
                     GKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIH
                     ALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSAL
                     VRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYS
                     DDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKL
                     HYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVY
                     DEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGS
                     IPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTM
                     KISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKR
                     PNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLP
                     SNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFN
                     SEKKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILF
                     LSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI
                     "
     exon            464..716
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            717..786
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            787..959
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1198
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1265
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1324
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1469
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1645
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1746
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1965
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2111
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2147
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2278
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2411
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2618
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2747
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2892
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3039
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3162
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3309
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..4475
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4653
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4654..4763
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4939
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5122
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5123..5318
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5319..5564
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..5682
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5683..5833
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..5898
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5899..8143
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7977..7982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="hexamer: AATGAA"
     polyA_site      8001
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="major polyA site"
     regulatory      8108..8113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
                     /note="hexamer: ATTAAA"
     polyA_site      8143
                     /gene="DENND4C"
                     /gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
ORIGIN      
        1 agaccggact gaggcggcgg cggccgctgg agctagtccc ccgccctgcc ctgccgagcg
       61 cgcccagtcc gcgaatccgg tgctttcttg ccccaggaag aagccgtgtc ggggctgcgc
      121 tgacagagga gcaggcagca gaaaatacag tagcagccat gatagaagac aaaggaccaa
      181 gagtgacaga ctactttgtc gtagctggtc tcactgacac atctactctt ttggatcaag
      241 aaataaatcg tttagatact aagtcaactg gacctaaagc tccaattaca gacattgcca
      301 ttattatcaa atcagctgga gaaacagtac ctgaaggtta cacctgtgta gaagccactc
      361 catcagctct ccaagcaaac ttgaactatg gaagtctgaa aagcccagaa cttttcctct
      421 gttataagag agggagagat aaaccaccgc ttacagatat tggagttcta tatgaaggga
      481 aagaacggct tattccagga tgtgaagtga tcctagccac accctatggt cgctgtgcca
      541 atgtcaacaa tagttcaact acttcacaaa gaatctttat cacttatcga agggctcctc
      601 cagttcgacc ccagaattcc ttggctgtaa ctgatatctg tgttattgta accagtaaag
      661 gagaaactcc tcctcatacc ttctgcaaag ttgacaaaaa cttaaattgt ggaatgtggg
      721 gttccagcgt gtttctgtgt tataagaagt ctgtacctgc ttcaaatgca atagcatata
      781 aggctggttt aatttttaga tatccagaag aggactatga gtcatttcca ctctcagaat
      841 cagatgtacc tcttttctgc cttcctatgg gagctactat tgagtgctgg gatcctgaaa
      901 ccaaatatcc acttccagtt ttttcaactt ttgtcttgac aggttcttca gccaaaaagg
      961 tatatggagc tgccattcag ttttatgaac cttactctcg ggaacttcta tcagagaaac
     1021 agcttatgca cctgggcttg ttgacgcctg tggagagaaa aatggtctcc aaatccatca
     1081 atacaaacaa atgcatttgt ttactctcac actggccttt ttttgaagct tttaggaaat
     1141 ttcttatgtt tatctacaaa ctttctgtgt ctggaccaca tcctcttccc attgaaaagc
     1201 acatttcaca ttttatgcaa aacatccctt ttccttcacc acaaagaccg agaatccttg
     1261 tccagctgtc agtccatgat gcattaatat tatcacagcc agtttctaca cctttaccac
     1321 taagtggagc caactttagc accttgctaa tgaatctggg tcctgagaat tgtgcaacac
     1381 tgctgctctt tgttttactt gagagtaaaa ttctgctgca ttctcttagg ccagctgtct
     1441 tgactggggt agctgaagct gttgtagcta tgatctttcc atttcagtgg caatgcccat
     1501 atattcccct ttgtcctctt tcactggctg cagtgcttag tgcaccttta ccatttatag
     1561 ttggagttga ctcaaggtat tttgatcttc atgacccacc acaagatgtt gtttgcattg
     1621 acttggatac gaacatgtta tatgtatcag atgaaaagaa gaacatgaac tggaagcaac
     1681 ttcccaaaaa gccgtgcaaa aatctactta gcaccttaaa gaaattgtat ccccagctgt
     1741 cttcagttca ccaaaaaact caagaaggct cagcgattga catgactcca attgaagcag
     1801 atttctcctg gcaaaagaag atgacacagc ttgagatgga aattcaagag gcatttttgc
     1861 gctttatggc gtctatttta aaaggatata gaacatatct cagaccaatc acagaggctc
     1921 cttcaaataa agccacagct gctgattcat tgtttgaccg acagggattt ttaaaaagtc
     1981 gagatcgtgc ctatgcaaaa ttctataccc ttttatccaa aacacagatt tttattcgtt
     2041 tcattgaaga atgcagtttt gtaagtgata aagatactgg attagcattt tttgatgact
     2101 gcatagaaaa gttgtttcct gataaaggca cagagaaaac agataaggtt gattttgatt
     2161 cagcagaaga taccagattg atagaactag atgattcaca gaaaagtgag catactgtat
     2221 ttataatgcc gccagagcca cctcctgatg atggaaagga cctgtcacca aagtacagtt
     2281 acaaatactt tccaagactg gaccttaagc tttttgacag accgcaggag ttgaaacttt
     2341 gttttagtag acaccctact gggaatagca ttacaaagag tccacctctc atggctaaga
     2401 gaactaaaca ggaaataaaa acagctcata aattggcgaa gagatgttat acaaatccac
     2461 cacagtgggc caagtgtctg tttagtcatt gttacagttt atggtttatt tgtcttccgg
     2521 cctatgttag agtttctcat cctaaagtca gagcacttca gcaggcatat gatgtactta
     2581 ttaagatgag gaaaacagat gtggatccct tagatgaggt gtgctatcga gtagtgatgc
     2641 agctttgtgg actttggggt catcctgttt tagcagtgag agtcttattt gaaatgaaaa
     2701 ctgctaggat aaagcctaat gctattactt atggttatta taataaggta gtcttggaga
     2761 gcccgtggcc tagcagtacc cgcagtggta ttttcttatg gacgaaggta cggaatgtgg
     2821 tacgtggctt ggcacagttt aggcagccgc ttaaaaagac tgtgcaaagg tcacaggtct
     2881 cctcaatatc agctcttcaa aatgtcacag gtggaagtga tggggacacg gtgagccacg
     2941 gtagtgtgga tagttctaat gatgctaaca atggggagca cacagtcttc gtcagagatt
     3001 taatcaggct tgagtccatt gataatcact ctagcacagg tggtcagtct gaccaaggat
     3061 acgggtctaa ggatgaactt ataaaggatg atgcagaaat tcatgtgcct gaagaacagg
     3121 cagcaagaga attgataact aaaacaaaaa tgcaaacaga agaggtgtgt gatgcctctg
     3181 ctattgtggc aaaacattca caacctagtc cagagcctca cagtcctact gaacctcctg
     3241 catggggcag cagtattgtg aaagttccgt ctggtatatt tgatgtcaac agcaggaaaa
     3301 gtagcactgg tagtatatca aatgtgctgt tttctactca agatccagtt gaagatgcag
     3361 tctttggcga agctactaat ctcaagaaga atggtgatag aggagaaaaa agacaaaagc
     3421 attttcctga gaggagttgt agttttagtt ctgaaagtcg agcaggaatg ttgcttaaga
     3481 agagtagttt ggattcgaat tcaagtgaaa tggctatcat gatgggagca gatgccaaga
     3541 ttctcacagc agcattgaca tgtcctaaga cttctctact tcatattgca agaacccata
     3601 gctttgagaa tgttagctgt cacctacctg atagtaggac ttgtatgtct gaaagcactt
     3661 ggaatcctga gcacagatca tctccggtgc cagagatgct tgaggaaagc caagaactcc
     3721 ttgagcctgt ggttgatgac gtacctaaaa ctactgcaac agtagataca tatgagagtc
     3781 tactaagtga tagtaacagt aatcagtcca gagacttgaa aacagtatcc aaagatctga
     3841 ggaataagag aagtagttta tatggtattg ctaaggtggt tcagagggaa gatgttgaaa
     3901 ctggactaga tcctttgtct cttttagcca ctgaatgtac aggaggaaaa actcctgatt
     3961 ctgaagataa gttgttttct ccagttattg cacgtaatct ggctgatgaa atagaaagct
     4021 atatgaacct aaaaagtccc ctaggtagta aatcttctag tatggaatta cacagagagg
     4081 aaaacagaga gtctggcatg actactgcat ttattcatgc tctagagagg agatcaagcc
     4141 tacctttaga tcatggttca ccagcacagg aaaatcctga aagtgaaaag agctcacctg
     4201 cagtgtccag gtctaaaact tttactgggc gtttcaagca gcaaaccccc tctcgaactc
     4261 ataaagaacg ttcaacttct ttgtcagcac tggtgcgttc ttcgccacat ggctcgttgg
     4321 gttctgtagt aaattctttg tcagggctaa agctggataa tatactctca gggcccaaga
     4381 tagatgtcct gaaatctggt atgaaacaag cagcgacagt agccagtaag atgtgggtag
     4441 ctgttgcgtc tgcctacagc tactcagatg atgaggaaga aactaataga gactacagct
     4501 tcccagctgg cctagaagac catattttgg gggagaatat atcgcctaac acaagtatct
     4561 cagggttggt ccccagtgaa cttacccaga gcaacacaag tcttggcagt agcagcagta
     4621 gtggagatgt aggaaaactg cattatccaa caggtgaagt tccatttcca agaggcatga
     4681 aagggcaaga ctttgaaaaa tcagatcatg gttcttctca aaataccagc atgtctagca
     4741 tctatcagaa ttgtgcaatg gaggttttga tgtccagttg ttcacagtgt agagcttgtg
     4801 gagctttagt ttatgatgaa gaaattatgg ctggatggac agcagatgac tcaaatttga
     4861 atacagcttg tccattctgt aaaagcaact tcttgcctct tctcaatata gaattcaaag
     4921 atttgagagg ttctgcaagc tttttcctga aaccaagtac ctctggtgac agtttacaaa
     4981 gtggaagcat tccattggca aatgaatcct tggagcacaa acctgtatcc agtttagcag
     5041 aacctgactt gatcaacttt atggacttcc caaaacataa ccagatcata actgaagaaa
     5101 caggctctgc agttgaacca agtgatgaaa taaagagagc cagtggagat gtccaaacta
     5161 tgaaaatttc atctgtgcct aatagtttat caaagcgaaa tgtgtctttg actcgaagtc
     5221 acagtgttgg aggcccattg cagaatattg actttaccca gcgaccgttt catggcatct
     5281 caacagttag tcttccaaat agtctgcagg aagttgtgga tcctttagga aaaagaccca
     5341 atcctccccc tgtttctgtg ccctacttga gtcctctagt actccgtaaa gaacttgaat
     5401 ctttgctaga aaatgaaggt gatcaggtga ttcatacatc ttctttcatc aatcaacatc
     5461 caatcatttt ctggaacctc gtttggtatt tcagacgttt ggaccttcct agtaacttgc
     5521 caggacttat cctcacatct gaacattgta atgaaggtgt acagcttcct ctgtcatctc
     5581 tgtcccagga tagcaaactt gtgtatattc agctgttatg ggataatatc aaccttcatc
     5641 aggaaccaag agaacctctg tatgtctcat ggaggaattt taattctgaa aagaaatcat
     5701 ctctcctgtc agaggaacaa caagaaacaa gcactttagt agaaaccatc aggcagagta
     5761 ttcagcacaa taatgttctt aaacccatca acctactttc acagcaaatg aagccaggca
     5821 tgaaaagaca aaggagttta tacagagaaa tcctcttctt atcattagtg tctctaggaa
     5881 gagagaatat tgatattgag gcatttgaca atgaatatgg aattgcatac aatagtctgt
     5941 cttcagagat tcttgaaagg ttgcagaaaa ttgatgctcc accaagtgcc agtgtcgagt
     6001 ggtgcaggaa gtgttttgga gcgcctctca tttaaataga gattcactag aatgttgaca
     6061 cacaaggctt ggggattaga tttcatctgg aaacattcaa gttttttttt ccaaatcgta
     6121 agaactggtg aatacggaat tgaagtaact cttggggaca atatataatg aattatgatt
     6181 catattgcat taccttgaaa tatgaagtgc catttgaatg tcccagggct tattaatatt
     6241 gaagattttc aacccctgaa ctgcttttct gcctctgtgg aaaactactt tgggattctt
     6301 cagtatttgt agtagtttga tagaaataat gaggaaccat attcattcta ggcattgttt
     6361 atatttgaag ttactgagtt tgaggaatgg caaattaaat ttgcctaacc cccaaaacaa
     6421 atgaaatatc tcaattataa aagcaacatg gccgggcacg gtggctcagg cctgtaatcc
     6481 cagcactttg ggaggctgag caaggtgggt ggatcacttg aggccaggag ttcgagacca
     6541 gcctggccaa cacggtgaga ccctgtcttt actaaaaata caaaaattag ccaggcgcac
     6601 cactgtagtc ccagctactc aggctgaggc aggagaatcg cttgaactga ggcagaggct
     6661 acagtgagtg gagatcacgc cactgcaact ccagcttggg tgacagagtg agaccgtctc
     6721 aaaaaaaaaa aaaaaaaaaa aagagagcaa catatttgtg taagtttgta tatgtgtagg
     6781 gctgtgtagg tatgtgtata tacagccata ttctaagtgt atatttatta aaatagattg
     6841 catgttgcaa tacggttttc tgaaaggggt ctcattgact attaaataaa tgactactac
     6901 taaacttgtc tgtagtcatt aatcttaaaa ttacctgaaa atctgatgac agctgccttc
     6961 cctaacttta atgtattagg ttggcacaaa attaattgta gtttttgcca ctattaatgg
     7021 caaaaaccgc aattattttt gtaccaacat aatacacctt tcatattatg tattatcttg
     7081 cttaatgggt tttatcttga ttatccagtt acttccatcc tcttcccaat gttaatttgc
     7141 aatagtttta aaatgggaac aaatgaatca atcatcagat agttaaaatg aaattaaatc
     7201 agctgcctaa taatttatgg aattcattgg aatgtgctta aaatgctaaa gtgtatgtca
     7261 ttgaacatga aatctttttt caggcacata cattgttggt attgatgact ttttaaaacc
     7321 tgtgggataa acttgcactg cacacggaag ttttattctt gtatatttag atttgtatgc
     7381 ttgtgagtaa aaatgtgcat ttgtaaatac tgtgttttta ggttgaatca attaagtctt
     7441 aaaactgtaa atttattaag cttgttgcca gtaggtttaa gaaaatcatg atctcacatg
     7501 cctcactttg acatttatca tgccttttat taaaaatatc ccttaggaac agtaagtttg
     7561 ccttaactct ctgcatggtt taaaaagcca ttggttttgt gtgtgtttac agtaattatg
     7621 cagatgacta aatgagttga cacagtaaaa ttacttccat atggtacagt aacaacctaa
     7681 ctcccttcta cctgatgtaa ccatttacaa attatagtta ttgtaccagt ctttcaacat
     7741 ttcagggtta atctgaccta tgcagaattc tagtgtgaat ttattgtgaa aatgctaaat
     7801 gaaacaattt gtcagaaatt atgtacaatt ttcattacct tcaaaatgga tcttttgcac
     7861 tgtctgagag tatatatttt tgcaactcaa gacttggtac tagttttaat acttaacact
     7921 tactgaccca acagaagttt ggaattacct tgcatataaa aattgaggtt gaataaaatg
     7981 aaaaattgtt gttttctgtt acattaagcc tcttgaaatc tgtaatcttt agaatcccaa
     8041 tattttgttt tttccattcc ttcactcgta acttgaactc aagttttcac ttactgacgc
     8101 gcttcccatt aaaaaaaatc tgtaaagatc tctaccttga aaa
//
