LOCUS       NM_001320835            8837 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DENN domain containing 4A (DENND4A), transcript
            variant 3, mRNA.
ACCESSION   NM_001320835 XM_005254119
VERSION     NM_001320835.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8837)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 8837)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 8837)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8837)
  AUTHORS   Neelagandan,N., Gonnella,G., Dang,S., Janiesch,P.C., Miller,K.K.,
            Kuchler,K., Marques,R.F., Indenbirken,D., Alawi,M., Grundhoff,A.,
            Kurtz,S. and Duncan,K.E.
  TITLE     TDP-43 enhances translation of specific mRNAs linked to
            neurodegenerative disease
  JOURNAL   Nucleic Acids Res 47 (1), 341-361 (2019)
   PUBMED   30357366
  REMARK    GeneRIF: our data reveal that TDP-43 can function as an
            mRNA-specific translational enhancer. Moreover, since CAMTA1 and
            DENND4A are linked to neurodegeneration, they suggest that this
            function could contribute to disease.
REFERENCE   5  (bases 1 to 8837)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8837)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   7  (bases 1 to 8837)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 8837)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 8837)
  AUTHORS   Semova,N., Kapanadze,B., Corcoran,M., Kutsenko,A., Baranova,A. and
            Semov,A.
  TITLE     Molecular cloning, structural analysis, and expression of a human
            IRLB, MYC promoter-binding protein: new DENN domain-containing
            protein family emerges
  JOURNAL   Genomics 82 (3), 343-354 (2003)
   PUBMED   12906859
REFERENCE   10 (bases 1 to 8837)
  AUTHORS   Stasiv,Y.Z., Mashkova,T.D., Chernov,B.K., Sokolova,I.V., Itkes,A.V.
            and Kisselev,L.L.
  TITLE     Cloning of a cDNA encoding a human protein which binds a sequence
            in the c-myc gene similar to the interferon-stimulated response
            element
  JOURNAL   Gene 145 (2), 267-272 (1994)
   PUBMED   8056341
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011939.9.
            
            On Mar 9, 2016 this sequence version replaced XM_005254119.2.
            
            Summary: This gene encodes a DENN domain-containing protein that
            may function as a guanine nucleotide exchange factor that
            specifically activates ras-related protein Rab-10. This protein
            also contains a interferon stimulated response element-binding
            domain and may be involved in regulating the v-myc avian
            myelocytomatosis viral (MYC) oncogene. Alternate splicing results
            in multiple transcript variants. A pseudogene of this gene is found
            on chromosome 8. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            compared to variant 1. The encoded isoform (3) is longer than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1439223.1,
                                           SRR14038197.499883.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443035.8/ ENSP00000391167.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC011939.9         9165-9448
            285-363             AC011939.9         40020-40098
            364-696             AC011939.9         44986-45318
            697-946             AC011939.9         48830-49079
            947-1016            AC011939.9         59674-59743
            1017-1186           AC011939.9         62583-62752
            1187-1425           AC011939.9         63513-63751
            1426-1492           AC011939.9         68640-68706
            1493-1551           AC011939.9         69758-69816
            1552-1696           AC011939.9         71780-71924
            1697-1872           AC011939.9         72211-72386
            1873-1973           AC011939.9         78510-78610
            1974-2192           AC011939.9         83462-83680
            2193-2338           AC011939.9         85835-85980
            2339-2472           AC011939.9         95234-95367
            2473-2608           AC011939.9         98450-98585
            2609-2815           AC011939.9         98947-99153
            2816-2944           AC011939.9         99568-99696
            2945-3086           AC011939.9         100266-100407
            3087-3218           AC011939.9         100783-100914
            3219-3335           AC011939.9         104075-104191
            3336-3467           AC011939.9         104961-105092
            3468-4564           AC011939.9         109947-111043
            4565-4754           AC011939.9         124824-125013
            4755-4849           AC011939.9         129572-129666
            4850-5025           AC011939.9         131270-131445
            5026-5172           AC011939.9         131533-131679
            5173-5371           AC011939.9         133335-133533
            5372-5626           AC011939.9         133755-134009
            5627-5744           AC011939.9         135996-136113
            5745-5907           AC011939.9         136736-136898
            5908-5972           AC011939.9         137064-137128
            5973-8837           AC011939.9         139471-142335
FEATURES             Location/Qualifiers
     source          1..8837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..8837
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="DENN domain containing 4A"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
     exon            1..284
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            285..363
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            364..696
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..6109
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="isoform 3 is encoded by transcript variant 3; c-myc
                     promoter binding protein; DENN domain-containing protein
                     4A; DENN/MADD domain containing 4A"
                     /codon_start=1
                     /product="C-myc promoter-binding protein isoform 3"
                     /protein_id="NP_001307764.1"
                     /db_xref="CCDS:CCDS92025.1"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
                     /translation="MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEP
                     ITDVSVIIKSLGEEVPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTD
                     LGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTD
                     ICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQ
                     EDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFY
                     EPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYR
                     YSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGK
                     FSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVP
                     LCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKIL
                     PKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAF
                     LFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQM
                     FIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEI
                     PHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTK
                     QEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLK
                     KMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVL
                     ESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLSADGSDLDAVSHGSM
                     DSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVRRGDTSTEDIQE
                     EKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGKISGESMEST
                     PELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGGVLMGFML
                     NRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKESSDDD
                     TPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKPFEK
                     TDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSSP
                     LTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPR
                     DRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKA
                     SKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSAT
                     SGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSC
                     SRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKS
                     SPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQ
                     IPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLE
                     WHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRL
                     DLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN
                     AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRS
                     LYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRK
                     TFGEPYL"
     exon            697..946
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1016
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1186
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1425
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1492
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1551
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1696
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1872
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1973
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2192
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2338
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2472
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2608
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2815
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2944
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3086
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3218
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3335
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3467
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..4564
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..4754
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4849
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4850..5025
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5026..5172
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5173..5371
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5372..5626
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5627..5744
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5745..5907
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..5972
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5973..8837
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6157..6162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="hexamer: TATAAA"
     polyA_site      6183
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="major polyA site"
     regulatory      6604..6609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="hexamer: AATGAA"
     polyA_site      6620
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
     regulatory      8812..8817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="hexamer: AATAAA"
     polyA_site      8837
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /note="major polyA site"
ORIGIN      
        1 attgccaaga tggcgccggt cgcggtggcc gcggaggcta gagtcggaga aagaggcgga
       61 ggcagtggcg gccgcgaggg gagggggagt cccgtctgac tgagacggca ggcctgggcg
      121 ggcgggcggg ggtgccgcga agggcggagc gccgggctgg ggatgagcta agcgggctca
      181 gagcgccgcg gcattcagcc cctcgtgttc cgctaccgcg cgtgcgggat tccggcgccg
      241 ctctccgagc tcgatccgct gctcgcacgg gagccagctg ggtgttattt ctcaaactct
      301 gaggctgcgg agttcacaca ttgaaatctg tcatcttttt cagagagaaa ctttcggtaa
      361 tgtatgtaac cttctgtaat ggaagatgat tgaagacaag gggcctcgtg ttgctgacta
      421 ctttgttgta gcaggattaa ctgatgtttc aaagcctcta gaagaagaaa ttcacttcaa
      481 tgatgcttgt cataaagtag ctaaaccaaa agaacctatt acagatgttt cagttattat
      541 caaatctctt ggggaggaag tcccacagga ttatatctgt attgatgtta ccccaactgg
      601 attgtcagct gatcttaata atggaagtct tgtggggcca cagatttacc tttgctatag
      661 aagaggaaga gataagcctc cacttacaga tctgggggtt ttatatgact ggaaagaaag
      721 attgaaacag ggttgtgaaa ttattcagag tactccctat gggcgccccg caaatattag
      781 tgggagtacc tcatcacaaa gaatttatat cacttaccga agagcctctg aaaacatgac
      841 tcagaatacg ttggctgtca ctgacatatg tattattata cccagtaaag gagaaagccc
      901 accacacacg ttctgcaaag tcgacaagaa tctcaataac agtatgtggg gatcagcagt
      961 atacttgtgt tataaaaaat cggtggcaaa gacgaacact gtatcttaca aagctggcct
     1021 aatttgtaga tatcctcaag aagattatga gtcattctca ctaccggaat ctgttcctct
     1081 attttgttta ccaatgggtg caaccattga atgttggcca tcaaatagca aataccctct
     1141 gcctgtattt tctacttttg ttttaactgg agcctcagct gaaaaggttt atggtgctgc
     1201 tattcagttt tatgaaccat actctgagga gaatctcaca gaaaagcaga gacttctttt
     1261 gggtttaaca tcagcagatg ggaagtctga tagttccaaa acaattcata ctaacaaatg
     1321 catctgtctt ctttctcact ggcctttttt tgatgcattc aggaagtttc tgacttttct
     1381 gtatcgttat tccatctctg ggcctcatgt ccttccaatt gagaagcata tttctcattt
     1441 tatgcataaa gttccttttc catctcctca gagaccacgg attttagttc agttatcacc
     1501 acatgataat ctgattctca gtcagcctgt gtcttcacct cttccactaa gtggtggcaa
     1561 gttttcaaca ctactgcaga atttaggccc tgaaaatgct gtgacactac tggtgtttgc
     1621 agtaacagaa cataaaattc ttatccattc cctacggcca tccgtgctta ctagtgtgac
     1681 agaagcatta gtgtctatga ttttcccttt ccactggcca tgcccgtatg ttcctctctg
     1741 cccactggct ttagcagatg tcttgagtgc accatgtcca ttcatagtag ggattgattc
     1801 aagatacttt gatctctatg atcctccacc agatgtcagt tgtgttgatg tagataccaa
     1861 cactatttct caaattggtg acaagaaaaa tgtagcctgg aagatacttc caaagaagcc
     1921 atgtaaaaat ctgatgaaca cactgaataa tttgcatcag caattggcaa aattgcagca
     1981 gagaccgaga gatgatggac tcatggattt agcaataaat gactatgatt ttaattctgg
     2041 aaagaggttg cacatgatag atttggaaat ccaagaggca tttttgtttt tcatggcctc
     2101 tattttaaaa ggttacagat catacttaag gccaataaca caagccccat ctgagacagc
     2161 cacagatgca gcctctctct ttgccctaca agctttctta agaagccggg accggtcaca
     2221 tcaaaaattc tataacatga tgaccaaaac acaaatgttt attcgcttca ttgaagaatg
     2281 ttcttttgtt agtgacaaag atgcaagcct ggcatttttt gatgattgtg tagataaagt
     2341 ggatatggac aagagcggtg aagtacgact tatagaactg gatgaatctt tcaaaagtga
     2401 acacactgtt tttgtaacac cacctgagat cccccaccta cccaatggtg aagaaccccc
     2461 tttacagtac agctataatg gatttccagt tcttaggaac aatttatttg aaagacctga
     2521 aggatttcta caagcaaaga agaacaaatt gccttcaaaa tcaagtagtc ctaatagccc
     2581 tttgcccatg ttcagaagaa caaaacagga aattaaatca gcccataaaa ttgcaaagag
     2641 gtactcttcc atccctcaga tgtggtctag gtgtctactg cgccactgtt atggactgtg
     2701 gtttatttgt ctcccagctt atgtgaaagt ctgtcattca aaagtcaggg ctctgaaaac
     2761 agcatatgat gtgcttaaaa aaatgcagtc aaagaagatg gatccacctg atgaggtatg
     2821 ctaccgcatt cttatgcaac tctgtggaca atatgatcag ccagtgcttg cagttcgagt
     2881 gctttttgaa atgcagaaag ctggtattga ccccaatgcc attacttatg gttattataa
     2941 taaggctgtt ttggaaagta cctggccttc aagaagtcgt agtggctatt ttctttggac
     3001 aaaagtaaga aatgttgttt taggagtaac acagttcaaa agagctttaa agaagcatgc
     3061 acacttatca caaacaactc tctcagcaga tggcagtgac ctggatgctg ttagtcatgg
     3121 cagcatggat agtggtcatg ggacacacac tgtggagcag gcacctttta atacgggttt
     3181 aatcaaagta tatgctactg atgatagatc tagtacaggt ggccagtctg atcttggata
     3241 taattcatta tctaaagatg aagttagaag aggggataca tctactgaag acattcaaga
     3301 agaaaaagat aaaaaaggga gtgattgtag ttccttgtca gagagtgaga gtacaaaagg
     3361 aagtgctgat tgccttccta agctcagtta tcaaaattct tccagtatcg ttcgcctcac
     3421 tggtacaagt aacaacagtg ctggtaaaat atcaggagaa agcatggaaa gcacacctga
     3481 gctgctctta atatcatctc ttgaagatac aaatgaaaca cgaaacattc aaagtagatg
     3541 cttcaggaaa agacataaaa gtgacaatga aactaatttg cagcagcaag tggtctgggg
     3601 aaatagaaac cgtaatctta gtggaggggt actgatggga tttatgctca atagaattaa
     3661 ccaggaagca acccctggag atatagttga aaaattggga gctgatgcaa aaattctttc
     3721 aaatgttatc tcaaaaagca cgagaccaaa tactcttgat attgggaagc cacctttaag
     3781 atcaaaaaga gacagtctag aaaaggaatc tagtgatgat gatacacctt ttgatggttc
     3841 taactatttg gcagataaag tggattctcc tgttattttt gacttagaag acttagacag
     3901 tgaaacagat gtatcaaaag caggatgtgt tgctacacaa aatcccaaga ggattcaacg
     3961 tatgaacagc agcttttcag taaaaccttt tgaaaaaact gatgtcgcaa caggatttga
     4021 tcccctctct cttttggttg ctgagactga acagcagcaa aaagaagaag aggaggagga
     4081 tgaagatgat agcaaaagca tttcaacacc atctgctagg cgtgatttag ctgaagaaat
     4141 tgtgatgtat atgaataaca tgagcagtcc tttgacaagt cgtacaccaa gcattgattt
     4201 acaacgggca tgtgatgata aattaaataa gaaaagtcca ccattggtca aggcatgcag
     4261 aagatctagt ctgcctccta attctcctaa gccagtgaga cttaccaaat ctaaaagtta
     4321 cacaaaaagt gaggagaaac caagggatag actttggtct tctccagcct tctcacctac
     4381 ttgcccattt agggaagaat ctcaggatac attaacccac tcatcacctt catttaactt
     4441 agatacacta ctagtaccta aactagatgt tctaagaaac agtatgttca ctgctggaaa
     4501 aggagttgca gagaaagcaa gcaaatggta ttcaagattc accatgtaca ccacatcatc
     4561 taaggatcaa agttctgatc gtaccagtct ttcttcagtg ggagcccagg attctgaatc
     4621 tacctcttta acagatgaag atgtctgcca tgagttggaa ggacctatct cctctcaaga
     4681 gaccagtgct acttcaggga ctaagagaat tgatctcagc cgaataagcc tggaaagttc
     4741 tgcatccttg gaaggatctc tgtcgaagtt tgccttacct gggaaatcag aagtgacatc
     4801 ttccttcaac gcgagtaata caaatatctt ccagaactat gcaatggagg ttctcatctc
     4861 aagttgctct cggtgtagaa cttgtgattg tcttgtccat gatgaggaaa tcatggctgg
     4921 ctggacagca gatgattcaa atctcaatac tacatgccca ttctgtggca atatcttctt
     4981 accctttctg aatatagaaa taagagattt aagacgacct ggaagatact ttctaaagtc
     5041 aagcccatca acagaaaata tgcactttcc atcctccatt tcaagtcaga cgaggcagtc
     5101 ttgcatttca acatcagcct ctggtcttga cacatctgct ctctctgttc aagggaattt
     5161 tgatctaaat agcaaatcta aactgcagga aaatttttgc acccgaagta ttcagatccc
     5221 tgctaataga tcaaaaacag ctatgtctaa atgtccaata tttccaatgg ccaggagtat
     5281 tagtacttct ggccccttgg ataaggaaga tactggaaga cagaagctca tttctacagg
     5341 cagcctgcca gctactttac aaggagctac agattcttta ggtttagaat ggcaccttcc
     5401 aagtcccgat cctgtcactg ttccgtatct tagtccttta gtggtatgga aagaacttga
     5461 aagcttattg gaaaatgaag gtgatcatgc aataacagta gcagactttg tggaccatca
     5521 tccaattgtt ttttggaacc tggtatggta tttcagacgt cttgacttgc ccagtaactt
     5581 acctggattg attctttctt ctgagcactg taacaagtat tcaaagattc cccgccactg
     5641 tatgtctgaa gatagcaaat atgttttaat acaaatgtta tgggacaata tgaagttaca
     5701 tcaggatccg ggacagccct tgtacattct ctggaatgca cacacccaaa aatatccaat
     5761 ggtccattta ttgcaaaaaa gtgataactc atttaaccag gaactgttga aaagtatggt
     5821 aaaaagcatt aaaatgaatg atgtctatgg accaatgagt cagattttag agacactgaa
     5881 taagtgtcca cattttaaaa gacagaggag tttatacaga gaaatactat ttctctcact
     5941 tgtggcactg ggaagagaaa acattgatat agatgctttt gataaagagt acaagatggc
     6001 atacgatcgt ctcacaccta gtcaagtcaa gagtacacac aactgtgata gaccaccaag
     6061 tacaggggtg atggaatgtc gaaaaacctt tggagaacct tatctttaag atgtatttgt
     6121 atgtgtaaac attcaatgta tattgtatag tcagtgtata aaataacact tttagactct
     6181 aaatattttt tcttcaattt ttgaaaatac aatttgtaaa tggttcaaaa gactcagaca
     6241 gcttatgtac agaatgtttg aagaagagaa tagtgacaag tggggagaaa gccactttgt
     6301 ttctcatttc ttttttcttc ttctttaact cccctgtaat aggaaataaa gtatttttgt
     6361 gatgaggaaa tccctaaaca aaattagttg ccataaaata tgacaactgc tttatggttt
     6421 cttttggaag agacagattg aaaaatcatg aatggaatct aaacagaaat gtcagatgaa
     6481 cgtatttcct gttttcatag actattcaaa tgttttgacc atgaagttgt attatacata
     6541 ttttaaattg tttatagtaa gttgatattt ttttaatttt taaatttaat atagcaaact
     6601 taaaatgaat ttaaacttaa gcaagcaagc gtgtattttc cttgtctgct gctatttgaa
     6661 gtaattagta cagctgcaga tctctctgtg tatatctatc tatatatata ttttttatta
     6721 cttgggagaa tgaattttaa aatgtcagtg ctagtgtcaa gtgttgtcct aggattgcat
     6781 gttagtaccc ctaagcctga gtgtggggag tgagttatgc aagggtagcg tgcactgccc
     6841 agactgactc atggagcctt gtgcaaggag agccagagag gttcactata ccatgactcc
     6901 aaaattgtct ctattgctaa tagatacgta tagtatacag ggaaaacagc ttataaatcc
     6961 aaatatcaat ttaaatttta atattctaca tgaaaactta cattgggaaa tatgcagaca
     7021 agtgattata ttccaaattt tacccttatt ttaatatcta aaatattggg tatgatgcaa
     7081 attatactat agaatattta tctgaaatat gacttactgg ggtattctgt taatactata
     7141 tataaatatt cagaattttt ttcaaaagta gaaaaattcc cctctaaaag tacagccaga
     7201 tagattttca tccatattga ggaacttagc tttttcaaca agcttcagaa tctgaagtct
     7261 gtagaatcta aaatacagaa atatccagaa atcagacaat aaattgaaag tttagacatc
     7321 atgagtatta aatagcttta aaaatatatt tttagtcata ttatttctaa tgtaactttc
     7381 tttgggtaat ttctggtaag gaaaaacatc ttttggctgc tagaattagt tatagatttt
     7441 caatatgtgt gtgtgtttgc acacattatc attagtgaag gaattcccta gccagcttta
     7501 aagaaggaaa aaatggatag tcccaaatta ggtgtataaa gccagtagag tccacgacac
     7561 ttggactgga ggtatcttgg agtcctgaga cttagaatca gttcagctgc agaaaaccca
     7621 ccttttgagt tcacaccatt agtgaatagc accatgctga aacatttcac agcttccaac
     7681 tctgggaaat aatggagaga gtttaaaaat gtaaaacttc agttagtttg gggctgaact
     7741 tgcttacttg aaaaatctgg tgctaggcac atatatctgc ctctcctttg taaataccac
     7801 tccaatatta ttctttacta ttcagatcca agcttcatgt tctacttgtt cttcatgttc
     7861 tttaaatcat ttgaaagttg tcaactgaga gaaacatttc agagggggga ggcttttggc
     7921 actggtgata aacatccctc caagagaacc gtctggggtt ctcttctatt tgtggttggt
     7981 ggtttttatt cttttaaaaa cagctttcat tgttgtttac tttttgtgta atacaaacaa
     8041 aatgtaggaa tcatagttta ttgatttcaa atggctgaca aagaatgagt aaaaccattc
     8101 tttatggttt tacgattcag actcatttgg aaaagcgaat gtaattttta cctcctcttt
     8161 ccaccccaag ttttgtttct gcttttggag agggttgtat ttcccctact tttaatccct
     8221 agggaatatt attgcacaga tttagtctta aaacctaaaa cacaaataca aagtggtaaa
     8281 cctgttcaaa agaaaattaa aatgtgaatc attcttgagc tgggcgtggt tgctcatgga
     8341 ggcctgtaat cccagcactt tgggaggctg aagcagggag gattgcttga gtccaggagt
     8401 tcaaaaccag cctgagcaac atagagagac cctgtctcta caaaaaaatt ttttaaattt
     8461 gctcggtatg gtggctcatg cttggtaatc ccagctactc gggaggctga agcaggagga
     8521 tcactttgag cctgggggtt tggggctgca atgagctgtg atcatgccat tgcactctag
     8581 cctggattac agagcaagac cctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaacca
     8641 gaaaatatca atcatttaaa ataactctat acaaactttt cttcaatttt ctgttaacca
     8701 tacattttgg agaataatgg ccaatcatgt tggagagaaa tgcccttttg ctacagcatc
     8761 tgtcttttat tttcttactc ttagttttgt ttatatgttt aaatggttga caataaacca
     8821 tgtcctgtgc tgatgta
//
