LOCUS       NM_001352964            5208 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens DENN domain containing 1A (DENND1A), transcript
            variant 3, mRNA.
ACCESSION   NM_001352964 XM_005252109
VERSION     NM_001352964.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5208)
  AUTHORS   Samma,Z.H., Khan,H.N., Riffat,S., Ashraf,M. and Rehman,R.
  TITLE     Unraveling the Genetic Associations of DENND1A (rs9696009) and
            ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females
            in Pakistan
  JOURNAL   Biochem Genet 62 (3), 2148-2165 (2024)
   PUBMED   37870708
  REMARK    GeneRIF: Unraveling the Genetic Associations of DENND1A (rs9696009)
            and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome
            Females in Pakistan.
REFERENCE   2  (bases 1 to 5208)
  AUTHORS   Larsen,C.B., Kudela,E. and Biringer,K.
  TITLE     Association of FSHR and DENND1A polymorphisms with polycystic ovary
            syndrome: a meta-analysis
  JOURNAL   JBRA Assist Reprod 27 (1), 60-70 (2023)
   PUBMED   36350975
  REMARK    GeneRIF: Association of FSHR and DENND1A polymorphisms with
            polycystic ovary syndrome: a meta-analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5208)
  AUTHORS   Sun,Y.V., Li,C., Hui,Q., Huang,Y., Barbano,R., Rodriguez,R.,
            Malaty,I.A., Reich,S., Bambarger,K., Holmes,K., Jankovic,J.,
            Patel,N.J., Roze,E., Vidailhet,M., Berman,B.D., LeDoux,M.S.,
            Espay,A.J., Agarwal,P., Pirio-Richardson,S., Frank,S.A., Ondo,W.G.,
            Saunders-Pullman,R., Chouinard,S., Natividad,S., Berardelli,A.,
            Pantelyat,A.Y., Brashear,A., Fox,S.H., Kasten,M., Kramer,U.M.,
            Neis,M., Baumer,T., Loens,S., Borsche,M., Zittel,S., Maurer,A.,
            Gelderblom,M., Volkmann,J., Odorfer,T., Kuhn,A.A., Borngraber,F.,
            Konig,I.R., Cruchaga,C., Cotton,A.C., Kilic-Berkmen,G., Freeman,A.,
            Factor,S.A., Scorr,L., Bremner,J.D., Vaccarino,V., Quyyumi,A.A.,
            Klein,C., Perlmutter,J.S., Lohmann,K. and Jinnah,H.A.
  TITLE     A Multi-center Genome-wide Association Study of Cervical Dystonia
  JOURNAL   Mov Disord 36 (12), 2795-2801 (2021)
   PUBMED   34320236
  REMARK    GeneRIF: A Multi-center Genome-wide Association Study of Cervical
            Dystonia.
REFERENCE   4  (bases 1 to 5208)
  AUTHORS   Zhu,Y.N., Zhang,Y.T., Liu,Q., Shen,S.M., Zou,X., Cao,Y.X.,
            Wang,W.J., Yi,L., Gao,Q., Yang,W.D. and Wang,Y.
  TITLE     Association analysis between the tag single nucleotide
            polymorphisms of DENND1A and the risk of polycystic ovary syndrome
            in Chinese Han women
  JOURNAL   BMC Med Genet 21 (1), 14 (2020)
   PUBMED   31941453
  REMARK    GeneRIF: The tagging SNPs rs2479106 and rs2468819 in the DENND1A
            gene are associated with polycystic ovary syndrome (PCOS) in the
            Chinese population, whereas rs2670139, rs2536951 and rs2479102 are
            not correlated with PCOS in the same population
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5208)
  AUTHORS   McAllister,J.M., Han,A.X., Modi,B.P., Teves,M.E., Mavodza,G.R.,
            Anderson,Z.L., Shen,T., Christenson,L.K., Archer,K.J. and
            Strauss,J.F.
  TITLE     miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2
            Expression and Androgen Biosynthesis
  JOURNAL   Endocrinology 160 (8), 1964-1981 (2019)
   PUBMED   31184707
  REMARK    GeneRIF: decreased miR-130b-3p expression in PCOS theca cells,
            which was correlated with increased DENND1A.V2, cytochrome P450
            17alpha-hydroxylase (CYP17A1) mRNA and androgen biosynthesis.
REFERENCE   6  (bases 1 to 5208)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5208)
  AUTHORS   Marat,A.L. and McPherson,P.S.
  TITLE     The connecdenn family, Rab35 guanine nucleotide exchange factors
            interfacing with the clathrin machinery
  JOURNAL   J Biol Chem 285 (14), 10627-10637 (2010)
   PUBMED   20154091
REFERENCE   8  (bases 1 to 5208)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5208)
  AUTHORS   Allaire,P.D., Ritter,B., Thomas,S., Burman,J.L., Denisov,A.Y.,
            Legendre-Guillemin,V., Harper,S.Q., Davidson,B.L., Gehring,K. and
            McPherson,P.S.
  TITLE     Connecdenn, a novel DENN domain-containing protein of neuronal
            clathrin-coated vesicles functioning in synaptic vesicle
            endocytosis
  JOURNAL   J Neurosci 26 (51), 13202-13212 (2006)
   PUBMED   17182770
REFERENCE   10 (bases 1 to 5208)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006450.13, AL390774.10, AL161790.23 and AL445489.10.
            
            On Aug 14, 2020 this sequence version replaced NM_001352964.1.
            
            Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major
            mechanism for internalization of proteins and lipids. Members of
            the connecdenn family, such as DENND1A, function as guanine
            nucleotide exchange factors (GEFs) for the early endosomal small
            GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor
            protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35
            activation with the clathrin machinery (Marat and McPherson, 2010
            [PubMed 20154091]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.20888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394215.7/ ENSP00000377763.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC006450.13        102642-102879
            239-309             AC006450.13        153747-153817
            310-353             AL390774.10        142574-142617       c
            354-403             AL390774.10        119501-119550       c
            404-523             AL390774.10        107690-107809       c
            524-593             AL390774.10        26707-26776         c
            594-674             AL390774.10        21278-21358         c
            675-728             AL390774.10        17013-17066         c
            729-839             AL390774.10        2000-2110           c
            840-940             AL161790.23        99259-99359         c
            941-986             AL161790.23        78319-78364         c
            987-1088            AL161790.23        52052-52153         c
            1089-1214           AL161790.23        26453-26578         c
            1215-1319           AL445489.10        100557-100661       c
            1320-1407           AL445489.10        100112-100199       c
            1408-1448           AL445489.10        97503-97543         c
            1449-1520           AL445489.10        95040-95111         c
            1521-1577           AL445489.10        93457-93513         c
            1578-1709           AL445489.10        83124-83255         c
            1710-1763           AL445489.10        54540-54593         c
            1764-1852           AL445489.10        46166-46254         c
            1853-1981           AL445489.10        30494-30622         c
            1982-2240           AL445489.10        26419-26677         c
            2241-5208           AL445489.10        22422-25389         c
FEATURES             Location/Qualifiers
     source          1..5208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..5208
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /note="DENN domain containing 1A"
                     /db_xref="GeneID:57706"
                     /db_xref="HGNC:HGNC:29324"
                     /db_xref="MIM:613633"
     exon            1..238
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3434
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /note="isoform 3 is encoded by transcript variant 3; DENN
                     domain-containing protein 1A; connecdenn 1; DENN/MADD
                     domain containing 1A"
                     /codon_start=1
                     /product="DENN domain-containing protein 1A isoform 3"
                     /protein_id="NP_001339893.1"
                     /db_xref="CCDS:CCDS94479.1"
                     /db_xref="GeneID:57706"
                     /db_xref="HGNC:HGNC:29324"
                     /db_xref="MIM:613633"
                     /translation="MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQ
                     EVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSY
                     LPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDT
                     RELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAML
                     YPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE
                     TPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEP
                     ITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMG
                     EYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLK
                     QKDIAENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQLQRLRPTRPPPK
                     IQRSRPVRPPRPHVVKRPKSNIAVEGRRTSVPSPEHLVKPLRHYAVFLSEDSSDDECQ
                     REEGPSSGFTESFFFSAPFEWPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPD
                     RAASIDLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSER
                     SRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDS
                     ILNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSER
                     LQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSG
                     STLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAG
                     PFGAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMPMGTHTSPLQPL
                     GPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQ
                     ARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLRKQWETFE"
     exon            239..309
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            310..353
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            354..403
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            404..523
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            524..593
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            594..674
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            675..728
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            729..839
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            840..940
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            941..986
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1088
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1214
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1319
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1407
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1448
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1520
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1577
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1709
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1763
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1852
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1981
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2240
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..5208
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5189..5194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /note="hexamer: AATAAA"
     polyA_site      5208
                     /gene="DENND1A"
                     /gene_synonym="FAM31A; KIAA1608"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcgccg gcgaccatgg cgttcgccgg gctggagcga gtacattaac ccctggaggc
       61 ggcggcggcg gcgagggagc gagcctcgag cgggcgggcc ccagcctgag ggaagggagg
      121 aaggggcggg gagagcgcca gagggaggcc ggtcggccgc gggcgggcgg gcagcgcagc
      181 gccgagcggg gcccgcgggc ccatgaggag gcctggggac catgggctcc aggatcaagc
      241 agaatccaga gaccacattt gaagtatatg ttgaagtggc ctatcccagg acaggtggca
      301 ctctttcaga tcctgaggtg cagaggcaat tcccggagga ctacagtgac caggaagttc
      361 tacagacttt gaccaagttt tgtttcccct tctatgtgga cagcctcaca gttagccaag
      421 ttggccagaa cttcacattc gtgctcactg acattgacag caaacagaga ttcgggttct
      481 gccgcttatc ttcaggagcg aagagctgct tctgtatctt aagctatctc ccctggttcg
      541 aggtatttta taagctgctt aacatcctgg cagattacac gacaaaaaga caggaaaatc
      601 agtggaatga gcttcttgaa actctgcaca aacttcccat ccctgaccca ggagtgtctg
      661 tccatctcag cgtgcattct tattttactg tgcctgatac cagagaactt cccagcatac
      721 ctgagaatag aaatctgaca gaatattttg tggctgtgga tgttaacaac atgttgcatc
      781 tgtacgccag tatgctgtac gaacgccgga tactcatcat ttgcagcaaa ctcagcactc
      841 tgactgcctg catccacggg tctgcggcga tgctctaccc catgtactgg cagcacgtgt
      901 acatccccgt gctgccgccg catctgctgg actactgctg tgctcccatg ccctacctca
      961 taggaatcca tttaagttta atggagaaag tcagaaacat ggccctggat gatgtcgtga
     1021 tcctgaatgt ggacaccaac accctggaaa cccccttcga tgacctccag agcctcccaa
     1081 acgacgtgat ctcttccctg aagaacaggc tgaaaaaggt ctccacaacc actggggatg
     1141 gtgtggccag agcgttcctc aaggcccagg ctgctttctt cggtagctac cgaaacgctc
     1201 tgaaaatcga gccggaggag ccgatcactt tctgtgagga agccttcgtg tcccactacc
     1261 gctccggagc catgaggcag ttcctgcaga acgccacaca gctgcagctc ttcaagcagt
     1321 ttattgatgg tcgattagat cttctcaatt ccggcgaagg tttcagtgat gtttttgaag
     1381 aggaaatcaa catgggcgag tacgctggca gtgacaaact gtaccatcag tggctctcca
     1441 ctgtccggaa aggaagtgga gcaattctga atactgtaaa gaccaaagca aatccggcca
     1501 tgaagactgt ctacaagttc gcaaaagatc atgcaaaaat gggaataaaa gaggtgaaaa
     1561 accgcttgaa gcaaaaggac attgccgaga atggctgcgc ccccacccca gaagagcagc
     1621 tgccaaagac tgcaccgtcc ccactggtgg aggccaagga ccccaagctc cgagaagacc
     1681 ggcggccaat cacagtccac tttggacagc tgcagagact gcgtcccacc cgaccgcctc
     1741 ccaagataca gcgctcgagg cccgtgcgcc cacctcgtcc acatgttgtt aagagaccaa
     1801 agagcaacat cgcagtggaa ggccggagga cgtctgtgcc gagccctgag cacctggtaa
     1861 agcccttgcg acactatgcg gtcttcctct ccgaagactc ctctgatgat gaatgccagc
     1921 gggaagaggg cccgagctct ggcttcaccg agagcttttt cttctccgct ccctttgaat
     1981 ggccgcagcc gtatcggaca ctcagggagt cagacagcgc ggaaggcgac gaggcagaga
     2041 gtccagagca gcaagtgcgg aagtccacag gccctgtccc agctccccct gaccgggctg
     2101 ccagcatcga ccttctggaa gacgtcttca gcaacctgga catggaggcc gcactgcagc
     2161 cactgggcca ggccaagagc ttagaggacc ttcgtgcccc caaagacctg agggagcagc
     2221 cagggacctt tgactatcag aggctggatc tgggcgggag tgagaggagc cgcggggtga
     2281 cagtggcctt gaagcttacc cacccgtaca acaagctctg gagcctgggc caggacgaca
     2341 tggccatccc cagcaagccc ccagctgcct cccctgagaa gccctcagcc ctgctcggaa
     2401 actccctggc cctgcctcga aggccccaga accgggacag catcctgaac cccagtgaca
     2461 aggaggaggt gcccacccct actctgggca gcatcaccat cccccggccc caaggcagga
     2521 agaccccaga gctgggcatc gtgcctccac cgcccattcc ccgcccggcc aagctccagg
     2581 ctgccggcgc cgcacttggt gacgtctcag agcggctgca gacggatcgg gacaggcgag
     2641 ctgccctgag tccagggctc ctgcctggtg ttgtccccca aggccccact gaactgctcc
     2701 agccgctcag ccctggcccc ggggctgcag gcacgagcag tgacgccctg ctcgccctcc
     2761 tggacccgct cagcacagcc tggtcaggca gcaccctccc gtcacgcccc gccaccccga
     2821 atgtagccac cccattcacc ccccaattca gcttcccccc tgcagggaca cccaccccat
     2881 tcccacagcc accactcaac ccctttgtcc catccatgcc agcagcccca cccaccctgc
     2941 ccctggtctc cacaccagcc gggcctttcg gggcccctcc agcttccctg gggccggctt
     3001 ttgcgtccgg cctcctgctg tccagtgctg gcttctgtgc ccctcacagg tctcagccca
     3061 acctctccgc cctctccatg cccaacctct ttggccagat gcccatgggc acccacacga
     3121 gccccctaca gccgctgggt cccccagcag ttgccccgtc gaggatccga acgttgcccc
     3181 tggcccgctc aagtgccagg gctgctgaga ccaagcaggg gctggccctg aggcctggag
     3241 accccccgct tctgcctccc aggccccctc aaggcctgga gccaacactg cagccctctg
     3301 ctcctcaaca ggccagagac ccctttgagg atttgttaca gaaaaccaag caagacgtga
     3361 gcccgagtcc ggccctggcc ccggccccag actcggtgga gcagctcagg aagcagtggg
     3421 agaccttcga gtgagccggg ccctgagggt gggggatgca ccgaggcccg agggtccgtc
     3481 cactgctgcg gttccgaggc tcccccgcca ctctctctct gcccaggttc tgctggtggg
     3541 aagggatggg acccctctct gctgccccct cctcccctcc acactgccca tctctgatgt
     3601 ctggccctgg ggaatggcac cagttccagc ctgggaatca acccagttcc tgagtgccca
     3661 tcccaccccg cggttgcctc tcctcggcac ccttgattgg gttttgcact aaagaggtca
     3721 gctgggccaa tgatattgct ccagaccgag tcctacccac cttcccccgg aagtgtccca
     3781 agaggctccg aaggcctccc ctccgagccc agctctcctg tctcctccac agccaggccc
     3841 tgcacgccca cctcctcgga cacaggtgac agggttaccc tccagtttga gctcatctgc
     3901 acgagacaca ggtagcttgg ggttgaagtt aggactcctc ctgggctgga ggatttacct
     3961 ggtggggcac ttccagactg tttctagcaa tatacacaca cgttctttcc tgtgtcttca
     4021 ccccaaaact tcagttgatt ctgacctggg aggatctggg gaccaggggg tcttgggctg
     4081 ccttgtgata cacagcccca gccaccctgc acgggggctg cgagcaccag caactttgat
     4141 ttatagaagg aaaatggaaa cccccatctg agtattttgg gaggagcccc cagccctcat
     4201 ccagctctgg cacgctgata cctccaggta ctcccctcac tgtcaaagct ggggctcagc
     4261 ctcttgtcat ctggagcttt gtgggcaaag ctgagaagct gcaacccaga tttcaaccca
     4321 aaaaggtcaa gctgaatgcc tcagactgat gtggaaggca gctggccttc ctgggttgga
     4381 acgaggcagt ggccctgagc cccttctcca gggccaggta gaaaggacaa acttggtctc
     4441 tgcctcgggg aagcaggagg agggctagaa gccagtccct ccccacctgc ccagagctcc
     4501 aggccagcac agaaattcct gaggccaacg tcaccaaagt tagattgaat gtttattatc
     4561 tttctttttc ctttttacct tattgatttg atgaatcttg aaatggattc atttccataa
     4621 accaagttaa agtatggccc gaccatttaa gaaaacaacc atctgagaca cgcaggaaat
     4681 tgtgagcatt tcgacccgag ctctcatttc ctatttgtga agggtcagac acagtctacc
     4741 caggggtgtc tgggggacaa gggggtctct ggagatgtca cccagggagc cccctctatg
     4801 tctgagaggc tgccactgct gcacatgctc agtgaggctt ggcggccatc ctggcacatg
     4861 gctcttcctg ggtcaaccgt gacctgtctg gctcaggaat gggctctggc tgctggggga
     4921 gccgtgtcac tcctgggcca tgggggcacc tcctgggcac ttaggtgttt cagcatagat
     4981 tccagtttcg caccctgggc agacccccag gccccatccg ggatagggca gaggaggtgc
     5041 tggcggcccc agggaaggag ggtgtgtacc ccaaggcccc ctggctgtgc tgaggggctg
     5101 gggtgagcgc tccatgttca catgagcact gctgcctctt cacttgtggg actttttgca
     5161 aacccaagga tgaactttgt gtgcattcaa taaaatcatc ttggggaa
//
