LOCUS       NM_001080392            7309 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens DENN domain containing 11 (DENND11), mRNA.
ACCESSION   NM_001080392 XM_001126074
VERSION     NM_001080392.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7309)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004918.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080392.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032973.2, SRR12921934.1162421.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536163.6/ ENSP00000445768.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC004918.1         70742-70754         c
            14-281              AC004918.1         70474-70741         c
            282-381             AC004918.1         55147-55246         c
            382-540             AC004918.1         54066-54224         c
            541-694             AC004918.1         42655-42808         c
            695-833             AC004918.1         34875-35013         c
            834-965             AC004918.1         33775-33906         c
            966-1116            AC004918.1         33492-33642         c
            1117-1185           AC004918.1         32760-32828         c
            1186-7309           AC004918.1         25316-31439         c
FEATURES             Location/Qualifiers
     source          1..7309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..7309
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /note="DENN domain containing 11"
                     /db_xref="GeneID:57189"
                     /db_xref="HGNC:HGNC:29472"
                     /db_xref="MIM:620122"
     exon            1..281
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1381
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /note="protein LCHN; predicted protein of HQ2561"
                     /codon_start=1
                     /product="DENN domain-containing protein 11"
                     /protein_id="NP_001073861.1"
                     /db_xref="CCDS:CCDS47726.1"
                     /db_xref="GeneID:57189"
                     /db_xref="HGNC:HGNC:29472"
                     /db_xref="MIM:620122"
                     /translation="MVEQGDAAPLLRWAEGPAVSLPQAPQPQAGGWGRGGGGGARPAA
                     EPPRRREPEEPAAPEVLLQPGRLELGDVEEDQVVAVFVVTFDPRSGNMVEWCLPQDID
                     LEGVEFKSMASGSHKIQSDFIYFRKGPFFGLACFANMPVESELERGARMKSVGILSPS
                     YTLLYRYMHFLENQVRHQLEMPGHYSHLAAFYEDKKGVLHAGPGRGSSLPPVYWLPSI
                     HRYMYPEMKITHPAGCMSQFIKFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYC
                     CCCLANVSLPGIGGTIPESKPFFYVNVADIESLEVEVSYVACTTEKIFEEKRELYDVY
                     VDNQNVKTHHDHLQPLLKINSADREKYRRLNEQRQMLLYSQEVEEDYNPCEEDLFVLF
                     FLEQNNRIFQTLLEVSASQDKTLTAEHARGMGLDPQGDRSFLLDLLEAYGIDVMLVID
                     NPCCP"
     exon            282..381
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            382..540
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            541..694
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            695..833
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            834..965
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1116
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1185
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..7309
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7285..7290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /note="hexamer: ATTAAA"
     polyA_site      7309
                     /gene="DENND11"
                     /gene_synonym="KIAA1147; LCHN; PRO2561"
                     /note="major polyA site"
ORIGIN      
        1 gcctcgccta gccatggtgg agcagggaga cgcggcgccg ctgctgcgct gggccgaggg
       61 ccccgccgtc tccctgccgc aggccccgca gccgcaggcg ggaggctggg gccggggcgg
      121 cggcgggggc gcccggccgg ccgcggagcc gccccggagg cgggagcccg aggagccggc
      181 cgccccggag gtgctgctgc agcccgggcg cctggagctg ggcgacgtgg aggaggacca
      241 ggtggtggcc gtgttcgtgg tcaccttcga cccccgctcg ggaaacatgg tagaatggtg
      301 cttacctcaa gatattgacc ttgaaggtgt tgagttcaag tctatggcca gtgggtccca
      361 taaaatccaa tctgatttca tctatttccg aaaggggccc ttcttcggcc tggcctgctt
      421 tgccaacatg cccgtggaga gcgagctgga acgtggcgcg cggatgaagt ctgtgggcat
      481 cctctctccc tcctacacac tgctttaccg ctacatgcac ttcttggaga accaggttcg
      541 gcaccagttg gagatgccag gacattactc tcatctggct gccttctatg aggacaaaaa
      601 gggggtgctc catgctggtc ccggcagagg cagcagcctg ccccctgtct actggctgcc
      661 ttccatccac cgatacatgt accctgagat gaagatcaca cacccagctg gctgcatgtc
      721 tcagtttata aagttctttg gagaacagat cctcatcctc tggaaatttg ccttacttcg
      781 aaagcgcatt ttgatatttt ctcccccacc tgtgggcgtg gtgtgctata gagtgtactg
      841 ctgctgctgc ttggccaacg tttcactgcc tggcatcggg ggcaccattc ctgagtccaa
      901 acctttcttc tacgtgaacg tggctgacat cgagagcctg gaggtagagg tgtcctatgt
      961 ggcctgcacc acagagaaga tattcgagga gaagcgggag ctgtatgacg tctacgtgga
     1021 taaccagaat gtgaagacac accacgacca cctgcagccg ctgctgaaga tcaacagtgc
     1081 tgacagggag aagtaccgcc ggctcaacga gcagaggcag atgctgttgt actcccagga
     1141 agtagaagaa gactacaacc cttgtgaaga ggacctcttc gtgctgtttt tcctagaaca
     1201 aaacaaccgg atatttcaga ctttgttgga ggtgtctgcc agtcaagaca aaactctgac
     1261 agcagagcat gcccggggca tgggcctaga cccccaagga gaccggagct ttctcctgga
     1321 cctgctggag gcctatggca ttgatgtcat gctggttatc gacaacccct gttgcccgta
     1381 ggaggagcca acaggactgg gagccacttc acgtgggatg tcagcagccc ggagttcacc
     1441 ccagggcccc agagggcctc attttttatt aagttgacac aaaggaatat tgtttatact
     1501 ttccaacaaa cataattttt gcaatttcct ttctgccctt ttccctagag ataaggtgag
     1561 atcaccttgg ttttgtgtcc tgccatgtta ggatattgga atctgccact ttctcccaga
     1621 gctgctggtc ctctgggctt ggtcatggga gttgtatcac taggagtagg ctgagctctg
     1681 gaaacattgg gatggactgt tcagaaagtc tgtgtggtct ttgtcccttg atgtatttga
     1741 gaataagaca accacctgtc ccctgtggcc ttagatgttc atctgcctaa aggcagaaac
     1801 tagaccagat gatcttttaa ggtttttagt agttctagga gtctatagtc ttgggatcaa
     1861 atcccttttc ttgttcatta gggcaacttt atgtcttctc tgtttacttg agtagggacc
     1921 acaaagaggg aaaaaaggat gtttctgaca ccaaatatga gcttatctta tggtcagaat
     1981 gaaagaggtt gcttatcagt gagctgaaaa ctaaaattat agaatgaagc ctggaaacct
     2041 tcctcaaagt aacttgatgg tggccatgca atgtaatgtt cctctttgtc tgaaccttcc
     2101 tcttcttggg atgaattggt gaattgctaa gggccaatgc tggccttgga gcttgcaagc
     2161 aaattaattt tccagtttag tctcttaagg gttcaataat gctcttggag taagttgggt
     2221 atttttaaag gctgaagttt ggactaccgg aggatagagc aattgaagtt cgagcaggat
     2281 ggagaagcca ctctaagtct cttcatctgg acacgaattc tctggaggca ttagcagcag
     2341 cacctctggg tcaacacaga tttactggat tccaaaatct agcaaggatc tgagctggtt
     2401 aactcagagg gtggagcatg atgctaacaa gacggtttat cattttggac ccctcacaaa
     2461 cacacttctc tttagcagag gtgacattcc ttaggctaaa taattggatc cagggacata
     2521 acagatttgt tgagagaaaa tgtggcagtg ccttcacccg ggacagtggt caggaagccc
     2581 tgagcatccc tgatggattt atccatcctc ttctgaagtg ctctgctcta ggctgggtcc
     2641 tgttgccacc tgcctgttct ctggttggct tttgcaggag ggcagcttac gtgtttgtca
     2701 accagttaga aagccagttc ctgtgggtcg agtttaggcc tttttggcca tagttgagaa
     2761 ttttgacttg ggatactggg ttgttggtga caaataatgt cttccttttc ccccttcccg
     2821 cctggctcgg ttatgggaat agccgtcagt gcatccatgt ctgtgaccaa cacccagcca
     2881 gactaatgta cacagcaggg agaaataaca ttcaaatggt ggttcacaca tctcatctca
     2941 agataagatt cttagggttc actgctttat tcaaaagtgt tttcactgta gctccttcat
     3001 atggaatatc aaaactgaag aaattcacat gtggaaatgc aaatagacat tgattaatca
     3061 aggtagcatc tttatgtaaa tatataaata agtttgggca ttgaaatgta aactgtacag
     3121 ctaatagact tttctcctct gcaatgtggg ttgctgtcat ttcagtaatg tgtatgttta
     3181 caaaagaaaa aaaaatctgt gtttcgaggt tgaagcctca ccttttattc tcctttacat
     3241 gcaaccctct cttcttgcct ctcaagggtt gaggggtcct ttctgtcaag taatggttat
     3301 ttttcgtggt atcctgaggt tcagggtgtt ttaagctggg ggtaggtggt tagaggcagg
     3361 agtagaagtg aaaggaaagg tctgattctc ctagaggaca caagaagacc tcctttttct
     3421 ggaattaggg aatctgccgg aaggagctgt ttgaggcatt tctgctctga gccttctata
     3481 tgcaaacact gcagttttaa ctgcaagctc agaagtgctg gtgtaaacat agcagggtga
     3541 gaatgaagtt cctgtttttt cctttgaatg gtgagtcagg gcttctgggt tcccttaact
     3601 ttgtgcttgt ctcggtagct ttctgtctca catctccacg tgtccaccct cctgctcatg
     3661 cagagggcca gggtatgggt ggccccagag gagaacgtgc cagtgaggca gtgccatgtt
     3721 tcaggtcata ggggccttgg gctcagctga ccccaatgca gaacttctcc ctttaagaga
     3781 gattccaata aattggtcct tccctacctt gccagcttct tcataggacc agaaatcttg
     3841 tgcagagcct ctgcttggct gaacagcgtg tgctttatct cttcagttac ctttgccact
     3901 gttgagcatc ctcagagtat gtcttgcctg ggctatgaag tggagcctgt ggcttcggaa
     3961 atcacctttc gaagccttgc tctatgccag attctgctcc ccaacatgac agattaacag
     4021 gcacaaccta ggatcctttg ctaccagttc tctactaggg aattccacag tggcagcaga
     4081 agctaggagc catgtggacc tgcttttctg ccagtcttga aatattttct gagaaaccat
     4141 ctgcttttgt tcagaagaaa gtgctgaaca tcgttcacag acttctaggt ctgtaagctc
     4201 tttaggggcg ggcattatga tgaccaccgg cctcctggag gagggttgga tacctgtggt
     4261 gtgacacctt ctgccaccat ctcctgccgg gcctcagccc tcgcctgcct gagcaggcct
     4321 agttctcctg tgaagctgtc agcctgatct catgccacac tgtgaaatga actatgtgcc
     4381 agtttggaaa tgattgctga cctgagatgc tggctgggct gccctgttgt tcctgaataa
     4441 gtcagaagaa gttccaggtg ggagtggaat tcaggtttgg ggctcgttgg tatccatgca
     4501 aaatatgaca aaggcctgtt caagagggca ttttcaattc tgtaggctca gcagatgata
     4561 ctgcccagcc tttgggaaaa tgtccagttg gcccctggct taggactctc cacaaggagt
     4621 ttgaaatggt agggcttatc ccctaccaga ctaaaagtat ggcccaaatt atgtgtttag
     4681 aatttgcttg gcctttaaac acgaaccatt ccctatgcct ggtagagacc attccagtgt
     4741 cagtgtccca cctgggacct gtacagtcct cagtaaatta tgattgcaat gaattagaag
     4801 gcttttgcct tccatatcca tcatccatta tagcatctgt gcttccacct ggttaggggg
     4861 agggaagctg aaatcattga tgtatcaata gaagtaattt agcttaggaa cttgcatcta
     4921 taacttacct tgttttgttc cactttaaag tcaagacaag aaagttaaga tagcacacag
     4981 gtgcacatgc ttccagatgc cacatgtgaa catttgttga tcatgtgact accgatgaca
     5041 ctttagctag aagataaatt aaatcttagc taaatcattg tttttccttc tggtggctat
     5101 gaggatgaat ttgctctcag tcttgatgca ctgaaagccc ttcaaacaca gtaaaagatg
     5161 aaatcactca tctttaaact gaggccttca gggaagcttt tgtaaaggac agtaatgaat
     5221 taggctttca gttttaggac atcaaccctc cgagaaaagg cagaaacccg agggaccatt
     5281 tatttccctt cgaaactgta tagcccaggg aatggattga gatgctttct ccagaccctg
     5341 tataggtcaa ccttgcagag gtaaaggagg aggggcaggt ggatgaataa aataggataa
     5401 tgctcagctt ggcagtggac ttgccttagt gtgatgacag gtctaacatg ggcaagacaa
     5461 ttagaatggg gaccaatatg ccaggcatgg gcttttatct ccctagtaga tcccaagcta
     5521 gtaggcttgg attctgccaa atggccagcc ctcctgtctt ctccccgtac cttgtagtta
     5581 gaccgaggtg agaatcctgc tgaccccagt cccatcccct ctcatttcag gaaaaccctt
     5641 ttgtgattca ggtaggggga gaggaggagt taagggctcc gtttactccc aagtcatgga
     5701 tttttaatat tccattttta tcactaatat acctctcttc ctagaagcta ctggagtatt
     5761 gagtgttgtg ggaaaaggct aactgtgaat taagttaatg tttttcttat aagaaatgga
     5821 agtttatttt tttattgata ttactatgtg atgaactgag tatgcatata ctgaaatgga
     5881 aggaaatttt aaaactatta ttctagaaga aatgggcagt tttgtaattt ggtggtggct
     5941 gagaccccat agaagtttta ctatgtaaat aatttggaga gtgaataagg agattgtgct
     6001 atgaaatcct gacagcgctc tttaggaggc agacttgaca gtcctaggaa ggttgacata
     6061 aaaataccaa ccttcagtaa agctctagta caaaaaaggg taaatgtcat cattcttatt
     6121 tttaggcctc tttcttgaga gaggtgggag tgggaggtag tgttataact ggcactttaa
     6181 tttgtttttg gaactagaat ttaggggcag ttggatgaaa ttgcaaattt agaaggggaa
     6241 taagaatttt ctagtgctat ataaagaaat gatgatggag acaaaagcct tgctttcctc
     6301 tttttagaat ttattttcga tttttagcat actgtggggc ttttagagct aatatgatct
     6361 aaattcagaa aatttaattt tcatagtagg ccaggtgtga attacttatg tttgctatag
     6421 aatgcttatt tagactaaca ataaatttac tttgctttct aaggccagtc agcgaatgtg
     6481 gggatgaggc aggatgtttt aaatgagcca gagatgatcc acaaagtgaa cagtcgacac
     6541 agaggtcttt gagttggatg gttgcaaata tattgacatt agagtgaaaa ctccttcctt
     6601 tgggtaaact aaagaaagat aaagtatact aaaaaatttt aagatggtgt tatacaaaaa
     6661 aaagtttggg tctaacgtgt ccacaaagac tgtcaagtga agaatggtgg agattcttgg
     6721 tgtttgagca gccaacctgg atgagtgact tcagggacag agcagaggaa agcaaaatga
     6781 atttccttta tttacccaaa acttgttgac tgaatttttg tataggtccg ggaaaataag
     6841 cctaaacaaa tagttgtagc cttagaaaaa ctgttttccc atttctttct gagttagaat
     6901 cagcatagcc tccctgtcgc cttaaatgta aaaatcctat tttgattaat accccagcct
     6961 aagagttata gcaatacgag agactgaatc tatttttgtt tcgggtcttt acctcatagt
     7021 atgaaattag taagacactg catagatttt gccctgaata ctggtgtgcc caggtatgcc
     7081 gtgctctctc tctgtttcca gtggtggtaa ttttaaggcc taaagaaagc tggggttaat
     7141 cctgaagcta aaagtaaatg tttcttgaat tgattttgtt ctgtggtaca aataacatct
     7201 atgaatatca tatctgtata tatctgaacc aagttgtgtg cagagaggtt gatataacta
     7261 tatttacaga aaatgatttt tacaattaaa gttcacattt taacatgaa
//
