LOCUS       NM_015689               3874 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DENN domain containing 2A (DENND2A), transcript
            variant 1, mRNA.
ACCESSION   NM_015689 XM_005249976 XM_371960 XM_374538
VERSION     NM_015689.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3874)
  AUTHORS   Hashimoto,S., Shirasaki,T., Yamashita,T., Iwabuchi,S., Suzuki,Y.,
            Takamura,Y., Ukita,Y., Deshimaru,S., Okayama,T., Ikeo,K.,
            Kuroki,K., Kawaguchi,K., Mizukoshi,E., Matsushima,K., Honda,M. and
            Kaneko,S.
  TITLE     DOCK11 and DENND2A play pivotal roles in the maintenance of
            hepatitis B virus in host cells
  JOURNAL   PLoS One 16 (2), e0246313 (2021)
   PUBMED   33539396
  REMARK    GeneRIF: DOCK11 and DENND2A play pivotal roles in the maintenance
            of hepatitis B virus in host cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3874)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3874)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   4  (bases 1 to 3874)
  AUTHORS   Macgregor,S., Hewitt,A.W., Hysi,P.G., Ruddle,J.B., Medland,S.E.,
            Henders,A.K., Gordon,S.D., Andrew,T., McEvoy,B., Sanfilippo,P.G.,
            Carbonaro,F., Tah,V., Li,Y.J., Bennett,S.L., Craig,J.E.,
            Montgomery,G.W., Tran-Viet,K.N., Brown,N.L., Spector,T.D.,
            Martin,N.G., Young,T.L., Hammond,C.J. and Mackey,D.A.
  TITLE     Genome-wide association identifies ATOH7 as a major gene
            determining human optic disc size
  JOURNAL   Hum Mol Genet 19 (13), 2716-2724 (2010)
   PUBMED   20395239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006452.5, AB033103.2, AK290056.1, BC115004.1, DA401015.1,
            BC049193.1 and AI040169.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015689.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2 and 5
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290056.1, ERR3218371.175139.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496613.6/ ENSP00000419654.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC006452.5         79047-79083         c
            38-268              AB033103.2         1-231
            269-462             AK290056.1         1-194
            463-1023            BC115004.1         234-794
            1024-1259           DA401015.1         327-562
            1260-2458           AK290056.1         992-2190
            2459-3630           BC049193.1         790-1961
            3631-3830           AK290056.1         3363-3562
            3831-3874           AI040169.1         10-53               c
FEATURES             Location/Qualifiers
     source          1..3874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3874
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /note="DENN domain containing 2A"
                     /db_xref="GeneID:27147"
                     /db_xref="HGNC:HGNC:22212"
                     /db_xref="MIM:620120"
     exon            1..310
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            311..412
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            413..1552
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..3587
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /note="isoform a is encoded by transcript variant 1; DENN
                     domain-containing protein 2A; DENN/MADD domain containing
                     2A"
                     /codon_start=1
                     /product="DENN domain-containing protein 2A isoform a"
                     /protein_id="NP_056504.3"
                     /db_xref="CCDS:CCDS43659.1"
                     /db_xref="GeneID:27147"
                     /db_xref="HGNC:HGNC:22212"
                     /db_xref="MIM:620120"
                     /translation="MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSL
                     NIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPG
                     TESTEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVL
                     KQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVH
                     PSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHA
                     GEGDKDGKPGIGFRKEKRNLPPLPSLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKS
                     YEFEDLLQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHGRC
                     LGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPS
                     KISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSME
                     SNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFE
                     YFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVP
                     VQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILD
                     EVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEH
                     VDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTY
                     IPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSI
                     LPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHY
                     SLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGL
                     FEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK"
     exon            1553..1680
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1802
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..2003
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2097
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2148
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2336
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2446
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2516
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2594
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2735
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2884
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3062
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3104
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3222
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3468
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3555
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3874
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /note="hexamer: ATTAAA"
     polyA_site      3874
                     /gene="DENND2A"
                     /gene_synonym="FAM31D; KIAA1277"
                     /note="major polyA site"
ORIGIN      
        1 gcagatcgtc gcggagccac ggcaggagga ggcaggggcc gcgggcgagc ctgcgctggg
       61 ccggccgagg gaagcgcgcc gctggggccg ggggcggcgg ggaccccacg ggagcgcgcg
      121 cggcggggac ccccaggggc ttgcgggcgg ccgggggagg ctcggcggac aaaggggcgg
      181 agggcggagg gccatggcgt ccccggcacc cgccgccgcc cgcccccgag ccgcgccgcc
      241 agccgtcccg gcccgccccg gagcccccaa gatgcgcccc agagcccgcg gagccgccgc
      301 ccgcggggag gtgacctgga actcccctcg gtactgacat gatgacagtg tgcaggccgg
      361 ccaagggcag ccacagccag actgaaaacc tgagctacaa attggctgac aaggtcaagg
      421 tggaaggtcc aaggactgag aaagaccctc gaaggcatcc actttagtcc tccattccat
      481 tcctagagac tgatcaggag tcaggcttca gaaggagtcc cctggaaggc ctccacaacc
      541 tcacgctaga gtcaagaatg gatatgttca gcttggatat gatcatcagt gacccagctg
      601 cagaagccag cagggctggg aagaagcagc tcagaggtgt tcagaaccct tgcccatctg
      661 ccagagccag accccggcac aagtccctca acataaagga caagatatca gaatgggaag
      721 ggaagaaaga ggtgcccact cctgcaccca gcaggagagc agacggacag gaggattatc
      781 tgccgtcctc tacggtggag aggaggagta gtgatggggt gagaactcag gtcacagagg
      841 ctaagaatgg aatgaggcca ggaacagaga gcacagagaa ggagaggaat aaaggagcag
      901 tgaacgtcgg gggacaggac ccagagccgg ggcaagacct aagccagcca gaacgggaag
      961 tggatcctag ctggggccga ggccgagagc caagacttgg caagctacgc tttcagaacg
     1021 atcccctctc cgtgctgaag caggtcaaga aactcgagca ggctttgaag gatgggtcgg
     1081 cagggctgga tccccagtta ccagggactt gttactcccc acactgccct cctgacaagg
     1141 cagaggcagg gtccaccctt cctgagaacc tgggaggcgg gagtggctca gaagtcagcc
     1201 agagggtcca cccctcggac ctggaaggca gggagcccac ccctgagctt gtggaggaca
     1261 ggaaaggttc atgcagaagg ccctgggacc ggagccttga gaacgtgtat aggggctcgg
     1321 agggttcccc cacaaagccc ttcatcaacc ctctgccaaa accccggaga acgttcaaac
     1381 atgccggaga aggggacaaa gatgggaagc ctggcatcgg cttcaggaaa gagaaaagaa
     1441 atctgcctcc tctgccctct ctacctcccc cgcctctgcc ctcctctccc ccaccttcct
     1501 ctgtgaacag aagactgtgg accgggagac agaaatccag tgcagaccac agaaagtcct
     1561 atgagtttga agatttactg cagtcttcct ctgagagcag cagggtggac tggtacgcgc
     1621 agactaagct ggggctgaca cgcactttat cggaggagaa cgtctatgaa gacattctag
     1681 atccgccaat gaaggagaac ccttatgagg acatcgagtt acatggtcgc tgcctgggaa
     1741 agaagtgtgt cttgaatttt cctgcttctc ccacctcttc catccctgac acactcacca
     1801 agcagtcatt gtccaaacct gcttttttcc gacaaaattc agagaggagg aacttcaagc
     1861 tgctggacac taggaagctg agtcgggatg gaactgggtc cccttccaaa atcagccctc
     1921 cctccactcc cagcagccct gatgacattt tctttaacct tggagaccca cagaacggca
     1981 ggaagaagag aaagataccc aagctggtgt tgcgaatcaa cgccatttat gaggtccgga
     2041 gaggaaagaa acgggtgaag aggctgtccc agtcaatgga gagcaactca ggaaaagtga
     2101 cagatgagaa cagtgagtct gacagtgaca cagaggagaa gctgaaagct cacagccagc
     2161 gcctggtcaa cgtgaagtcc cggctgaagc aggcgcctcg gtacccatca cttgcccggg
     2221 aactcatcga gtaccaggag aggcagctct tcgagtactt tgtggttgtg tctttgcaca
     2281 agaagcaggc cggggctgcc tacgtgccag aactcaccca acagttccct ctgaagttgg
     2341 aaaggtcttt caagttcatg agagaagctg aggaccaact gaaggccatt ccccagttct
     2401 gttttcccga tgccaaggat tgggttcctg tccagcagtt caccagtgaa acattctcat
     2461 ttgtcttaac tggagaagat gggagcagaa ggttcggtta ctgccgaaga ctgctgcctg
     2521 gaggcaaagg gaagcgcctt cctgaagttt actgcattgt gagccgcctg ggatgcttca
     2581 gcctcttttc aaggatcttg gatgaggtgg aaaaaagacg aggcatctct cctgccctgg
     2641 ttcagccact catgagaagt gtcatggaag cccctttccc agccctgggc aaaaccatcc
     2701 ttgtcaagaa cttcctgcca ggttcaggaa ctgaggtgat cgaactgtgc cgcccgctgg
     2761 actcccggct cgagcacgtg gactttgagt ctctcttctc ctccctcagc gtccgccacc
     2821 tggtctgtgt gtttgcctcc ctgcttctgg agaggagggt catcttcatt gcagacaagc
     2881 tcagcatcct gtccaagtgc tgccacgcga tggtggcgct gatctacccc ttcgcctggc
     2941 agcacaccta catcccggtg ctgccacccg ccatggtcga catcgtgtgc tcgccgacgc
     3001 ccttcctcat cgggctgctc tccagctcgc tgccactgct cagggagctg ccgctggaag
     3061 aggtccttgt ggttgacctc gtcaacagcc ggttcctcag acagatggac gatgaggact
     3121 ccatcctgcc ccggaagctt caggtggccc tggaacacat tctggaacag aggaacgagc
     3181 tggcttgtga gcaggacgaa gggcccctag acggcaggca cggtccagag tccagcccct
     3241 tgaacgaggt ggtgtctgaa gcctttgtcc gcttcttcgt ggagattgtg ggacactact
     3301 ctttgttcct gacgtcgggc gagcgtgagg agagaaccct gcagcgggag gccttccgca
     3361 aagctgtctc ctccaagagc ctccgccact tcctggaggt cttcatggag actcagatgt
     3421 ttcggggctt catccaggag cgggagctgc gccggcagga tgccaaaggt ctgtttgagg
     3481 tccgagccca agagtatctg gaaacactcc ccagtggaga gcacagcggt gtcaataagt
     3541 tcctgaaggg actaggcaat aaaatgaaat ttctccacaa gaaataactc tcagcctcaa
     3601 gggaaaactt cctcctagtg cagccctatg ctttaaaaac agttcctggt ggcctttctg
     3661 aaaggctggg tcccaggttg tcacggtgcg gaactggagg ccgcggtggc ttctggccga
     3721 ggctgggctc ttccctggat gaggacctgg gagccgcctg ggaggacagc cccagaaagg
     3781 gagcccgaga ccaggcgtgt cgccgacatg caaatgggtt gttttggtgg ttgggttttt
     3841 ttttttatct tagatattaa aagtaagaaa aatg
//
