LOCUS       NM_014856               5728 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DENN domain containing 4B (DENND4B), transcript
            variant 1, mRNA.
ACCESSION   NM_014856 XM_001130684 XM_375806
VERSION     NM_014856.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5728)
  AUTHORS   Hibar,D.P., Stein,J.L., Ryles,A.B., Kohannim,O., Jahanshad,N.,
            Medland,S.E., Hansell,N.K., McMahon,K.L., de Zubicaray,G.I.,
            Montgomery,G.W., Martin,N.G., Wright,M.J., Saykin,A.J., Jack,C.R.
            Jr., Weiner,M.W., Toga,A.W. and Thompson,P.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association identifies genetic variants associated with
            lentiform nucleus volume in N = 1345 young and elderly subjects
  JOURNAL   Brain Imaging Behav 7 (2), 102-115 (2013)
   PUBMED   22903471
REFERENCE   2  (bases 1 to 5728)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   3  (bases 1 to 5728)
  AUTHORS   Semova,N., Kapanadze,B., Corcoran,M., Kutsenko,A., Baranova,A. and
            Semov,A.
  TITLE     Molecular cloning, structural analysis, and expression of a human
            IRLB, MYC promoter-binding protein: new DENN domain-containing
            protein family emerges
  JOURNAL   Genomics 82 (3), 343-354 (2003)
   PUBMED   12906859
REFERENCE   4  (bases 1 to 5728)
  AUTHORS   Li,S.H., McInnis,M.G., Margolis,R.L., Antonarakis,S.E. and
            Ross,C.A.
  TITLE     Novel triplet repeat containing genes in human brain: cloning,
            expression, and length polymorphisms
  JOURNAL   Genomics 16 (3), 572-579 (1993)
   PUBMED   8325628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358472.54 and AB007945.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014856.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007945.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361217.9/ ENSP00000354597.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL358472.54        27305-27344         c
            41-5728             AB007945.2         1-5688
FEATURES             Location/Qualifiers
     source          1..5728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5728
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /note="DENN domain containing 4B"
                     /db_xref="GeneID:9909"
                     /db_xref="HGNC:HGNC:29044"
                     /db_xref="MIM:619843"
     exon            1..418
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            419..758
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..4932
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 4B; DENN/MADD domain containing
                     4B"
                     /codon_start=1
                     /product="DENN domain-containing protein 4B isoform 1"
                     /protein_id="NP_055671.2"
                     /db_xref="CCDS:CCDS44228.1"
                     /db_xref="GeneID:9909"
                     /db_xref="HGNC:HGNC:29044"
                     /db_xref="MIM:619843"
                     /translation="MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPA
                     EPITDVAVIARALGEEVPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPL
                     VELGVLYEGKERPKPGFQVLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALG
                     ITDLCLVLPSKGEGTPHTYCRLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGR
                     YPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAAL
                     QFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFL
                     TFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLP
                     LSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQ
                     CPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTLFQTEEKKLL
                     SPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREV
                     QGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLL
                     HTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQEKPEPTPLVELEELSGSELTVF
                     ITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPR
                     RTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQALHTAYH
                     VLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNK
                     AVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVS
                     AHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQP
                     TVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQST
                     EALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPELPPDLPPP
                     ARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQ
                     SPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLD
                     SRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVESG
                     AWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL
                     VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRV
                     VWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFL
                     TMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPP
                     EC"
     exon            759..1011
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1081
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1251
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1496
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1563
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1622
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1767
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1943
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2044
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2260
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2406
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2546
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2673
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2880
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3009
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3214
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3382
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3771
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3894
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4064
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4200
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4437
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4555
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4721
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4722..4786
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..5728
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5704..5709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /note="hexamer: AGTAAA"
     polyA_site      5728
                     /gene="DENND4B"
                     /gene_synonym="KIAA0476"
                     /note="major polyA site"
ORIGIN      
        1 agacgcttgc cagggtcacg gccgccggcc gaggaggagg ggtgggggta gcggcggcgc
       61 ccgcggcccg gagcgggggt tgggggagta gagaaagcgg ggcgcgcgga ggaacgctgg
      121 gtccccggcg ccgcgggagc tgggaggacc gagccggccg agcgagcagc gcggcagcac
      181 agtccccgcg tggcgcagcg cggcggggac gcggggaccg cccggatctc cttccactgc
      241 gccccgcgct ctgcggtcct cggccgcctc ttcttccttc actcactgcc cgggcgggag
      301 cggcgcccaa gtcgggtgcg ccatgtctgg ggccgggtag ccccgccgcc cgccggcccg
      361 ccagctcgcc ctccgagcca cccgccagcg ggccggccgg ccgggaagcg cgggacagat
      421 gcagtgagtg aggggggggc catggcggag gagcggcccc cccggctggt ggattacttc
      481 gtggtagctg ggcttgcagg gaacggagca cccatccctg aggaaacgtg ggttcctgaa
      541 cccagtgggc ccctgcgccc tccccggcca gctgagccca tcacagatgt ggcagtcatc
      601 gctagggcac tgggcgagga agtgccccag ggctacacat gcatccaggc ttctgctggg
      661 ggccacccct tggaactcag tgctggactt ctgggtggaa ctcaacccgt catctgctac
      721 cgcaggggcc gtgacaagcc ccccctcgtt gagctggggg tgttgtatga ggggaaggaa
      781 cgtcccaagc ctggcttcca agtgcttgac acgacaccct acagccactc agcaaacctg
      841 gcccctccag gccccgggca cccccgcacc tacctcactt accggcgggc agcagagggg
      901 gcagggctgc atgccctggg catcactgac ctctgcctgg tgctgcccag taagggcgag
      961 ggcactcctc atacttactg ccggctgccc cgcaacctca accctggcat gtggggccca
     1021 gcagtgtacc tgtgctataa ggtgggcctg gcgaaggcca acacgctggt gtacgaggca
     1081 gagctgctgg gccgctaccc ggaggaggac aatgaggcgt tcccgctgcc cgagtcagtg
     1141 cccgtcttct gcctgcccat gggggccact atcgagtgct ggcctgccca gaccaagtac
     1201 cccgtgcccg tcttctccac ctttgtgctc acgggtgcag ctggtgataa ggtgtatggt
     1261 gccgccctgc agttctacga ggcgttccca agggccaggc tatcagagcg acaggcacgg
     1321 gcactgggcc tgctgagcgc cgtggagcgg ggtcgggcac tggggggcag agctgtgcgc
     1381 agccggcgtg ccatcgctgt gctgtcccgc tggcctgcct tccctgcctt ccgcgccttc
     1441 ctcaccttcc tttaccgcta ctccgtctca ggcccccacc gcctaccctt ggaagcgcac
     1501 atctcccact tcattcacaa cgttcccttc ccttccccac agagaccccg catcctagtg
     1561 cagatgtctc cctatgacaa cttgctcctc tgtcagcctg tatcctcacc cctgcccctc
     1621 agtggtgcca gcttcctgca gctgctgcag agcctgggcc ctgagctggc tatcacactg
     1681 ctgctggctg tgctcacaga gcacaagctg ctagtccact cgctgcggcc agacctgctc
     1741 accagcgtct gtgaggccct cgtctcgatg atcttcccac tgcactggca gtgcccctac
     1801 attcctctgt gcccgctggt gctggcagat gtgctgagtg ccccagtgcc cttcattgtg
     1861 ggtatccact ccagctactt tgatctgcat gacccgcctg ctgatgtcat ctgtgtagac
     1921 cttgatacca acacgctctt ccagactgag gaaaagaagc tcctctcccc tcggaccctg
     1981 ccccgcagac cctacaaggt tctgctggcc acactgacaa acctgtacca gcagctggac
     2041 cagacataca ctggacctga ggaggaagca tccctggagt tcctactgac agactacgag
     2101 gcagtgtgtg gccgcagggc ccggctggag cgcgaagtcc aaggagcctt cctccgcttc
     2161 atggcctgtc tgctcaaggg ctaccgggtc ttcctgcgcc cactcaccca ggccccctcc
     2221 gagggagctc gtgatgttga caaccttttc ttcctgcagg gcttcctcaa atcccgggaa
     2281 cgctccagcc acaaacttta ctctcagctg ctgcacacac agatgttctc acagttcatt
     2341 gaggagtgct cttttggctc tgctcgccat gctgcccttg aattctttga ctcttgtgtt
     2401 gaaaaggtcc acccagagca ggagaagcct gagccgacac ccttagtgga gctagaggag
     2461 ctgtcaggaa gtgagctcac tgtctttatc acacctcccg aggagcctgc cttaccagag
     2521 ggcagtgaat ccactcccca gtactgctat gatggattcc cagagctacg ggctgagttg
     2581 tttgagtctc ttcaagagca acctggggcc ctgcctgtgc caggcccttc ccgtagcgcc
     2641 cccagcagtc ctgctcctcg ccgtaccaaa caggagatga aagttgcaca gcggatggca
     2701 cagaagtcag cagctgtgcc tgagctgtgg gcccggtgcc tgctggggca ctgctatggg
     2761 ctgtggttcc tgtgtctgcc tgcctatgtg cggtcggcac cctcccgagt gcaggcactg
     2821 cacacagcct accatgtgct gcgccagatg gagagcggca aggtggtgct ccctgatgag
     2881 gtgtgttacc gggtactgat gcagctctgc tcacactatg ggcagcctgt gctgtctgtg
     2941 cgggtcatgc tggagatgcg tcaggcaggc attgtgccca acaccatcac ctatggctac
     3001 tacaataagg ctgtgttgga aagcaagtgg ccgtctggca caccaggtgg gcgtctgcgc
     3061 tgggccaagc tccggaatgt tgtcctgggg gctgctcagt tccgccagcc cttgagagaa
     3121 cggcaacagc agcagcagca gcaacagcag cagcagcagc agcagcagca ggagcaggtg
     3181 tcagcacatc aagaggcagg cagctcccag gcagagccct atttggagcg cccttcccct
     3241 actcgccctc ttcagcgcca gactacttgg gctgggcgaa gtctgagaga cccagcctca
     3301 ccccctggac gcctggtgaa gagtggtagc ctgggcagtg cccgaggggc acagcccact
     3361 gtggaggccg gtgtggccca catgatagag gccttggggg tcctggaacc ccggggatca
     3421 cctgtgccct ggcacgatgg aagtctctca gacctgagcc tgacagggga ggagccgctc
     3481 cctggaggca gcccaggggg ctcaggctca gccctgagtg cccagtccac tgaggccctg
     3541 gaagggctaa gtgggcgggg acccaaggct ggtgggcgac aggatgaggc aggcaccccc
     3601 cgacgagggc tgggtgcccg cctccaacag ctgctcactc cttcccgcca ctcccctgcc
     3661 tcccgcattc ccccacctga gctgcctcct gacctgccac ccccagcccg ccgcagcccc
     3721 atggacagtc ttctgcaccc ccgggagcgc cctggatcca ctgcctccga gagctcagcc
     3781 tctctgggca gtgagtggga cctctcagaa tcttctctca gcaacctgag tcttcgccgt
     3841 tcctcagagc gcctcagtga cacccctgga tccttccagt caccttccct ggaaattctg
     3901 ctgtccagct gctccctgtg ccgtgcctgt gattcgctgg tgtatgatga ggaaatcatg
     3961 gctggctggg cacctgatga ctctaacctc aacacaacct gccccttctg cgcctgcccc
     4021 tttgtgcccc tgctcagtgt ccagaccctt gattcccggc ccagtgtccc cagccccaaa
     4081 tctgctggtg ccagtggcag caaagatgct cctgtccctg gtggtcctgg ccctgtgctc
     4141 agtgaccgaa ggctctgcct tgctctggat gagccccagc tctgcaacgg gcacatgggg
     4201 ggagcctccc ggcgggttga gagtggggca tgggcatacc tgagccccct ggtgctgcgt
     4261 aaggagctgg agtcgctggt agagaacgag ggcagtgagg tgctggcgtt gcctgaactg
     4321 ccctctgccc accccatcat cttctggaac cttttgtggt atttccaacg gctacgcctg
     4381 cccagtattc taccaggcct ggtgctggcc tcctgtgatg ggccttcgca ctcccaggcc
     4441 ccatctcctt ggctaacccc tgatccagcc tctgttcagg tacggctgct gtgggatgta
     4501 ctgacccctg accccaatag ctgcccacct ctctatgtgc tctggagggt ccacagccag
     4561 atcccccagc gggtggtatg gccaggccct gtacctgcat cccttagttt ggcactgttg
     4621 gagtcagtgc tgcgccatgt tggactcaat gaagtgcaca aggctgtggg gctcctgctg
     4681 gaaactctag ggcccccacc cactggcctg cacctgcaga ggggaatcta ccgtgagata
     4741 ttattcctga caatggctgc tctgggcaag gaccacgtgg acatagtggc cttcgataag
     4801 aagtacaagt ctgcctttaa caagctggcc agcagcatgg gcaaggagga gctgaggcac
     4861 cggcgggcgc agatgcccac tcccaaggcc attgactgcc gaaaatgttt tggagcacct
     4921 ccagaatgct agagacctta agcttccctc tccagcctag ggtggggaag tgaggaagaa
     4981 gggattctag agttaaactg cttccctgtt gccttcatgg agttgggaac aggctgggaa
     5041 ggatgcccag tcaaaggctc caagcgagga caacaggaag agggatccac tgttaccaaa
     5101 agtcctgatt cccccatcac caacctaccc agtttgttcg tgctgatgtt gggggagatc
     5161 tggggggagt tggtacagct ctgttcttcc cttgtcctat accgggaact cccctccagg
     5221 gtacccacag atctgcattg ccctggtcat tttagaagtt tttgttttaa aaaacaactg
     5281 gaaagatgca gagctactga gcctttgccc tgaatgggag gtagggatgt cattctccac
     5341 caataatggt ccctcttccc tgacgttgct gaaggagccc aaggctctcc atgcctttct
     5401 acctaagtgt ttgtatttta ttttaaatta tttattctgg agccacagcc cccttgctta
     5461 tgaggttctt atggagagtg agaaagggaa gggaaatagg gcaccatggt ccggtggttt
     5521 gtagttcctt caaagtcagg cactgggagc tagaggagtc tcaagctccc cttaggaaga
     5581 actggtgccc cctccagtcc taatttttct tgcctgcccc gccttgggga atgcctcacc
     5641 cacccaggtc ctgacctgtg caataaggat tgttccctgc gaagttttgt tggatgtaaa
     5701 tatagtaaaa gctgcttctg tctttttc
//
