LOCUS       NM_024898               2795 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DENN domain containing 1C (DENND1C), transcript
            variant 1, mRNA.
ACCESSION   NM_024898
VERSION     NM_024898.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Marat,A.L., Ioannou,M.S. and McPherson,P.S.
  TITLE     Connecdenn 3/DENND1C binds actin linking Rab35 activation to the
            actin cytoskeleton
  JOURNAL   Mol Biol Cell 23 (1), 163-175 (2012)
   PUBMED   22072793
  REMARK    GeneRIF: whereas connecdenn 1 and 2 activate Rab35 for endosomal
            trafficking, connecdenn 3 uniquely activates Rab35 for its role in
            actin regulation
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   Marat,A.L. and McPherson,P.S.
  TITLE     The connecdenn family, Rab35 guanine nucleotide exchange factors
            interfacing with the clathrin machinery
  JOURNAL   J Biol Chem 285 (14), 10627-10637 (2010)
   PUBMED   20154091
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC378383.1, BC033437.1 and
            BE674790.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024898.3.
            
            Summary: The protein encoded by this gene functions as a guanine
            nucleotide exchange factor for the early endosomal small GTPase
            RAB35, which regulates endosomal membrane trafficking and is
            involved in actin polymerization. The encoded protein activates
            RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This
            gene may play a role in linking RAB35 activation with the clathrin
            machinery. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026410.1, BC033437.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381480.7/ ENSP00000370889.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC378383.1         22-33
            13-2556             BC033437.1         1-2544
            2557-2795           BE674790.1         25-263              c
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2795
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="DENN domain containing 1C"
                     /db_xref="GeneID:79958"
                     /db_xref="HGNC:HGNC:26225"
                     /db_xref="MIM:613634"
     exon            1..109
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2498
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 31, member C; DENN
                     domain-containing protein 1C; connecdenn 3; DENN/MADD
                     domain containing 1C"
                     /codon_start=1
                     /product="DENN domain-containing protein 1C isoform 1"
                     /protein_id="NP_079174.2"
                     /db_xref="CCDS:CCDS45938.1"
                     /db_xref="GeneID:79958"
                     /db_xref="HGNC:HGNC:26225"
                     /db_xref="MIM:613634"
                     /translation="MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEA
                     MQMVPKFCFPFDVEREPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLP
                     WFEVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQG
                     IPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVL
                     LTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAER
                     VREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLK
                     AQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARL
                     EKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGGALLHSVKAKTQPAVKN
                     MYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQQRLPITQHFGKNRP
                     LRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSGEELDLLSEILDS
                     LSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQ
                     NASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSPLTEPLILH
                     LTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQPLDPSSD
                     PSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVADLKKC
                     FEG"
     exon            110..174
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            175..218
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            219..268
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..388
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            389..458
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            459..539
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            540..605
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            606..659
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            660..770
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            771..871
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            872..917
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1019
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1145
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1250
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1341
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1382
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1454
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1499
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1607
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1675
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1883
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2795
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="major polyA site"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="hexamer: AATAAA"
     polyA_site      2795
                     /gene="DENND1C"
                     /gene_synonym="FAM31C"
                     /note="major polyA site"
ORIGIN      
        1 acacaggaag ctgagccggc ttggggccca gcatacacag gcccccagga cccctgggga
       61 gagggccccg ctgggctggc cctgcaggga ccatggaatc cagagctgaa gggggctccc
      121 ctgctgtgtt tgattggttc ttcgaagcgg cctgccctgc ctccctgcag gaggatcccc
      181 ccatcctgcg gcagttccct ccagacttca gggaccagga agctatgcag atggtgccta
      241 aattctgctt cccttttgat gtggaaaggg agccccccag ccccgccgtg cagcatttca
      301 ccttcgccct cacagacctt gccggcaacc gcagatttgg tttctgccgc ctgcgggcgg
      361 gtacccagag ctgtctctgc atcctcagcc acctgccttg gttcgaggtg ttttacaagc
      421 tattgaacac agtgggagac ctcctagccc aggaccaagt caccgaggca gaggaacttc
      481 ttcaaaatct gtttcagcag tccctgtctg ggccccaggc ctcagtgggg cttgagctgg
      541 gcagcggagt gacggtctcc agcgggcagg gtatcccccc ccctacccgg gggaatagca
      601 agccgctttc ctgcttcgtg gccccggact ccggccgcct gccatccatc cctgagaaca
      661 ggaacctaac ggagctggtg gtggccgtga ctgacgagaa catcgtgggg ctgttcgcgg
      721 cgctcctggc cgagagaaga gtcctgctca ccgccagcaa actcagcacc ctgacctcgt
      781 gcgtccacgc gtcctgcgcg ctcctgtacc ccatgcgctg ggagcacgtg ctgatcccca
      841 cgctgccccc acacctgctg gactactgct gcgcgcccat gccctacctc attggagtgc
      901 acgccagtct cgccgagaga gtacgagaaa aagccctgga ggacgtcgtg gtgctgaacg
      961 tggacgccaa taccttggag acgaccttta acgacgtgca ggcgctgcct ccagacgtgg
     1021 tgtccctgct gaggctccgg ctcaggaagg tcgccctggc ccccggggaa ggggtgtccc
     1081 gtctcttcct caaagcccag gccctgctct tcggggggta ccgcgacgca ctcgtctgca
     1141 gcccgggcca gccagtgacc ttcagtgagg aagtcttctt ggcccagaag cctggggcac
     1201 ctctgcaggc cttccaccgg cgggctgtgc acctgcagct gttcaaacag ttcatcgaag
     1261 cccggctgga gaagctcaac aagggggagg gcttctcaga tcaattcgag caggagatca
     1321 ctggctgcgg ggcctcctca ggggcccttc gatcctatca gctctgggcc gacaatctaa
     1381 agaaaggtgg tggcgccctc ctgcactcag tcaaggccaa gacccaacca gccgtcaaga
     1441 acatgtaccg ctcggccaag agtggcttga agggggtgca gagccttcta atgtataagg
     1501 atggggactc tgtcctgcag agggggggct ctctgagggc cccagccctc cccagccgct
     1561 cagaccgcct gcagcaacgc ctcccaatca ctcagcactt tggaaagaac cggccccttc
     1621 gccccagcag gagacgccag ctggaagagg gaacttccga gcccccaggg gcggggacac
     1681 ccccactgag ccctgaggat gaggggtgcc cgtgggcaga agaagctctg gacagcagct
     1741 tcttggggtc tggagaagaa ctggatttgt tgagcgagat tctggacagt cttagcatgg
     1801 gagccaagag cgcaggcagc ctgagaccga gccagagttt agactgctgt cacagaggag
     1861 acctggacag ctgcttcagc ctgcccaaca taccaagatg gcaaccagac gataagaaac
     1921 taccagagcc ggagccccag cccctttccc tgccatccct gcaaaatgcc tcgtctttgg
     1981 atgccaccag ctcttcaaag gactccaggt cccagctgat accctcagag tccgaccaag
     2041 aagtcacgtc tccatcccag tcctcaacag cttctgcaga cccaagcatc tggggggacc
     2101 ccaaaccctc tcctctcaca gagcccctaa ttcttcatct caccccttcc cacaaggcag
     2161 ctgaagattc tacagcccag gaaaacccca ctccctggct ctccactgca cccactgagc
     2221 ccagccctcc agaaagcccc caaattctgg cccccacaaa gcccaacttt gatatagcct
     2281 ggacgtccca gccccttgat ccttcctcag accccagttc tctggaggac cccagagccc
     2341 ggcctcccaa agccctgctg gcagagcgcg ctcacctcca gccacgggag gaaccaggag
     2401 ccctgaattc ccctgctaca cccaccagca actgtcaaaa gtcccagccc agcagccggc
     2461 ccagagtcgc tgatcttaag aagtgctttg agggttaaga atcaggggtc caagagagac
     2521 cccagtccct caataaagcc acaagagccc aaaaaagctg gtttttttcc tggtgaattt
     2581 ctctggtgcc ctcactctgc tcggaaatcc atcccaccca cctctgtccc tccaagggca
     2641 gcctctctaa ctggctccta gcagggaatt ccaggaagcc tcctggtctt ctagaatcct
     2701 ggcaacctta caattcctct cggcatttgt cacttccatc tcagctaatg cacccaccag
     2761 ctcaaacaca ccaataaagc ttttgttaca tctca
//
